Lactacystin and clasto-lactacystin β-lactone modify multiple proteasome β-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation

Journal of Biological Chemistry

Volumn 272, Issue 20, 1997, Pages 13437-13445

  Craiu, Abie ^a   Gaczynska, Maria ^b   Akopian, Tatos ^b   Gramm, Colette F ^a   Fenteany, Gabriel ^c   Goldberg, Alfred L ^b   Rock, Kenneth L ^a,b,d  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD UNIVERSITY   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; LACTACYSTIN; LACTONE DERIVATIVE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; OVALBUMIN; PEPTIDASE; PROTEASOME; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; ENDOCYTOSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBUNIT; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEINASE INHIBITION;

NON-PROGRAMMATIC;

ACETYLCYSTEINE; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIGEN PRESENTATION; BASE SEQUENCE; BETA-LACTAMS; CELL LINE; CRICETINAE; CYSTEINE ENDOPEPTIDASES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; LACTONES; MICE; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX;

ANIMALIA; MAMMALIA;

EID: 0030926777     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.20.13437     Document Type: Article

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