Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells

Endocrinology

Volumn 138, Issue 6, 1997, Pages 2610-2614

  Delaney, Carol A ^b   Pavlovic, Dejan ^b   Hoorens, Anne ^b   Pipeleers, Daniel G ^b   Eizirik, Décio L ^a  

^a DIABETES RESEARCH CENTER   (Belgium)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE;

APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; DNA INTEGRATION; DNA STRAND BREAKAGE; ENZYME INDUCTION; GEL ELECTROPHORESIS; HUMAN; HUMAN TISSUE; INNER CELL MASS; INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION;

EID: 0030923812     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.6.5204     Document Type: Article

References (47)

1. Pipeleers D, Ling Z 1992 Pancreatic beta cells in insulin-dependent diabetes. Diabetes Metab Rev 8:209-227
2. Rabinovitch A 1993 Roles of cytokines in IDDM pathogenesis and islet β-cell destruction. Diabetes Rev 1:215-240
3. Bach J-F 1995 Insulin-dependent diabetes mellitus as a β-cell targeted disease of immunoregulation. J Autoimmun 8:439-463
4. Mandrup-Poulsen T 1996 The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 39:1005-1029
5. Eizirik DL, Flodström M, Karlsen AE, Welsh N 1996 The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells. Diabetologia 39:875-890
6. Welsh N, Eizirik DL, Bendtzen K, Sandler S 1991 Interleukin-1β-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase. Endocrinology 129:3167-3173
7. Eizirik DL, Welsh N, Niemann A, Velloso LA, Malaisse WJ 1994 Succinic acid monomethyl ester protects rat pancreatic islet secretory potential against interleukin-1β (IL-1β) without affecting glutamate decarboxylase expression or nitric oxide production. FEBS Lett 337:298-302
8. Delaney CA, Green MHL, Lowe JE, Green IC 1993 Endogenous nitric oxide induced by interleukin-1β in rat islets of Langerhans and HIT-T15 cells causes significant DNA damage as measured by the 'comet' assay. FEBS Lett 333:291-295
9. Raff MC, Barres BA, Burnes BF, Coles HS, Ishizaki Y, Jacobson MD 1993 Programmed cell death and the control of cell survival: lessons from the central nervous system. Science 262:695-700
10. Steller H 1995 Mechanisms and genes of cellular suicide. Science 267:1445-1449
11. Hoorens A, Van de Casteele M, Klöppel G, Pipeleers DG 1996 Glucose promotes survival of rat pancreatic b cells by activating synthesis of proteins which suppress a constitutive apoptotic program. J Clin Invest 98:1568-1574
12. Iwahashi H, Hanafusa T, Eguchi Y, Nakajima H, Miyagawa J, Itoh N, Tomita K, Namba M, Kuwajima M, Noguchi T, Tsujimoto Y, Matsuzawa Y 1996 Cytokine-induced apoptotic cell death in a mouse pancreatic beta-cell line: inhibition by Bcl-2. Diabetologia 39:530-536
13. Dunger A, Augstein P, Schmidt S, Fischer U 1996 Identification of interleukin 1-induced apoptosis in rat islets using in situ specific labelling of fragmented DNA. J Autoimmun 9:309-313
14. Eizirik DL, Welsh N, Hellerström C 1993 Predominance of stimulatory effects of interleukin-1b on isolated human pancreatic islets. J Clin Endocrinol Metab 76:399-403
15. Corbett JA, Sweetland MA, Wang JL, Lancaster JR, McDaniel ML 1993 Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc Natl Acad Sci USA 90:1731-1735
16. Eizirik DL, Sandler S, Welsh N, Cetkovic-Cvrlje M, Nieman A, Geller DA, Pipeleers DG, Bendtzen K, Hellerström C 1994 Cytokines suppress human islet function irrespective of their effects on nitric oxide generation. J Clin Invest 93:1968-1974
17. Rabinovitch A, Sumoski W, Rajotte RV, Warnock GL 1990 Cytotoxic effects of cytokines on human pancreatic islet cells in monolayer culture. J Clin Endocrinol Metab 71:152-156
18. Soldevila G, Buscema M, Doshi M, James RFL, Bottazzo GF, Pujol-Borrell R 1991 Cytotoxic effect of IFN-g plus TNF-a on human islet cells. J Autoimmun 4:291-306
19. Eizirik DL, Sandler S, Welsh N, Bendtzen K, Hellerström C 1994 Nicotinamide decreases nitric oxide production and partially protects human pancreatic islets against the suppressive effects of combinations of cytokines. Autoimmunity 19:193-198
20. Eizirik DL, Pipeleers DG, Ling Z, Welsh N, Hellerström C, Andersson A 1994 Major species differences between man and rodents in the susceptibility to pancreatic β-cell injury. Proc Natl Acad Sci USA 91:9253-9256
21. Delaney CA, Tyrberg B, Bouwens L, Vaghef H, Hellman B, Eizirik DL 1996 Sensitivity of human pancreatic islets to peroxynitrite-induced cell dysfunction and death. FEBS Lett 394:300-306
22. Pipeleers DG, In't Veld PA, Van de Winkel M, Maes E, Schuit F, Gepts W 1985 A new in vitro model for the study of pancreatic A and B cells. Endocrinology 117:806-816
23. Ling Z, Pipeleers D 1996 Prolonged exposure of human β-cells to elevated glucose levels results in sustained cellular activity leading to a loss of glucose regulation. J Clin Invest 98:2805-2812
24. Eizirik DL, Korbutt GS, Hellerström C 1992 Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the β-cell function. J Clin Invest 90:1263-1268
25. 15N)nitrate in biological fluids. Anal Biochem 126:131-138
26. Niemann A, Björklund A, Eizirik DL 1994 Studies on the molecular regulation of the inducible form of nitric oxide synthase (iNOS) in insulin-producing cells. Mol Cell Endocrinol 106:151-155
27. Fairbairn DW, Olive PL, O'Neill KL 1995 The comet assay: a comprehensive review. Mutation Res 339:37-59
28. Hellman B, Vaghef H, Boström B 1995 The concepts of tail moment and tail inertia in the single cell gel electrophoresis assay. Mutation Res 336:123-131
29. Pipeleers D, Van de Winkel M 1986 Pancreatic B cells possess defense mechanisms against cell-specific toxicity. Proc Natl Acad Sci USA 83:5267-5271
30. Vaux DL, Strasser A 1996 The molecular biology of apoptosis. Proc Natl Acad Sci USA 93:2239-2244
31. Pender MP, Nguyen KB, McCombe PA, Kerr JFR 1991 Apoptosis in the nervous system in experimental allergic encephalomyelitis. J Neurol Sci 104:81-87
32. Kurrer MO, Syamasundar VP, Hanson HL, Katz JD 1997 β cell apoptosis in T-cell-mediated autoimmune diabetes. Proc Natl Acad Sci 94:213-218
33. Southern C, Schulster D, Green IC 1990 Inhibition of insulin secretion by interleukin-1β and tumour necrosis factor-α via an L-arginine-dependent nitric oxide generating mechanism. FEBS Lett 276:42-44
34. Delaney CA, Eizirik DL 1996 Intracellular targets for nitric oxide toxicity to pancreatic α-cells. Braz J Med Biol Res 29:569-579
35. Rabinovitch A, Suarez-Pinzon WL, Strynadka K, Schulz R, Lakey JRT, Warnock GL, Rajotte RV 1994 Human pancreatic islet α-cell destruction by cytokines is independent of nitric oxide production. J Clin Endocrinol Metab 79:1058-1062
36. Rabinovitch A, Suarez-Pinzon WL, Strynadka K, Lakey JRT, Rajotte RV 1996 Human pancreatic islet α-cell destruction by cytokines involves oxygen free radicals and aldehyde production. J Clin Endocrinol Metab 81:3197-3202
37. Ji L, Zhang G, Uematsu S, Akahori Y, Hirabayashi Y 1995 Induction of apoptotic DNA fragmentation and cell death by natural ceramide. FEBS Lett 358:211-214
38. 2-terminal kinase and the transcription factor ATF2 in the insulin-producing cell line RINm5F. J Biol Chem 271:8307-8312
39. Yamada K, Takanegyotoku N, Yuan X, Ichikawa F, Inada C, Nonaka K 1996 Mouse islet cell lysis mediated by interleukin-1-induced Fas. Diabetologia 39:1306-1312
40. Eizirik DL, Delaney CA, Green MHL, Cunningham JM, Thorpe JR, Pipeleers DG, Hellerström C, Green IC 1996 Nitric oxide donors decrease the function and survival of human pancreatic islets. Mol Cell Endocrinol 118:71-83
41. Welsh N, Margulis B, Borg LAH, Wiklund H, Saldeen J, Flodström M, Mello MA, Andersson A, Pipeleers DG, Hellerström C, Eizirik DL 1995 Differences in the expression of heat shock proteins and antioxidant enzymes between human and rodent pancreatic islets: implications for the pathogenesis of insulin-dependent diabetes mellitus. Mol Med 1:806-820
42. Eizirik DL 1996 Beta-cell defence and repair mechanisms in human pancreatic islets. Horm Metab Res 28:302-305
43. Bellman K, Wenz A, Radons J, Burkart V, Kleemann R, Kolb H 1995 Heat shock induces resistance in rat pancreatic islets against nitric oxide, oxygen radicals and streptozotocin toxicity in vitro. J Clin Invest 95:2840-2845
44. Bellman K, Jaattela M, Wissing D, Burkart D, Kolb H 1996 Heat shock protein hsp70 overexpression confers resistance against nitric oxide. FEBS Lett 391:185-188
45. Kröncke K-D, Kolb-Bachofen V, Berschick B, Burkart V, Kolb H 1991 Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation. Biochem Biophys Res Commun 175:752-758
46. Kröncke K-D, Rodriguez ML, Kolb H, Kolb-Bachofen V 1993 Cytotoxicicy of activated rat macrophages against syngeneic islet cells is arginine-dependent, correlates with citrulline and nitrite concentrations and is identical to lysis by the nitric oxide donor nitroprusside. Diabetologia 36:17-24
47. Steiner L, Kröncke K-D, Fehsel K, Kolb-Bachfen V 1997 Endothelial cells as cytotoxic effector cells: cytokine-activated rat islets lyse syngeneic islet cells via nitric oxide. Diabetologia 40:150-155