The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic β-cells

Diabetes

Volumn 49, Issue 9, 2000, Pages 1468-1476

  Ammendrup, A ^a   Maillard, A ^a   Nielsen, K ^a   Andersen, A N ^a   Serup, P ^a   Madsen, O D ^a   Mandrup Poulsen, T ^a   Bonny, C ^a  

^a STENO DIABETES CENTER   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLIN; GLUCAGON; HEAT SHOCK PROTEIN 25; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NITRIC OXIDE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 2;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; HOMEOBOX; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0033850451     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.49.9.1468     Document Type: Article

References (37)

1. Regulation of pancreatic β-cell mass in vivo
2. Dynamics of the β-cell mass in the growing rat pancreas
3. Apoptosis contributes to the involution of β-cell mass in the postpartum rat pancreas
4. Potent inhibitory effects of transplantable rat glucagonomas and insulinomas on the respective endogenous islet cells are associated with pancreatic apoptosis
5. Glucose promotes survival of rat pancreatic β-cells by activating synthesis of proteins which suppress a constitutive apoptotic program
6. PDX-1 induces insulin and glucokinase gene expression in αTC1 clone 6 cells in the presence of betacellulin
7. The role of interleukin-1 in the pathogenesis of IDDM
8. The harmony of the spheres: Inducible nitric oxide synthase and related genes in pancreatic β-cells
9. Nitric oxide production in islets from nonobese diabetic mice: Aminoguanidine-sensitive and -resistant stages in the immunological diabetic process
10. Inhibition of insulin secretion by interleukin-1β and rumor necrosis factor-α via an L-arginine-dependent nitric oxide generating mechanism
11. β-cell maturation leads to in vitro sensitivity to cytotoxins
12. Interleukin-1β-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases
13. Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen or a thromboxane analogue
14. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
15. Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors
16. A synthetic inhibitor of the mitogen-activated protein kinase cascade
17. Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor
18. PD-098059 is a specific inhibitor of the activation of mitogen-activated protein-kinase kinase in vitro and in vivo
19. Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1
20. Pancreatic development and maturation of islet β-cells: Studies of pluripotent islet cultures
21. β-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes
22. Independent development of pancreatic α- and β-cells from neurogenin3-expression precursors: A role for the Notch pathway in repression of premature differentiation
23. β-cell lines derived from transgenic mice expressing a hybrid-insulin gene-oncogene
24. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines
25. Development of a propidium iodide fluorescence assay for proliferation and cytotoxicity assays
26. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assay
27. Use of the MTT assay for rapid determination of chemosensitivity of human leukemic blast cells
28. IB1, a JIP-1-related nuclear protein present in insulin-secreting cells
29. A cytoplasmic inhibitor of the JNK signal-transducting pathway
30. Activation of the 1κBα kinase complex by MEKK1, a kinase of the JNK pathway
31. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
32. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
33. 15N]nitrate in biological fluids
34. Kinase inhibitor effects on spontaneous and cytokine-induced apoptosis in HIT-T15 cells and neonatal rat islets
35. Potentiation of apoptosis by low-dose stress stimuli in cells expressing activated MEK kinase 1
36. Jun N-terminal kinase mediates activation of skeletal muscle glycogen synthase by insulin in vivo
37. Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1β-induced cytotoxicity and reduces nitric oxide production