Mechanisms of coxsackievirus-induced damage to human pancreatic β-cells

Journal of Clinical Endocrinology and Metabolism

Volumn 85, Issue 1, 2000, Pages 432-440

  Roivainen, Merja ^a   Rasilainen, Suvi ^b   Ylipaasto, Petri ^a   Nissinen, Riikka ^a   Ustinov, Jarkko ^b   Bouwens, Luc ^d   Eizirik, Décio L ^d   Hovi, Tapani ^a   Otonkoski, Timo ^b,c  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d DIABETES RESEARCH CENTER   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; GLUCOSE; INSULIN; MESSENGER RNA; NITRIC OXIDE SYNTHASE; NITRITE; THEOPHYLLINE;

ARTICLE; CELL DEATH; CELL MEMBRANE; CONTROLLED STUDY; COXSACKIE VIRUS; COXSACKIE VIRUS A; COXSACKIE VIRUS B; COXSACKIE VIRUS B3; COXSACKIE VIRUS B4; DIABETES MELLITUS; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; PANCREAS INJURY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; VIRUS INFECTION; VIRUS REPLICATION; VIRUS STRAIN;

ADULT; APOPTOSIS; CELL SURVIVAL; COXSACKIEVIRUS INFECTIONS; DNA; DNA FRAGMENTATION; ENTEROVIRUS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INSULIN; ISLETS OF LANGERHANS; MICROSCOPY, ELECTRON; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RNA, MESSENGER; VIRUS REPLICATION;

CHICKEN ANEMIA VIRUS; COXSACKIEVIRUS; COXSACKIEVIRUS B; HUMAN COXSACKIEVIRUS B3; HUMAN ENTEROVIRUS B; RNA VIRUSES;

EID: 0034455489     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.85.1.432     Document Type: Article

References (48)

1. Isolation of a virus from the pancreas of a child with diabetic ketoacidosis
2. The role of viruses and environmental factors in the induction of diabetes
3. Coxsackie-B-virus-specific IgM responses in children with insulin-dependent (juvenileonset; type 1) diabetes mellitus
4. Coxsackie B, mumps, rubella and cytomegalovirus specific IgM responses in patients with juvenile-onset insulin-dependent diabetes mellitus in Britain, Austria, and Australia
5. The possible role of Coxsackie A and Echo viruses in the pathogenesis of type 1 diabetes mellitus studied by IgM analysis
6. Serological evidence of an association between enteroviruses and the onset of type 1 diabetes mellitus
7. Maternal enteroviral infection during pregnancy as a risk factor for childhood IDDM. A population-based case-control study
8. A prospective study on the role of coxsackie B and other enterovirus infections in the pathogenesis of IDDM
9. ICA seroconversion in children is temporally associated with enterovirus infections
10. Apparent epidemic of insulin-dependent diabetes mellitus in midwestern Poland
11. Increased incidence of insulin-dependent diabetes mellitus following an epidemic of coxsackievirus B5
12. Enteroviruses: Polioviruses (poliomyelitis), coxsackieviruses, echoviruses, and enteroviruses
13. Pancreatic islet-cell damage in children with fatal viral infections
14. Pancreatic islet cell damage. Its occurrence in neonatal coxsackievirus encephalomyocarditis
15. Diabetes and coxsackie virus B5 infection
16. Virus-induced diabetes mellitus. Glucose abnormalities produced in mice by the six members of the coxsackie B virus group
17. Biochemical changes induced by coxsackie B4 virus in short-term culture of mouse pancreatic islets
18. Coxsackie virus B4 produces transient diabetes in nonhuman primates
19. Virus-induced diabetes mellitus. XI. Replication of coxsackie B3 virus in human pancreatic β cell cultures
20. Coxsackievirus B3 and mumps virus infection in human fetal islet cell cultures
21. Autoantigen (64 000-Mr) expression in coxsackievirus B4-induced experimental diabetes
22. Pathogenesis of virus-induced diabetes in mice
23. Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus
24. Antibody cross-reactivity induced by the homologous regions in glutamic acid decarboxylase (GAD65) and 2C protein of coxsackievirus B4
25. Major species differences between humans and rodents in the susceptibility to pancreatic β-cell injury
26. Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: Implications for the pathogenesis of insulin-dependent diabetes mellitus
27. Implantation of standardized β-cell grafts in a liver segment of IDDM patients: Graft and recipient characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft
28. General principles underlying laboratory diagnosis of viral and rickettsial infections
29. Peptide antisera targeted to a conserved sequence in poliovirus capsid protein VP1 cross-react widely with members of the genus Enterovirus
30. An improved fluorometric assay for DNA
31. Nicotinamide is a potent inducer of endocrine differentiation in cultured human fetal pancreatic cells
32. 15N]nitrate in biological fluids
33. Contribution of ductal cells to cytokine responses by human pancreatic islets
34. Constitution of a biphasic insulin response to glucose in human fetal pancreatic β-cells with glucagon-like peptide 1
35. Coxsackievirus B4 infection of the mouse pancreas: Acute and persistent infection
36. Two types of death of poliovirusinfected cells: Caspase involvement in the apoptosis but not cytopathic effect
37. Is there a role for nitric oxide in β-cell dysfunction and damage in IDDM?
38. Natural resistance and nitric oxide
39. Double-stranded RNA-induced inducible nitric oxide synthase expression and interleukin-1 release by routine macrophages requires NF-κB activation
40. The nucleotide sequence of wild-type coxsackievirus A9 strains imply that RGD motif in VP1 is functionally significant
41. Pathogenic differences between coxsackie A and B virus infections in newborn mice
42. Several different enterovirus serotypes can be associated with prediabetic autoimmune episodes and onset of overt IDDM
43. Pancreatic β-cells in insulin-dependent diabetes
44. Heterogeneity in pancreatic β-cell population
45. Intercellular differences in interleukin-1β-induced suppression of insulin synthesis and stimulation of noninsulin protein synthesis by rat pancreatic β-cells
46. Virus-induced diabetes mellitus: Infection of mice with variants of encephalomyocarditis virus, coxsackievirus B4, and reovirus type 3
47. Virus-induced diabetes mellitus. XV. β Cell damage and insulin-dependent hyperglycemia in mice infected with coxsackie B4
48. Relative abundance of enterovirus serotypes in sewage differs from that in patients: Clinical and epidemiological implications