The role of interferon regulatory factor-1 in cytokine-induced mRNA expression and cell death in murine pancreatic β-cells

European Cytokine Network

Volumn 10, Issue 3, 1999, Pages 403-411

  Pavlovic, Dejan ^a,b   Chen, Meng Chi ^a   Gysemans, Conny A ^c   Mathieu, Chantal ^c   Eizirik, Décio L ^a  

^a DIABETES RESEARCH CENTER   (Belgium)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^c NONE

Author keywords

Apoptosis; Interferon ; Interleukin 1 ; Nitric oxide; Pancreatic islets; Serine protease inhibitor 3

Indexed keywords

CYTOKINE; DYE; GAMMA INTERFERON; INTERFERON REGULATORY FACTOR 1; MESSENGER RNA; NITRIC OXIDE SYNTHASE; NITRITE; SERINE PROTEINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; GENE EXPRESSION REGULATION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; BASE SEQUENCE; CYTOKINES; DNA PRIMERS; DNA-BINDING PROTEINS; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HISTOCOMPATIBILITY ANTIGENS CLASS I; INSULIN; INTERFERON REGULATORY FACTOR-1; ISLETS OF LANGERHANS; MALE; MICE; MICE, KNOCKOUT; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; PHOSPHOPROTEINS; RNA, MESSENGER; SERINE PROTEINASE INHIBITORS;

EID: 0032858007     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Foulis A K. 1987. The pathogenesis of beta cell destruction in type I (insulin-dependent) diabetes mellitus. (Review) J. Pathol. 152: 141.
2. Eizirik D L, Pavlovic D. 1997. Is there a role for nitric oxide in β-cell dysfunction and damage in IDDM? Diabetes Metab. Rev. 13: 293.
3. Rabinovitch A. 1993. Roles of cytokines in IDDM pathogenesis and islet β-cell destruction. Diabetes Rev. 1: 215.
4. Mauricio D, Mandrup-Poulsen T. 1998. Apoptosis and the pathogenesis of IDDM: a question of life and death. (Review) Diabetes 47: 1537.
5. Mandrup-Poulsen T. 1996. The role of interleukin-1 in the pathogenesis of IDDM. (Review) Diabetologia 39: 1005.
6. Pavlovic D, van de Winkel M, van der Auwera B, Chen M C, Schuit F, Bouwens L, Pipeleers D. 1997. Effect of IFN-γ and glucose on major histocompatibility complex class I and class II expression by pancreatic β- and non-β-cells. J. Clin. Endocrinol. Metab. 82: 2329.
7. Wiegand F, Kroncke K D, Kolb-Bachofen V. 1993. Macro-phage-generated nitric oxide as cytotoxic factor in destruction of alginate-encapsulated islets. Protection by arginine analogs and/or coencapsulated erythrocytes. Transplantation 56: 1206.
8. Steiner L, Kroncke K D, Fehsel K, Kolb-Bachofen V. 1997. Endothelial cells as cytotoxic effector cells: cylokine-activated rat islet endothelial cells lyse syngeneic islet cells via nitric oxide. Diabetologia 40: 150.
9. Pavlovic D, Chen M C, Bouwens L, Eizirik D L, Pipeleers D. 1999. Contribution of ductal cells to cytokine responses by human pancreatic islets. Diabetes 48: 29.
10. Eizirik D L, Sandler S, Palmer J P. 1993. Repair of pancreatic beta-cells. A relevant phenomenon in early IDDM? (Review) Diabetes 42: 1383.
11. Eizirik D L. 1996. Beta-cells defence and repair mechanisms in human pancreatic islets. Horm. Metab. Res. 28: 302.
12. Chen M C, Schuit F, Pipeleers D G, Eizirik D L. 1999. IL-1β induces serin protease inhibitor 3 (SPI-3) gene expression in rat pancreatic β cells detection by differential display of mRNA. Cytokine (in press).
13. Tsuda M, Kitagawa K, Imaizumi K, Wanaka A, Tohyama M, Takagi T. 1996. Induction of SPI-3 mRNA, encoding a serine protease inhibitor, in gerbil hippocampus after transient forebrain ischemia. Brain Res. Mol. Brain Res. 35: 314.
14. Welsh N, Bendtzen K, Sandler S. 1990, Influence of proteases on inhibitory and stimulatory effects of interleukin-1β on β-cell function. Diabetes 40: 290.
15. Eizirik D L, Bendtzen K, Sandier S. 1991. Short exposure of rat pancreatic islets to interleukin-1β induces a sustained but reversible impairment in β-cell function: influence of protease activation, gene transcription, and protein synthesis. Endocrinology 128: 1611.
16. Schindler C, Darnell J E Jr. 1995. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. (Review) Annu. Rev. Biochem. 64: 621.
17. Li X, Leung S, Qureshi S, Darnell J E Jr, Stark G R. 1996. Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-α. J. Biol. Chem. 271: 5790.
18. Hobart M, Ramassar V. Goes N, Urmson J, Halloran PF. 1996. The induction of class I and class II major histocompatibility complex by allogeneic stimulation is dependent on the transcription factor interferon regulatory factor-1 (IRF-1): observations in IRF-1 knockout mice. Transplantation 62: 1895.
19. Kamijo R, Harada H, Matsuyama T, Bosland M, Gerecitano J, Shapiro D, Le J, Koh S I, Kimura T, Green S J, et al. 1994. Requirements for transcription factor IRF-1 in NO synthase induction in macrophages. Science 263: 1612.
20. Tamura T, Ishihara M. Lamphier M S, Tanaka N, Oishi I, Aizawa S, Mitsuyama T, Mak T W, Tahi S, Taniguchi T. 1995. An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature 376: 596.
21. Tada Y, Ho A, Matsuyama T, Mak TW. 1997. Reduced incidence and severity of antigen-induced autoimmune disease in mice lacking interferon regulatory factor-1 J. Exp. Med. 185: 231.
22. Flodström M, Eizirik D L. 1997. Interferon-γ-induced interferon regulatory factor-1 (IRF-1) expression in rodent and human islet cells precedes nitric oxide production. Endocrinology 138: 2747.
23. Nakazawa T, Satoh J, Takakashi K, Sakata Y, Masuda T, Taniguchi T, Kato I, Okamoto H, Toyota T. 1998. IRF-1-deficient nonobesc diabetic mice do not develop autoimmune diabetes. Diabetes 45 (Suppl. 3): 0806 (Abstract).
24. Matsuyama T, Kimura T, Kitagawa M, Pfeffer K, Kawakami T, Watanabe N, Kündig T M, Amakawa R, Kishikara K, Wakeham A, et al. 1993. Targeted disruption of IRF-1 or IRF-2 results in abnormal type 1 TFN gene induction and aberrant lymphocyte development. Cell 75: 83.
25. Pipeleers D G, In't Veld P A, van de Winkel M, Maes E, Schuit F, Gepts W. 1985 A new in vitro model for the study of pancreatic A and B cells. Endocrinology 117: 806.
26. Ling Z, Hannaert J C, Pipeleers D. 1994. Effects of nutrients, hormones and serum on survival of rat islet beta cells in culture. Diabetologia 37: 15.
27. Hoorens A, van de Casteele M, Klöppel G. Pipeleers D. 1996. Glucose promotes survival of rat pancreatic β cells by activating synthesis of proteins which suppress a constitutive apoptotic program. J. Clin. Invest. 98: 1568.
28. Cetkovic-Cvrlje M, Eizirik D L. 1994. TNF-α and IFN-γ potentiate the deleterious effects of IL-1β on mouse pancreatic islets mainly via generation of nitric oxide. Cytokine 6: 399.
29. Delaney C A, Pavlovic D, Hoorens A, Pipeleers D G, Eizirik D L. 1997. Cytokines induce deoxyribonucleic acid strafed breaks and apoptosis in human pancreatic islet cells. Endocrinology 138: 2610.
30. 15N)nitrate in biological fluids. Anal Biochem. 126: 131.
31. Pipeleers D, van de Winkel M. 1986. Pancreatic β cells possess defense mechanisms against cell-specific toxicity. Proc. Natl. Acad. Sci. USA 83: 5267.
32. Heitmeier M R, Scarim A L, Corbett J A. 1997. Interferongamma increases the sensitivity of islets of Langerhans for inducible nitric-oxide synthase expression induced by interleukin-1. J. Biol. Chem. 272: 13697.
33. Darville M I, Eizirik D L. 1998. Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells. Diabetologia 41: 1101.
34. Ling Z, Chen M C, Smismans A, Pavlovic D, Schuit F, Eizirik D L, Pipeleers D G. 1998. Intercellular differences in interleukin-1β-induced suppression of insulin synthesis and stimulation of non-insulin protein synthesis by rat pancreatic β-cells. Endocrinology 139: 1540.
35. Eizirik D L, Sandler S, Welsh N, Cetkovic-Cvrlje M, Nieman A, Geller D A, Pipeleers D G, Bendtzen K, Hellerström C. 1994. Cytokines suppress human islet function irrespective of their effects on nitric oxide generation. J. Clin. Invest. 93: 1968.
36. Corbett J A, MCDaniel M L. 1995. Intraislet release of interleukin-1 inhibits beta-cell function by inducing beta-cell expression of inducible nitric oxide synthase. J. Exp. Med. 181: 559.
37. Pages G, Rouayrene J F, Le Cam G, Mariller M, Le Cam A. 1990. Molecular characterization of three rat liver serine-protease inhibitors affected by inflammation and hypophysectomy. Protein and mRNA analysis and cDNA cloning. Eur. J. Biochem. 190: 385.
38. Southern C, Schulster D, Green I C. 1990. Inhibition of insulin secretion by interleukin-1β and tumour necrosis factor-α via L-arginine-dependent nitric oxide generating mechanism. FEBS Lett. 276: 42.
39. Khan I A, Matsuura T, Fonseka S, Kasper L H. 1996. Production of nitric oxide (NO) is not essential for protection against acute Toxoplasma gondii infection in IRF-1 mice. J. Immunol. 156: 636.