Virus-induced autoimmune diabetes: Most β-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes

Diabetes

Volumn 49, Issue 11, 2000, Pages 1801-1809

  Seewaldt, Sonja ^a   Thomas, Helen E ^b   Ejrnaes, Mette ^c   Christen, Urs ^a   Wolfe, Tom ^a   Rodrigo, Evelyn ^a   Coon, Bryan ^a   Michelsen, Birgitte ^c   Kay, Thomas W H ^b   Von Herrath, Matthias G ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c HAGEDORN RESEARCH INSTITUTE   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PERFORIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CELL DEATH; CELL DESTRUCTION; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; DIABETES MELLITUS; DIABETOGENESIS; EFFECTOR CELL; IMMUNOPATHOGENESIS; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PANCREAS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; VIRUS INDUCTION; VIRUS INFECTION; VIRUS PATHOGENESIS;

EID: 0033755202     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.49.11.1801     Document Type: Article

References (54)

1. Insulin dependent diabetes mellitus as an autoimmune disease
2. Immunological aspects of type 1 and 2 diabetes mellitus
3. Cytokine secretion patterns in twins discordant for type 1 diabetes
4. Genetic determination of islet cell autoimmunity in monozygotic twin, dizygotic twin, and non-twin siblings of patients with type 1 diabetes: Prospective twin study
5. T-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA-2: Potential for mimicry with rotavirus and other environmental agents
6. Molecular mimicry and autoimmune disease
7. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes
8. Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry
9. IFN-gamma and tumor necrosis factor-alpha: Cytotoxicity to murine islets of Langerhans
10. Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library
11. + T cell response against one peptide/MHC complex in autoimmune diabetes
12. Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor alpha chain gene rearrangement
13. The role of Fas in autoimmune diabetes
14. Apoptosis of pancreatic β-cells detected in accelerated diabetes of NOD mice: No role of Fas-Fas ligand interaction in autoimmune diabetes
15. + T lymphocytes in transgenic nonobese diabetic mice
16. Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction
17. Preparation of rat islet β-cell enriched fractions by light-scatter flow cytometry
18. IFN-gamma gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice
19. In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha
20. Evidence that beta cell death in the nonobese diabetic mouse is Fas independent
21. Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice
22. Overexpression of class I major histocompatibility complex accompanies insulitis in the non-obese diabetic mouse and is prevented by anti-interferon-γ antibody
23. IFN-γ is essential for β-cell destruction by CTL
24. + T cells
25. The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses
26. Development of insulitis without diabetes in transgenic mice lacking perforin-dependent cytotoxicity
27. How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model
28. Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of antiself (virus) immune response
29. T helper cell subsets in IDDM
30. + Th1 and Th2 cells derived from the spleens of diabetic NOD mice
31. Pathological changes in the islet milieu precede infiltration of islets and destruction of β-cells by autoreactive lymphocytes in a transgenic model of virus-induced IDDM
32. Lymphocytic choriomeningitis virus
33. Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice
34. Bovine serum albumin density gradient isolation of rat pancreatic islets
35. A new model for isolation of murine islets with markedly improved yields
36. Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice
37. Autofluorescence-activated cell sorting of pancreatic islet cells: Purification of insulin-containing B-cells according to glucose-induced changes in cellular redox state
38. Islet cell analysis and purification by light scatter and autofluorescence
39. IFN-gamma action on pancreatic β-cells causes class I MHC upregulation but not diabetes
40. b major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes
41. Molecularly engineered vaccine which expresses an immunodominant T-cell epitope induces cytotoxic T lymphocytes that confer protection from lethal virus infection
42. CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge
43. Thymic tolerance to only one viral protein reduces lymphocytic choriomeningitis virus-induced immunopathology and increases survival in perforin-deficient mice
44. Ablation of 'tolerance' and induction of diabetes by virus infection in viral antigen transgenic mice
45. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
46. Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis
47. Lymphocytic choriomeningitis virus CTL
48. Coexpression of B7.1 and viral (self) transgenes in pancreatic β-cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes
49. Pancreas-infiltrating Th1 cells and diabetes develop in IL-12-deficient nonobese diabetic mice
50. TNF-α transgenic and knockout models of CNS inflammation and degeneration
51. Inhibition of cellular responsiveness to interferon-gamma (IFN-γ) induced by overexpression of inactive forms of the IFN gamma receptor
52. Initial and innate responses to viral infections - Pattern setting in immunity or disease
53. Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection
54. Expression of adenoviral E3 transgenes in β-cells prevents autoimmune diabetes