Crystal structure of human bleomycin hydrolase, a self- compartmentalizing cysteine protease

Structure

Volumn 7, Issue 6, 1999, Pages 619-627

  O'Farrell, Paul A ^a   Gonzalez, Fernando ^b   Zheng, Wenjin ^b   Johnston, Stephen Albert ^b   Joshua Tor, Leemor ^a  

^a W M Keck Structural Biology Laboratory   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Alzheimer's disease; Bleomycin hydrolase; Cancer; Crystal structure; Drug resistance; Nucleic acid binding

Indexed keywords

BLEOMYCIN; CYSTEINE PROTEINASE; HYDROLASE;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DNA BINDING; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME STRUCTURE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; STRUCTURE ANALYSIS;

EID: 0033152757     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(99)80083-5     Document Type: Article

References (44)

1. Lazo, J.S. & Sebti, S.M. (1988). In Anticancer Drug Resistance. (Kessel, D., ed.), pp. 267-279, CRC Press, Boca Raton, FL.
2. Schwartz, D.R., Homanics, G.E., Hoyt, D.G., Klein, E., Abernethy, J. & Lazo, J.S. (1999). The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance. Proc. Natl Acad. Sci. USA 96, 4680-4685.
3. Montoya, S.E., Aston, C.E., DeKosky, ST., Kamboh, M.I., Lazo, J.S. & Ferrell, R.E. (1998). Bleomycin hydrolase is associated with risk of sporadic Alzheimer's disease. Nat. Genet. 18, 211-212.
4. Vesanto, E., Varmanen, P., Steele, J.L. & Palva, A. (1994). Characterization and expression of the Lactobacillus helveticus PepC gene encoding a general aminopeptidase. Eur. J. Biochem. 224, 991-997.
5. Wohlrab, Y. & Bockelmann, W. (1993). Purification and characterization of a second aminopeptidase (PepC-like) from Lactobacillus delbrueckii subsp. bulgaricus B14. Int. Dairy J. 3, 685-701.
6. Fernandez, L., Bhowmik, T. & Steele, J.L. (1994). Characterization of the Lactobacillus helveticus CNRZ32 pepC gene. Appl. Env. Microbiol. 60, 333-336.
7. Chapot-Chartier, M.-P., Rul, F., Nardi, M. & Gripon, J.-C. (1994). Gene cloning and characterization of PepC, a cysteine aminopeptidase from Streptococcus thermophilus, with sequence similarity to the eucaryotic bleomycin hydrolase. Eur. J. Biochem. 224, 497-506.
8. Chapot-Chartier, M.-P., Mardi, M., Chopin, M.-C., Chopin, A. & Gripon, J.-C. (1993). Cloning and sequencing of pepC, a cysteine aminopeptidase gene from Lactococcus lactis subsp. Cremoris AM2. Appl. Env. Microbiol. 59, 330-333.
9. Fraser, C.M., et al., & Venter, J.C. (1998). Complete genome sequence of Treponema pallidum, the syphilis spirochete. Science 281, 375-388.
10. Enenkel, C. & Wolf, D.H. (1993). BLH1 codes for a yeast thiol aminopeptidase, the equivalent of mammalian bleomycin hydrolase. J. Biol. Chem. 268, 7036-7043.
11. Kambouris, N.G., Burke, D.J. & Creutz, C.E. (1992). Cloning and characterization of a cysteine proteinase from Saccharomyces cerevisiae. J. Biol. Chem. 267, 21570-21576.
12. Magdolen, U., Muller, G., Magdolen, V. & Bandlow, W. (1993). A yeast gene (BLH1) encodes a polypeptide with high homology to vertebrate bleomycin hydrolase, a family member of thiol proteinases. Biochim. Biophys. Acta 1171, 299-303.
13. Xu, H.E. & Johnston, S.A. (1994). Yeast bleomycin hydrolase is a DNA-binding cysteine protease. J. Biol. Chem. 269, 21177-21183.
14. Sebti, S.M. & Lazo, J.S. (1987). Separation of the protective enzyme bleomycin hydrolase from rabbit pulmonary aminopeptidases. Biochemistry 26, 432-437.
15. Adachi, H., et al., & Nishimura, T. (1997). cDNA cloning and expression of chicken aminopeptidase H, possessing endopeptidase as well as aminopeptidase activity. Eur. J. Biochem. 245, 283-288.
16. Brömme, D., Rossi, A.B., Smeekens, S.P., Anderson, D.C. & Payan, D.G. (1996). Human bleomycin hydrolase: Molecular cloning, sequencing, functional expression, and enzymatic characterization. Biochemistry 35, 6706-6714.
17. Ferrando, A.A., Velasco, G., Campo, E. & López-Otin, C. (1996). Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance. Cancer Res. 56, 1746-1750.
18. Takeda, A., Masuda, Y., Yamamoto, T., Hirabayashi, T., Nakamura, Y. & Nakaya, K. (1996). Cloning and analysis of cDNA encoding rat bleomycin hydrolase, a DNA-binding cysteine protease. J. Biochem. 120, 353-359.
19. Joshua-Tor, L., Xu, E.H., Johnston, S.A. & Rees, D.C. (1995). Crystal structure of a conserved protease that binds DNA: The bleomycin hydrolase, Gal6. Science 269, 945-950.
20. Lupas, A., Flanagan, J.M., Tamura, T. & Baumeister, W. (1997). Self-compartmentalizing proteases. Trends Biochem. Sci. 22, 399-404.
21. Baumeister, W., Walz, J., Zuhl, F. & Seemuller, E. (1998). The proteasome: Paradigm of a self-compartmentalizing protease. Cell 92, 367-380.
22. Zheng, W., Johnston, S.A. & Joshua-Tor, L. (1998). The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase and peptide ligase. Cell 93, 103-109.
23. Zheng, W., Xu, H.E. & Johnston, S.A. (1997). The cysteine peptidase bleomycin hydrolase is a member of the galactose regulon in yeast. J. Biol. Chem. 272, 30350-30355.
24. Koldamova, R.P., Lefterov, I.M., Gadjeva, V.G. & Lazo, J.S. (1998). Essential binding and functional domains of human bleomycin hydrolase. Biochemistry 37, 2282-2290.
25. Berger, A. & Schlechter, I. (1970). Mapping the active site of papain with the aid of peptide substrates and inhibitors. Philos. Trans. R. Soc. Lond. B 257, 249-264.
26. Barrett, A.J., Rawlings, N.D. & Woessner, J.F. (1998). Handbook of Proteolytic Enzymes. (Barrett, A.J., Rawlings, N.D. & Woessner, J.F., eds), pp xxv-xxix, Academic Press, London.
27. Zheng, W. & Johnston, S.A. (1998). The nucleic acid binding activity of bleomycin hydrolase is involved in bleomycin detoxification. Mol. Cell Biol. 18, 3580-3585.
28. Selkoe, D.J. (1996). Amyloid β-protein and the genetics of Alzheimer's disease. J. Biol. Chem. 271, 18295-18298.
29. Chang, T. & Abraham, C.R. (1996). A novel brain cysteine protease forms an SDS stable complex with the β-amyloid precursor protein. Annals NY Acad. Sci. 777, 183-188.
30. Farrer, L.A., et al., & George-Hyslop, P.H.S. (1998). Association between bleomycin hydrolase and Alzheimer's disease in caucasians. Ann. Neurol. 44, 808-811.
31. Young, R.C. (1989). In Drug Resistance in Cancer Therapy. (Ozols, RF., ed.), pp. 1-3, Kluwer Academic Publishers, Boston, MA.
32. Lazo, J.S. & Sebti, S.M. (1997). In Cancer Chemotherapy and Biological Modifiers, Vol. 17. (Pinedo, H.M., Longo, D.L. & Chabner. B.A., eds), pp. 40-45, Elsevier Science, The Netherlands.
33. Sebti, S.M., Jani, J.P., Mistry, J.S., Gorelik, E. & Lazo, J. (1991). Metabolic inactivation: A mechanism of human tumor resistance to bleomycin. Cancer Res. 51, 227-232.
34. Lazo, J.S. & Humphreys, C.J. (1983). Lack of metabolism as the biochemical basis of bleomycin-induced pulmonary toxicity. Proc. Natl Acad. Sci. USA 80, 3064-3068.
35. Löwe, J., Stock, D., Jap, R., Zwickl, P., Baumeister, W. & Huber, R. (1995). Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 Å resolution. Science 268, 533-539.
36. Otwinowski, Z. & Minor, W. (1997). Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307-326.
37. Navaza, J. & Saludjian, P. (1997). AMoRe: An automated molecular replacement program package. Methods Enzymol. 276, 581-594.
38. Jones, T.A., Zou, J.Y., Cowan, S.W. & Kjeldgaard, M. (1991). Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110-119.
39. Brünger, A.T., et al., & Warren, G.L. (1998). Crystallography and NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr. D 54, 905-921.
40. Pannu, N.S. & Read, R.J. (1996). Improved structure refinement through maximum likelihood. Acta Crystallogr. A 52, 659-668.
41. Esnouf, R.M. (1997). An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. J. Mol. Graph. 15, 132-134.
42. Kraulis, P.J. (1991). MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallogr. 24, 946-950.
43. Merritt, E.A. & Murphy, M.E.P. (1994). Raster3D version 2.0 - a program for photorealistic molecular graphics. Acta Crystallogr. D 50, 869-873.
44. Nicholls, A., Sharp, K.A. & Honig, B. (1991). Protein folding and association - Insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins 11, 281-296.