The RAG proteins in V(D)J recombination: More than just a nuclease

Nucleic Acids Research

Volumn 29, Issue 7, 2001, Pages 1399-1409

  Sadofsky, M ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CELL PROTEIN; DNA; NUCLEASE; RECOMBINATION ACTIVATING GENE PROTEIN; SIGNAL PEPTIDE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL CELL; ARTICLE; BIODIVERSITY; COMPLEX FORMATION; CONTROLLED STUDY; DNA CLEAVAGE; DNA PROTEIN COMPLEX; DNA RECOMBINATION; GENE; IMMUNE SYSTEM; MOUSE; NONHUMAN; PRIORITY JOURNAL; VERTEBRATE;

ANIMALIA; VERTEBRATA;

EID: 0035312712     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/29.7.1399     Document Type: Article

References (137)

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60. Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex
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62. Genetic evidence that the RAG1 protein directly participates in V(D)J recombination through substrate recognition
63. Conditional RAG-1 mutants block the hairpin formation step of V(D)J recombination
64. A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination
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68. Mutations in conserved regions of the predicted RAG2 kelch repeats block initiation of V(D)J recombination and result in primary immunodeficiencies
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