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Volumn 185, Issue 3, 1997, Pages 531-539

Interferon-γ is essential for destruction of β cells and development of insulin-dependent diabetes mellitus

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INSULIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PERFORIN; VIRUS GLYCOPROTEIN; VIRUS NUCLEOPROTEIN;

EID: 0031051747     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.185.3.531     Document Type: Article
Times cited : (207)

References (51)
  • 2
    • 0019230052 scopus 로고
    • The epidemiology of insulin-dependent diabetes with particular reference to the relationship of virus infection to its etiology
    • Gamble, D.R. 1980. The epidemiology of insulin-dependent diabetes with particular reference to the relationship of virus infection to its etiology. Epidemiol. Rev. 2:49-70.
    • (1980) Epidemiol. Rev. , vol.2 , pp. 49-70
    • Gamble, D.R.1
  • 3
    • 0028026652 scopus 로고
    • IDDM as an autoimmune disease
    • Bach, J.F. 1994. IDDM as an autoimmune disease. Endocr. Rev. 15:516-532.
    • (1994) Endocr. Rev. , vol.15 , pp. 516-532
    • Bach, J.F.1
  • 4
    • 0027908753 scopus 로고
    • Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
    • Tisch, R., X.-D. Yang, S.M. Singer, R.S. Liblau, L. Fugger, and H.O. McDevitt. 1993. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature (Lond.). 366:72-75.
    • (1993) Nature (Lond.) , vol.366 , pp. 72-75
    • Tisch, R.1    Yang, X.-D.2    Singer, S.M.3    Liblau, R.S.4    Fugger, L.5    McDevitt, H.O.6
  • 5
    • 0027291701 scopus 로고
    • Altered cytokine activity in adjuvant inhibition of autoimmune diabetes
    • Shehadeh, N., F. La Rosa, and K. Lafferty. 1993. Altered cytokine activity in adjuvant inhibition of autoimmune diabetes. J. Autoimmun. 6:291-300.
    • (1993) J. Autoimmun. , vol.6 , pp. 291-300
    • Shehadeh, N.1    La Rosa, F.2    Lafferty, K.3
  • 6
    • 0025754853 scopus 로고
    • Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of the anti-self (virus) immune response
    • Oldstone, M.B.A., M. Nerenberg, V. Southern, J. Price, and H. Lewicki. 1991. Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of the anti-self (virus) immune response. Cell. 65:319-331.
    • (1991) Cell , vol.65 , pp. 319-331
    • Oldstone, M.B.A.1    Nerenberg, M.2    Southern, V.3    Price, J.4    Lewicki, H.5
  • 7
    • 0026594436 scopus 로고
    • Inflammation but not autoimmunity occurs in transgenic mice expressing constitutive levels of interleukin-2 in islet beta-cells
    • Allison, J., L. Malcolm, N. Chosich, and J.F.A.P. Miller. 1992. Inflammation but not autoimmunity occurs in transgenic mice expressing constitutive levels of interleukin-2 in islet beta-cells. Enr.J. Immunol. 22:1115-1121.
    • (1992) Enr.J. Immunol. , vol.22 , pp. 1115-1121
    • Allison, J.1    Malcolm, L.2    Chosich, N.3    Miller, J.F.A.P.4
  • 9
    • 0025981388 scopus 로고
    • Essential role for interferon-gamma and interleukin-6 in autoimmune insulin dependent diabetes in NOD/Wehi mice
    • Campbell, I., T. Kay, L. Oxbrow, and L.C. Harrison. 1991. Essential role for interferon-gamma and interleukin-6 in autoimmune insulin dependent diabetes in NOD/Wehi mice. J. Clin. Invest. 87:739-742.
    • (1991) J. Clin. Invest. , vol.87 , pp. 739-742
    • Campbell, I.1    Kay, T.2    Oxbrow, L.3    Harrison, L.C.4
  • 10
    • 0025130361 scopus 로고
    • Molecular pathology of type I diabetes
    • Campbell, I., and L.C. Harrison. 1990. Molecular pathology of type I diabetes. Mol. Biol. Med. 7:299-309.
    • (1990) Mol. Biol. Med. , vol.7 , pp. 299-309
    • Campbell, I.1    Harrison, L.C.2
  • 13
    • 0028280636 scopus 로고
    • Pancreatic islet production of murine interleukin-10 does not inhibit immune-mediated tissue destruction
    • Lee, M-S., L. Wogensen, J. Shirzuru, M.B.A. Oldstone, and N. Sarvetnick. 1994. Pancreatic islet production of murine interleukin-10 does not inhibit immune-mediated tissue destruction. J. Clin. Invest. 93:1332-1338.
    • (1994) J. Clin. Invest. , vol.93 , pp. 1332-1338
    • Lee, M.-S.1    Wogensen, L.2    Shirzuru, J.3    Oldstone, M.B.A.4    Sarvetnick, N.5
  • 16
    • 0028361047 scopus 로고
    • Role of cytokines in determining T-lymphocyte function
    • O'Garra, A., and M. Kenneth. 1994. Role of cytokines in determining T-lymphocyte function. Curr. Opin. Immunol. 6: 458-466.
    • (1994) Curr. Opin. Immunol. , vol.6 , pp. 458-466
    • O'Garra, A.1    Kenneth, M.2
  • 17
    • 0027185291 scopus 로고
    • Type 2 cytokines and negative immune regulation in human infections
    • Modlin, R., and T.B. Nutman. 1993. Type 2 cytokines and negative immune regulation in human infections. Curr. Opin. Immunol. 5:511-517.
    • (1993) Curr. Opin. Immunol. , vol.5 , pp. 511-517
    • Modlin, R.1    Nutman, T.B.2
  • 18
    • 0027153198 scopus 로고
    • Analysis of IL-2, IL-4, and IFN-γ producing cells in situ during immune responses to protein antigens
    • Bogen, S., I. Fogelmann, and A. Abbas. 1993. Analysis of IL-2, IL-4, and IFN-γ producing cells in situ during immune responses to protein antigens. J. Immunol. 150:4197-4205.
    • (1993) J. Immunol. , vol.150 , pp. 4197-4205
    • Bogen, S.1    Fogelmann, I.2    Abbas, A.3
  • 19
    • 0027360333 scopus 로고
    • An essential role for interferon-γ in resistance to mycobacterium tuberculosis infection
    • Flynn, J.L., J. Chan, K. Riebold, D. Dalton, T. Stewart, and B. Bloom. 1993. An essential role for interferon-γ in resistance to mycobacterium tuberculosis infection. J. Exp. Med. 178:2249-2254.
    • (1993) J. Exp. Med. , vol.178 , pp. 2249-2254
    • Flynn, J.L.1    Chan, J.2    Riebold, K.3    Dalton, D.4    Stewart, T.5    Bloom, B.6
  • 20
    • 0027485028 scopus 로고
    • Response to influenza infection in mice with a targeted disruption of the interferon γ gene
    • Graham, M.B., D. Dalton, D. Giltinan, V. Braciale, T. Stewart, and T. Braciale. 1993. Response to influenza infection in mice with a targeted disruption of the interferon γ gene. J. Exp. Med. 178:1725-1732.
    • (1993) J. Exp. Med. , vol.178 , pp. 1725-1732
    • Graham, M.B.1    Dalton, D.2    Giltinan, D.3    Braciale, V.4    Stewart, T.5    Braciale, T.6
  • 21
    • 0028844073 scopus 로고
    • An essential role for type I interferon-γ in terminating persistent viral infection
    • Tishon, T., H. Lewicki, G. Rall, M.G. von Herrath, and M.B.A. Oldstone. 1995. An essential role for type I interferon-γ in terminating persistent viral infection. Virology. 212:244-250.
    • (1995) Virology , vol.212 , pp. 244-250
    • Tishon, T.1    Lewicki, H.2    Rall, G.3    Von Herrath, M.G.4    Oldstone, M.B.A.5
  • 22
    • 0023841728 scopus 로고
    • Insulin-dependent diabetes mellitus induced in transgenic mice by ecotopic expression of class II MHC and interferon-gamma
    • Sarvetnick, N., D. Liggitt, S.L. Pitts, S.E. Hansen, and T.A. Stewart. 1988. Insulin-dependent diabetes mellitus induced in transgenic mice by ecotopic expression of class II MHC and interferon-gamma. Cell. 52:773-782.
    • (1988) Cell , vol.52 , pp. 773-782
    • Sarvetnick, N.1    Liggitt, D.2    Pitts, S.L.3    Hansen, S.E.4    Stewart, T.A.5
  • 23
  • 24
    • 0029948898 scopus 로고    scopus 로고
    • Genetic absence of γ-interferon delays but does not prevent diabetes in NOD mice
    • Hultgren, B., X. Huang, N. Dybdal, and T. Stewart. 1996. Genetic absence of γ-interferon delays but does not prevent diabetes in NOD mice. Diabetes. 45:812-817.
    • (1996) Diabetes , vol.45 , pp. 812-817
    • Hultgren, B.1    Huang, X.2    Dybdal, N.3    Stewart, T.4
  • 25
    • 0028446546 scopus 로고
    • How virus induces a rapid and slow onset IDDM in a transgenic model
    • von Herrath, M.G., J. Dockter, H. Lewicki, and M.B.A. Oldstone. 1994. How virus induces a rapid and slow onset IDDM in a transgenic model. Immunity. 1:231-242.
    • (1994) Immunity , vol.1 , pp. 231-242
    • Von Herrath, M.G.1    Dockter, J.2    Lewicki, H.3    Oldstone, M.B.A.4
  • 26
    • 0029551987 scopus 로고
    • Coexpression of B7.1 and viral (self) transgenes in pancreatic β-cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes
    • von Herrath, M.G., S. Guerder, H. Lewicki, R. Flavell, and M.B.A. Oldstone. 1995. Coexpression of B7.1 and viral (self) transgenes in pancreatic β-cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes. Immunity. 3:727-738.
    • (1995) Immunity , vol.3 , pp. 727-738
    • Herrath, M.G.1    Guerder, S.2    Lewicki, H.3    Flavell, R.4    Oldstone, M.B.A.5
  • 27
    • 0028080014 scopus 로고
    • Selection and adaptability of CTL responses in tg mice expressing a viral protein in the thymus
    • von Herrath, M.G., J. Dockter, M. Nerenberg, J. Gairin, and M.B.A. Oldstone. 1994. Selection and adaptability of CTL responses in tg mice expressing a viral protein in the thymus. J. Exp. Med. 180:1901-1910.
    • (1994) J. Exp. Med. , vol.180 , pp. 1901-1910
    • Von Herrath, M.G.1    Dockter, J.2    Nerenberg, M.3    Gairin, J.4    Oldstone, M.B.A.5
  • 28
    • 13344294394 scopus 로고    scopus 로고
    • CD8 cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset diabetes in NOD mice in the absence of CD4 cells
    • Wong, S., L. Wen, I. Visintin, R.A. Flavell, C. Janeway, Jr. 1996. CD8 cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset diabetes in NOD mice in the absence of CD4 cells. J. Exp. Med. 183:67-76.
    • (1996) J. Exp. Med. , vol.183 , pp. 67-76
    • Wong, S.1    Wen, L.2    Visintin, I.3    Flavell, R.A.4    Janeway Jr., C.5
  • 29
    • 0021271733 scopus 로고
    • Virus persists in β-cells of islets of Langerhans and is associated with chemical manifestation of diabetes
    • Oldstone, M.B.A., P. Southern, M. Rodriguez, and P. Lampert. 1984. Virus persists in β-cells of islets of Langerhans and is associated with chemical manifestation of diabetes. Science (Wash. DC). 224:1440-1443.
    • (1984) Science (Wash. DC) , vol.224 , pp. 1440-1443
    • Oldstone, M.B.A.1    Southern, P.2    Rodriguez, M.3    Lampert, P.4
  • 30
    • 0028020331 scopus 로고
    • Analysis of the spontaneous T-cell response to insulin in NOD mice
    • Wegmann, D., R. Gill, M. Glaser, N. Schloot, and D. Daniel. 1994. Analysis of the spontaneous T-cell response to insulin in NOD mice. J. Autoimmun. 7:833-843.
    • (1994) J. Autoimmun. , vol.7 , pp. 833-843
    • Wegmann, D.1    Gill, R.2    Glaser, M.3    Schloot, N.4    Daniel, D.5
  • 31
    • 0025833190 scopus 로고
    • Morphological analysis of selective destruction of pancreatic β-cell by cytotoxic T lymphocytes in NOD mice
    • Hayakawa, M., K. Yokono, M. Nagata, N. Hatamori, W. Ogawa, A. Miki, H. Mizoguit, and S. Baba. 1991. Morphological analysis of selective destruction of pancreatic β-cell by cytotoxic T lymphocytes in NOD mice. Diabetes. 40:1210-1217.
    • (1991) Diabetes , vol.40 , pp. 1210-1217
    • Hayakawa, M.1    Yokono, K.2    Nagata, M.3    Hatamori, N.4    Ogawa, W.5    Miki, A.6    Mizoguit, H.7    Baba, S.8
  • 34
    • 0029942839 scopus 로고    scopus 로고
    • Development of insulitis without diabetes in transgenic mice lacking perforin dependent cytotoxicity
    • Kagi, D., B. Odermatt, F. Ohashi, R.M. Zinkernagel, and H. Hengartner. 1996. Development of insulitis without diabetes in transgenic mice lacking perforin dependent cytotoxicity. J. Exp. Med. 183:2143-2149.
    • (1996) J. Exp. Med. , vol.183 , pp. 2143-2149
    • Kagi, D.1    Odermatt, B.2    Ohashi, F.3    Zinkernagel, R.M.4    Hengartner, H.5
  • 35
    • 0027937745 scopus 로고
    • Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways
    • Lowin, B., M. Hahne, C. Mattmann, and J. Tschopp. 1994. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature (Lond.). 370:650-652.
    • (1994) Nature (Lond.) , vol.370 , pp. 650-652
    • Lowin, B.1    Hahne, M.2    Mattmann, C.3    Tschopp, J.4
  • 36
    • 0023092798 scopus 로고
    • Molecular characterization of the genome S RNA segment from lymphocytic choriomeningitis virus
    • Southern, P.J., M.K. Singh, Y. Riviere, D.R. Jacoby, M.J. Buchmeier, and M.B.A. Oldstone. 1987. Molecular characterization of the genome S RNA segment from lymphocytic choriomeningitis virus. Virology. 157:145-155.
    • (1987) Virology , vol.157 , pp. 145-155
    • Southern, P.J.1    Singh, M.K.2    Riviere, Y.3    Jacoby, D.R.4    Buchmeier, M.J.5    Oldstone, M.B.A.6
  • 37
    • 0020960565 scopus 로고
    • Genomic and biological variation among commonly used lymphocytic choriomeningitis virus strains
    • Dutko, F.J., and M.B.A. Oldstone. 1983. Genomic and biological variation among commonly used lymphocytic choriomeningitis virus strains. J. Gen. Virol. 64:1689-1698.
    • (1983) J. Gen. Virol. , vol.64 , pp. 1689-1698
    • Dutko, F.J.1    Oldstone, M.B.A.2
  • 38
    • 0027467252 scopus 로고
    • Virus and cytotoxic T lymphocytes. 1. Crucial role of viral peptide secondary structure in MHC class I interactions
    • Gairin, J.E., and M.B.A. Oldstone. 1993. Virus and cytotoxic T lymphocytes. 1. Crucial role of viral peptide secondary structure in MHC class I interactions. J. Virol. 67:2903-2907.
    • (1993) J. Virol. , vol.67 , pp. 2903-2907
    • Gairin, J.E.1    Oldstone, M.B.A.2
  • 39
    • 0011180717 scopus 로고
    • Analysis of the CTL responses to glycoprotein and nucleoprotein components of LCMV
    • Whitton, J.L., P.J. Southern, and M.B.A. Oldstone. 1988. Analysis of the CTL responses to glycoprotein and nucleoprotein components of LCMV. Virology. 162:3211-3217.
    • (1988) Virology , vol.162 , pp. 3211-3217
    • Whitton, J.L.1    Southern, P.J.2    Oldstone, M.B.A.3
  • 40
    • 0023858537 scopus 로고
    • Molecular definition of a major cytotoxic T lymphocyte epitope in the glycoprotein of lymphocytic choriomeningitis virus
    • Whitton, J.L., J.R. Gebhard, H. Lewicki, A. Tishon, and M.B.A. Oldstone. 1988. Molecular definition of a major cytotoxic T lymphocyte epitope in the glycoprotein of lymphocytic choriomeningitis virus. J. Virol. 62:687-695.
    • (1988) J. Virol. , vol.62 , pp. 687-695
    • Whitton, J.L.1    Gebhard, J.R.2    Lewicki, H.3    Tishon, A.4    Oldstone, M.B.A.5
  • 41
    • 0000912462 scopus 로고
    • Lymphocytic choriomeningitis virus CTL
    • Whitton, J.L. 1990. Lymphocytic choriomeningitis virus CTL. Semin. Virol. 1:257-262.
    • (1990) Semin. Virol. , vol.1 , pp. 257-262
    • Whitton, J.L.1
  • 43
    • 0028878129 scopus 로고
    • Focal expression of interleukin-2 does not break unresponsiveness to "self" (viral) antigen expressed in β cells but enhances development of autoimmune disease (diabetes) after initiation of an anti-self immune response
    • von Herrath, M.G., J. Allison, J.F.A.P. Miller, and M.B.A. Oldstone. 1995. Focal expression of interleukin-2 does not break unresponsiveness to "self" (viral) antigen expressed in β cells but enhances development of autoimmune disease (diabetes) after initiation of an anti-self immune response. J. Clin. Invest. 95:477-485.
    • (1995) J. Clin. Invest. , vol.95 , pp. 477-485
    • Von Herrath, M.G.1    Allison, J.2    Miller, J.F.A.P.3    Oldstone, M.B.A.4
  • 44
    • 0004287115 scopus 로고
    • Oxford University Press, New York
    • Silver, L.M. 1995. Mouse Genetics. Oxford University Press, New York. 233-306.
    • (1995) Mouse Genetics , pp. 233-306
    • Silver, L.M.1
  • 48
    • 0030036342 scopus 로고    scopus 로고
    • Induction of bystander T cell proliferation by viruses and type I interferon in vivo
    • Tough, D., P. Borrow, and J. Sprent. 1996. Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science (Wash. DC). 272:1947-1950.
    • (1996) Science (Wash. DC) , vol.272 , pp. 1947-1950
    • Tough, D.1    Borrow, P.2    Sprent, J.3
  • 50
    • 0025022154 scopus 로고
    • Immune pathogenesis of diabetes in the nonobese diabetic mouse: An overview
    • Hanafusa, T., and S. Tarui. 1990. Immune pathogenesis of diabetes in the nonobese diabetic mouse: an overview. Curr. Top. Microbiol. Immunol. 156:15-25.
    • (1990) Curr. Top. Microbiol. Immunol. , vol.156 , pp. 15-25
    • Hanafusa, T.1    Tarui, S.2
  • 51
    • 0029957071 scopus 로고    scopus 로고
    • Interferon-γ confers resistance to experimental allergic encephalomyelitis
    • Krakowski, M., and T. Owens. 1996. Interferon-γ confers resistance to experimental allergic encephalomyelitis. Eur. J. Immunol. 26:1641-1646.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1641-1646
    • Krakowski, M.1    Owens, T.2


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