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Volumn 9, Issue 5, 1998, Pages 733-743

Local expression of TNFα in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens

Author keywords

[No Author keywords available]

Indexed keywords

CELL ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; TUMOR NECROSIS FACTOR ALPHA; AUTOANTIGEN;

EID: 0032214715     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80670-6     Document Type: Article
Times cited : (181)

References (60)
  • 1
    • 0032485487 scopus 로고    scopus 로고
    • Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
    • Albert, M.L., Sauter, B., and Bhardwaj, N. (1998). Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392, 86-89.
    • (1998) Nature , vol.392 , pp. 86-89
    • Albert, M.L.1    Sauter, B.2    Bhardwaj, N.3
  • 2
  • 3
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau, J., and Steinman, R.M. (1998). Dendritic cells and the control of immunity. Nature 392, 245-252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 5
    • 0030858138 scopus 로고    scopus 로고
    • Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
    • Cella, M., Engering, A., Pinet, V., Pieters, J., and Lanzavecchia, A. (1997). Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature 388, 782-787.
    • (1997) Nature , vol.388 , pp. 782-787
    • Cella, M.1    Engering, A.2    Pinet, V.3    Pieters, J.4    Lanzavecchia, A.5
  • 6
    • 0027934873 scopus 로고
    • TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide
    • Cetkovic-Cvrlje, M., and Eizirik, D.L. (1994). TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide. Cytokine 6, 399-406.
    • (1994) Cytokine , vol.6 , pp. 399-406
    • Cetkovic-Cvrlje, M.1    Eizirik, D.L.2
  • 7
    • 0029979838 scopus 로고    scopus 로고
    • IFN-α induces autoimmune T cells through the induction of intracellular adhesion molecule-1 and B7-2
    • Chakrabarti, D., Hultgren, B., and Stewart, T.A. (1996). IFN-α induces autoimmune T cells through the induction of intracellular adhesion molecule-1 and B7-2. J. Immunol. 757, 522-528.
    • (1996) J. Immunol. , vol.757 , pp. 522-528
    • Chakrabarti, D.1    Hultgren, B.2    Stewart, T.A.3
  • 9
    • 0029066697 scopus 로고
    • Contenders in FasL/TNF death signaling
    • Cleveland, J.L., and Ihle, J.N. (1995). Contenders in FasL/TNF death signaling. Cell 81, 479-482.
    • (1995) Cell , vol.81 , pp. 479-482
    • Cleveland, J.L.1    Ihle, J.N.2
  • 11
    • 0030669280 scopus 로고    scopus 로고
    • Recombinant tumour necrosis factor enhances the locomotion of memory and naive B lymphocytes from human tonsils through the selective engagement of the type II receptor
    • Corcione, A., Ottonella, L, Tortolina, G., Tasso, P., Ghiotto, F., Airold I., Taborelli, G., Malavasi, F., Dalledgri, F., and Pistoia, V. (1997). Recombinant tumour necrosis factor enhances the locomotion of memory and naive B lymphocytes from human tonsils through the selective engagement of the type II receptor. Blood 90, 4493-4501.
    • (1997) Blood , vol.90 , pp. 4493-4501
    • Corcione, A.1    Ottonella, L.2    Tortolina, G.3    Tasso, P.4    Ghiotto, F.5    Airold, I.6    Taborelli, G.7    Malavasi, F.8    Dalledgri, F.9    Pistoia, V.10
  • 12
    • 0032055842 scopus 로고    scopus 로고
    • Dendritic cells and macrophages are the first and major producers of TNFα in pancreatic islets in the nonobese diabetic mouse
    • Dahlén, E., Dawe, K., Ohlsson, L, and Hedlund, G. (1998). Dendritic cells and macrophages are the first and major producers of TNFα in pancreatic islets in the nonobese diabetic mouse. J. Immunol. 160, 3585-3593.
    • (1998) J. Immunol. , vol.160 , pp. 3585-3593
    • Dahlén, E.1    Dawe, K.2    Ohlsson, L.3    Hedlund, G.4
  • 13
    • 0031423760 scopus 로고    scopus 로고
    • The nonobese diabetic mouse as a model of autoimmune diabetes: Immune dysregulation gets the NOD
    • Delovitch, T.L., and Singh, B. (1997). The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity 7, 727-738.
    • (1997) Immunity , vol.7 , pp. 727-738
    • Delovitch, T.L.1    Singh, B.2
  • 15
    • 4243786511 scopus 로고    scopus 로고
    • Effects of neonatal TNF and anti-TNF treatment of NOD mice on central and peripheral lymphoid development
    • Ettinger, R., Cope, A., van Ewijk, W., and McDevitt, H.O. (1998). Effects of neonatal TNF and anti-TNF treatment of NOD mice on central and peripheral lymphoid development. FASEB J. 12, A6354.
    • (1998) FASEB J. , vol.12
    • Ettinger, R.1    Cope, A.2    Van Ewijk, W.3    McDevitt, H.O.4
  • 17
    • 0029834839 scopus 로고    scopus 로고
    • Local expression of transgene encoded TNFα in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells
    • Grewal, I.S., Grewal, K.D., Wong, F.S., Picarella, D.E., Janeway, C.A., Jr., and Flavell, R.A. (1996). Local expression of transgene encoded TNFα in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells. J. Exp. Med. 184, 1963-1974.
    • (1996) J. Exp. Med. , vol.184 , pp. 1963-1974
    • Grewal, I.S.1    Grewal, K.D.2    Wong, F.S.3    Picarella, D.E.4    Janeway C.A., Jr.5    Flavell, R.A.6
  • 18
    • 0028428910 scopus 로고
    • The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen
    • Guerder, S., Meyerhoff, J., and Flavell, R. (1994). The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen. Immunity 1, 155-166.
    • (1994) Immunity , vol.1 , pp. 155-166
    • Guerder, S.1    Meyerhoff, J.2    Flavell, R.3
  • 19
    • 0032167602 scopus 로고    scopus 로고
    • Autoimmunity without diabetes in transgenic mice expressing β cell-specific CD86, but not CD80: Parameters that trigger progression to diabetes
    • Guerder, S., Eynon, E. E., and Flavell, R.A. (1998). Autoimmunity without diabetes in transgenic mice expressing β cell-specific CD86, but not CD80: parameters that trigger progression to diabetes. J. Immunol. 161, 2128-2140.
    • (1998) J. Immunol. , vol.161 , pp. 2128-2140
    • Guerder, S.1    Eynon, E.E.2    Flavell, R.A.3
  • 20
    • 0028199631 scopus 로고
    • Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness
    • Harlan, D., Hengartner, H., Huang, M., Kang, Y.-H., Abe, R., Moreadith, R., Pricher, H., Gray, G., Ohashi, P., Greeman, G., Nadler, L., June, C., and Aichele, P. (1994). Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness. Proc. Natl. Acad. Sci. USA 91, 3137-3141.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 3137-3141
    • Harlan, D.1    Hengartner, H.2    Huang, M.3    Kang, Y.-H.4    Abe, R.5    Moreadith, R.6    Pricher, H.7    Gray, G.8    Ohashi, P.9    Greeman, G.10    Nadler, L.11    June, C.12    Aichele, P.13
  • 21
    • 0025230418 scopus 로고
    • Genes encoding tumor necrosis factor-α and granzyme A are expressed during development of autoimmune diabetes
    • Held, W., MacDonald, H.R., Weissman, I.L, Hess, M.W., and Mueller, C. (1990). Genes encoding tumor necrosis factor-α and granzyme A are expressed during development of autoimmune diabetes. Proc. Natl. Acad. Sci. USA 87, 2239-2243.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 2239-2243
    • Held, W.1    MacDonald, H.R.2    Weissman, I.L.3    Hess, M.W.4    Mueller, C.5
  • 22
    • 0029380651 scopus 로고
    • Expression of murine VCAM-1 in vitro and in different models of inflammation in vivo: Correlation with immigration of monocytes
    • Henseleit, U., Steinbrink, K., Sunderkotter, C., Goebeler, M., Roth, J., and Sorg, C. (1995). Expression of murine VCAM-1 in vitro and in different models of inflammation in vivo: correlation with immigration of monocytes. Exp. Dermatol. 4, 249-256.
    • (1995) Exp. Dermatol. , vol.4 , pp. 249-256
    • Henseleit, U.1    Steinbrink, K.2    Sunderkotter, C.3    Goebeler, M.4    Roth, J.5    Sorg, C.6
  • 23
    • 0031568065 scopus 로고    scopus 로고
    • CD28/B7 costimulation regulates autoimmune diabetes induced with multiple low doses of strepozotocin
    • Herold, K.C., Vezys, V., Koons, A., Lenschow, D., Thomson, C., and Bluestone, J.A. (1997). CD28/B7 costimulation regulates autoimmune diabetes induced with multiple low doses of strepozotocin. J. Immunol. 158, 984-991.
    • (1997) J. Immunol. , vol.158 , pp. 984-991
    • Herold, K.C.1    Vezys, V.2    Koons, A.3    Lenschow, D.4    Thomson, C.5    Bluestone, J.A.6
  • 25
    • 0027255168 scopus 로고
    • An immunohistochemical study on organized lymphoid cell infiltrates in fetal and neonatal pancreas. A comparison with similar infiltrates found in the pancreas of a diabetic infant
    • Jansen, A., Voorbij, H.A.M., Jeucken, P.H.M., Bruining, G.J., Hooijkaas, H., and Drexhage, H.A. (1993). An immunohistochemical study on organized lymphoid cell infiltrates in fetal and neonatal pancreas. A comparison with similar infiltrates found in the pancreas of a diabetic infant. Autoimmunity 15, 31-38.
    • (1993) Autoimmunity , vol.15 , pp. 31-38
    • Jansen, A.1    Voorbij, H.A.M.2    Jeucken, P.H.M.3    Bruining, G.J.4    Hooijkaas, H.5    Drexhage, H.A.6
  • 26
    • 0028223127 scopus 로고
    • Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of insulitis and β cell destruction in NOD mice
    • Jansen, H., Homo-Delarche, F., Hooijkaas, H., Leenen, P.J., Dardenne, M., and Drexhage, H.A. (1994). Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of insulitis and β cell destruction in NOD mice. Diabetes 43, 667-675.
    • (1994) Diabetes , vol.43 , pp. 667-675
    • Jansen, H.1    Homo-Delarche, F.2    Hooijkaas, H.3    Leenen, P.J.4    Dardenne, M.5    Drexhage, H.A.6
  • 27
    • 0027367830 scopus 로고
    • Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice
    • Katz, J., Benoist, C., and Mathis, D. (1993a). Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice. Eur. J. Immunol. 23, 3358-3360.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 3358-3360
    • Katz, J.1    Benoist, C.2    Mathis, D.3
  • 28
    • 0027378612 scopus 로고
    • Following a diabetogenic T cell from genesis through pathogenesis
    • Katz, J.D., Wang, B., Haskins, K., Benoist, C., and Mathis, D. (1993b). Following a diabetogenic T cell from genesis through pathogenesis. Cell 74, 1089-1110.
    • (1993) Cell , vol.74 , pp. 1089-1110
    • Katz, J.D.1    Wang, B.2    Haskins, K.3    Benoist, C.4    Mathis, D.5
  • 30
    • 0030587871 scopus 로고    scopus 로고
    • RIP-beta2-microglobulin transgene expression restores insulitis but not diabetes in beta2-null nonobese diabetic mice
    • Kay, T.W., Parker, J.L., Stephens, L.A., Thomas, H.E., and Allison, J. (1996). RIP-beta2-microglobulin transgene expression restores insulitis but not diabetes in beta2-null nonobese diabetic mice. J. Immunol. 157, 3688-3693.
    • (1996) J. Immunol. , vol.157 , pp. 3688-3693
    • Kay, T.W.1    Parker, J.L.2    Stephens, L.A.3    Thomas, H.E.4    Allison, J.5
  • 32
    • 0024281396 scopus 로고
    • Diabetes and tolerance in transegnic mice expressing class II MHC molecules in pancreatic beta cells
    • Lo, D., Burkly, L.C., Widera, G., Cowing, C., Flavell, R.A., Palmiter, R.D., and Brinster, R.L. (1988). Diabetes and tolerance in transegnic mice expressing class II MHC molecules in pancreatic beta cells. Cell 53, 159-168.
    • (1988) Cell , vol.53 , pp. 159-168
    • Lo, D.1    Burkly, L.C.2    Widera, G.3    Cowing, C.4    Flavell, R.A.5    Palmiter, R.D.6    Brinster, R.L.7
  • 33
    • 0030815504 scopus 로고    scopus 로고
    • Immunological tolerance to a pancreatic antigen as a result of local expression of TNFα by islet β cells
    • McSorley, S.J., Soldera, S., Malherbe, L, Carnaud, C., Locksley, R.M., Flavell, R.A., and Glaichenhaus, N. (1997). Immunological tolerance to a pancreatic antigen as a result of local expression of TNFα by islet β cells. Immunity 7, 401-409.
    • (1997) Immunity , vol.7 , pp. 401-409
    • McSorley, S.J.1    Soldera, S.2    Malherbe, L.3    Carnaud, C.4    Locksley, R.M.5    Flavell, R.A.6    Glaichenhaus, N.7
  • 34
    • 0023905731 scopus 로고
    • + T cell subsets are required for the transfer of diabetes in nonobese diabetic mice
    • + T cell subsets are required for the transfer of diabetes in nonobese diabetic mice. J. Immunol. 140, 52-58.
    • (1988) J. Immunol. , vol.140 , pp. 52-58
    • Miller, B.1    Appel, M.2    O'Neil, J.3    Wicker, L.4
  • 36
    • 0030937468 scopus 로고    scopus 로고
    • Apoptosis is the mode of β cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse
    • O'Brien, B.A., Harmon, B.V., Cameron, D.P., and Allan, D.J. (1997). Apoptosis is the mode of β cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse. Diabetes 46, 750-757.
    • (1997) Diabetes , vol.46 , pp. 750-757
    • O'Brien, B.A.1    Harmon, B.V.2    Cameron, D.P.3    Allan, D.J.4
  • 37
    • 0030022742 scopus 로고    scopus 로고
    • Transfer of diabetes in the NOD-scid mouse by CD4 T-cell clones
    • Peterson, J.D., and Haskins, K. (1996). Transfer of diabetes in the NOD-scid mouse by CD4 T-cell clones. Diabetes 45, 328-336.
    • (1996) Diabetes , vol.45 , pp. 328-336
    • Peterson, J.D.1    Haskins, K.2
  • 38
    • 0027207669 scopus 로고
    • Transgenic tumour necrosis factor (TNF)-α production in pancreatic islets leads to insulitis, not diabetes
    • Picarella, D.E., Kratz, A., Li, C., Ruddle, N.H., and Flavell, R.A. (1993). Transgenic tumour necrosis factor (TNF)-α production in pancreatic islets leads to insulitis, not diabetes. J. Immunol. 150, 4136-4150.
    • (1993) J. Immunol. , vol.150 , pp. 4136-4150
    • Picarella, D.E.1    Kratz, A.2    Li, C.3    Ruddle, N.H.4    Flavell, R.A.5
  • 40
    • 0026554156 scopus 로고
    • The nonobese diabetic scid mouse: A model for spontaneous thymomagenesis associated with immunodeficiency
    • Prochazka, M., Gaskins, H., Shultz, L., and Leiter, E. (1992). The nonobese diabetic scid mouse: a model for spontaneous thymomagenesis associated with immunodeficiency. Proc. Natl. Acad. Sci. USA 89, 3290-3294.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 3290-3294
    • Prochazka, M.1    Gaskins, H.2    Shultz, L.3    Leiter, E.4
  • 43
    • 0032482337 scopus 로고    scopus 로고
    • A conditioned dendritic cell can be a temporal bridge between a CD4 T-helper cell and a T-killer cell
    • Ridge, F., Di Rosa, F., and Matzinger, P. (1998). A conditioned dendritic cell can be a temporal bridge between a CD4 T-helper cell and a T-killer cell. Nature 393, 474-478.
    • (1998) Nature , vol.393 , pp. 474-478
    • Ridge, F.1    Di Rosa, F.2    Matzinger, P.3
  • 44
    • 0029038921 scopus 로고
    • Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor and interleukin 1
    • Roake, J.A., Rao, A.S., Morris, P.J., Larsen, C.P., Hankins, D.F., and Austyn, J.M. (1995). Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor and interleukin 1. J. Exp. Med. 181, 2237-2247.
    • (1995) J. Exp. Med. , vol.181 , pp. 2237-2247
    • Roake, J.A.1    Rao, A.S.2    Morris, P.J.3    Larsen, C.P.4    Hankins, D.F.5    Austyn, J.M.6
  • 46
    • 0032472406 scopus 로고    scopus 로고
    • Changes in function of antigen-specific lymphocytes correlating with progression towards diabetes in a transgenic model
    • Sarukhan, A., Lanoue, A., Franzke, A., Brousse, N., Buer, J., and von Boehmer, H. (1998). Changes in function of antigen-specific lymphocytes correlating with progression towards diabetes in a transgenic model. EMBO J. 17, 71-80.
    • (1998) EMBO J. , vol.17 , pp. 71-80
    • Sarukhan, A.1    Lanoue, A.2    Franzke, A.3    Brousse, N.4    Buer, J.5    Von Boehmer, H.6
  • 48
    • 0029148825 scopus 로고
    • Relationship between β cell injury and antigen presentation in NOD mice
    • Shimizu, J., Carrasco-Marin, E., Kanagawa, O., and Unanue, E.R. (1995). Relationship between β cell injury and antigen presentation in NOD mice. J. Immunol. 755, 4095-4099.
    • (1995) J. Immunol. , vol.755 , pp. 4095-4099
    • Shimizu, J.1    Carrasco-Marin, E.2    Kanagawa, O.3    Unanue, E.R.4
  • 49
    • 0030796631 scopus 로고    scopus 로고
    • Pancreatic gene expression in rare cells of thymic medulla: Evidence for functional contribution to T cell tolerance
    • Smith, K.M., Olson, D.C., Hirose, R., and Hanahan, D. (1997). Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance. Int. Immunol. 9, 1355-1365.
    • (1997) Int. Immunol. , vol.9 , pp. 1355-1365
    • Smith, K.M.1    Olson, D.C.2    Hirose, R.3    Hanahan, D.4
  • 50
    • 0030731917 scopus 로고    scopus 로고
    • Nitric oxide primes pancreatic β cells for Fas-mediated destruction in insulin-dependent diabetes mellitus
    • Stassi, G., De Maria, R., Trucco, G., Rudert, W., Testi, R., Galluzzo, A., Giordana, C., and Trucco, M. (1997). Nitric oxide primes pancreatic β cells for Fas-mediated destruction in insulin-dependent diabetes mellitus. J. Exp. Med. 186, 1193-1200.
    • (1997) J. Exp. Med. , vol.186 , pp. 1193-1200
    • Stassi, G.1    De Maria, R.2    Trucco, G.3    Rudert, W.4    Testi, R.5    Galluzzo, A.6    Giordana, C.7    Trucco, M.8
  • 51
    • 0029954214 scopus 로고    scopus 로고
    • Insulin-dependent diabetes mellitus
    • Tisch, R., and McDevitt, H.O. (1996). Insulin-dependent diabetes mellitus. Cell 85, 291-297.
    • (1996) Cell , vol.85 , pp. 291-297
    • Tisch, R.1    McDevitt, H.O.2
  • 52
    • 0027908753 scopus 로고
    • Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
    • Tisch, R., Yang, S., Singer, S.M., Liblau, R.S., Fugger, L., and McDevitt, H.O. (1993). Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366, 72-75.
    • (1993) Nature , vol.366 , pp. 72-75
    • Tisch, R.1    Yang, S.2    Singer, S.M.3    Liblau, R.S.4    Fugger, L.5    McDevitt, H.O.6
  • 53
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-α function
    • Uysal, K.T., Weisbrock, S.M., Marino, M.W., and Hotamisligil, G.S. (1997). Protection from obesity-induced insulin resistance in mice lacking TNF-α function. Nature 389, 610-614.
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Weisbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 54
    • 0026717674 scopus 로고
    • The pathophysiology of tumor necrosis factors
    • Vassalli, P. (1992). The pathophysiology of tumor necrosis factors. Ann. Rev. Immunol. 10, 411-452.
    • (1992) Ann. Rev. Immunol. , vol.10 , pp. 411-452
    • Vassalli, P.1
  • 55
    • 0028918793 scopus 로고
    • Lipopolysaccharide interferes with the induction of peripheral T cell death
    • Vella, A.T., McCormack, J.E., Linsley, P., Kappler, J.W., and Marrack, P. (1995). Lipopolysaccharide interferes with the induction of peripheral T cell death. Immunity 2, 261-270.
    • (1995) Immunity , vol.2 , pp. 261-270
    • Vella, A.T.1    McCormack, J.E.2    Linsley, P.3    Kappler, J.W.4    Marrack, P.5
  • 57
    • 0028922437 scopus 로고
    • Genetic control of autoimmune diabetes in the NOD mouse
    • Wicker, L.S., Todd, J.A., and Peterson, L.B. (1995). Genetic control of autoimmune diabetes in the NOD mouse. Ann. Rev. Immunol. 13, 179-200.
    • (1995) Ann. Rev. Immunol. , vol.13 , pp. 179-200
    • Wicker, L.S.1    Todd, J.A.2    Peterson, L.B.3
  • 58
    • 0028921986 scopus 로고
    • Expression of the co-stimulator molecule B7-1 in pancreatic beta cells accelerates diabetes in the NOD mouse
    • Wong, F.S., Guerder, S., Visintin, I., Reich, E.-P., Swenson, K.E., Flavell, R.A., and Janeway, C.A., Jr. (1995). Expression of the co-stimulator molecule B7-1 in pancreatic beta cells accelerates diabetes in the NOD mouse. Diabetes 44, 326-329.
    • (1995) Diabetes , vol.44 , pp. 326-329
    • Wong, F.S.1    Guerder, S.2    Visintin, I.3    Reich, E.-P.4    Swenson, K.E.5    Flavell, R.A.6    Janeway C.A., Jr.7
  • 59
    • 13344294394 scopus 로고    scopus 로고
    • CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells
    • Wong, F.S., Visintin, I., Wen, L., Flavell, R.A., and Janeway, C.A., Jr. (1996). CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. J. Exp. Med. 183, 67-76.
    • (1996) J. Exp. Med. , vol.183 , pp. 67-76
    • Wong, F.S.1    Visintin, I.2    Wen, L.3    Flavell, R.A.4    Janeway C.A., Jr.5
  • 60
    • 0027990811 scopus 로고
    • Effect of tumour necrosis factor a on insulin-dependent diabetes mellitus in NOD mice: I. The early development of autoimmunity and thediabetogenic process
    • Yang, X.-D., Tisch, R., Singer, S.M., Cao, Z.A., Liblau, R.S., Schreiber, R.D., and McDevitt, H.O. (1994). Effect of tumour necrosis factor a on insulin-dependent diabetes mellitus in NOD mice: I. the early development of autoimmunity and thediabetogenic process. J. Exp. Med. 180, 995-1004.
    • (1994) J. Exp. Med. , vol.180 , pp. 995-1004
    • Yang, X.-D.1    Tisch, R.2    Singer, S.M.3    Cao, Z.A.4    Liblau, R.S.5    Schreiber, R.D.6    McDevitt, H.O.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.