β-Cell destruction in NOD mice correlates with Fas (CD95) expression on β-cells and proinflammatory cytokine expression in islets

Diabetes

Volumn 48, Issue 1, 1999, Pages 21-28

  Suarez Pinzon, Wilma ^a   Sorensen, Ole ^a   Bleackley, R Chris ^a   Elliott, John F ^a   Rajotte, Ray V ^a   Rabinovitch, Alex ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; FAS ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 1ALPHA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; MONKEY; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, CD95; CYTOKINES; DIABETES MELLITUS, TYPE 1; FAS LIGAND PROTEIN; FEMALE; INFLAMMATION MEDIATORS; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED NOD; REFERENCE VALUES; RNA, MESSENGER;

EID: 0032932324     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.1.21     Document Type: Article

References (25)

1. Kägi D, Vignaux F, Ledermann B, Bürki K, Depraetere V, Nagata S, Hengartner H, Golstein P: Fas and perforin pathways as major mechanisms of T-cell-mediated cytotoxicity. Science 265:528-530, 1994
2. Nagata S, Golstein P: The Fas death factor. Science 267:1449-1456, 1995
3. Enari M, Hug H, Nagata S: Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature 375:78-81, 1995
4. Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Scaffidi C, Bretz JD, Zhang M, Ni J, Gentz R, Mann M, Krammer PH, Peter ME, Dixit VM: FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85:817-827, 1996
5. O'Brien BA, Harmon BV, Cameron DP, Allan DJ: Apoptosis is the mode of β-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse. Diabetes 46:750-757, 1997
6. Chervonsky AV, Wang Y, Wong FS, Visintin I, Flavell RA, Janeway CA, Mattis LA: The role of Fas in autoimmune diabetes. Cell 89:17-24, 1997
7. Itoh N, Imagawa A, Hanafusa T, Waguri M, Yamamoto K, Iwahashi H, Moriwaki M, Nakajima H, Miyagawa J, Namba M, Makino S, Nagata S, Kono N, Matsuzawa Y: Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice. J Exp Med 186:613-618, 1997
8. Yamada K, Takane-Gyotoku N, Yuan X, Ichikawa F, Inada C, Nonaka K: Mouse islet lysis mediated by interleukin-1-induced Fas. Diabetologia 39:1306-1312, 1996
9. Stassi G, Todaro M, Richiusa P, Giordano M, Mattina A, Sbriglia MS, Lo Monte A, Buscemi G, Galluzzo A, Giordano C: Expression of apoptosis-inducing CD95 (Fas/Apo-1) on human β-cells sorted by flow-cytometry and cultured in vitro. Transplant Proc 27:3271-3275, 1995
10. Giordano C, Stassi G, Todaro M, Richiusa P, De Maria R, Giordano M, Mattina A, Sbriglia MS, Galluzzo A: Triggering of Fas (Apo-1/CD95)-induced apoptosis in human pancreatic β-cells (Abstract). Diabetologia 39 (Suppl. 1):A10, 1996
11. Stassi G, De Maria R, Trucco G, Rudert W, Testi R, Galluzzo A, Giordano C, Trucco M: Nitric oxide primes pancreatic β-cells for Fas-mediated destruction in insulin-dependent diabetes mellitus. J Exp Med 186:1193-1200, 1997
12. Bellgrau D, Gold D, Selawry H, Moore J, Franzusoff A, Duke RC: A role for CD95 ligand in preventing graft rejection. Nature 377:630-632, 1995
13. Lau HT, Yu M, Fontana A, Stoeckert CJ: Prevention of islet allograft rejection with engineered myoblasts expressing FasL in mice. Science 273:109-112, 1996
14. Allison J, Georgiou HM, Strasser A, Vaux DL: Transgenic expression of CD95 ligand on islet β-cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts. Proc Natl Acad Sci U S A 94:3943-3947, 1997
15. Kang S-M, Schneider DB, Lin Z, Hanahan D, Dichek DA, Stock PG, Baekkeskov S: Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction. Nat Med 3:738-743, 1997
16. Muruve DA, Nicolson AG, Manfro RC, Strom TB, Sukhatme VP, Liberman TA: Adenovirus-mediated expression of Fas ligand induces hepatic apoptosis after systemic administration and apoptosis of ex vivo-infected pancreatic islet allografts and isografts. Hum Gene Ther 8:955-963, 1997
17. Gotoh M, Maki J, Kiyoizumi T, Satomi S, Monaco AP: An improved method for isolation of mouse pancreatic islets. Transplantation 40:437-438, 1985
18. Wang T, Singh B, Warnock G, Rajotte RV: Prevention of recurrence of IDDM in islet-transplanted diabetic NOD mice by adjuvant immunotherapy. Diabetes 41:114-117, 1992
19. Alejandro R, Shienvold FL, Vaerewyck Hajek SA, Pierce M, Paul R, Mintz DH: A ganglioside antigen on the rat pancreatic β-cell surface identified by monoclonal antibody R2D6. J Clin Invest 74:25-38, 1984
20. Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter KT: Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299, 1979
21. Rabinovitch A, Suarez-Pinzon WL, Sorensen O, Bleackley RC, Power RF: IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice. J Immunol 154:4874-4882, 1995
22. Signore A, Annovazzi A, Procaccini E, Beales PE, Spencer J, Testi R, Ruberti G: CD95 and CD95-ligand expression in endocrine pancreas of NOD, NOR, and BALB/c mice. Diabetologia 40:1476-1479, 1997
23. French LE, Tschopp J: Constitutive Fas ligand expression in several non-lymphoid mouse tissues: implications for immune protection and cell turnover. Behring Inst Mitt 97:156-160, 1996
24. Giordano C, Stassi G, De Maria R, Todaro M, Richiusa P, Papoff G, Bagnasco M, Testi R, Galluzo A: Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis. Science 275:960-963, 1997
25. Loweth AC, Williams GT, James RFL, Scarpello JHB, Morgan NG: Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1β and Fas ligation. Diabetes 47:727-732, 1998