Local expression of transgene encoded TNFα in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells

Journal of Experimental Medicine

Volumn 184, Issue 5, 1996, Pages 1963-1974

  Grewal, Iqbal S ^a   Grewal, Kate D ^a   Wong, F Susan ^a   Picarella, Dominic E ^a   Janeway Jr , Charles A ^a   Flavell, Richard A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN ANTIBODY COMPLEX; ARTICLE; AUTOIMMUNITY; CELL CLONING; CELL SPECIFICITY; DISEASE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROMOTER REGION; RAT; TRANSGENE;

EID: 0029834839     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.184.5.1963     Document Type: Article

References (38)

1. Castano, L., and G.S. Eisenbarth. 1990. Type-I diabetes: a chronic autoimmune disease of human, mouse and rat. Ann. Rev. Immunol. 8:647-679.
2. Bosi, E., I. Todd, R. Pujol-Borrell, and G.F. Bottazzo. 1987. Mechanisms of autoimmunity: relevance to the pathogenesis of type I (insulin-dependent) diabetes mellitus. Diabetes-Metabolism Rev. 3:893-923.
3. Tarn, A.C., J.M. Thomas, B.M. Dean, D. Ingram, G. Schwarz, G.F. Bottazzo, and E.A. Gale. 1988. Predicting insulin-dependent diabetes. Lancet. 1:845-850.
4. Pozzilli, P., A. Signore, A.J. Williams, and P.E. Beales. 1993. NOD mouse colonies around the world - recent facts and figures. Immunol. Today. 14:193-196.
5. Marliss, E.B., A.F. Nakhooda, P. Poussier, and A.A. Sima. 1982. The diabetic syndrome of the 'BB' Wistar rat: possible relevance to type 1 (insulin-dependent) diabetes in man. Diabetologia. 22:225-232.
6. Rossini, A.A., J.P. Mordes, and A.A. Like. 1985. Immunology of insulin-dependent diabetes mellitus. Ann. Rev. Immunol. 3:289-320.
7. Kikutani, H., and Makino, S. 1992. The murine autoimmune diabetes model; NOD and related strains. Adv. Immunol. 51: 285-322.
8. Todd, J.A., T.J. Aitman, R.J. Cornall, S. Ghosh, J.R.S. Hall, C.M. Hearne, A.M. Knight, J.M. Love, M.A. McAleer, J.-B. Prins et al. 1991. Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Nature (Lond.). 351:542-547.
9. Prins, J.-B., J.A. Todd, N.R. Rodrigues, S. Ghosh, P.M. Hogarth, L.S. Wicker, E. Gaffney, L. Podolin, P.A. Fischer, A. Sirotina, and L.B. Peterson. 1993. Linkage on chromosome 3 of autoimmune diabetes and defective Fc Receptor for IgG in NOD mice. Science (Wash. DC). 260:695-698.
10. Hattori, M., J.B. Buse, R.A. Jackson, L. Glimcher, M.E. Dorf, M. Minami, S. Makino, K. Moriwaki, H. Kuzuya, H. Imura et al. 1986. The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex. Science (Wash. DC). 231:773-735.
11. Wicker, L.S., B.J. Miller, L. Coker, S.E. McNally, S. Scott, Y. Mullen, and M.C. Appel. 1987. Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse. J. Exp. Med. 165:1639-1655.
12. Wicker, L. S., B. J. Miller, P. A. Fischer, A. Pressey, and L. B. Peterson. 1989. Genetic control of diabetes and insulitis in the nonobese diabetic mouse. J. Immunol. 142:781-784.
13. Nepom, G.T. 1990. HLA and type 1 diabetes. Immunol. Today. 11:314-315.
14. Ghosh, S., S.M. Palmer, N.R. Rodrigues, H.J. Cordell, C.M. Hearne, R.J. Cornall, J.B. Prins, P. McShane, G.M. Lathrop, L.B. Peterson et al. 1993. Polygenic control of autoimmune diabetes in nonobese diabetic mice. Nature Genet. 4:404-409.
15. Charlton, B., A. Bacelj, R.M. Slattery, and T.E. Mandel. 1989. Cyclophosphamide-induced diabetes in NOD/WHEI mice. Diabetes. 38:441-447.
16. Mandrup-Poulsen, T., S. Helqvist, L.D. Wogensen, J. Molvig, F. Pociot, J. Johannesen, and J. Nerup. 1990. Cytokine and free radicals as effector molecules in the destruction of pancreatic beta cells. Curr. Top. Microbiol. Immunol. 164: 169-193.
17. Sandler, S. D. L. Eizirik, C. Svensson, E. Strandell, M. Welsh, and N. Welsh. 1991. Biochemical and molecular actions of interleukin-1 on pancreatic beta-cells. Autoimmunity. 10:241-253.
18. Corbett, J.A., and M.L. McDaniel. 1992. Does nitric oxide mediate autoimmune destruction of beta-cells? Possible therapeutic interventions in IDDM. Diabetes. 41:897-903.
19. Rabinovitch, A. 1993. Roles of cytokines in IDDM pathogenesis and islet β-cell destruction. Diabetes Rev. 1:215-240.
20. Rabinovitch, A. 1994. Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation? Diabetes. 43:613-21.
21. Pober, J.S., and R.S. Cotran. (1990) Cytokines and endothelial cell biology. Physiol. Rev. 70:427-451.
22. Collins, T., L.A. Lapierte, W. Fiers, J.L. Strominger, and J.S. Pober. 1986. Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A,B antigens in vascular endothelial cells and dermal fibroblasts in vitro. Proc. Natl. Acad. Sci. USA. 83:446-450.
23. Pujol-Borrell, R., I. Todd, M. Doshi, G.F. Bottazzo, R. Sutton, D. Gray, G.R. Adolf, and M. Feldmann. 1987. HLA class II induction in human islet cells by interferon-gamma plus tumour necrosis factor or lymphotoxin. Nature (Lond.). 326:304-306.
24. Keffer, J., L. Probert, H. Cazlaris, S. Georgopoulos, E. Kaslaris, D. Kioussis, and G. Kollias. 1991. Transgenic mice expressing human tumor necrosis factor: a predictive genetic model of arthritis. EMBO (Eur. Mol. Biol. Organ.) J. 10: 4025-4031.
25. Higuchi, Y., P. Herrera, P. Muniesa, J. Huarte, D. Belin, P. Ohashi, P. Aichele, L. Orci, J. D. Vassalli, and P. Vassalli. 1992. Expression of a tumor necrosis factor alpha transgene in murine pancreatic beta cells results in severe and permanent insulitis without evolution towards diabetes. J. Exp. Med. 176:1719-1731.
26. Picarella, D.E., A. Kratz, C.-B. Li, N.R. Ruddle, and R.A. Flavell. 1992. Insulitis in transgenic mice expressing TNF-β (lymphotoxin) in the pancreas. Proc. Natl. Acad. Sci. USA. 89: 10036-10040.
27. Picarella, D.E., A. Kratz, C.-B. Li, N.H. Ruddle, and R.A. Flavell. 1993. Transgenic tumor necrosis factor (TNF)-α and TNF-β transgenic mice. J. Immunol. 150:4136-4150.
28. Jacob, C.O., S. Aiso, S.A. Michie, H.O. McDevitt, and H. Acha-Orbea. 1990. Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-α and interleukin 1. Proc. Natl. Acad. Sci. USA. 87:968-972.
29. Reichlin, S. 1993. Neuroendocrine-immune interactions. New Eng. J. Med. 329:1246-1253.
30. Yang, X.D., R. Tisch, S. Singer, Z. Cao, R. Liblau, R. Schreiber, and H. McDevitt. 1994. Effect of tumor necrosis factor a on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process J. Exp. Med. 180:995-1004.
31. Jacob, C.O., S. Aiso, R.D. Schreiber, and H.O. McDevitt. 1992. Monoclonal anti-tumor necrosis factor antibody renders non-obese diabetic mice hypersensitive to irradiation and enhances insulitis development. Intl. Immunol. 4:611-614.
32. Kaufman, D.L., M. Clare-Salzler, J. Tian, T. Forsthuber, G. S. Ting, P. Robinson, M.A. Atkinson, E.E. Sercarz, A.J. Tobin, and P.V. Lehmann. 1993. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature (Lond.). 366:69-72.
33. Wong, F.S., I. Visintin, L. Wen, R.A. Flavell, and C.A. Janway, Jr. 1996. CD8 cell clone from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. J. Exp. Med. 183:67-76.
34. Satoh, J., H. Seino, T. Abo, S.I. Tanaka, S. Shintani, S. Ohta, K. Tamura, T. Sawai, T. Nobunaga, T. Oteki, K. Kumagai, and T. Toyota. 1989. Recombinant human tumor necrosis factor a suppresses autoimmune diabetes in nonobese diabetic mice. J. Clin. Invest. 84:1345-1348.
35. Satoh, J., H. Seino, S. Shintani, S.I. Tanaka, T. Ohteki, T. Masuda, T. Nobunaga, and T. Toyota. 1990. Inhibition of type I diabetes in BB rats with recombinant human tumor necrosis factor-α. J. Immunol. 145:1395-1399.
36. Tisch, R., X.D. Yang, S.M. Singer, R.S. Liblau, L. Fugger, and H.O. McDevitt. 1993. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature (Lond.). 366:72-75.
37. DiCosmo, B.F., D. Picarella, and R.A. Flavell. 1994. Local production of interleukin-6 promotes insulitis but retards the onset of insulin dependent diabetes mellitus in NOD mice. Intl. Immunol. 6:1829-1837.
38. Liu, Y., and C.A. Janeway, Jr. 1992. Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells. Proc. Natl. Acad. Sci. USA. 89:3845-3849.