메뉴 건너뛰기




Volumn 39, Issue 8, 1996, Pages 875-890

The harmony of the spheres: Inducible nitric oxide synthase and related genes in pancreatic beta cells

Author keywords

Beta cells; Insulin dependent diabetes mellitus; Insulin producing cells; Nitric oxide; Nitric oxide synthase; Nuclear factor B; Pancreatic islets; Promoter; Superoxide dismutase; Transcription factor

Indexed keywords

CYTOKINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NUCLEAR FACTOR; TRANSCRIPTION FACTOR;

EID: 0030005411     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00403906     Document Type: Review
Times cited : (312)

References (166)
  • 1
    • 0027752805 scopus 로고
    • The L-arginine-nitric oxide pathway
    • Moncada S, Higgs A (1993) The L-arginine-nitric oxide pathway. N Engl J Med 329: 2002-2012
    • (1993) N Engl J Med , vol.329 , pp. 2002-2012
    • Moncada, S.1    Higgs, A.2
  • 3
    • 0028902552 scopus 로고
    • Nitric oxide synthases: Properties and catalytic mechanism
    • Griffith OW, Stuher DJ (1995) Nitric oxide synthases: properties and catalytic mechanism. Annu Rev Physiol 57: 707-736
    • (1995) Annu Rev Physiol , vol.57 , pp. 707-736
    • Griffith, O.W.1    Stuher, D.J.2
  • 4
    • 0028035106 scopus 로고
    • The high-output nitric oxide pathway: Role and regulation
    • Xie Q-W, Nathan C (1994) The high-output nitric oxide pathway: role and regulation. J Leukoc Biol 56: 576-582
    • (1994) J Leukoc Biol , vol.56 , pp. 576-582
    • Xie, Q.-W.1    Nathan, C.2
  • 5
    • 0029098769 scopus 로고
    • Natural resistance and nitric oxide
    • Nathan CF (1995) Natural resistance and nitric oxide. Cell 82: 873-876
    • (1995) Cell , vol.82 , pp. 873-876
    • Nathan, C.F.1
  • 6
    • 0026734847 scopus 로고
    • Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin
    • Nussler AK, Di Silvio M, Billiar TR et al. (1992) Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin. J Exp Med 176: 261-264
    • (1992) J Exp Med , vol.176 , pp. 261-264
    • Nussler, A.K.1    Di Silvio, M.2    Billiar, T.R.3
  • 8
    • 0028296629 scopus 로고
    • Cytokines suppress human islet function irrespective of their effects on nitric oxide generation
    • Eizirik DL, Sandler S, Welsh N et al. (1994) Cytokines suppress human islet function irrespective of their effects on nitric oxide generation. J Clin Invest 93: 1968-1974
    • (1994) J Clin Invest , vol.93 , pp. 1968-1974
    • Eizirik, D.L.1    Sandler, S.2    Welsh, N.3
  • 9
    • 0029592781 scopus 로고
    • On the expression of nitric oxide synthase by human macrophages. Why no NO?
    • Albina JE (1995) On the expression of nitric oxide synthase by human macrophages. Why no NO? J Leukoc Biol 58: 643-649
    • (1995) J Leukoc Biol , vol.58 , pp. 643-649
    • Albina, J.E.1
  • 10
    • 0028982203 scopus 로고
    • Insulin-dependent diabetes mellitus as a β-cell targeted disease of immunoregulation
    • Bach J-F (1995) Insulin-dependent diabetes mellitus as a β-cell targeted disease of immunoregulation. J Autoimmun 8: 439-463
    • (1995) J Autoimmun , vol.8 , pp. 439-463
    • Bach, J.-F.1
  • 11
    • 0027293874 scopus 로고
    • Repair of pancreatic beta-cells. A relevant phenomenon in early IDDM?
    • Eizirik DL, Sandler S, Palmer JP (1993) Repair of pancreatic beta-cells. A relevant phenomenon in early IDDM? Diabetes 42: 1389-1391
    • (1993) Diabetes , vol.42 , pp. 1389-1391
    • Eizirik, D.L.1    Sandler, S.2    Palmer, J.P.3
  • 12
    • 0025197945 scopus 로고
    • Cytokines and free radicals as effector molecules in the destruction of pancreatic beta-cells
    • Mandrup-Poulsen T, Helquist S, Wogensen L et al. (1990) Cytokines and free radicals as effector molecules in the destruction of pancreatic beta-cells. Curr Top Microbiol Immunol 164: 169-193
    • (1990) Curr Top Microbiol Immunol , vol.164 , pp. 169-193
    • Mandrup-Poulsen, T.1    Helquist, S.2    Wogensen, L.3
  • 13
    • 0000836601 scopus 로고
    • Roles of cytokines in IDDM pathogenesis and islet β-cell destruction
    • Rabinovitch A (1993) Roles of cytokines in IDDM pathogenesis and islet β-cell destruction. Diabetes Rev 1: 215-240
    • (1993) Diabetes Rev , vol.1 , pp. 215-240
    • Rabinovitch, A.1
  • 15
    • 0028641691 scopus 로고
    • Nicotinamide decreases nitric oxide production and partially protects human pancreatic islets against the suppressive effects of combinations of cytokines
    • Eizirik DL, Sandler S, Welsh N, Bendtzen K, Hellerström C (1994) Nicotinamide decreases nitric oxide production and partially protects human pancreatic islets against the suppressive effects of combinations of cytokines. Autoimmunity 19: 193-198
    • (1994) Autoimmunity , vol.19 , pp. 193-198
    • Eizirik, D.L.1    Sandler, S.2    Welsh, N.3    Bendtzen, K.4    Hellerström, C.5
  • 16
    • 0028109668 scopus 로고
    • Human islet destruction by cytokines is independent of nitric oxide production
    • Rabinovitch A, Suarez-Pinzon WL, Strynadka K et al. (1994) Human islet destruction by cytokines is independent of nitric oxide production. J Clin Endocrinol Metab 79: 1058-1062
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 1058-1062
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2    Strynadka, K.3
  • 17
    • 0025685395 scopus 로고
    • Inhibition of insulin secretion by interleukin-1β and tumor necrosis factor-α via an L-arginine dependent nitric oxide generating mechanism
    • Southern C, Schulster D, Green IC (1990) Inhibition of insulin secretion by interleukin-1β and tumor necrosis factor-α via an L-arginine dependent nitric oxide generating mechanism. FEBS Lett 276: 42-44
    • (1990) FEBS Lett , vol.276 , pp. 42-44
    • Southern, C.1    Schulster, D.2    Green, I.C.3
  • 18
    • 0028626360 scopus 로고
    • The inducible form of nitric oxide synthase (iNOS) in insulin-producing cells
    • Eizirik DL, Leijerstam F (1994) The inducible form of nitric oxide synthase (iNOS) in insulin-producing cells. Diabet Metab 20: 116-122
    • (1994) Diabet Metab , vol.20 , pp. 116-122
    • Eizirik, D.L.1    Leijerstam, F.2
  • 19
    • 0025833992 scopus 로고
    • Interleukin-1β-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase
    • Welsh N, Eizirik DL, Bendtzen K, Sandler S (1991) Interleukin-1β-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase. Endocrinology 129: 3167-3173
    • (1991) Endocrinology , vol.129 , pp. 3167-3173
    • Welsh, N.1    Eizirik, D.L.2    Bendtzen, K.3    Sandler, S.4
  • 20
    • 0028084944 scopus 로고
    • Succinic acid monomethyl ester protect rat pancreatic islet secretory potential against interleukin-1β (IL-1β) without affecting glutamate decarboxylase expression or nitric oxide production
    • Eizirik DL, Welsh N, Niemann A, Velloso LA, Malaisse WJ (1994) Succinic acid monomethyl ester protect rat pancreatic islet secretory potential against interleukin-1β (IL-1β) without affecting glutamate decarboxylase expression or nitric oxide production. FEBS Lett 337: 298-302
    • (1994) FEBS Lett , vol.337 , pp. 298-302
    • Eizirik, D.L.1    Welsh, N.2    Niemann, A.3    Velloso, L.A.4    Malaisse, W.J.5
  • 21
    • 0027428461 scopus 로고
    • Endogenous nitric oxide induced by interleukin-1β in rat islets of Langerhans and HIT-T15 cells causes significant DNA damage as measured by the "comet" assay
    • Delaney CA, Green MHL, Lowe JE, Green IC (1993) Endogenous nitric oxide induced by interleukin-1β in rat islets of Langerhans and HIT-T15 cells causes significant DNA damage as measured by the "comet" assay. FEBS Lett 333: 291-295
    • (1993) FEBS Lett , vol.333 , pp. 291-295
    • Delaney, C.A.1    Green, M.H.L.2    Lowe, J.E.3    Green, I.C.4
  • 22
    • 0027536123 scopus 로고
    • Islet cell DNA is a target of inflammatory attack by nitric oxide
    • Fehsel K, Jalowy A, Qi S, Burkart V, Harmann B, Kolb H (1993) Islet cell DNA is a target of inflammatory attack by nitric oxide. Diabetes 42: 496-500
    • (1993) Diabetes , vol.42 , pp. 496-500
    • Fehsel, K.1    Jalowy, A.2    Qi, S.3    Burkart, V.4    Harmann, B.5    Kolb, H.6
  • 23
    • 0026683354 scopus 로고
    • Does nitric oxide mediate autoimmune destruction of β-cells? Possible therapeutic interventions in IDDM
    • Corbett JA, McDaniel ML (1992) Does nitric oxide mediate autoimmune destruction of β-cells? Possible therapeutic interventions in IDDM. Diabetes 41: 897-903
    • (1992) Diabetes , vol.41 , pp. 897-903
    • Corbett, J.A.1    McDaniel, M.L.2
  • 24
    • 0026684463 scopus 로고
    • Type 1 (insulin-dependent) diabetes mellitus and nitric oxide
    • Kolb H, Kolb-Bachofen V (1992) Type 1 (insulin-dependent) diabetes mellitus and nitric oxide. Diabetologia 35: 796-797
    • (1992) Diabetologia , vol.35 , pp. 796-797
    • Kolb, H.1    Kolb-Bachofen, V.2
  • 26
    • 0029915909 scopus 로고    scopus 로고
    • Nitric oxide donors decrease the function and survival of human pancreatic islets
    • Eizirik DL, Delaney CA, Green MHL et al. (1996) Nitric oxide donors decrease the function and survival of human pancreatic islets. Mol Cell Endocrinol 118: 71-83
    • (1996) Mol Cell Endocrinol , vol.118 , pp. 71-83
    • Eizirik, D.L.1    Delaney, C.A.2    Green, M.H.L.3
  • 27
    • 0026755720 scopus 로고
    • Interleukin-1β induces the expression of an isoform of nitric oxide synthase in insulin-producing cells which is similar to that observed an activated macrophages
    • Eizirik DL, Cagliero E, Björklund A, Welsh N (1992) Interleukin-1β induces the expression of an isoform of nitric oxide synthase in insulin-producing cells which is similar to that observed an activated macrophages. FEBS Lett 308: 249-252
    • (1992) FEBS Lett , vol.308 , pp. 249-252
    • Eizirik, D.L.1    Cagliero, E.2    Björklund, A.3    Welsh, N.4
  • 28
    • 0029082331 scopus 로고
    • Cloning and expression of a cytokine inducible nitric oxide synthase cDNA from rat islets of Langerhans
    • Karlsen AE, Andersen HU, Vissing SB et al. (1995) Cloning and expression of a cytokine inducible nitric oxide synthase cDNA from rat islets of Langerhans. Diabetes 44: 753-758
    • (1995) Diabetes , vol.44 , pp. 753-758
    • Karlsen, A.E.1    Andersen, H.U.2    Vissing, S.B.3
  • 29
    • 0025802065 scopus 로고
    • Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase
    • Bredt DS, Hwang PM, Glatt CE, Lowenstein C, Reed RR, Snyder SH (1991) Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature 351: 714-718
    • (1991) Nature , vol.351 , pp. 714-718
    • Bredt, D.S.1    Hwang, P.M.2    Glatt, C.E.3    Lowenstein, C.4    Reed, R.R.5    Snyder, S.H.6
  • 30
  • 31
    • 0026623110 scopus 로고
    • Endothelial nitric oxide synthase: Molecular cloning and characterization of a distinct constitutive enzyme isoform
    • Lamas S, Marsden PA, Gordon KL, Tempst P, Michel T (1992) Endothelial nitric oxide synthase: Molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc Natl Acad Sci USA 89: 6348-6352
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6348-6352
    • Lamas, S.1    Marsden, P.A.2    Gordon, K.L.3    Tempst, P.4    Michel, T.5
  • 32
    • 0026764084 scopus 로고
    • Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase
    • Janssens SP, Shimouchi A, Quertermous T, Block DB, Block KD (1992) Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. J Biol Chem 267: 14519-14522
    • (1992) J Biol Chem , vol.267 , pp. 14519-14522
    • Janssens, S.P.1    Shimouchi, A.2    Quertermous, T.3    Block, D.B.4    Block, K.D.5
  • 34
    • 0026669125 scopus 로고
    • Nitric oxide: First in a new class of neurotransmitters
    • Snyder SH (1992) Nitric oxide: first in a new class of neurotransmitters. Science 257: 494-496
    • (1992) Science , vol.257 , pp. 494-496
    • Snyder, S.H.1
  • 35
    • 0001599370 scopus 로고
    • Role of endothelium-derived nitric oxide in the regulation of blood pressure
    • Rees DD, Palmer RMJ, Moncada S (1989) Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci USA 86: 3375-3378
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 3375-3378
    • Rees, D.D.1    Palmer, R.M.J.2    Moncada, S.3
  • 36
    • 0026729267 scopus 로고
    • Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme
    • Lowenstein CJ, Glatt CS, Bredt DS, Snyder SH (1992) Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. Proc Nat Acad Sci USA 89: 6711-6715
    • (1992) Proc Nat Acad Sci USA , vol.89 , pp. 6711-6715
    • Lowenstein, C.J.1    Glatt, C.S.2    Bredt, D.S.3    Snyder, S.H.4
  • 37
    • 0026569273 scopus 로고
    • Cloning and characterization of inducible nitric oxide synthase from mouse macrophages
    • Xie Q-W, Cho HJ, Calaycay J et al. (1992) Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 256: 225-228
    • (1992) Science , vol.256 , pp. 225-228
    • Xie, Q.-W.1    Cho, H.J.2    Calaycay, J.3
  • 38
    • 0026744830 scopus 로고
    • Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line
    • Lyons RC, Orloff GJ, Cunningham JM (1992) Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J Biol Chem 267: 6370-6374
    • (1992) J Biol Chem , vol.267 , pp. 6370-6374
    • Lyons, R.C.1    Orloff, G.J.2    Cunningham, J.M.3
  • 39
    • 0027482241 scopus 로고
    • Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte
    • Charles JG, Palmer RMJ, Hickery MS et al. (1993) Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte. Proc Natl Acad Sci USA 90: 11419-11423
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11419-11423
    • Charles, J.G.1    Palmer, R.M.J.2    Hickery, M.S.3
  • 40
    • 0027538176 scopus 로고
    • Molecular cloning and expression of inducible nitric oxide synthase from human hepatocyles
    • Geller DA, Lowenstein CJ, Shapiro RA et al. (1993) Molecular cloning and expression of inducible nitric oxide synthase from human hepatocyles. Proc Natl Acad Sci USA 90: 3491-3495
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 3491-3495
    • Geller, D.A.1    Lowenstein, C.J.2    Shapiro, R.A.3
  • 41
    • 0028271899 scopus 로고
    • Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene
    • Chartrain NA, Geller DA, Koty PP et al. (1994) Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene. J Biol Chem 269: 6765-6772
    • (1994) J Biol Chem , vol.269 , pp. 6765-6772
    • Chartrain, N.A.1    Geller, D.A.2    Koty, P.P.3
  • 42
    • 0028818035 scopus 로고
    • Nitric oxide synthase: Expression and expressional control of the three isoforms
    • Förstermann U, Kleinert H (1995) Nitric oxide synthase: expression and expressional control of the three isoforms. Naunyn-Schmiedeberg's Arch Pharmacol 352: 351-364
    • (1995) Naunyn-Schmiedeberg's Arch Pharmacol , vol.352 , pp. 351-364
    • Förstermann, U.1    Kleinert, H.2
  • 43
    • 0027325255 scopus 로고
    • Nitric oxide synthase structure and mechanism
    • Marletta MA (1993) Nitric oxide synthase structure and mechanism. J Biol Chem 268: 12231-12234
    • (1993) J Biol Chem , vol.268 , pp. 12231-12234
    • Marletta, M.A.1
  • 44
    • 0026724223 scopus 로고
    • Calmodulin is a subunit of nitric oxide synthase from macrophages
    • Cho HJ, Xie O, Calaycay J et al. (1992) Calmodulin is a subunit of nitric oxide synthase from macrophages. J Exp Med 176: 599-604
    • (1992) J Exp Med , vol.176 , pp. 599-604
    • Cho, H.J.1    Xie, O.2    Calaycay, J.3
  • 45
    • 0028429097 scopus 로고
    • The inducible nitric oxide synthase gene, Nos2, maps to mouse chromosome 11
    • Gerling I, Karlsen AE, Chapman HD et al. (1994) The inducible nitric oxide synthase gene, Nos2, maps to mouse chromosome 11. Mammal Genome 5: 318-320
    • (1994) Mammal Genome , vol.5 , pp. 318-320
    • Gerling, I.1    Karlsen, A.E.2    Chapman, H.D.3
  • 46
    • 0027170073 scopus 로고
    • Regional localization of the gene coding for human brain nitric oxide synthase (NOS1) to 12q24.1 to 24.31 by fluorescent in situ hybridization
    • Xu W, Gorman P, Sheer D et al. (1993) Regional localization of the gene coding for human brain nitric oxide synthase (NOS1) to 12q24.1 to 24.31 by fluorescent in situ hybridization. Cytogenet Cell Genet 64: 62-63
    • (1993) Cytogenet Cell Genet , vol.64 , pp. 62-63
    • Xu, W.1    Gorman, P.2    Sheer, D.3
  • 47
    • 0027183208 scopus 로고
    • Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene
    • Marsden PA, Heng HHQ, Scherer SW et al. (1993) Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J Biol Chem 268: 17478-17488
    • (1993) J Biol Chem , vol.268 , pp. 17478-17488
    • Marsden, P.A.1    Heng, H.H.Q.2    Scherer, S.W.3
  • 48
    • 0028055070 scopus 로고
    • Localization of the human gene for inducible nitric oxide synthase (NOS2) to chromosome 17q11.2-q12
    • Marsden PA, Heng HH, Duff CL, Shi X-M, Tsui L-C, Hall AV (1994) Localization of the human gene for inducible nitric oxide synthase (NOS2) to chromosome 17q11.2-q12. Genomics 19: 183-185
    • (1994) Genomics , vol.19 , pp. 183-185
    • Marsden, P.A.1    Heng, H.H.2    Duff, C.L.3    Shi, X.-M.4    Tsui, L.-C.5    Hall, A.V.6
  • 49
    • 0027172544 scopus 로고
    • Polygenic control of autoimmune diabetes in nonobese diabetic mice
    • Ghosh S, Palmer S, Rodrigues N et al. (1993) Polygenic control of autoimmune diabetes in nonobese diabetic mice. Nature Genet 4: 404-409
    • (1993) Nature Genet , vol.4 , pp. 404-409
    • Ghosh, S.1    Palmer, S.2    Rodrigues, N.3
  • 50
    • 0027489210 scopus 로고
    • Nitric oxide production in islets from nonobese diabetic mice: Aminoguanidine-sensitive and -resistant stages in the immunological diabetic process
    • Corbett JA, Mikhael A, Shimizu J et al. (1993) Nitric oxide production in islets from nonobese diabetic mice: aminoguanidine-sensitive and -resistant stages in the immunological diabetic process. Proc Natl Acad Sci USA 90: 8992-8995
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8992-8995
    • Corbett, J.A.1    Mikhael, A.2    Shimizu, J.3
  • 51
    • 0027164671 scopus 로고
    • Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats
    • Kleemann R, Rothe H, Kolb-Bachofen V et al. (1993) Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats. FEBS Lett 328: 9-12
    • (1993) FEBS Lett , vol.328 , pp. 9-12
    • Kleemann, R.1    Rothe, H.2    Kolb-Bachofen, V.3
  • 52
    • 8944258975 scopus 로고    scopus 로고
    • Strain-dependent differences in sensitivity of rat betacells to IL-1β in vitro and in vivo
    • in press
    • Reimers JI, Andersen HU, Mauricio D et al. (1996) Strain-dependent differences in sensitivity of rat betacells to IL-1β in vitro and in vivo. Diabetes "in press"
    • (1996) Diabetes
    • Reimers, J.I.1    Andersen, H.U.2    Mauricio, D.3
  • 53
    • 0028285560 scopus 로고
    • Mapping of the genes encoding human inducible and endothelial nitric oxide synthase (NOS2 and NOS3) to the pericentric region of chromosome 17 and to chromosome 7, respectively
    • Xu W, Charles IG, Moncada S, Gorman P, Sheer D, Liu L. Emson P (1994) Mapping of the genes encoding human inducible and endothelial nitric oxide synthase (NOS2 and NOS3) to the pericentric region of chromosome 17 and to chromosome 7, respectively. Genomics 21: 419-422
    • (1994) Genomics , vol.21 , pp. 419-422
    • Xu, W.1    Charles, I.G.2    Moncada, S.3    Gorman, P.4    Sheer, D.5    Liu, L.6    Emson, P.7
  • 54
    • 0028015870 scopus 로고
    • Differential expression and induction of mRNAs encoding two inducible nitric oxide synthase in rat kidney
    • Mohaupt MG, Elzie JL, Ahn KY, Clapp WL, Wilcox CS, Kone BC (1994) Differential expression and induction of mRNAs encoding two inducible nitric oxide synthase in rat kidney. Kidney Int 46: 653-665
    • (1994) Kidney Int , vol.46 , pp. 653-665
    • Mohaupt, M.G.1    Elzie, J.L.2    Ahn, K.Y.3    Clapp, W.L.4    Wilcox, C.S.5    Kone, B.C.6
  • 55
    • 0029064775 scopus 로고
    • Three members of the nitric oxide synthase II gene family (NOS2A, NOS2B, and NOS2c) colocalize to human chromosome 17
    • Bloch KD, Wolfram JR, Brown DM et al. (1995) Three members of the nitric oxide synthase II gene family (NOS2A, NOS2B, and NOS2c) colocalize to human chromosome 17. Genomics 27: 526-530
    • (1995) Genomics , vol.27 , pp. 526-530
    • Bloch, K.D.1    Wolfram, J.R.2    Brown, D.M.3
  • 56
    • 0029088383 scopus 로고
    • Molecular genetic analysis of the duplication of human inducible nitric oxide synthase (NOS2) sequences
    • Xu W, Charles IG, Liu L. Koni PA, Moncada S, Emson P (1995) Molecular genetic analysis of the duplication of human inducible nitric oxide synthase (NOS2) sequences. Biochem Biophys Res Commun 212: 466-472
    • (1995) Biochem Biophys Res Commun , vol.212 , pp. 466-472
    • Xu, W.1    Charles, I.G.2    Liu, L.3    Koni, P.A.4    Moncada, S.5    Emson, P.6
  • 57
    • 0027255749 scopus 로고
    • Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide
    • Xie Q-W, Whisnant R, Nathan C (1993) Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide. J Exp Med 177: 1779-1784
    • (1993) J Exp Med , vol.177 , pp. 1779-1784
    • Xie, Q.-W.1    Whisnant, R.2    Nathan, C.3
  • 58
    • 0027368278 scopus 로고
    • Macrophage nitric oxide synthase gene: Two upstream regions mediate induction by interferon gamma and lipopolysaccharide
    • Lowenstein CJ, Alley EW, Raval P et al. (1993) Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide. Proc Natl Acad Sci USA 90: 9730-9734
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 9730-9734
    • Lowenstein, C.J.1    Alley, E.W.2    Raval, P.3
  • 59
    • 0028329887 scopus 로고
    • Promoter analysis of human inducible nitric oxide synthase gene associated with cardiovascular homeostasis
    • Nunokawa Y, Ishida N, Tanaka S (1994) Promoter analysis of human inducible nitric oxide synthase gene associated with cardiovascular homeostasis. Biochem Biophys Res Commun 200: 802-807
    • (1994) Biochem Biophys Res Commun , vol.200 , pp. 802-807
    • Nunokawa, Y.1    Ishida, N.2    Tanaka, S.3
  • 60
    • 0028786601 scopus 로고
    • A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
    • Melillo G, Musso T, Sica A, Taylor LS, Cox GW, Varesio L (1995) A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J Exp Med 182: 1683-1693
    • (1995) J Exp Med , vol.182 , pp. 1683-1693
    • Melillo, G.1    Musso, T.2    Sica, A.3    Taylor, L.S.4    Cox, G.W.5    Varesio, L.6
  • 61
    • 0023706894 scopus 로고
    • Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production
    • Ding AH, Nathan CF, Stuehr DJ (1988) Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J Immunol 141: 2407-2412
    • (1988) J Immunol , vol.141 , pp. 2407-2412
    • Ding, A.H.1    Nathan, C.F.2    Stuehr, D.J.3
  • 62
    • 0028850008 scopus 로고
    • The cytokine responsive smooth muscle cell enhancer of inducible nitric oxide synthase. Activation by nuclear factor (greek small letter script kappa)B
    • Spink J, Cohen J, Evans TJ (1995) The cytokine responsive smooth muscle cell enhancer of inducible nitric oxide synthase. Activation by nuclear factor (greek small letter script kappa)B. J Biol Chem 270: 29541-29547
    • (1995) J Biol Chem , vol.270 , pp. 29541-29547
    • Spink, J.1    Cohen, J.2    Evans, T.J.3
  • 63
    • 0028917561 scopus 로고
    • Structural diversity on the 5′-untranslated region of cytokine-stimulated human inducible nitric oxide synthase mRNA
    • Chu SC, Wu H-P, Banks TC, Eissa NT, Moss J (1995) Structural diversity on the 5′-untranslated region of cytokine-stimulated human inducible nitric oxide synthase mRNA. J Biol Chem 270: 10625-10630
    • (1995) J Biol Chem , vol.270 , pp. 10625-10630
    • Chu, S.C.1    Wu, H.-P.2    Banks, T.C.3    Eissa, N.T.4    Moss, J.5
  • 64
    • 0030061515 scopus 로고    scopus 로고
    • Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: Initial analysis of the human NOS2 promoter
    • De Vera ME, Shapiro RA, Nussler AK et al. (1996) Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter. Proc Natl Acad Sci USA 93: 1054-1059
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1054-1059
    • De Vera, M.E.1    Shapiro, R.A.2    Nussler, A.K.3
  • 65
    • 0027279421 scopus 로고
    • Messenger RNA degradation in eukaryotes
    • Sachs AB (1993) Messenger RNA degradation in eukaryotes. Cell 74: 413-421
    • (1993) Cell , vol.74 , pp. 413-421
    • Sachs, A.B.1
  • 66
    • 0027979899 scopus 로고
    • Inducible nitric oxide synthase mRNA is transiently expressed and destroyed by a cycloheximide-sensitive process
    • Evans T, Carpenter A, Cohen J (1994) Inducible nitric oxide synthase mRNA is transiently expressed and destroyed by a cycloheximide-sensitive process. Eur J Biochem 219: 563-569
    • (1994) Eur J Biochem , vol.219 , pp. 563-569
    • Evans, T.1    Carpenter, A.2    Cohen, J.3
  • 67
    • 0028978604 scopus 로고
    • 2+ selectively suppresses IL-1-induced NO production by reducing iNOS mRNA stability
    • 2+ selectively suppresses IL-1-induced NO production by reducing iNOS mRNA stability. J Cell Biol 129: 1651-1657
    • (1995) J Cell Biol , vol.129 , pp. 1651-1657
    • Geng, Y.1    Lotz, M.2
  • 68
    • 0027203305 scopus 로고
    • Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor β
    • Vodovotz Y, Bogdan C, Paik J, Xie Q-W, Nathan C (1993) Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor β. J Exp Med 178: 605-613
    • (1993) J Exp Med , vol.178 , pp. 605-613
    • Vodovotz, Y.1    Bogdan, C.2    Paik, J.3    Xie, Q.-W.4    Nathan, C.5
  • 69
    • 0028596498 scopus 로고
    • Studies on the molecular regulation of the inducible form of nitric oxide synthase (iNOS) in insulin-producing cells
    • Niemann A, Björklund A, Eizirik DL (1994) Studies on the molecular regulation of the inducible form of nitric oxide synthase (iNOS) in insulin-producing cells. Mol Cell Endocrinol 106: 151-155
    • (1994) Mol Cell Endocrinol , vol.106 , pp. 151-155
    • Niemann, A.1    Björklund, A.2    Eizirik, D.L.3
  • 70
    • 0027406798 scopus 로고
    • Interleukin-1-induced expression of nitric oxide synthase in insulin-producing cells is preceded by c-fos induction and depends on gene transcription and protein synthesis
    • Eizirik DL, Björklund A, Welsh N (1993) Interleukin-1-induced expression of nitric oxide synthase in insulin-producing cells is preceded by c-fos induction and depends on gene transcription and protein synthesis. FEBS Lett 317: 62-66
    • (1993) FEBS Lett , vol.317 , pp. 62-66
    • Eizirik, D.L.1    Björklund, A.2    Welsh, N.3
  • 71
    • 0028237083 scopus 로고
    • Nitric oxide limits transcriptional induction of nitric oxide synthase in CNS glial cells
    • Park SK, Lin HL, Murphy S (1994) Nitric oxide limits transcriptional induction of nitric oxide synthase in CNS glial cells. Biochem Biophys Res Commun 201: 762-768
    • (1994) Biochem Biophys Res Commun , vol.201 , pp. 762-768
    • Park, S.K.1    Lin, H.L.2    Murphy, S.3
  • 72
    • 0028885764 scopus 로고
    • Induction of nitric oxide synthase mRNA expression. Suppression by exogenous nitric oxide
    • Colasanti M, Persichini T, Menegazzi M et al. (1995) Induction of nitric oxide synthase mRNA expression. Suppression by exogenous nitric oxide. J Biol Chem 270: 26731-26733
    • (1995) J Biol Chem , vol.270 , pp. 26731-26733
    • Colasanti, M.1    Persichini, T.2    Menegazzi, M.3
  • 73
    • 0028084722 scopus 로고
    • Coinduction of nitric oxide synthase and argininosuccinate synthetase in a murine macrophage cell line. Implications for regulation of nitric oxide production
    • Nussler AK, Billiar TR, Liu Z-Z, Morris SM Jr (1994) Coinduction of nitric oxide synthase and argininosuccinate synthetase in a murine macrophage cell line. Implications for regulation of nitric oxide production. J Biol Chem 269: 1257-1261
    • (1994) J Biol Chem , vol.269 , pp. 1257-1261
    • Nussler, A.K.1    Billiar, T.R.2    Liu, Z.-Z.3    Morris Jr., S.M.4
  • 74
    • 0029011129 scopus 로고
    • Induction and stabilization of I(greek small letter script kappa)B alpha by nitric oxide mediates inhibition of NF-(greek small letter script kappa)B
    • Peng H-B, Libby P, Liao JK (1995) Induction and stabilization of I(greek small letter script kappa)B alpha by nitric oxide mediates inhibition of NF-(greek small letter script kappa)B. J Biol Chem 270: 14214-14219
    • (1995) J Biol Chem , vol.270 , pp. 14214-14219
    • Peng, H.-B.1    Libby, P.2    Liao, J.K.3
  • 75
    • 0027374973 scopus 로고
    • Inducible nitric oxide synthase from a rat alveolar macrophage cell line is inhibited by nitric oxide
    • Griscavage JM, Rogers NE, Sherman MP, Ignarro LJ (1993) Inducible nitric oxide synthase from a rat alveolar macrophage cell line is inhibited by nitric oxide. J Immunol 151: 6329-6337
    • (1993) J Immunol , vol.151 , pp. 6329-6337
    • Griscavage, J.M.1    Rogers, N.E.2    Sherman, M.P.3    Ignarro, L.J.4
  • 76
    • 0027243274 scopus 로고
    • What are the types and cellular sources of free radicals in the pathogenesis of type 1 (insulin-dependent) diabetes mellitus
    • Mandrup-Poulsen T, Corbett JA, McDaniel ML, Nerup J (1993) What are the types and cellular sources of free radicals in the pathogenesis of type 1 (insulin-dependent) diabetes mellitus. Diabetologia 36: 470-473
    • (1993) Diabetologia , vol.36 , pp. 470-473
    • Mandrup-Poulsen, T.1    Corbett, J.A.2    McDaniel, M.L.3    Nerup, J.4
  • 77
    • 0027488923 scopus 로고
    • Nicotinamide and dexamethasone inhibit interleukin-1-induced nitric oxide production by RINm5F cells without decreasing messenger ribonucleic acid expression for nitric oxide synthase
    • Cetkovic-Cvrlje M, Sandier S, Eizirik DL (1993) Nicotinamide and dexamethasone inhibit interleukin-1-induced nitric oxide production by RINm5F cells without decreasing messenger ribonucleic acid expression for nitric oxide synthase. Endocrinology 133: 1739-1743
    • (1993) Endocrinology , vol.133 , pp. 1739-1743
    • Cetkovic-Cvrlje, M.1    Sandier, S.2    Eizirik, D.L.3
  • 78
    • 0028112591 scopus 로고
    • Tyrosine kinase involvement in IL-1β-induced expression of iNOS by β-cells purified from islets of Langerhans
    • Corbett JA, Kwon G, Misko TP, Rodi CP, McDaniel ML (1994) Tyrosine kinase involvement in IL-1β-induced expression of iNOS by β-cells purified from islets of Langerhans. Am J Physiol 267: C48-C54
    • (1994) Am J Physiol , vol.267
    • Corbett, J.A.1    Kwon, G.2    Misko, T.P.3    Rodi, C.P.4    McDaniel, M.L.5
  • 79
    • 0028900805 scopus 로고
    • Intraislet release of interleukin-1 inhibits β-cell function by inducing β-cell expression of inducible nitric oxide synthase
    • Corbett JA, McDaniel ML (1995) Intraislet release of interleukin-1 inhibits β-cell function by inducing β-cell expression of inducible nitric oxide synthase. J Exp Med 181: 559-568
    • (1995) J Exp Med , vol.181 , pp. 559-568
    • Corbett, J.A.1    McDaniel, M.L.2
  • 80
    • 0027934873 scopus 로고
    • TNF-α and IFN-γ potentiate the deleterious effects of IL-1β on mouse pancreatic islets mainly via generation of nitric oxide
    • Cetkovic-Cvrlje M, Eizirik DL (1994) TNF-α and IFN-γ potentiate the deleterious effects of IL-1β on mouse pancreatic islets mainly via generation of nitric oxide. Cytokine 6: 399-406
    • (1994) Cytokine , vol.6 , pp. 399-406
    • Cetkovic-Cvrlje, M.1    Eizirik, D.L.2
  • 81
    • 0029086027 scopus 로고
    • Expression of the citrulline-nitric oxide cycle in rodent and human pancreatic β-cells: Induction of argininosuccinate synthase by cytokines
    • Flodström M, Niemann A, Bedoya FJ, Morris SM Jr, Eizirik DL (1995) Expression of the citrulline-nitric oxide cycle in rodent and human pancreatic β-cells: induction of argininosuccinate synthase by cytokines. Endocrinology 136: 3200-3206
    • (1995) Endocrinology , vol.136 , pp. 3200-3206
    • Flodström, M.1    Niemann, A.2    Bedoya, F.J.3    Morris Jr., S.M.4    Eizirik, D.L.5
  • 82
    • 0028170683 scopus 로고
    • Dissociation between interleukin-1β-induced expression of mRNA for Superoxide dismutase and nitric oxide synthase in insulin-producing cells
    • Bigdeli N, Niemann A, Sandier S, Eizirik DL (1994) Dissociation between interleukin-1β-induced expression of mRNA for Superoxide dismutase and nitric oxide synthase in insulin-producing cells. Biochem Biophys Res Commun 203: 1542-1547
    • (1994) Biochem Biophys Res Commun , vol.203 , pp. 1542-1547
    • Bigdeli, N.1    Niemann, A.2    Sandier, S.3    Eizirik, D.L.4
  • 83
    • 23444448553 scopus 로고
    • Modulation of inducible nitric oxide synthase in RINm5F cells
    • Messmer U, Brüne B (1994) Modulation of inducible nitric oxide synthase in RINm5F cells. Cell Signal 6: 17-24
    • (1994) Cell Signal , vol.6 , pp. 17-24
    • Messmer, U.1    Brüne, B.2
  • 84
    • 0029670692 scopus 로고    scopus 로고
    • Interleukin-1β-induced nitric oxide production from isolated rat islets is modulated by D-glucose and 3-isobutyl-1-methyl xanthine
    • Andersen HU, Mauricio D, Karlsen AE, Mandrup-Poulsen T, Nielsen JH, Nerup J (1996) Interleukin-1β-induced nitric oxide production from isolated rat islets is modulated by D-glucose and 3-isobutyl-1-methyl xanthine. Eur J Endocrinol 134: 251-260
    • (1996) Eur J Endocrinol , vol.134 , pp. 251-260
    • Andersen, H.U.1    Mauricio, D.2    Karlsen, A.E.3    Mandrup-Poulsen, T.4    Nielsen, J.H.5    Nerup, J.6
  • 85
    • 0026042191 scopus 로고
    • A possible novel pathway of regulation by murine T helper type-2 (Th2) cells of a Th1 cell activity via the modulation of the induction of nitric oxide synthase on macrophages
    • Liew FY, Li Y, Severn A, Millot S, Schmidt J, Salter M, Moncada S (1992) A possible novel pathway of regulation by murine T helper type-2 (Th2) cells of a Th1 cell activity via the modulation of the induction of nitric oxide synthase on macrophages. Eur J Immunol 21: 2489-2494
    • (1992) Eur J Immunol , vol.21 , pp. 2489-2494
    • Liew, F.Y.1    Li, Y.2    Severn, A.3    Millot, S.4    Schmidt, J.5    Salter, M.6    Moncada, S.7
  • 86
    • 0026510069 scopus 로고
    • Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by Interferon γ in murine macrophages
    • Cunha FO, Moncada S, Liew FY (1992) Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by Interferon γ in murine macrophages. Biochem Biophys Res Commun 182: 1155-1159
    • (1992) Biochem Biophys Res Commun , vol.182 , pp. 1155-1159
    • Cunha, F.O.1    Moncada, S.2    Liew, F.Y.3
  • 87
    • 0027203910 scopus 로고
    • Interleukin-10 stimulates rat pancreatic islets in vitro, but fails to protect against interleukin-1
    • Sandler S, Welsh N (1993) Interleukin-10 stimulates rat pancreatic islets in vitro, but fails to protect against interleukin-1. Biochem Biophys Res Commun 195: 859-865
    • (1993) Biochem Biophys Res Commun , vol.195 , pp. 859-865
    • Sandler, S.1    Welsh, N.2
  • 88
    • 0028855583 scopus 로고
    • The lethal effects of cytokine-induced nitric oxide on cardiac myocites are blocked by nitric oxide synthase antagonism or transforming growth factor β
    • Pinsky DJ, Cai B, Yang X, Rodriquez. C, Sciacca RR, Cannon PJ (1995) The lethal effects of cytokine-induced nitric oxide on cardiac myocites are blocked by nitric oxide synthase antagonism or transforming growth factor β. J Clin Invest 95: 677-685
    • (1995) J Clin Invest , vol.95 , pp. 677-685
    • Pinsky, D.J.1    Cai, B.2    Yang, X.3    Rodriquez, C.4    Sciacca, R.R.5    Cannon, P.J.6
  • 89
    • 0028970526 scopus 로고
    • Transforming growth factor-β inhibits the cytokine-mediated expression of the inducible nitric oxide synthase mRNA in human retinal pigment epithelial cells
    • Kutty RK, Kutty G, Hooks JJ, Wiggert B, Nagineni CN (1995) Transforming growth factor-β inhibits the cytokine-mediated expression of the inducible nitric oxide synthase mRNA in human retinal pigment epithelial cells. Biochem Biophys Res Commun 215: 386-393
    • (1995) Biochem Biophys Res Commun , vol.215 , pp. 386-393
    • Kutty, R.K.1    Kutty, G.2    Hooks, J.J.3    Wiggert, B.4    Nagineni, C.N.5
  • 90
    • 0011115947 scopus 로고
    • Transforming growth factor β 1 protects rat islets from the inhibitory effects of interleukin-1 on insulin secretion
    • Abstract
    • Marbley JG, Cunningham JM, Schulster D, Green IC (1994) Transforming growth factor β 1 protects rat islets from the inhibitory effects of interleukin-1 on insulin secretion. Diabetologia 37 [Suppl 1 ]: A44 (Abstract)
    • (1994) Diabetologia , vol.37 , Issue.1 SUPPL.
    • Marbley, J.G.1    Cunningham, J.M.2    Schulster, D.3    Green, I.C.4
  • 91
    • 0029621794 scopus 로고
    • Recombinant human transforming growth factor β does not inhibit the effects of interleukin-1β on pancreatic islet cells
    • Hao W, Palmer JP (1995) Recombinant human transforming growth factor β does not inhibit the effects of interleukin-1β on pancreatic islet cells. J Interferon Cyt Res 15: 1075-1082
    • (1995) J Interferon Cyt Res , vol.15 , pp. 1075-1082
    • Hao, W.1    Palmer, J.P.2
  • 92
    • 0024642728 scopus 로고
    • A natural interleukin 1 (IL-1) inhibitor counteracts the inhibitory effect of IL-1 on insulin production in cultured rat pancreatic islets
    • Dayer-Métroz MD, Wollheim CB, Seckinger P, Dayer JM (1989) A natural interleukin 1 (IL-1) inhibitor counteracts the inhibitory effect of IL-1 on insulin production in cultured rat pancreatic islets. J Autoimmun 2: 163-171
    • (1989) J Autoimmun , vol.2 , pp. 163-171
    • Dayer-Métroz, M.D.1    Wollheim, C.B.2    Seckinger, P.3    Dayer, J.M.4
  • 94
    • 0025806641 scopus 로고
    • An interleukin-1 receptor antagonist protein protects insulinproducing beta cells against suppressive effects of interleukin-1β
    • Eizirik DL, Tracey DE, Bendtzen K, Sandler S (1991) An interleukin-1 receptor antagonist protein protects insulinproducing beta cells against suppressive effects of interleukin-1β. Diabetologia 34: 445-448
    • (1991) Diabetologia , vol.34 , pp. 445-448
    • Eizirik, D.L.1    Tracey, D.E.2    Bendtzen, K.3    Sandler, S.4
  • 95
    • 0026652844 scopus 로고
    • Role of receptor binding and gene transcription for both the stimulatory and inhibitory effects of interleukin-1 in pancreatic β-cells
    • Eizirik DL, Tracey DE, Bendtzen K, Sandler S (1992) Role of receptor binding and gene transcription for both the stimulatory and inhibitory effects of interleukin-1 in pancreatic β-cells. Autoimmunity 12: 127-133
    • (1992) Autoimmunity , vol.12 , pp. 127-133
    • Eizirik, D.L.1    Tracey, D.E.2    Bendtzen, K.3    Sandler, S.4
  • 96
    • 0027227773 scopus 로고
    • Differential interleukin-1 receptor antagonism on pancreatic beta and alpha cells. Studies in rodent and human islets and in normal rats
    • Zumsteg U, Reimers JI, Pociot F et al. (1993) Differential interleukin-1 receptor antagonism on pancreatic beta and alpha cells. Studies in rodent and human islets and in normal rats. Diabetologia 36: 759-766
    • (1993) Diabetologia , vol.36 , pp. 759-766
    • Zumsteg, U.1    Reimers, J.I.2    Pociot, F.3
  • 97
    • 0028223737 scopus 로고
    • Interleukin-1 stimulates the expression of type I and type II interleukin-1 receptors in the rat insulinoma cell line RINm5F; sequencing a rat type II interleukin-1 receptor cDNA
    • Bristulf J, Gatti S, Malinowksy D, Björk L, Sundgren AK, Barfai T (1994) Interleukin-1 stimulates the expression of type I and type II interleukin-1 receptors in the rat insulinoma cell line RINm5F; sequencing a rat type II interleukin-1 receptor cDNA. Eur Cytokine Net 5: 319-330
    • (1994) Eur Cytokine Net , vol.5 , pp. 319-330
    • Bristulf, J.1    Gatti, S.2    Malinowksy, D.3    Björk, L.4    Sundgren, A.K.5    Barfai, T.6
  • 98
    • 0028942160 scopus 로고
    • Localization and characterization of interleukin-1 receptors in the islets of Langerhans from control and nonobese diabetic mice
    • Jafarian-Tehrani M, Amrani A, Homo-Delarche F, Marquette C, Dardenne M, Haour F (1995) Localization and characterization of interleukin-1 receptors in the islets of Langerhans from control and nonobese diabetic mice. Endocrinology 136: 609-613
    • (1995) Endocrinology , vol.136 , pp. 609-613
    • Jafarian-Tehrani, M.1    Amrani, A.2    Homo-Delarche, F.3    Marquette, C.4    Dardenne, M.5    Haour, F.6
  • 99
    • 0028964465 scopus 로고
    • Cytokine signaling through nonreceptor protein tyrosine kinases
    • Taniguchi T (1995) Cytokine signaling through nonreceptor protein tyrosine kinases. Science 268: 251-255
    • (1995) Science , vol.268 , pp. 251-255
    • Taniguchi, T.1
  • 100
    • 0028240827 scopus 로고
    • Interleukin-1-induced activation of a protein kinase coprecipitating with the type 1 interleukin-1 receptor in T cells
    • Martin M, Bol GF, Eriksson A, Resch K, Brigelius-Flohe R (1994) Interleukin-1-induced activation of a protein kinase coprecipitating with the type 1 interleukin-1 receptor in T cells. Eur J Immunol 24: 1566-1571
    • (1994) Eur J Immunol , vol.24 , pp. 1566-1571
    • Martin, M.1    Bol, G.F.2    Eriksson, A.3    Resch, K.4    Brigelius-Flohe, R.5
  • 101
    • 0028982919 scopus 로고
    • NF-(greek small letter script kappa)B activation by interleukin-1 (IL-1) requires an IL-1-receptor-associated protein kinase activity
    • Croston GE, Cao Z, Goeddel DV (1995) NF-(greek small letter script kappa)B activation by interleukin-1 (IL-1) requires an IL-1-receptor-associated protein kinase activity. J Biol Chem 270: 16514-16517
    • (1995) J Biol Chem , vol.270 , pp. 16514-16517
    • Croston, G.E.1    Cao, Z.2    Goeddel, D.V.3
  • 102
    • 0029865142 scopus 로고    scopus 로고
    • IRAK: A kinase associated with the interleukin-1 receptor
    • Cao Z, Henzel WJ, Gao X (1996) IRAK: a kinase associated with the interleukin-1 receptor. Science 271: 1128-1131
    • (1996) Science , vol.271 , pp. 1128-1131
    • Cao, Z.1    Henzel, W.J.2    Gao, X.3
  • 103
    • 0027536852 scopus 로고
    • The inducible transcription factor NF-(greek small letter script kappa) B: Structure-function relationship of its protein subunits
    • Grimm S, Baeuerle PA (1993) The inducible transcription factor NF-(greek small letter script kappa) B: structure-function relationship of its protein subunits. Biochem J 290: 297-308
    • (1993) Biochem J , vol.290 , pp. 297-308
    • Grimm, S.1    Baeuerle, P.A.2
  • 104
    • 0023280348 scopus 로고
    • Protein-hinding sites in Ig gene enhancers determine transcriptional activity and inducibility
    • Lenardo MJ, Pierce JW, Baltimore D (1987) Protein-hinding sites in Ig gene enhancers determine transcriptional activity and inducibility. Science 236: 1573-1577
    • (1987) Science , vol.236 , pp. 1573-1577
    • Lenardo, M.J.1    Pierce, J.W.2    Baltimore, D.3
  • 105
    • 0028167680 scopus 로고
    • Interleukin-1β induced activation of NF-(greek small letter script kappa) B in insulin producing RINm5F cells is prevented by the protease inhibitor Nα-p-tosyl-l-lysine choromethylketone
    • Saldeen J, Welsh N (1994) Interleukin-1β induced activation of NF-(greek small letter script kappa) B in insulin producing RINm5F cells is prevented by the protease inhibitor Nα-p-tosyl-l-lysine choromethylketone. Biochem Biophys Res Commun 203: 149-155
    • (1994) Biochem Biophys Res Commun , vol.203 , pp. 149-155
    • Saldeen, J.1    Welsh, N.2
  • 106
    • 0026033219 scopus 로고
    • Influence of protease on inhibitory and stimulatory effects of interleukin1β on β-cell function
    • Welsh N, Bendtzen K, Sandler S (1991) Influence of protease on inhibitory and stimulatory effects of interleukin1β on β-cell function. Diabetes 40: 290-294
    • (1991) Diabetes , vol.40 , pp. 290-294
    • Welsh, N.1    Bendtzen, K.2    Sandler, S.3
  • 107
    • 0027176524 scopus 로고
    • Rapid proteolysis of I(greek small letter script kappa) B-α is necessary for activation of transcription factor NF-(greek small letter script kappa)B
    • Henkel T, Macleidt T, Alkalay I, Krönke M, Ben-Neriah Y, Baeuerle PA (1993) Rapid proteolysis of I(greek small letter script kappa) B-α is necessary for activation of transcription factor NF-(greek small letter script kappa)B. Nature 365: 182-185
    • (1993) Nature , vol.365 , pp. 182-185
    • Henkel, T.1    Macleidt, T.2    Alkalay, I.3    Krönke, M.4    Ben-Neriah, Y.5    Baeuerle, P.A.6
  • 108
    • 0029092387 scopus 로고
    • Pyrrolidine dithiocarbamate prevents IL-1-induced nitric oxide synthase mRNA, but not Superoxide dismutase mRNA, in insulin producing cells
    • Bedoya FJ, Flodström M, Eizirik DL (1995) Pyrrolidine dithiocarbamate prevents IL-1-induced nitric oxide synthase mRNA, but not Superoxide dismutase mRNA, in insulin producing cells. Biochem Biophys Res Commun 210: 816-822
    • (1995) Biochem Biophys Res Commun , vol.210 , pp. 816-822
    • Bedoya, F.J.1    Flodström, M.2    Eizirik, D.L.3
  • 109
    • 0028973284 scopus 로고
    • Interleukin-1β-induced nitric oxide synthase expression by rat pancreatic β-cells: Evidence for the involvement of nuclear factor (greek small letter script kappa)B in the signaling mechanism
    • Kwon G, Corbett JA, Rodi CP, Sullivan P, McDaniel ML (1995) Interleukin-1β-induced nitric oxide synthase expression by rat pancreatic β-cells: Evidence for the involvement of nuclear factor (greek small letter script kappa)B in the signaling mechanism. Endocrinology 136: 4790-4795
    • (1995) Endocrinology , vol.136 , pp. 4790-4795
    • Kwon, G.1    Corbett, J.A.2    Rodi, C.P.3    Sullivan, P.4    McDaniel, M.L.5
  • 110
    • 0026590541 scopus 로고
    • Dithiocarbamates as potent inhibitors of nuclear factor (greek small letter script kappa)B activation in intact cells
    • Schreck R, Meier B, Mannel DN, Droge W, Baeuerle PA (1992) Dithiocarbamates as potent inhibitors of nuclear factor (greek small letter script kappa)B activation in intact cells. J Exp Med 175: 1181-1194
    • (1992) J Exp Med , vol.175 , pp. 1181-1194
    • Schreck, R.1    Meier, B.2    Mannel, D.N.3    Droge, W.4    Baeuerle, P.A.5
  • 111
    • 0028040827 scopus 로고
    • Liposomal delivery of antioxidant enzymes protects against hydrogen peroxide- but not interleukin-1β-induced inhibition of glucose metabolism in rat pancreatic islets
    • Welsh N, Margulis B, Bendtzen K, Sandler S (1994) Liposomal delivery of antioxidant enzymes protects against hydrogen peroxide- but not interleukin-1β-induced inhibition of glucose metabolism in rat pancreatic islets. J Endocrinol 143: 152-156
    • (1994) J Endocrinol , vol.143 , pp. 152-156
    • Welsh, N.1    Margulis, B.2    Bendtzen, K.3    Sandler, S.4
  • 112
    • 0020625894 scopus 로고
    • Flow cytometric studies of oxidative product formation by neutrophils: A graded response to membrane stimulation
    • Bass DA, Parce JW, Dechatelet LR, Szejda P, Seeds MC, Thomas M (1983) Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. J Immunol 130: 1910-1917
    • (1983) J Immunol , vol.130 , pp. 1910-1917
    • Bass, D.A.1    Parce, J.W.2    Dechatelet, L.R.3    Szejda, P.4    Seeds, M.C.5    Thomas, M.6
  • 113
    • 0029665049 scopus 로고    scopus 로고
    • Cytokines activate the nuclear factor (greek small letter script kappa)B (NF-(greek small letter script kappa)B) and induce nitric oxide production in human pancreatic islets
    • Flodström M, Welsh N, Eizirik DL (1996) Cytokines activate the nuclear factor (greek small letter script kappa)B (NF-(greek small letter script kappa)B) and induce nitric oxide production in human pancreatic islets. FEBS Lett: 385: 4-6
    • (1996) FEBS Lett , vol.385 , pp. 4-6
    • Flodström, M.1    Welsh, N.2    Eizirik, D.L.3
  • 114
    • 0028348307 scopus 로고
    • Requirement for transcription factor 1RF-1 in NO synthase induction in macrophages
    • Kamijo R, Harada H, Matsuyama T et al. (1994) Requirement for transcription factor 1RF-1 in NO synthase induction in macrophages. Science 263: 1612-1615
    • (1994) Science , vol.263 , pp. 1612-1615
    • Kamijo, R.1    Harada, H.2    Matsuyama, T.3
  • 115
    • 0028861996 scopus 로고
    • Nicotinamide inhibits IRF-I mRNA induction and prevents IL-1β-induced nitric oxide synthase expression in pancreatic β cells
    • Akabane A, Kato I, Takasawa S et al. (1995) Nicotinamide inhibits IRF-I mRNA induction and prevents IL-1β-induced nitric oxide synthase expression in pancreatic β cells. Biochem Biophys Res Commun 215: 524-530
    • (1995) Biochem Biophys Res Commun , vol.215 , pp. 524-530
    • Akabane, A.1    Kato, I.2    Takasawa, S.3
  • 116
    • 0025341797 scopus 로고
    • Interleukin-1 induces rapid and transient expression of the c-fos proto-oncogene in isolated pancreatic islets and in purified β-cells
    • Hughes JH, Watson MA, Easom RA, Turk J, McDaniel ML (1990) Interleukin-1 induces rapid and transient expression of the c-fos proto-oncogene in isolated pancreatic islets and in purified β-cells. FEBS Lett 266: 33-36
    • (1990) FEBS Lett , vol.266 , pp. 33-36
    • Hughes, J.H.1    Watson, M.A.2    Easom, R.A.3    Turk, J.4    McDaniel, M.L.5
  • 117
    • 0025720735 scopus 로고
    • The role of Jun, Fos and the AP-1 complex in cell proliferation and transformation
    • Angel P, Karin M (1991) The role of Jun, Fos and the AP-1 complex in cell proliferation and transformation. Biochim Biophys Acta 1072: 129-157
    • (1991) Biochim Biophys Acta , vol.1072 , pp. 129-157
    • Angel, P.1    Karin, M.2
  • 118
    • 0028329953 scopus 로고
    • JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylated the c-Jun activation domain
    • Dérijard B, Hibi M, Wu I-H et al. (1994) JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylated the c-Jun activation domain. Cell 76: 1025-1037
    • (1994) Cell , vol.76 , pp. 1025-1037
    • Dérijard, B.1    Hibi, M.2    Wu, I.-H.3
  • 119
    • 0029055812 scopus 로고
    • The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signalling pathway
    • Coso OA, Chiariello M, Yu J-C et al. (1995) The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signalling pathway. Cell 81: 1137-1146
    • (1995) Cell , vol.81 , pp. 1137-1146
    • Coso, O.A.1    Chiariello, M.2    Yu, J.-C.3
  • 120
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
    • Marshall CJ (1995) Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80: 179-185
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 121
    • 0028022750 scopus 로고
    • A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
    • Rouse J, Cohen P, Trigon S et al. (1994) A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 78: 1027-1037
    • (1994) Cell , vol.78 , pp. 1027-1037
    • Rouse, J.1    Cohen, P.2    Trigon, S.3
  • 122
    • 0028558986 scopus 로고
    • Role of SAPK/ERK kinase-1 in the stress-activated pathway reg ulating transcription factor c-Jun
    • Sanchez I, Hughes RT, Mayer BJ et al. (1994) Role of SAPK/ERK kinase-1 in the stress-activated pathway reg ulating transcription factor c-Jun. Nature 372: 794-798
    • (1994) Nature , vol.372 , pp. 794-798
    • Sanchez, I.1    Hughes, R.T.2    Mayer, B.J.3
  • 123
    • 0028905076 scopus 로고
    • Transcription factor ATF2 regulation by the JNK signal transduction pathway
    • Gupta S, Campbell D, Dérijard B, Davis RJ (1995) Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 267: 389-393
    • (1995) Science , vol.267 , pp. 389-393
    • Gupta, S.1    Campbell, D.2    Dérijard, B.3    Davis, R.J.4
  • 124
    • 0347537940 scopus 로고    scopus 로고
    • Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
    • Verheij M, Bose R, Lin XH et al. (1996) Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380: 75-79
    • (1996) Nature , vol.380 , pp. 75-79
    • Verheij, M.1    Bose, R.2    Lin, X.H.3
  • 126
    • 0028122397 scopus 로고
    • Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction
    • Wolff RA, Dobrowsky RT, Bielawska A, Abeid LM, Hannun YA (1994) Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J Biol Chem 269: 19605-19609
    • (1994) J Biol Chem , vol.269 , pp. 19605-19609
    • Wolff, R.A.1    Dobrowsky, R.T.2    Bielawska, A.3    Abeid, L.M.4    Hannun, Y.A.5
  • 127
    • 0029932759 scopus 로고    scopus 로고
    • 2-terminal kinase and the transcription factor ATF2 in the insulin-producing cell line RINm5F
    • 2-terminal kinase and the transcription factor ATF2 in the insulin-producing cell line RINm5F. J Biol Chem 271: 8307-8312
    • (1996) J Biol Chem , vol.271 , pp. 8307-8312
    • Welsh, N.1
  • 128
    • 0028979944 scopus 로고
    • Interleukin-1β-induced stimulation of insulin release in mouse pancreatic islets is related to diacylglycerol production and protein kinase C activation
    • Eizirik DL, Sandler S, Welsh N, Juntti-Berggren L, Berggren P-O (1995) Interleukin-1β-induced stimulation of insulin release in mouse pancreatic islets is related to diacylglycerol production and protein kinase C activation. Mol Cell Endocrinol 111: 159-165
    • (1995) Mol Cell Endocrinol , vol.111 , pp. 159-165
    • Eizirik, D.L.1    Sandler, S.2    Welsh, N.3    Juntti-Berggren, L.4    Berggren, P.-O.5
  • 129
    • 0024456533 scopus 로고
    • Effects of protein kinase C activation on the regulation of the stimulus-secretion coupling in pancreatic β-cells
    • Arkhammar P, Nilsson T, Welsh M, Welsh N, Berggren PO (1989) Effects of protein kinase C activation on the regulation of the stimulus-secretion coupling in pancreatic β-cells. Biochem J 264: 207-215
    • (1989) Biochem J , vol.264 , pp. 207-215
    • Arkhammar, P.1    Nilsson, T.2    Welsh, M.3    Welsh, N.4    Berggren, P.O.5
  • 130
    • 0026458406 scopus 로고
    • TNF activates NF-(greek small letter script kappa) B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown
    • Schutze S, Potthoff K, Macleidt T et al. (1992) TNF activates NF-(greek small letter script kappa) B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown. Cell 71: 765-776
    • (1992) Cell , vol.71 , pp. 765-776
    • Schutze, S.1    Potthoff, K.2    Macleidt, T.3
  • 131
    • 0023555012 scopus 로고
    • 1,2-diacylglycerols, but not phorbol esters, stimulate sphingomyelin hydrolysis in GH3 pituitary cells
    • Kolesnick RN (1987) 1,2-diacylglycerols, but not phorbol esters, stimulate sphingomyelin hydrolysis in GH3 pituitary cells. J Biol Chem 262: 16759-16762
    • (1987) J Biol Chem , vol.262 , pp. 16759-16762
    • Kolesnick, R.N.1
  • 132
    • 0027186357 scopus 로고
    • Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain
    • Trautwein C, Caelles C, van der Geer P, Hunter T, Karin M, Chojkier M (1993) Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain. Nature 364: 544-547
    • (1993) Nature , vol.364 , pp. 544-547
    • Trautwein, C.1    Caelles, C.2    Van Der Geer, P.3    Hunter, T.4    Karin, M.5    Chojkier, M.6
  • 133
    • 0025158578 scopus 로고
    • IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins to C/EBP
    • Poli V, Mancini FP, Cortese R (1990) IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins to C/EBP. Cell 63: 643-653
    • (1990) Cell , vol.63 , pp. 643-653
    • Poli, V.1    Mancini, F.P.2    Cortese, R.3
  • 134
    • 0029411321 scopus 로고
    • Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: Regulation by upstream antioxidant-responsive elements (ARE)
    • Prestera T, Talalay P, Alam J, Ahn YI, Lee PJ, Choi MK (1995) Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: regulation by upstream antioxidant-responsive elements (ARE). Mol Med 1: 827-837
    • (1995) Mol Med , vol.1 , pp. 827-837
    • Prestera, T.1    Talalay, P.2    Alam, J.3    Ahn, Y.I.4    Lee, P.J.5    Choi, M.K.6
  • 135
    • 0028363524 scopus 로고
    • A role for tyrosine kinase activation in interleukin-1β induced nitric oxide production in the insulin producing cell line RINm5F
    • Welsh N (1994) A role for tyrosine kinase activation in interleukin-1β induced nitric oxide production in the insulin producing cell line RINm5F. Bioscience Rep 14: 43-50
    • (1994) Bioscience Rep , vol.14 , pp. 43-50
    • Welsh, N.1
  • 136
    • 0030050143 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors, genistein and herbimycin A do not block interleukin-1β-induced activation of NF-(greek small letter script kappa)B in rat mesangial cells
    • Tetsuka T, Srivastava SK, Morrison AR (1996) Tyrosine kinase inhibitors, genistein and herbimycin A do not block interleukin-1β-induced activation of NF-(greek small letter script kappa)B in rat mesangial cells. Biochem Biophys Res Commun 218: 808-812
    • (1996) Biochem Biophys Res Commun , vol.218 , pp. 808-812
    • Tetsuka, T.1    Srivastava, S.K.2    Morrison, A.R.3
  • 137
    • 0028954346 scopus 로고
    • Two dimensional gel electrophoresis of rat islet proteins. Interleukin-1β-induced changes in protein expression are reduced by L-arginine depletion and nicotinamide
    • Andersen HU, Larsen PM, Fey SJ, Karlsen AE, Mandrup-Poulsen T, Nerup J (1995) Two dimensional gel electrophoresis of rat islet proteins. Interleukin-1β-induced changes in protein expression are reduced by L-arginine depletion and nicotinamide. Diabetes 44: 400-407
    • (1995) Diabetes , vol.44 , pp. 400-407
    • Andersen, H.U.1    Larsen, P.M.2    Fey, S.J.3    Karlsen, A.E.4    Mandrup-Poulsen, T.5    Nerup, J.6
  • 138
    • 0027947675 scopus 로고
    • New insights into the regulation of inducible nitric oxide synthesis
    • Morris SM Jr, Billiar TR (1994) New insights into the regulation of inducible nitric oxide synthesis. Am J Physiol 266: E829-E839
    • (1994) Am J Physiol , vol.266
    • Morris Jr., S.M.1    Billiar, T.R.2
  • 139
    • 0023408236 scopus 로고
    • Macrophage synthesis of nitrite, nitrate, and N-nitrosoamines: Precursors and role of the respiratory burst
    • Iyengar R, Stuher D, Marietta M (1987) Macrophage synthesis of nitrite, nitrate, and N-nitrosoamines: precursors and role of the respiratory burst. Proc Natl Acad Sci USA 84: 6369-6373
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 6369-6373
    • Iyengar, R.1    Stuher, D.2    Marietta, M.3
  • 141
    • 0028237017 scopus 로고
    • Argininosuccinate synthetase mRNA and activity are induced by immunostimulants in vascular smooth muscle. Role in the regeneration of arginine for nitric oxide synthesis
    • Hattori Y, Cambell EB, Gross SS (1994) Argininosuccinate synthetase mRNA and activity are induced by immunostimulants in vascular smooth muscle. Role in the regeneration of arginine for nitric oxide synthesis. J Biol Chem 269: 9405-9408
    • (1994) J Biol Chem , vol.269 , pp. 9405-9408
    • Hattori, Y.1    Cambell, E.B.2    Gross, S.S.3
  • 142
    • 0030043717 scopus 로고    scopus 로고
    • Coinduction of nitric oxide synthase, argininosuccinate synthetase, and argininosuccinate lyase in lipopolysaccharide-treated rat
    • Nagasaki A, Gotoh T, Takeya M et al, (1996) Coinduction of nitric oxide synthase, argininosuccinate synthetase, and argininosuccinate lyase in lipopolysaccharide-treated rat. J Biol Chem 271: 2658-2662
    • (1996) J Biol Chem , vol.271 , pp. 2658-2662
    • Nagasaki, A.1    Gotoh, T.2    Takeya, M.3
  • 143
    • 0029122586 scopus 로고
    • Coinduction of arginase and nitric oxidase synthase in murine macrophages activated by lipopolysaccharide
    • Wang WW, Jenkinson CP, Griscavage JM et al. (1995) Coinduction of arginase and nitric oxidase synthase in murine macrophages activated by lipopolysaccharide. Biochem Biophys Res Commun 210: 1009-1016
    • (1995) Biochem Biophys Res Commun , vol.210 , pp. 1009-1016
    • Wang, W.W.1    Jenkinson, C.P.2    Griscavage, J.M.3
  • 144
    • 0023895149 scopus 로고
    • Production of urea but absence of urea cycle in pancreatic islet cells
    • Sener A, Blaicher F, Malaisse WJ (1988) Production of urea but absence of urea cycle in pancreatic islet cells. Med Sci Res 16: 483-484
    • (1988) Med Sci Res , vol.16 , pp. 483-484
    • Sener, A.1    Blaicher, F.2    Malaisse, W.J.3
  • 145
    • 0028170690 scopus 로고
    • (1)-hydroxy-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase
    • (1)-hydroxy-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase. Biochem Biophys Res Commun 203: 1614-1621
    • (1994) Biochem Biophys Res Commun , vol.203 , pp. 1614-1621
    • Boucher, J.-L.1    Custot, J.2    Vadon, S.3
  • 146
    • 0027788115 scopus 로고
    • IL-1β induces coexpression of both nitric oxide synthase and cyclooxygenase by islets of Langerhans: Activation of cyclooxygenase by nitric oxide
    • Corbett JA, Kwon G, Turk J, McDaniel ML (1993) IL-1β induces coexpression of both nitric oxide synthase and cyclooxygenase by islets of Langerhans: activation of cyclooxygenase by nitric oxide. Biochemistry 32: 13767-13770
    • (1993) Biochemistry , vol.32 , pp. 13767-13770
    • Corbett, J.A.1    Kwon, G.2    Turk, J.3    McDaniel, M.L.4
  • 148
    • 0028972876 scopus 로고
    • Interleukin-1β regulates the expression of a leukocyte type of 12-lypoxygenase in rat islets and RINm5F cells
    • Bleich D, Chen S, Gu J-L et al. (1995) Interleukin-1β regulates the expression of a leukocyte type of 12-lypoxygenase in rat islets and RINm5F cells. Endocrinology 136: 5736-5744
    • (1995) Endocrinology , vol.136 , pp. 5736-5744
    • Bleich, D.1    Chen, S.2    Gu, J.-L.3
  • 149
    • 0030042403 scopus 로고    scopus 로고
    • Interleukin-1 enhances pancreatic islet arachidonic acid 12-lypoxygenase product generation by increasing substrate availability through a nitric oxide-dependent mechanism
    • Ma Z, Ramanadham S, Corbett JA et al. (1996) Interleukin-1 enhances pancreatic islet arachidonic acid 12-lypoxygenase product generation by increasing substrate availability through a nitric oxide-dependent mechanism. J Biol Chem 271: 1029-1042
    • (1996) J Biol Chem , vol.271 , pp. 1029-1042
    • Ma, Z.1    Ramanadham, S.2    Corbett, J.A.3
  • 150
    • 0024240524 scopus 로고
    • Functional characteristics of rat pancreatic islets maintained in tissue culture following exposure to interleukin-1
    • Eizirik DL, Strandell E, Bendtzen K, Sandler S (1988) Functional characteristics of rat pancreatic islets maintained in tissue culture following exposure to interleukin-1. Diabetes 37: 916-919
    • (1988) Diabetes , vol.37 , pp. 916-919
    • Eizirik, D.L.1    Strandell, E.2    Bendtzen, K.3    Sandler, S.4
  • 151
    • 0026633029 scopus 로고
    • Interleukin-1β increases the activity of Superoxide dismutase in rat pancreatic islets
    • Borg LAH, Cagliero E, Sandler S, Welsh N, Eizirik DL (1992) Interleukin-1β increases the activity of Superoxide dismutase in rat pancreatic islets. Endocrinology 130: 2851-2857
    • (1992) Endocrinology , vol.130 , pp. 2851-2857
    • Borg, L.A.H.1    Cagliero, E.2    Sandler, S.3    Welsh, N.4    Eizirik, D.L.5
  • 152
    • 0025009733 scopus 로고
    • Interleukin-1β depletes insulin messenger ribonucleic acid and increases the heat shock protein hsp70 in mouse pancreatic islets without impairing the glucose metabolism
    • Eizirik DL, Welsh M, Strandell E, Welsh N, Sandler S (1990) Interleukin-1β depletes insulin messenger ribonucleic acid and increases the heat shock protein hsp70 in mouse pancreatic islets without impairing the glucose metabolism. Endocrinology 127: 2290-2297
    • (1990) Endocrinology , vol.127 , pp. 2290-2297
    • Eizirik, D.L.1    Welsh, M.2    Strandell, E.3    Welsh, N.4    Sandler, S.5
  • 153
    • 0025845721 scopus 로고
    • Interleukin-1β increases the biosynthesis of the heal shock protein hsp70 and specifically decreases the biosynthesis of five proteins in rat pancreatic islets
    • Welsh N, Welsh M, Lindquist S, Eizirik DL, Bendtzen K, Sandler S (1991) Interleukin-1β increases the biosynthesis of the heal shock protein hsp70 and specifically decreases the biosynthesis of five proteins in rat pancreatic islets. Autoimmunity 9: 33-40
    • (1991) Autoimmunity , vol.9 , pp. 33-40
    • Welsh, N.1    Welsh, M.2    Lindquist, S.3    Eizirik, D.L.4    Bendtzen, K.5    Sandler, S.6
  • 154
    • 0026029006 scopus 로고
    • Heat shock protein induction in rat pancreatic islets by human recombinant interleukin-1β
    • Helqvist S, Polla BS, Johannensen JH, Nerup J (1991) Heat shock protein induction in rat pancreatic islets by human recombinant interleukin-1β. Diabetologia 34: 150-156
    • (1991) Diabetologia , vol.34 , pp. 150-156
    • Helqvist, S.1    Polla, B.S.2    Johannensen, J.H.3    Nerup, J.4
  • 155
    • 0029401861 scopus 로고
    • Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: Implications for the pathogenesis of insulin-dependent diabetes mellitus
    • Welsh N, Margulis B, Borg LAH et al. (1995) Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: implications for the pathogenesis of insulin-dependent diabetes mellitus. Mol Med 1: 806-820
    • (1995) Mol Med , vol.1 , pp. 806-820
    • Welsh, N.1    Margulis, B.2    Borg, L.A.H.3
  • 156
    • 0029417040 scopus 로고
    • Interleukin-1β induces the expression of hsp70. heme oxygenase and MnSOD in FACS purified rat islet β-cells, but not in α-cells
    • Strandell E, Buschard K, Saldeen J, Welsh N (1995) Interleukin-1β induces the expression of hsp70. heme oxygenase and MnSOD in FACS purified rat islet β-cells, but not in α-cells. Immunol Lett 48: 145-148
    • (1995) Immunol Lett , vol.48 , pp. 145-148
    • Strandell, E.1    Buschard, K.2    Saldeen, J.3    Welsh, N.4
  • 157
    • 0023147156 scopus 로고
    • Secretory products of macrophages
    • Nathan CF (1987) Secretory products of macrophages. J Clin Invest 79: 319-326
    • (1987) J Clin Invest , vol.79 , pp. 319-326
    • Nathan, C.F.1
  • 158
    • 0026676388 scopus 로고
    • The simultaneous generation of Superoxide anion and nitric oxide can initiate lipid peroxidation in human low density lipoprotein
    • Darley-Usmar VM, Hogg N, O'Leary WJ, Wilson MT, Moncada S (1992) The simultaneous generation of Superoxide anion and nitric oxide can initiate lipid peroxidation in human low density lipoprotein. Free Rad Res Commun 17: 9-20
    • (1992) Free Rad Res Commun , vol.17 , pp. 9-20
    • Darley-Usmar, V.M.1    Hogg, N.2    O'Leary, W.J.3    Wilson, M.T.4    Moncada, S.5
  • 159
    • 0027960215 scopus 로고
    • Superoxide and peroxynitrite inactivate aconitase, nitric oxide does not
    • Hausladen A, Fridovich I (1994) Superoxide and peroxynitrite inactivate aconitase, nitric oxide does not. J Biol Chem 269: 29405-29408
    • (1994) J Biol Chem , vol.269 , pp. 29405-29408
    • Hausladen, A.1    Fridovich, I.2
  • 160
    • 0028090219 scopus 로고
    • Aconitase is readily inactivated by peroxynitrite, hut not by its precursor, nitric oxide
    • Castro L, Rodriguez M, Radi R (1994) Aconitase is readily inactivated by peroxynitrite, hut not by its precursor, nitric oxide. J Biol Chem 269: 29409-29415
    • (1994) J Biol Chem , vol.269 , pp. 29409-29415
    • Castro, L.1    Rodriguez, M.2    Radi, R.3
  • 161
    • 0026052415 scopus 로고
    • Liposomal delivery of purified heat shock protein hsp70 into rat pancreatic islets as protection against interleukin 1β-induced impaired β-cell function
    • Margulis BA, Sandier S, Eizirik DL, Welsh N, Welsh M (1991) Liposomal delivery of purified heat shock protein hsp70 into rat pancreatic islets as protection against interleukin 1β-induced impaired β-cell function. Diabetes 40: 1418-1422
    • (1991) Diabetes , vol.40 , pp. 1418-1422
    • Margulis, B.A.1    Sandier, S.2    Eizirik, D.L.3    Welsh, N.4    Welsh, M.5
  • 162
    • 0029064481 scopus 로고
    • Heat shock induces resistance in rat pancreatic islets against nitric oxide, oxygen radicals and streptozotocin toxicity
    • Bellman K, Wenz A, Radons J, Burkart V, Kleeman R, Kolb H (1995) Heat shock induces resistance in rat pancreatic islets against nitric oxide, oxygen radicals and streptozotocin toxicity. J Clin Invest 95: 2840-2845
    • (1995) J Clin Invest , vol.95 , pp. 2840-2845
    • Bellman, K.1    Wenz, A.2    Radons, J.3    Burkart, V.4    Kleeman, R.5    Kolb, H.6
  • 163
    • 0029035476 scopus 로고
    • Altered immune responses in mice lacking inducible nitric oxide synthase
    • Wei X, Charles IG, Smith A et al. (1995) Altered immune responses in mice lacking inducible nitric oxide synthase. Nature 375: 408-411
    • (1995) Nature , vol.375 , pp. 408-411
    • Wei, X.1    Charles, I.G.2    Smith, A.3
  • 164
    • 0028999596 scopus 로고
    • Altered response to bacterial infection and endoloxic shock in mice lacking inducible nitric oxide synthase
    • MacMicking JD, Nathan C, Hom G et al. (1995) Altered response to bacterial infection and endoloxic shock in mice lacking inducible nitric oxide synthase. Cell 81: 641-650
    • (1995) Cell , vol.81 , pp. 641-650
    • MacMicking, J.D.1    Nathan, C.2    Hom, G.3
  • 165
    • 0028889439 scopus 로고
    • Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death
    • Leubach VE, Shesely EG, Smithies O, Sherman PA (1995) Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proc Natl Acad Sci USA 92: 10688-10692
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10688-10692
    • Leubach, V.E.1    Shesely, E.G.2    Smithies, O.3    Sherman, P.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.