A low voltage-activated Ca2+ current mediates cytokine-induced pancreatic β-cell death

Endocrinology

Volumn 140, Issue 3, 1999, Pages 1200-1204

  Wang, Lin ^a   Bhattacharjee, Arin ^a   Zuo, Zhuang ^a   Hu, Fuquan ^a   Honkanen, Richard E ^a   Berggren, Per Olof ^b   Li, Ming ^a  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CELL DEATH; CELL FUNCTION; CELL KILLING; GLUCAGON RELEASE; LANGERHANS CELL; LIPID PEROXIDATION; MEDIATOR RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0032933208     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.3.6556     Document Type: Article

References (53)

1. 1. Foulis AK, Liddle CN, Farquharson MA 1986 The histopathology of the pancreas in type I (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia 29:267-274
2. 2. Hamaguchi K, Leiter EH 1990 Comparision of cytokine effects on mouse pancreatic α-cell and β-cell line: viability, secretory function, and MHC antigen expression. Diabetes 39:415-425
3. 3. Rabinovitch A, Suarez-Pinzon WL, Shi Y, Morgan AR, Bleackley RC 1994 DNA fragmentation is an early event in cytokine-induced islet β-cell destruction. Diabetologia 37:733-738
4. 4. Iwahashi H, Hanafusa T, Eguchi Y, Nakajima H, Miyagawa J, Itoh N, Tomita K, Namba M, Kuwajima M, Noguchi T, Tsujimoto Y, Matsuzawa Y 1996 Cytokine-induced apoptotic cell death in a mouse pancreatic beta-cell line: inhibition by Bcl-2. Diabetologia 39:530-536
5. 5. Dunger A, Cunningham JM, Delaney CA, Lowe JE, Green MHL, Bone AJ, Green IC 1996 Tumor necrosis factor-α and interferon-γ inhibit insulin secretion and cause DNA damage in unweaned-rat islets. Diabetes 45:183-189
6. 6. Delaney CA, Pavlovic D, Hoorens A, Pipeleers DG, Eizirik DL 1997 Cytokine induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells. Endocrinology 138:2610-2614
7. 7. Wang L, Bhattacharjee A, Fu J, Li M 1996 Abnormally expressed low-voltage-activated calcium channels in β-cells from NOD mice and a related clonal cell line. Diabetes 45:1678-1683
8. 2+ channels are abnormal in genetically determined cardiomyopathic hamster hearts. Circ Res 75:149-155
9. 2+ current is expressed in hypertrophied adult feline left ventricular myocytes. Circ Res 73:777-782
10. 10. Schmitt R, Clozel Z-P, Iberg N, Bühler FR 1995 Mibefradil prevents neointima formation after vascular injury in rats, possible role of the blockade of the T-type voltage-operated calcium channel. Arteroscler Thromb Vasc Biol 15:1161-1165
11. 11. Hopkins WF, Satin LS, Cook DL 1991 Inactivation kinetics and pharmacology distinguish two calcium currents in mouse pancreatic B-cells. J Membr Biol 119:229-239
12. 12. Kaneto H, Fujii J, Seo HG, Suzuki K, Matsuoka T-A, Nakamura N, Tatsumi H, Yamasaki Y, Kamada T, Taniguchi N 1995 Apoptotic cell death triggered by nitric oxide in pancreatic β-cells. Diabetes 44:733-738
13. 13. Rorsman P, Ashcroft FM, Trube G 1988 Single Ca channel currents in mouse pancreatic B-cells. Pflugers Arch 412:597-603
14. 2+ channels by glucose metabolism in mouse pancreatic B-cells. Nature 342:550-553
15. 15. Ashcroff FM, Rorsman P 1989 Electrophysiology of the pancreatic β-cell. Prog Biophys Mol Biol 54:87-143
16. 16. Plant TD 1988 Properties of calcium-dependent inactivation of calcium channels in cultured mouse pancreatic β-cells. J Physiol (Lond) 404:731-747
17. 17. Fox AP, Nowycky MC, Tsien RW 1987 Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones. J Physiol (Lond) 394:149-172
18. 18. Narahashi T, Tsunoo A, Yoshii M 1987 Characterization of two types of calcium channels in mouse neuroblastoma cells. J Physiol (Lond) 383:231-249
19. 19. Hagiwara N, Irisawa H, Kameyama M 1988 Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells. J Physiol (Lond) 395:233-253
20. 20. Huguenard JR 1996 Low-threshold calcium currents in central nervous system neurons. Annu Rev Physiol 58:329-348
21. 21. Bhattacharjee A, Whitehurst Jr RM, Zhang M, Wang L, Li M 1997 T-type calcium channels facilitate insulin secretion by enhancing general excitability in the insulin secreting cell line, INS-1. Endocrinology 138:3735-3740
22. 2+ channels exposed to serum from patients with type 1 diabetes. Science 261:86-90
23. 23. Helqvist S, Zumsteg UW, Spinas GA, Palmer JP, Mandrup-Poulsen T, Nerup J 1991 Repetitive exposure of pancreatic islets to interleukin-1β. An in vitro model of pre-diabetes? Autoimmunity 10:311-318
24. 24. Powers AC, Efrat S, Mojsov S, Speclor D, Habener JF, Hanahan D 1990 Proglucagon processing similar to normal islets in pancreatic α-like cell line derived from transgenic mouse tumor. Diabetes 39:406-414
25. 25. Hamaguchi K, Leiter EH 1990 Comparision of cytokine effects on mouse pancreatic α-cell and β-cell line: viability, secretory function, and MHC antigen expression. Diabtetes 39:415-425
26. 26. O'Brien BA, Harmon BV, Cameron DP, Allan DJ 1997 Apoptosis is the mode of β-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse. Diabetes 46:750-757
27. 27. O'Brien BA, Harmon BV, Cameron DP, Allan DJ 1996 β-Cell apoptosis is responsible for the development of IDDM in the multiple low-dose streptozotocin model. J Pathol 178:176-181
28. 28. Hamaguchi K, Gaskins HR, Leiter EH 1991 NIT-1, a pancreatic β cell line established from a transgenic NOD/Lt mouse. Diabetes 40:842-849
29. 29. Delaney CA, Green MHL, Lowe JE, Green IC 1993 Endogenous nitric oxide induced by interleukin-1β in rat islets of Langerhans and HIT-T15 cells causes significant DNA damage as measured by the 'comet' assay. FEBS Lett 333:291-295
30. 30. Hanahan D 1985 Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315:115-122
31. 31. Tang C-M, Presser F, Morad M 1988 Amiloride selectively blocks the low threshold (T) calcium channel. Science 240:213-215
32. 2+ channels in acutely isolated hippocampal CA3 neurones of the guinea-pig. J Physiol (Lond) 433:259-281
33. 2+ channel blockade by amiloride. J Pharmacol Exp Ther 254:546-551
34. 2+ channels by Ro 40-5967. Circ Res 75:144-148
35. 35. Vacher E, Richer C, Fornes P, Clozel J-P, Giudicelli J-F 1996 Mibefradil, a selective calcium T-channel blocker, in stroke-prone spontaneously hypertensive rats. J Cardiovascular Pharmacol 27:686-694
36. 36. Welsh N, Margulis B, Borg LA,Wiklund HJ, Saldeen J, Flodstrom M, Mello MA, Andersson A, Pipeleers DG, Hellerstrom C, Eizirik DL 1995 Differences in the expression of heat-shock proteins and antioxident enzymes between human and rodent pancreatic islets: implications for the pathogenesis of insulin-dependent diabetes mellitus. Mol Med 1:806-820
37. 37. Hussain MJ, Peakman M, Gallati H, Lo SS, Hawa M, Viberti GC, Watkins PJ, Leslie RD, Vergani D 1996 Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM. Diabetologia 39:60-69
38. 38. Mandrup-Poulsen T, Zumsteg U, Reimers J, Pociot F, Morch L, Helqvist S, Dinarello CA, Nerup J 1993 Involvement of interleukin-1 and interleukin-1 antagonist in pancreatic β-cell destruction in insulin-dependent diabetes mellitus. Cytokine 5:185-191
39. 39. Andersen HU, Jorgensen KH, Egeberg J, Mandrup-Poulsen T, Nerup J 1994 Nicotinamide prevents interleukin-1 effected on accumulated insulin release and nitric oxide production in rat islets of Langerhnns. Diabetes 43:770-777
40. 40. Welsh N, Eizirik DL, Bendtzen K, Sandler S 1991 Interleukin-1β-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase. Endocrinology 129:3167-3173
41. 41. Eizirik DL, Sandler S, Welsh N, Cetkovic-Cvrije M, Nieman A, Geller DA, Pipeleers DG, Bendtzen K, Hellerström C 1994 Cytokines suppress human islet function irrespective of their effects on nitric oxide generation. J Clin Invest 93:1968-1974
42. 42. Welsh N, Eizirik DL, Sandler S 1994 Nitric oxide and pancreatic β-cell destruction in insulin dependent diabetes mellitus: don't take NO for an answer. Autoimmunity 18:285-290
43. 43. Suarez-Pinzon WL, Strynadka K, Rabinovitch A 1996 Destruction of rat pancreatic islet β-cells by cytokines involves the production of cytotoxic aldehydes. Endocrinology 137:5290-5296
44. 44. Pipeleers DG, Van De Winkel M 1986 Pancreatic B cells possess defense mechanisms against cell-specific toxicity. Proc Natl Acad Sci USA 83:5261-5271
45. 45. Kröncke K-D, Funda J, Berschick B, Kolb H, Kolb-Bechofen V 1991 Macrophage cytotoxicity towards isolated rat islet cells: neither lysis nor its protection by nicotinamide are β-cell specific. Diabetologia 34:232-238
46. 2+ curents in rat aortic smooth muscle cells in primary culture. Circ Res 79:14-19
47. 47. Gu D, Molony L, Krahl T, Sarvetnick N 1995 Treatment of IFN-γ transgenic mice with anti-IFN-γ reveals the remodeling capacity of the adult pancreas. Diabetes 44:1161-1164
48. 48. Perez-Reyes E, Cribbs LL, Daud A, Lacerda AE, Barclay J, Williamson MP, Fox M, Rees M, Lee J-H 1998 Molecular characterization of a neuronal low-voltage-activated T-type calcium channel. Nature 391:896-900
49. 2 receptor modulates T-type calcium current in nondifferentiated NG108-15 cells. FEBS Lett 309:161-164
50. 50. Furukawa T, Ito H, Nitta J, Tsujino M, Adachi S, Hiroe M, Marumo F, Sawanobori T, Hiraoka M 1992 Endothelin-1 enhances calcium entry through T-type calcium channels in cultured neonatal rat ventricular myocytes. Circ Res 71:1242-1253
51. 2+ influx via T-type channels modulates PDGF-induced replication of mouse fibroblasts. Am J Physiol 865:C1239-C1246
52. 52. Schwartzman RA, Cidlowski JA 1993 Apoptosis: the biochemistry and molecular biology of programmed cell death. Endocr Rev 14:133-151
53. 2+ stores and arachdonic acid metabolism. J Clin Invest 101:1623-1632