Apoptosis and remodelling of beta cells by paracrine interferon-γ without insulitis in transgenic mice

Diabetologia

Volumn 42, Issue 5, 1999, Pages 566-573

  Yamaoka, T ^b   Yano, M ^c   Idehara, C ^c   Yamada, T ^a   Tomonari, S ^c   Moritani, M ^c   Ii, S ^c   Yoshimoto, K ^c   Hata, J ^a   Itakura, M ^c  

^a KEIO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c NONE

Author keywords

Apoptosis; Insulin secretion; Interferon ; Transgenic mice; Tumour necrosis factor; Type I diabetes

Indexed keywords

GAMMA INTERFERON; GLUCAGON; INSULIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL REGENERATION; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; INSULIN RELEASE; INSULITIS; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; FEMALE; GENE EXPRESSION; GLUCAGON; GLUCOSE; GLUCOSE TOLERANCE TEST; IN SITU NICK-END LABELING; INSULIN; INSULIN RESISTANCE; INTERFERON TYPE II; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); RATS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033044467     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051196     Document Type: Article

References (47)

1. Sarvetnick N (1997) IFN-γ, IGIF and IDDM. J Clin Invest 99: 371-372
2. Wilson SB, Kent SC, Patton KT et al. (1998) Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes. Nature 391: 177-181
3. Kallmann BA, Huther M, Tubes M et al. (1997) Systemic bias of cytokine production toward cell-mediated immune regulation in IDDM and toward humoral immunity in Graves' disease. Diabetes 46: 237-243
4. Katz JD, Benoist C, Mathis D (1995) T helper cell subsets in insulin-dependent diabetes. Science 268: 1185-1188
5. Rabinovitch A, Suarez-Pinzon W, El-Sheikh A, Sonrensen O, Power RF (1996) Cytokine gene expression in pancreatic islet-infiltration leukocytes of BB rats: expression of Th1 cytokines correlates with beta-cell destructive insulitis and IDDM. Diabetes 45: 749-754
6. Hancock WW, Polanski M, Zhang J, Blogg N, Weiner HL (1995) Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and -10, transforming growth factor-β, and prostaglandin-E. Am J Pathol 147: 1193-1199
7. Ploix C, Bergerot I, Fabien N, Perche S, Moulin V, Thivolet C (1998) Protection against autoimmune diabetes with oral insulin is associated with the presence of IL-4 type 2 T-cells in the pancreas and pancreatic lymph nodes. Diabetes 47: 39-44
8. Tian J, Atkinson MA, Clare-Salzler M et al. (1996) Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J Exp Med 183: 1561-1567
9. Trembleau S, Penna G, Gregori S, Gately MK, Adorini L (1997) Deviation of pancreas-infiltrating cells to Th2 by interleukin-12 antagonist administration inhibits autoimmune diabetes. Eur J Immunol 27: 2330-2339
10. Solimena M, DeCamilli P (1996) From Th1 to Th2: diabetes immunotherapy shifts gears. Nat Med 2: 1311-1312
11. Sarvetnick N, Liggitt D, Pitts SL, Hansen SE, Stewart TA (1988) Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma. Cell 52: 773-782
12. Hultgren B, Huang X, Dybdal N, Stewart TA (1996) Genetic absence of γ-interferon delays but does not prevent diabetes in NOD mice. Diabetes 45: 812-817
13. Efrat S, Fleischer N, Hanahan D (1990) Diabetes induced in male transgenic mice by expression of human H-ras oncoprotein in pancreatic beta cells. Mol Cell Biol 10: 1779-1783
14. Epstein PN, Overbeek PA, Means AR (1989) Calmodulin-induced early-onset diabetes in transgenic mice. Cell 58: 1067-1073
15. Allison J, Campbell IL, Marahan G, Mandel TE, Harrison LC, Miller JF (1988) Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic beta cells. Nature 333: 529-533
16. Lo D, Burkly LC, Widera G et al. (1988) Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells. Cell 53: 159-168
17. Moritani M, Yoshimoto K, Tashiro F et al. (1994) Transgenic expression of IL-10 in pancreatic islet A cells accelerates autoimmune insulitis and diabetes in non-obese diabetic mice. Int Immunol 6: 1927-1936
18. Yamaoka T, Nishimura C, Yamashita K et al. (1995) Acute onset of diabetic pathological changes in transgenic mice with human aldose reductase cDNA. Diabetologia 38: 255-261
19. Hogan B, Beddington R, Costantini F, Lacy E (1994) Manipulating the Mouse Embryo. A Laboratory Manual. 2nd edn. Cold Spring Harbor Laboratory Press, New York
20. Moritani M, Yoshimoto K, Ii S et al. (1996) Prevention of adoptively transferred diabetes in nonobese diabetic mice with IL-10-transduced islet-specific Th1 lymphocytes. J Clin Invest 98: 1851-1859
21. Yamada T, Brunstedt J, Solomon T (1983) Chronic effects of caerulein and secretin on the endocrine pancreas of the rat. Am J Physiol 244:G541-G545
22. Egwuagu CE, Sztein J, Chan CC et al. (1994) Ectopic expression of gamma interferon in the eyes of transgenic mice induces ocular pathology and MHC class II gene expression. Invest Ophthalmol Vis Sci 35: 332-341
23. Geiger K, Howes E, Gallina M, Huang XJ, Travis GH, Sarvetnick N (1994) Transgenic mice expressing IFN-γ in the retina develop inflammation of the eye and photoreceptor. Invest Ophthalmol Vis Sci 35: 2667-2681
24. Hill JA, Polgar K, Anderson DJ (1995) T-helper 1-type immunity to trophoblast in women with recurrent spontaneous abortion. JAMA 273: 1933-1936
25. Hill JA, Haimovici F, Anderson DJ (1987) Products of activated lymphocytes and macrophages inhibit mouse embryo development in vitro. J Immunol 139: 2250-2254
26. Tangri S, Wegmann TG, Lin H, Raghupathy R (1994) Maternal anti-placental reactivity in natural, immunologically-mediated fetal resorptions. J Immunol 152: 4903-4911
27. Chaouat G, Assal-Meliani A, Martal J et al. (1995) IL-10 prevents naturally occurring fetal loss in the CBA × DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-τ. J Immunol 154: 4261-4268
28. Rabinovitch A, Suarez WL, Thomas PD, Strynadka K, Simpson I (1992) Cytotoxic effects of cytokines on rat islets: evidence for involvement of free radicals and lipid peroxidation. Diabetologia 35: 409-413
29. Laffranchi R, Spinas GA (1997) Interferon-γ inhibits insulin release and induces cell death in the pancreatic β-cell line INS-1 independently of nitric oxide production. Exp Cell Res 237: 217-222
30. Hamaguchi K, Leiter EH (1990) Comparison of cytokine effects on mouse pancreatic α-cell and β-cell lines. Viability, secretary function, and MHC antigen expression. Diabetes 39: 415-425
31. Tuch BE, Simpson AM, Campbell IL (1991) Role of tumor necrosis factor and interferon-γ as growth factors to the human fetal β-cell. J Clin Endocrinol Metab 73: 1044-1050
32. Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 259: 87-91
33. Uysal KT, Weisbrock SM, Marino MW, Hotamisligil GS (1997) Protection from obesity-induced insulin resistance in mice lacking TNF-α function. Nature 389: 610-614
34. Miles PD, Romeo OM, Higo K, Cohen A, Rafaat K, Olefsky JM (1997) TNF-α-induced insulin resistance in vivo and its prevention by troglitazone. Diabetes 46: 1678-1683
35. Font-de-More J, Porras A, Ahn N, Santos E (1997) Mitogen-activated protein kinase activation is not necessary for, but antagonizes, 3T3-L1 adipocytic differentiation. Mol Cell Biol 17: 6068-6075
36. Saghizadeh M, Ong JM, Garvey WT, Henry RR, Kern PA (1996) The expression of TNF alpha by human muscle. Relationship to insulin resistance. J Clin Invest 97: 1111-1116
37. Gu D, Sarvetnick N (1993) Epithelial cell proliferation and islet neogenesis in IFN-γ transgenic mice. Development 118: 33-46
38. Tuch BE, Chen J (1993) Resistance of the human fetal β-cell to the toxic effect of multiple low-dose streptozotocin. Pancreas 8: 305-311
39. Gu D, Arnush M, Sawyer SP, Sarvetnick N (1995) Transgenic mice expressing IFN-γ in pancreatic β-cells are resistant to streptozotocin-induced diabetes. Am J Physiol 269:E1089-E1094
40. Dusetti NJ, Mallo GV, Ortiz EM, Keim V, Dagorn JC, Iovanna JL (1996) Induction of lithostathine/reg mRNA expression by serum from rats with acute pancreatitis and cytokines in pancreatic acinar AR42J cells. Arch Biochem Biophys 330: 129-132
41. Watanabe T, Yonekura H, Terazono K, Yamamoto H, Okamoto H (1990) Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. J Biol Chem 265: 7432-7439
42. Rothe H, Hibino T, Itoh Y, Kolb H, Martin S (1997) Systemic production of interferon-γ inducing factor (IGIF) versus local IFN-γ expression involved in the development of Th1 insulitis in NOD mice. J Autoimmun 10: 251-256
43. Leiter EH, Christianson GJ, Serreze DV, Ting AT, Worhen SM (1989) MHC antigen induction by interferon gamma on cultured mouse pancreatic β cells and macrophages. Genetic analysis of strain differences and discovery of an "occult" class I-like antigen in NOD/Lt mice. J Exp Med 170: 1243-1262
44. Pujol-Borrell R, Todd I, Doshi M et al. (1987) HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxin. Nature 326: 304-306
45. Tomei LD, Cope FO (1994) Apoptosis II: the Molecular Basis of Apoptosis in Disease. Cold Spring Harbor Laboratory Press, New York
46. Higuchi Y, Herrera P, Muniesa P et al. (1992) Expression of a tumor necrosis factor alpha transgene in murine pancreatic beta cells results in severe and permanent insulitis without evolution towards diabetes. J Exp Med 176: 1719-1731
47. Guerder S, Picarella DE, Linsley PS, Flavell RA (1994) Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice. Proc Natl Acad Sci USA 91: 5138-5142