Double-stranded ribonucleic acid (RNA) induces β-cell Fas messenger RNA expression and increases cytokine-induced β-cell apoptosis

Endocrinology

Volumn 142, Issue 6, 2001, Pages 2593-2599

  Liu, Dongbo ^a   Darville, Martine ^a   Eizirik, Décio L ^a  

^a DIABETES RESEARCH CENTER   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; FAS ANTIBODY; GAMMA INTERFERON; INTERLEUKIN 1BETA; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; POLYINOSINIC POLYCYTIDYLIC ACID;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ISOLATION; CELL VIABILITY; CYTOKINE PRODUCTION; FLUORESCENCE ACTIVATED CELL SORTER; GENE EXPRESSION; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS INFECTION;

EID: 0035013235     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.6.8188     Document Type: Article

References (55)

1. 1. Atkinson MA, Maclaren NK 1994 The pathogenesis of insulin-dependent diabetes mellitus. N Engl J Med 331:1428-1436
2. 2. Bach JF 1995 Insulin-dependent diabetes mellitus as a β-cell targeted disease of immunoregulation. J Autoimmun 8:439-463
3. 3. Yoon JW 1995 A new look at viruses in type 1 diabetes. Diabetes Metab Rev 11:83-107
4. 4. Von Herrath MG, Holz A, Homann D, Oldstone MB 1998 Role of viruses in type I diabetes. Semin Immunol 10:87-100
5. 5. Roivainen M, Rasilainen S, Ylipaasto P, Nissinen R, Ustinov J, Bouwens L, Eizirik DL, Hovi T, Otonkoski T 2000 Mechanisms of coxsackievirus-induced damage to human pancreatic β-cells. J Clin Endocrinol Metab 85:432-440
6. 6. Jacobs BL, Langland JO 1996 When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA. Virology 219:339-349
7. 7. Kibler KV, Shors T, Perkins KB, Zeman CC, Banaszak MP, Biesterfeldt J, Langland JO, Jacobs BL 1997 Double-stranded RNA is a trigger for apoptosis in vaccinia virus-infected cells. J Virol 71:1992-2003
8. 8. Mauricio D, Mandrup-Poulsen T 1998 Apoptosis and the pathogenesis of IDDM: a question of life and death. Diabetes 47: 1537-1543
9. 9. Eizirik DL, Hoorens A 1999 β-Cell dysfunction/death. In: Howell S (ed) Advances in Molecular and Cell Biology: The Biology of the Pancreatic β Cell. JAI Press Stamford, vol 29:47-73
10. 10. Mandrup-Poulsen T 1996 The role of interleukin-1 in the pathogenesis of insulin-dependent diabetes mellitus. Diabetologia 39:1005-1029
11. 11. Eizirik DL, Pavlovic D 1997 Is there a role for nitric oxide in β-cell dysfunction and damage in IDDM? Diabetes Metab Rev 13:293-307
12. 12. Rabinovitch A 1998 An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus. Diabetes Metab Rev 14: 129-151
13. 13. Eizirik DL, Darville MI 2001 β-Cell apoptosis and defence mechanisms: lessons from type 1 diabetes. Diabetes [Suppl 1] 50:564-569
14. 14. Hirasawa K, Jun HS, Maeda K, Kawaguchi Y, Itagaki S, Mikami T, Baek HS, Doi K, Yoon JW 1999 Possible role of macrophage-derived soluble mediators in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice. J Virol 71:4024-4031
15. 15. Rhodes CJ, Taylor KW 1985 Effect of interferon and double-stranded RNA on β-cell function in mouse islets of Langerhans. Biochem J 228:87-94
16. 16. Heitmeier MR, Scarim AL, Corbett JA 1999 Double-stranded RNA inhibits β-cell function and induces islet damage by stimulating β-cell production of nitric oxide. J Biol Chem 274:12531-12536
17. 17. Pipeleers DG, In't Veld PA, Van de Winkel M, Maes E, Schuit FC, Gepts W 1985 A new in vitro model for the study of pancreatic A and B cells. Endocrinology 117:806-816
18. 18. Ling Z, Hannaert JC, Pipeleers D 1994 Effects of nutrients, hormones and serum on survival of rat islet β-cells in culture. Diabetologia 37:15-21
19. 19. Ling Z, Chen M-C, Smismans A, Pavlovic D, Schuit F, Eizirik DL, Pipeleers DG 1998 Intercellular differences in interleukin-1β-induced suppression of insulin synthesis and stimulation of noninsulin protein synthesis by rat pancreatic β-cells. Endocrinology 139:1540-1545
20. 20. Chen M-C, Schuit F, Eizirik DL 203 1999 Identification of IL-1β-induced messenger RNAs in rat pancreatic β cells by differential display of messenger RNA. Diabetologia 42:1199-1191
21. 21. Ling Z, Van de Casteele M, Eizirik DL, Pipeleers DG 2000 Interleukin-1β-induced alteration in a β-cell phenotype can reduce cellular sensitivity to conditions that cause necrosis but not to cytokine-induced apoptosis Diabetes 49:340-345
22. -/-). Diabetes 49:1116-1122
23. 23. Tang NM, Korth MJ, Gale M Jr, Wambach M, Der SD, Bandyopadhyay SK, Williams BR, Katze MG 1999 Inhibition of double-stranded RNA-and tumor necrosis factor α-mediated apoptosis by tetratricopeptide repeat protein and co-chaperone P58(IPK). Mol Cell Biol 19:4757-4765
24. 24. Uetani K, Der SD, Zamanian-Daryoush M, de La Motte C, Lieberman BY, Williams BR, Erzurum SC 2000 Central role of double-stranded RNA-activated protein kinase in microbial induction of nitric oxide synthase. J Immunol 165:988-996
25. 15N]nitrate in biological fluids. Anal Biochem 126:131-138
26. 26. Pavlovic D, Chen M-C, Gysemans CA, Mathieu C, Eizirik DL 1999 The role of interferon regulatory factor-1 in cytokine-induced mRNA expression and cell death in murine pancreatic β-cells. Eur Cytokine Network 10:403-411
27. 27. Darville MI, Ho YS, Eizirik DL 2000 NF-κB is required for cytokine-induced manganese superoxide dismutase expression in insulin-producing cells. Endocrinology 141:153-162
28. 28. Chen MC, Schuit F, Pipeleers DG, Eizirik DL 1999 IL-1β induces serine protease inhibitor 3 (SPI-3) gene expression in pancreatic β-cells. Detection by differential display of messenger RNA. Cytokine 11:856-62
29. 29. Eizirik DL, Björklund A, Cagliero E 1993 Genotoxic agents increase expression of growth arrest and DNA damage inducible genes GADD 153 and GADD 45 in rat pancreatic islets. Diabetes 42:738-745
30. 30. Darville MI, Eizirik DL 1998 Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells. Diabetologia 41:1101-1108
31. 31. Delaney CA, Pavlovic D, Hoorens A, Pipeleers DG, Eizirik DL 1997 Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells. Endocrinology 138:2610-2614
32. 32. Hoorens A 1999 Distinction between Necrosis and Apoptosis of Pancreatic β Cells. PhD Thesis, Faculty of Medicine and Pharmacy, Vrije University Brussel, Brussels, Belgium
33. 33. Hoorens A, Van de Casteele M, Kloppel G, Pipeleers D 1996 Glucose promotes survival of rat pancreatic β-cells by activating synthesis of proteins which suppress a constitutive apoptotic program. J Clin Invest 98:1568-1574
34. 34. Pipeleers D, Van de Winkel M 1986 Pancreatic β cells possess defence mechanisms against cell-specific toxicity. Proc Natl Acad Sci USA 83:5267-5271
35. 35. Yoon JW, Austin M, Onodera T, Notkins AL 1979 Isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N Engl J Med 300:1173-1179
36. 36. Gerling I, Chatterjee NK 1990 Autoantigen (64000-Mr) expression in coxsackievirus B4-induced experimental diabetes. Curr Top Microbiol Immunol 156:55-62
37. 37. Horwitz MS, Sarvetnick N 1999 Viruses, host responses, and autoimmunity Immunol Rev 169:241-253
38. 38. Kaufman DL, Erlander MG, Clare-Salzler M, Atkinson MA, Maclaren NK, Tobin AJ 1992 Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus. J Clin Invest 89:283-292
39. 39. Lonnrot M, Hyoty H, Knip M, Roivainen M, Kulmala P, Leinikki P, Akerblom HK 1996 Antibody cross-reactivity induced by the homologous regions in glutamic acid decarboxylase (GAD65) and 2C protein of coxsackievirus B4. Clin Exp Immunol 104:398-405
40. 40. Horwitz MS, Bradley LM, Harbertson J, Krahl T, Lee J, Sarvetnick N 1998 Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry. Nat Med 4:781-785
41. 41. Arnush M, Scarim AL, Heitmeier MR, Kelly CB, Corbett JA 1998 Potential role of resident islet macrophage activation in the initiation of autoimmune diabetes. J Immunol 160:2684-2691
42. 42. Pavlovic D, Chen M-C, Bouwens L, Eizirik DL, Pipeleers D 1999 Contribution of ductal cells to cytokine responses by human pancreatic islets. Diabetes 48:29-33
43. 43. Saldeen J, Welsh N 203 1994 Interleukin-1 β induced activation of NF-κB in insulin producing RINm5F cells is prevented by the protease inhibitor N-α-p-tosyl-L-lysine chloromethylketone. Biochem Biophys Res Commun 149-155
44. 44. Bedoya FJ, Flodström M, Eizirik DL 1995 Pyrrolidine dithiocarbamate prevents IL-1-induced nitric oxide synthase mRNA, but not superoxide dismutase mRNA, in insulin producing cells. Biochem Biophys Res Commun 210:816-822
45. 45. Flodström M, Eizirik DL 1997 Interferon-γ-induced interferon regulatory factor-1 (IRF-1) expression in rodent and human islet cells precedes nitric oxide production. Endocrinology 138:2747-2753
46. 46. Kumar A, Haque J, Lacoste J, Hiscott J, Williams BR 1994 Double-stranded RNA-dependent protein kinase activates transcription factor NF-κB by phosphorylating I κB. Proc Natl Acad Sci USA 91:6288-6292
47. 47. Gil J, Alcami J, Esteban M 1999 Induction of apoptosis by double-srranded-RNA-dependent protein kinase (PKR) involves the α subunit of eukaryotic translation initiation factor 2 and NF-κB. Mol Cell Biol 19:4653-4663
48. 48. Balachandran S, Kim CN, Yeh WC, Mak TW, Bhalla K, Barber GN 1998 Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling. EMBO. J 17:6888-6902
49. 49. Kaufman RJ 1999 Double-stranded RNA-activated protein kinase mediates virus-induced apoptosis: a new role for an old actor. Proc Natl Acad Sci USA 96:11693-11695
50. 50. Chervonsky AV, Wang Y, Wong FS, Visintin I, Flavell RA, Janeway Jr CA, Matis LA 1997 The role of Fas in autoimmune diabetes. Cell 89:17-24
51. 51. Itoh N, Imagawa A, Hanafusa T, Waguri M, Yamamoto K, Iwahashi H, Moriwaki M, Nakajima H, Miyagawa J, Namba M, Makino S, Nagata S, Kono N, Matsuzawa Y 1997 Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice. J Exp Med 186:613-618
52. 52. Amrani A, Verdaguer J, Anderson B, Utsugi T, Bou S, Santamaria P 1999 Perforin-independent β-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice. J Clin Invest 103:1201-1
53. 53. Suarez-Pinzon W, Sorensen O, Bleackley RC, Elliott JF, Rajotte RV, Rabinovitch A 1999 β-cell destruction in NOD mice correlates with Fas (CD95) expression on β-cells and proinflammatory cytokine expression in islets. Diabetes 48:21-28
54. 54. Moriwaki M, Itoh N, Miyagawa J, Yamamoto K, Imagawa A, Yamagata K, Iwahashi H, Nakajima H, Namba M, Nagata S, Hanafusa T, Matsuzawa Y 1999 Fas and Fas ligand expression in inflamed islets in pancreas sections of patients with recent-onset type I diabetes mellitus. Diabetologia 42:1332-1340
55. 55. Dahlquist G, Frisk G, Ivarsson SA, Svanberg L, Forsgren M, Diderholm H 1995 Indications that maternal coxsackie B virus infection during pregnancy is a risk factor for childhood-onset IDDM. Diabetologia 38:1371-1373