Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells

Diabetologia

Volumn 41, Issue 9, 1998, Pages 1101-1108

  Darville, M I ^a   Eizirik, D L ^a  

^a DIABETES RESEARCH CENTER   (Belgium)

Author keywords

Beta cells; Diabetes mellitus; iNOS; Interleukin 1; NF B; Nitric oxide

Indexed keywords

CIS ACTING ELEMENT; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; NITRIC OXIDE SYNTHASE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; DIABETES MELLITUS; DNA RESPONSIVE ELEMENT; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION;

ANIMALS; CYTOKINES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INTERFERON TYPE II; INTERLEUKIN-1; ISLETS OF LANGERHANS; MUTAGENESIS, SITE-DIRECTED; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PROMOTER REGIONS (GENETICS); RATS; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031827241     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051036     Document Type: Article

References (42)

1. Rabinovitch A (1993) Roles of cytokines in IDDM pathogenesis and islet β-cell destruction. Diabetes Rev 1: 215-240
2. Mandrup-Poulsen T (1996) The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 39: 1005-1029
3. Kolb H, Kolb-Bachofen V (1992) Type 1 (insulin-dependent) diabetes mellitus and nitric oxide. Diabetologia 35: 796-797
4. Corbett JA, McDaniel ML (1992) Does nitric oxide mediate autoimmune destruction of β-cells? Possible therapeutic interventions in IDDM. Diabetes 41: 897-903
5. Eizirik DL, Pavlovic D (1997) Is there a role for nitric oxide in β-cell dysfunction and damage in IDDM? Diabetes Metab Rev 13: 293-308
6. Takamura T, Kato I, Kimura N et al. (1998) Transgenic mice overexpressing Type 2 nitric-oxide synthase in pancreatic β cells develop insulin-dependent diabetes without insulitis. J Biol Chem 273: 2493-2496
7. Corbett JA, Sweetland MA, Wang JL, Lancaster JJ, McDaniel ML (1993) Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc Natl Acad Sci USA 90: 1731-1735
8. Eizirik DL, Sandler S, Welsh N et al. (1994) Cytokines suppress human islet function irrespective of their effects on nitric oxide generation. J Clin Invest 93: 1968-1974
9. Rabinovitch A, Suarez-Pinzon WL, Strynadka K et al. (1994) Human pancreatic islet β-cell destruction by cytokines is independent of nitric oxide production. J Clin Endocrinol Metab 79: 1058-1062
10. Eizirik DL, Delaney CA, Green MH et al. (1996) Nitric oxide donors decrease the function and survival of human pancreatic islets. Mol Cell Endocrinol 118: 71-83
11. Delaney CA, Tyrberg B, Bouwens L, Vaghef H, Hellman B, Eizirik DL (1996) Sensitivity of human pancreatic islets to peroxynitrite-induced cell dysfunction and death. FEBS Lett 394: 300-306
12. Eizirik DL, Flodström M, Karlsen AE, Welsh N (1996) The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells. Diabetologia 39: 875-890
13. Fostermann U, Gath I, Schwarz P, Closs EI, Kleinert H (1995) Isoforms of nitric oxide synthase: properties, cellular distribution and expressional control. Biochem Pharmacol 50: 1321-1332
14. Xie QW, Whisnant R, Nathan C (1993) Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inductibility by interferon γ and bacterial lipopolysaccharide. J Exp Med 177: 1779-1784
15. Eberhardt W, Kunz D, Hummel R, Pfeilshifter J (1996) Molecular cloning of the rat inducible nitric oxide synthase gene promoter. Biochem Biophys Res Commun 223: 752-756
16. Xie QW, Kashiwabara Y, Nathan C (1994) Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase. J Biol Chem 269: 4705-4708
17. Kim YM, Lee BS, Yi KY, Paik SG (1997) Upstream NF-κB site is required for the maximal expression of mouse inducible nitric oxide synthase gene in interferon-γ plus lipopolysaccharide-induced RAW 264.7 macrophages. Biochem Biophys Res Commun 236: 655-660
18. Spink J, Cohen J, Evans TJ (1995) The cytokine responsive vascular smooth muscle cell enhancer of inductible nitric oxide synthase. J Biol Chem 270: 29541-29547
19. Gao J, Morrison DC, Parmely TJ, Russell SW, Murphy WJ (1997) An interferon-γ-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-γ and lipopolysaccharide. J Biol Chem 272: 1226-1230
20. Martin E, Nathan C, Xie QW (1994) Role of interferon regulatory factor 1 in induction of nitric oxide synthase. J Exp Med 180: 977-984
21. Spink J, Evans T (1997) Binding of the transcription factor interferon regulatory factor-1 to the inductible nitric-oxide synthase promoter. J Biol Chem 272: 24417-24425
22. Kamijo R, Harada H, Matsuyama T et al. (1994) Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science 263: 1612-1615
23. Saldeen J, Welsh N (1994) Interleukin-1β induced activation of NF-κB in insulin producing RINm5F cells is prevented by the protease inhibitor Na-p-tosyl-L-lysine chloromethylketone. Biochem Biophys Res Commun 203: 149-155
24. Bedoya F, Flodström M, Eizirik DL (1995) Pyrrolidine dithiocarbamate prevents IL-1-induced nitric oxide synthase mRNA, but not superoxide dismutase mRNA, in insulin-producing cells. Biochem Biophys Res Commun 210: 816-822
25. Kwon G, Corbett JA, Rodi CP, Sullivan P, McDaniel ML (1995) Interleukin-1β-induced nitric oxide synthase by rat pancreatic islets: evidence for the involvement of nuclear factor κB in the signaling mechanism. Endocrinology 136: 4790-4795
26. Flodström M, Welsh N, Eizirik DL (1996) Cytokines activate the nuclear factor κB (NF-κB) and induce nitric oxide production in human pancreatic islets. FEBS Lett 385: 4-6
27. Akabane A, Kato I, Takasawa S et al. (1995) Nicotinamide inhibits IRF-1 mRNA induction and prevents IL-1β-induced nitric oxide synthase expression in pancreatic β-cells. Biochem Biophys Res Commun 215: 524-530
28. Flodström M, Eizirik DL (1997) Interferon-γ-induced interferon regulatory factor-1 (IRE-1) expression in rodent and human islet cells precedes nitric oxide production. Endocrinology 138: 2747-2753
29. Pipeleers DG, in't Veld PA, Van De Winkel M, Maes E, Schuit FC, Gepts W (1985) A new in vitro model for the study of pancreatic A and B cells. Endocrinology 117: 806-816
30. Ling Z, Hannaert JC, Pipeleers D (1994) Effect of nutrients, hormones and serum on survival of rat islet β cells in culture. Diabetologia 37: 15-21
31. Schuit FC, Pipeleers DG (1985) Regulation of adenosine 3′,5′-monophosphate levels in lhe pancreatic B cell. Endocrinology 117: 834-840
32. Ausubel FM, Brent R, Kingston RE et al. (1994) Current Protocols in Molecular Biology. Wiley & Sons. New York, pp 2.2.1-2.2.3
33. Coolidge CJ, Patton JG (1995) Run-around PCR: a novel way to create duplications using polymerase chain reaction. BioTechniques 18: 763-764
34. 15N]nitrate in biological fluids. Anal Biochem 126: 131-138
35. Ling Z, Chen MC, Smismans A et al. (1998) Intercellular differences in interleukin-1β-induced suppression of insulin synthesis and stimulation of non-insulin protein synthesis by rat pancreatic β cells. Endocrinology 139: 1540-1545
36. Eizirik DL, Björklund A, Cagliero E (1993) Genotoxic agents increase expression of growth arrest and DNA damage-inducible genes gadd 153 and gadd 45 in rat pancreatic islets. Diabetes 42: 738-745
37. Corbett JA, McDaniel ML (1995) Intraislet release of interleukin-1 inhibits beta-cell function by inducing β-cell expression of inducible nitric oxide synthase. J Exp Med 181: 559-568
38. Cetkovic-Cvrlje M, Eizirik DL (1994) TNF-α and INF-γ potentiate the deleterious effect of IL-1β on mouse pancreatic islets mainly via generation of nitric oxide. Cytokine 6: 399-406
39. Xie OW (1997) A novel lipopolysaccharide-response element contributes to induction of nitric oxide synthase. J Biol Chem 272: 14867-14872
40. Leaman DW, Leung S, Li X, Stark GR (1996) Regulation of STAT-dependent pathways by growth factors and cytokines. FASEB J 10: 1578-1588
41. Rein T, Muller M, Zorbas H (1994) In vivo footprinting of the IRF-1 promoter: inducible occupation of a GAS element next to a persistent structural alteration of the DNA. Nucleic Acids Res 22: 3033-3037
42. Salkowski CA, Barber SA, Detore GR, Vogel SN (1996) Differential dysregulation of nitric oxide production in macrophages with targeted disruptions in IFN regulatory factor-1 and -2 genes. J Immunol 156: 3107-3110