Reduced incidence and severity of antigen-induced autoimmune diseases in mice lacking interferon regulatory factor-1

Journal of Experimental Medicine

Volumn 185, Issue 2, 1997, Pages 231-238

  Tada, Yoshifumi ^a   Ho, Alexandra ^a   Matsuyama, Toshifumi ^a   Mak, Tak W ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b AMGEN INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 2; INTERFERON; MESSENGER RNA; NITRIC OXIDE SYNTHASE; TRANSCRIPTION FACTOR;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALITIS; ANIMAL MODEL; ARTHRITIS; ARTICLE; AUTOIMMUNITY; DISEASE SEVERITY; ETIOLOGY; GENE EXPRESSION REGULATION; IMMUNOPATHOGENESIS; IMMUNOREGULATION; INTERFERON PRODUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTIGENS; ARTHRITIS, EXPERIMENTAL; AUTOIMMUNE DISEASES; DISEASE SUSCEPTIBILITY; DNA-BINDING PROTEINS; INFLAMMATION MEDIATORS; INTERFERON REGULATORY FACTOR-1; INTERFERON TYPE II; JOINTS; MICE; MICE, INBRED STRAINS; NITRIC OXIDE SYNTHASE; PHOSPHOPROTEINS; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; SPINAL CORD;

EID: 0031048823     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.185.2.231     Document Type: Article

References (40)

1. Miyamoto, M., T. Fujita, Y. Kimura, M. Maruyama, H. Harada, Y. Sudo, T. Miyata, and T. Taniguchi. 1988. Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements. Cell. 54:903-913.
2. Harada, H., T. Fujita, M. Miyamoto, Y. Kimura, M. Maruyama, A. Furia, T. Miyata, and T. Taniguchi. 1989. Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell. 58:729-739.
3. Friedman, R.L., and G.R. Stark. 1985. α-interferon-induced transcription of HLA and metallothionein genes containing homologous upstream sequences. Nature (Lond.). 314:637-639.
4. Levy, D.E., D.S. Kessler, R. Pine, N. Reich, and J.E. Darnell, Jr. 1988. Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transctiptional control. Genes & Dev. 2:383-393.
5. Tanaka, N., T. Kawakami, and T. Taniguchi. 1993. Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system. Mol. Cell. Biol. 13:4531-4538.
6. Matsuyama, T., T. Kimura, M. Kitagawa, K. Pfeffer, T. Kawakami, N. Watanabe, T.M. Kundig, R. Amakawa, K. Kishihara, A. Wakeham et al. 1993. Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Cell. 75:83-97.
7. Tanaka, N., M. Ishihara, M. Kitagawa, H. Harada, T. Kimura, T. Matsuyama, M.S. Lamphier, S. Aizawa, T.W. Mak, and T. Taniguchi. 1994. Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. Cell. 77:829-839.
8. Harada, H., M. Kitagawa, N. Tanaka, H. Yamamoto, K. Harada, M. Ishihara, and T. Taniguchi. 1993. Anti-oncogenic and oncogenic potentials of transcnptional regulators IRF-1 and -2. Science (Wash. DC). 259:971-974.
9. Kamijo, R., H. Harada, T. Matsuyama, M. Bosland, J. Gerecitano, D. Shapiro, J. Le, S.I. Koh, T. Kimura, S.J. Green, T.W. Mak, T. Taniguchi, and J. Vicek. 1994. Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science (Wash. DC). 263:1612-1615.
10. Martin, E., C. Nathan, and Q. Xie. 1994. Role of interferon regulatory factor 1 in induction of nitric oxide synthase. J. Exp. Med. 180:977-984.
11. Reis, L.F.L., H. Ruffner, G. Stark, M. Aguet, and C. Weissman. 1994. Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes. EMBO (Eur. Mol. Biol. Organ.) J. 13:4798-4806.
12. Harald, H.H., W. Schmidt, and U. Walter. 1994. NO at work. Cell. 78:919-925.
13. MacMicking, J.D., C. Nathan, G. Hom, N. Chartrain, D.S. Fletcher, M. Trumbauer, K. Stevens, Q-w. Xie, K. Sokol, N. Hutchinson, H. Chen, and J.S. Mudgett. 1995. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell. 81:641-650.
14. Wei, X.-q., I.G. Charies, A. Smith, J. Ure, G.-J. Feng, F.-P. Huang, D. Xu, W. Muller, S. Moncada, and F.Y. Liew. 1995. Altered immune responses in mice lacking inducible nitric oxide synthase. Nature (Lond.). 375:408-411.
15. McCartney-Francis, N., J.B. Allen, D.E. Mizel, J.E. Albina, Q. Xie, C.F. Nathan, and S.M. Wahl. 1993. Suppression of arthritis by an inhibitor of nitric oxide synthase. J. Exp. Med. 178:749-754.
16. G-Monomethyl-L-Arginine. J. Exp. Med. 179:651-660.
17. Cross, A.H., T.P. Misko, R.F. Lin, W.F. Hickey, J.L. Trotter, and R.G. Tilton. 1994. Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice. J. Clin. Invest. 93: 2684-2690.
18. Koprowski, H., Y.M. Zheng, E. Heber-Katz, N. Fraser, L. Rorke, Z.F. Fu, C. Hanlon, and B. Dietzschold. 1993. In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases. Proc. Natl. Acad. Sci. USA. 90:3024-3027.
19. Lin., R.F., T.-S. Lin, R.G. Tilton, and A.H. Cross. 1993. Nitric oxide localized to spinal cords of mice with experimental allergic encephalomyelitis: An electron paramagnetic resonance study. J. Exp. Med. 178:643-648.
20. Hopper, D.C., S.T. Ohnishi, R. Kean, Y. Numagami, B. Dietzschold, and H. Koprowski. 1995. Local nitric oxide production in viral and autoimmune diseases of the central nervous system. Proc. Natl. Acad. Sci. USA. 92:5312-5316.
21. Tamura, T., M. Ishihara, M.S. Lamphier, N. Tanaka, I. Oishi, S. Aizawa, T. Matsuyama, T.W. Mak, S. Taki, and T. Taniguchi. 1995. An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature (Lond.). 376:596-599.
22. Li, P., H. Allen, S. Banerjee, S. Franklin, L. Herzog, C. Johnston, J. McDowell, M. Paskind, L. Rodman, J. Salfeld et al. 1995. Mice deficient in IL-1β-converting enzyme are defective in production ot mature IL-1β and resistant to endotoxic shock. Cell. 80:401-411.
23. Kuida, K., J.A. Lippke, G. Ku, M.W. Harding, D.J. Livingston, M.S.S. Su, and R.A. Flavell. 1995. Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme. Science (Wash. DC). 267:2000-2003.
24. + T cells play a role in the initiation and regulate the recovery phase ot arthritis. J. Immunol. 156:4520-4526.
25. -/- mice. Science (Wash. DC). 256:1210-1213.
26. Rottenberg, M.E., L. Sporrong, I. Persson, H. Wigzell, and A. Örn. 1995. Cytokine gene expression during infection of mice lacking CD4 and/or CD8 with Trypanosoma cruzi. Scand. J. Immunol. 41:164-170.
27. Hom, J.T., A.M. Bendele, and D.G. Carlson. 1988. In vivo administration with IL-1 accelerates the development of collagen-induced arthritis in mice. J. Immunol. 141:834-841.
28. Thorbecke, G.J., R. Shah, C.H. Leu, A.P. Kuruvilla, A.M. Hardison, and M.A. Palladino. 1992. Involvement of endogenous tumor necrosis factor α and transforming growth factor β during induction of collagen type II arthritis mice. Proc. Natl. Acad. Sci. USA. 89:7375-7379.
29. Williams, R.O., M. Feldmann, and R.N. Maini. 1992. Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc. Natl. Acad. Sci. USA. 89:9784-9788.
30. Goldschmidt, T.J., and R. Holmdahl. 1991. Anti-T cell receptor antibody treatment of rats with established autologous collagen-induced arthritis: suppression of arthritis without reduction of anti-type II collagen autoantibody levels. Eur. J. Immunol. 21:1327-1330.
31. Yoshino, S., and L.G. Cleland. 1992. Depletion of α/β T cells by a monoclonal antibody against the α/β T cell receptor suppresses established adjuvant arthritis, but not established collagen-induced arthritis in rats. J. Exp. Med. 175:907-915.
32. + T lymphocytes and class II antigen-expressing cells in joints of DBA/1 mice immunized with type II collagen. Lab. Invest. 58:53-60.
33. Dejoy, S.Q., K.M. Ferguson, A.L. Oronsky, and S.S. Kerwar. 1988. Studies on the synergy between collagen and adjuvant arthritis in rats. Cell. Immunol. 113:117-129.
34. Stamier, J.S. 1994. Redox signaling: Nitrosylation and related target interactions of nitric oxide. Cell. 78:931-936.
35. Farrell, A.J., D.R. Blake, R.M.J. Palmer, and S. Moncada. 1992. Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Ann. Rheum. Dis. 51:1219-1222.
36. Merrill, J.E., L.J. Ignarro, M.P. Sherman, J. Melinek, and T.E. Lane. 1993. Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J. Immunol. 151:2132-2141.
37. Boje, K.M., and P.K. Arora. 1992. Microglia-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res. 587:250-256.
38. Chao, C.C., S. Hu, T.W. Molitor, E.G. Shaskan, and P.K. Peterson. 1992. Activated microglia mediated neuronal cell death injury via a nitric oxide mechanism. J. Immunol. 149: 2736-2741.
39. Black, R.A., S.R. Kronheim, M. Cantrell, M.G. Deeley, C.J. March, K.S. Prickett, J. Wignall, P.J. Conlon, D. Cosman, T.P. Hopp, and D.Y. Mochizuki. 1988. Generation of biologically active interleukin-1β by proteolytic cleavage of the inactive precursor. J. Biol. Chem. 263:9437-9442.
40. Kostura, M.J., M.J. Tocci, G. Limjuco, J. Chin, P. Cameron, A.G. Hillman N.A. Chartrain, and J.A. Schmidt. 1989. Identification of a monocyte specific pre-interleukin 1β convertase activity. Proc. Natl. Acad. Sci. USA. 86:5227-5231.