Dual role of interferon-γ signalling pathway in sensitivity of pancreatic beta cells to immune destruction

Diabetologia

Volumn 44, Issue 5, 2001, Pages 567-574

  Gysemans, C A ^a   Pavlovic, D ^b   Bouillon, R ^a   Eizirik, D L ^b   Mathieu, C ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b DIABETES RESEARCH CENTER   (Belgium)

Author keywords

Cytokines; Interferon regulatory factor 1; Interferon ; Islet destruction; Signal transduction; Type I diabetes

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERFERON REGULATORY FACTOR 1; NITRIC OXIDE; STREPTOZOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DESTRUCTION; CELL KILLING; CELL SURVIVAL; CONTROLLED STUDY; GRAFT REJECTION; IMMUNE SYSTEM; IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; CROSSES, GENETIC; DIABETES MELLITUS, EXPERIMENTAL; DNA-BINDING PROTEINS; GRAFT SURVIVAL; INTERFERON REGULATORY FACTOR-1; INTERFERON TYPE II; INTERLEUKIN-1; INTERLEUKIN-6; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, KNOCKOUT; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHOPROTEINS; RECEPTORS, INTERFERON; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSPLANTATION, HOMOLOGOUS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035004613     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051662     Document Type: Article

References (33)

1. The role of interleukin-1 in the pathogenesis of IDDM
2. The harmony of the spheres: Inducible nitric oxide synthase and related genes in pancreatic beta cells
3. An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus
4. Cytokines and nitric oxide in islet inflammation and diabetes
5. Is there a role for nitric oxide in β cell dysfunction and damage in IDDM?
6. Inducible nitric oxide synthase (iNOS) in pancreatic islet of nonobese diabetic mice: Identification of iNOS-expressing cells and relationship to cytokines in the islets
7. Interleukin-1-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase
8. Endogenous nitric oxide induced by interleukin-1β in rat islets of Langerhans and HIT-T15 cells causes significant DNA damage as measured by the "comet" assay
9. Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells
10. Nitric oxide: Discovery and impact on clinical medicine
11. IFN-gamma gene expression in pancreatic-islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice
12. Prevention of diabetes in NOD mice treated with antibody to murine IFN-gamma
13. Cellular responses to interferon-γ
14. JAKS and STATS: Biological implications
15. Interferon regulatory factors: The next generation
16. Interferon-γ-induced interferon regulatory factor-1 (IRF-1) expression in rodent and human islet cells precedes nitric oxide production
17. Regulation by cytokines of the inducible nitric oxide synthase promotor in insulin producing cells
18. DNA damage-induced apoptosis and Ice gene induction in mitogenically activated T lymphocytes require IRF-1
19. Multistage regulation of Th1-Type immune responses by the transcription factor IRF-1
20. Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo
21. Targeted disruption of IRF-1 and IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development
22. The role of interferon regulatory factor-1 in cytokine-induced mRNA expression and cell death in murine pancreatic β cells
23. Mouse models of insulin dependent diabetes: Low-dose streptozotocin-induced diabetes and non-obese diabetic (NOD) mice
24. 3 analogue and cyclosporine
25. 3 prevents insulitis in NOD mice
26. Islet xenograft destruction in hu-PBL-severe combined immunodeficient (SCID) mouse necessitates preactivation of human immune cells
27. Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR
28. IFN-γ action on pancreatic beta cells causes class I MHC upregulation but not diabetes
29. Apoptosis and remodelling of beta cells by paracrine interferon-gamma without insulitis in transgenic mice
30. Tumor necrosis factor-α and the progression of diabetes in non-obese diabetic mice
31. Interleukin-1beta-induced alteration in a beta-cell phenotype can reduce cellular sensitivity to conditions that cause necrosis but not to cytokine-induced apoptosis
32. Role of autoreactive CD8 + T cells in organ-specific autoimmune diseases: Insights form transgenic mouse models
33. Prolonged STAT1 activation is associated with IFN-γ priming for interleukin-1-induced inducible nitric-oxide synthase expression by islets of Langerhans