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Volumn 436, Issue 2, 1999, Pages 157-178

Somatic hypermutation and the three R's: Repair, replication and recombination

Author keywords

Affinity; Antibody; B cell; DNA repair; DNA replication; Germinal center; Immunoglobulin; Mismatch repair; Recombination; Selection; Somatic hypermutation

Indexed keywords

ANIMAL; ANTIGENIC VARIATION; B LYMPHOCYTE; BIOLOGICAL MODEL; DNA REPAIR; DNA REPLICATION; GENE REARRANGEMENT; GENETIC RECOMBINATION; GENETICS; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOLOGY; MUTATION; REVIEW; SACCHAROMYCES CEREVISIAE;

EID: 33645700119     PISSN: 13835742     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5742(99)00003-4     Document Type: Article
Times cited : (63)

References (166)
  • 1
    • 0028673962 scopus 로고
    • Formation of the chicken B cell repertoire: Ontogenesis, regulation of Ig gene rearrangement, and diversification by gene conversion
    • C.A. Reynaud, B. Bertocci, A. Dahan, J.C. Weill, Formation of the chicken B cell repertoire: ontogenesis, regulation of Ig gene rearrangement, and diversification by gene conversion, Adv. Immunol. 57 (1994) 353-378.
    • (1994) Adv. Immunol. , vol.57 , pp. 353-378
    • Reynaud, C.A.1    Bertocci, B.2    Dahan, A.3    Weill, J.C.4
  • 2
    • 0025763426 scopus 로고
    • Avian B cell development: Generation of an immunoglobulin repertoire by gene conversion
    • W.T. McCormack, L.W. Tjoelker, C.B. Thompson, Avian B cell development: generation of an immunoglobulin repertoire by gene conversion, Annu. Rev. Immunol. 9 (1991) 219-241.
    • (1991) Annu. Rev. Immunol. , vol.9 , pp. 219-241
    • McCormack, W.T.1    Tjoelker, L.W.2    Thompson, C.B.3
  • 3
    • 0030932541 scopus 로고    scopus 로고
    • Generation of antibody diversity in rabbits
    • K.L. Knight, C.R. Winstead, Generation of antibody diversity in rabbits, Curr. Opin. Immunol. 9 (1997) 228-232.
    • (1997) Curr. Opin. Immunol. , vol.9 , pp. 228-232
    • Knight, K.L.1    Winstead, C.R.2
  • 6
    • 0344936724 scopus 로고    scopus 로고
    • The origins of V(D)J recombination
    • S.M. Lewis, G.E. Wu, The origins of V(D)J recombination, Cell 88 (1997) 159-162.
    • (1997) Cell , vol.88 , pp. 159-162
    • Lewis, S.M.1    Wu, G.E.2
  • 7
    • 0031171282 scopus 로고    scopus 로고
    • Accessibility and the developmental regulation of V(D)J recombination
    • M.S. Schlissel, P. Stanhope-Baker, Accessibility and the developmental regulation of V(D)J recombination, Semin. Immunol. 9 (1997) 161-170.
    • (1997) Semin. Immunol. , vol.9 , pp. 161-170
    • Schlissel, M.S.1    Stanhope-Baker, P.2
  • 9
    • 0026060620 scopus 로고
    • Intraclonal generation of antibody mutants in germinal centres
    • J. Jacob, G. Kelsoe, K. Rajewsky, U. Weiss, Intraclonal generation of antibody mutants in germinal centres, Nature 354 (1991) 389-392.
    • (1991) Nature , vol.354 , pp. 389-392
    • Jacob, J.1    Kelsoe, G.2    Rajewsky, K.3    Weiss, U.4
  • 10
    • 0029895262 scopus 로고    scopus 로고
    • The germinal center: A crucible for lymphocyte selection
    • G. Kelsoe, The germinal center: a crucible for lymphocyte selection, Semin. Immunol. 8 (1996) 179-184.
    • (1996) Semin. Immunol. , vol.8 , pp. 179-184
    • Kelsoe, G.1
  • 11
    • 0028005612 scopus 로고
    • Somatic mutation. from the dark zone to the light
    • I.C. MacLennan, Somatic mutation. From the dark zone to the light, Curr. Biol. 4 (1994) 70-72.
    • (1994) Curr. Biol. , vol.4 , pp. 70-72
    • MacLennan, I.C.1
  • 12
    • 0023161406 scopus 로고
    • Mutation drift and repertoire shift in the maturation of the immune response
    • C. Berek, C. Milstein, Mutation drift and repertoire shift in the maturation of the immune response, Immunol. Rev. 96 (1987) 23-41.
    • (1987) Immunol. Rev. , vol.96 , pp. 23-41
    • Berek, C.1    Milstein, C.2
  • 14
    • 0029879794 scopus 로고    scopus 로고
    • Somatic mutation of immunoglobulin V genes in vitro
    • E. Kallberg, S. Jainandunsing, D. Gray, T. Leanderson, Somatic mutation of immunoglobulin V genes in vitro, Science 271 (1996) 1285-1289.
    • (1996) Science , vol.271 , pp. 1285-1289
    • Kallberg, E.1    Jainandunsing, S.2    Gray, D.3    Leanderson, T.4
  • 16
    • 0032435650 scopus 로고    scopus 로고
    • TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively mutating cell line
    • J. Sale, M. Neuberger, TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively mutating cell line, Immunity 9 (1999) 859-869.
    • (1999) Immunity , vol.9 , pp. 859-869
    • Sale, J.1    Neuberger, M.2
  • 17
    • 0030221606 scopus 로고    scopus 로고
    • Strategies for expressing human antibody repertoires in transgenic mice
    • M. Bruggemann, M.S. Neuberger, Strategies for expressing human antibody repertoires in transgenic mice, Immunol. Today 17 (1996) 391-397.
    • (1996) Immunol. Today , vol.17 , pp. 391-397
    • Bruggemann, M.1    Neuberger, M.S.2
  • 19
    • 0023090516 scopus 로고
    • Somatic hypermutation of an immunoglobulin transgene in K transgenic mice
    • R.L. O'Brien, R.L. Brinster, U. Storb, Somatic hypermutation of an immunoglobulin transgene in K transgenic mice, Nature 326 (1987) 405-409.
    • (1987) Nature , vol.326 , pp. 405-409
    • O'Brien, R.L.1    Brinster, R.L.2    Storb, U.3
  • 20
    • 0027499308 scopus 로고
    • Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: Clustering, polarity, and specific hot spots
    • A.G. Betz, C. Rada, R. Pannell, C. Milstein, M.S. Neuberger, Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots, Proc. Natl. Acad. Sci. USA 90 (1993) 2385-2388.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 2385-2388
    • Betz, A.G.1    Rada, C.2    Pannell, R.3    Milstein, C.4    Neuberger, M.S.5
  • 21
    • 0027227311 scopus 로고
    • Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes
    • A.G. Betz, M.S. Neuberger, C. Milstein, Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes, Immunol. Today 14 (1993) 405-411.
    • (1993) Immunol. Today , vol.14 , pp. 405-411
    • Betz, A.G.1    Neuberger, M.S.2    Milstein, C.3
  • 22
    • 0023107028 scopus 로고
    • Patterns of somatic mutations in immunoglobulin variable genes
    • G.B. Golding, P.J. Gearhart, B.W. Glickman, Patterns of somatic mutations in immunoglobulin variable genes, Genetics 115 (1987) 169-176.
    • (1987) Genetics , vol.115 , pp. 169-176
    • Golding, G.B.1    Gearhart, P.J.2    Glickman, B.W.3
  • 23
    • 0032478071 scopus 로고    scopus 로고
    • Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease
    • T. Goossens, U. Klein, R. Küppers, Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease, Proc. Natl. Acad. Sci. USA 95 (1998) 2463-2468.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 2463-2468
    • Goossens, T.1    Klein, U.2    Küppers, R.3
  • 25
    • 0014943022 scopus 로고
    • Variability in the lambda light chain sequences of mouse antibody
    • M.G. Weigert, I.M. Cesari, S.J. Yonkovich, M. Cohn, Variability in the lambda light chain sequences of mouse antibody, Nature 228 (1970) 1045-1047.
    • (1970) Nature , vol.228 , pp. 1045-1047
    • Weigert, M.G.1    Cesari, I.M.2    Yonkovich, S.J.3    Cohn, M.4
  • 27
  • 28
    • 0028794835 scopus 로고
    • Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process
    • C.A. Reynaud, C. Garcia, W.R. Hein, J.C. Weill, Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process, Cell 80 (1995) 115-125.
    • (1995) Cell , vol.80 , pp. 115-125
    • Reynaud, C.A.1    Garcia, C.2    Hein, W.R.3    Weill, J.C.4
  • 30
    • 0029879839 scopus 로고    scopus 로고
    • Somatic hypermutagenesis in immunoglobulin genes: III. Somatic mutations in the chicken light chain locus
    • I.B. Rogozin, N.E. Sredneva, N.A. Kolchanov, Somatic hypermutagenesis in immunoglobulin genes: III. Somatic mutations in the chicken light chain locus, Biochim. Biophys. Acta 1306 (1996) 171-178.
    • (1996) Biochim. Biophys. Acta , vol.1306 , pp. 171-178
    • Rogozin, I.B.1    Sredneva, N.E.2    Kolchanov, N.A.3
  • 31
    • 0030450401 scopus 로고    scopus 로고
    • Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation
    • B. Goyenechea, C. Milstein, Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation, Proc. Natl. Acad. Sci. USA 93 (1996) 13979-13984.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13979-13984
    • Goyenechea, B.1    Milstein, C.2
  • 36
    • 0032555232 scopus 로고    scopus 로고
    • Both DNA strands of antibody genes are hypermutation targets
    • C. Milstein, M.S. Neuberger, R. Staden, Both DNA strands of antibody genes are hypermutation targets, Proc. Natl. Acad. Sci. USA 95 (1998) 8791-8794.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 8791-8794
    • Milstein, C.1    Neuberger, M.S.2    Staden, R.3
  • 37
    • 0020569881 scopus 로고
    • Somatic mutations of immunoglobulin variable genes are restricted to the rearranged V gene
    • J. Gorski, P. Rollini, B. Mach, Somatic mutations of immunoglobulin variable genes are restricted to the rearranged V gene, Science 220 (1983) 1179-1181.
    • (1983) Science , vol.220 , pp. 1179-1181
    • Gorski, J.1    Rollini, P.2    Mach, B.3
  • 38
    • 0024517665 scopus 로고
    • V gene rearrangement is required to fully activate the hypermutation mechanism in B cells
    • J. Roes, K. Huppi, K. Rajewsky, F. Sablitzky, V gene rearrangement is required to fully activate the hypermutation mechanism in B cells, J. Immunol. 142 (1989) 1022-1026.
    • (1989) J. Immunol. , vol.142 , pp. 1022-1026
    • Roes, J.1    Huppi, K.2    Rajewsky, K.3    Sablitzky, F.4
  • 39
    • 0019424555 scopus 로고
    • Somatic mutation of immunoglobulin light-chain variable-region genes
    • E. Selsing, U. Storb, Somatic mutation of immunoglobulin light-chain variable-region genes, Cell 25 (1981) 47-58.
    • (1981) Cell , vol.25 , pp. 47-58
    • Selsing, E.1    Storb, U.2
  • 40
    • 0023321780 scopus 로고
    • Somatic point mutations in unrearranged immunoglobulin gene segments encoding the variable region of λ light chains
    • S. Weiss, O.E. Wu, Somatic point mutations in unrearranged immunoglobulin gene segments encoding the variable region of λ light chains, EMBO J. 6 (1987) 927-932.
    • (1987) EMBO J. , vol.6 , pp. 927-932
    • Weiss, S.1    Wu, O.E.2
  • 41
    • 0028063853 scopus 로고
    • Comparison of somatic mutation frequency among immunoglobulin genes
    • N. Motoyama, T. Miwa, Y. Suzuki, H. Okada, T. Azuma, Comparison of somatic mutation frequency among immunoglobulin genes, J. Exp. Med. 179 (1994) 395-403.
    • (1994) J. Exp. Med. , vol.179 , pp. 395-403
    • Motoyama, N.1    Miwa, T.2    Suzuki, Y.3    Okada, H.4    Azuma, T.5
  • 42
    • 0031391172 scopus 로고    scopus 로고
    • Expression and function of recombination activating genes in mature B cells
    • H. Ohmori, M. Hikida, Expression and function of recombination activating genes in mature B cells, Crit. Rev. Immunol. 18 (1998) 221-235.
    • (1998) Crit. Rev. Immunol. , vol.18 , pp. 221-235
    • Ohmori, H.1    Hikida, M.2
  • 43
    • 0031897509 scopus 로고    scopus 로고
    • Immunoglobulin gene hypermutation in germinal centers is independent of the RAG-1 V(D)J recombinase
    • B. Zheng, S. Han, E. Spanopoulou, G. Kelsoe, Immunoglobulin gene hypermutation in germinal centers is independent of the RAG-1 V(D)J recombinase, Immunol. Rev. 162 (1998) 133-141.
    • (1998) Immunol. Rev. , vol.162 , pp. 133-141
    • Zheng, B.1    Han, S.2    Spanopoulou, E.3    Kelsoe, G.4
  • 44
    • 0025630537 scopus 로고
    • Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is approximately 1 kb from V(D)J gene
    • S.O. Lebecque, P.J. Gearhart, Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is approximately 1 kb from V(D)J gene, J. Exp. Med. 172 (1990) 1717-1727.
    • (1990) J. Exp. Med. , vol.172 , pp. 1717-1727
    • Lebecque, S.O.1    Gearhart, P.J.2
  • 45
    • 0026739367 scopus 로고
    • Defining the nucleic acid substrate for somatic hypermutation
    • E.J. Steele, H.S. Rothenfluh, G.W. Both, Defining the nucleic acid substrate for somatic hypermutation, Immunol. Cell Biol. 70 (1992) 129-144.
    • (1992) Immunol. Cell Biol. , vol.70 , pp. 129-144
    • Steele, E.J.1    Rothenfluh, H.S.2    Both, G.W.3
  • 46
    • 2642652230 scopus 로고    scopus 로고
    • The 5′ hypermutation boundary of κ chains is independent of local and neighbouring sequences and related to the distance from the initiation of transcription
    • C. Rada, J. Yélamos, W. Dean, C. Milstein, The 5′ hypermutation boundary of κ chains is independent of local and neighbouring sequences and related to the distance from the initiation of transcription, Eur. J. Immunol. 27 (1997) 3115-3120.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 3115-3120
    • Rada, C.1    Yélamos, J.2    Dean, W.3    Milstein, C.4
  • 47
    • 0028243803 scopus 로고
    • The 5′ boundary of somatic hypermutation in a Vκ gene is in the leader intron
    • C. Rada, A. González-Fernández, J.M. Jarvis, C. Milstein, The 5′ boundary of somatic hypermutation in a Vκ gene is in the leader intron, Eur. J. Immunol. 24 (1994) 1453-1457.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 1453-1457
    • Rada, C.1    González-Fernández, A.2    Jarvis, J.M.3    Milstein, C.4
  • 48
    • 0028125606 scopus 로고
    • Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes
    • B.J. Rogerson, Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes, Mol. Immunol. 31 (1994) 83-98.
    • (1994) Mol. Immunol. , vol.31 , pp. 83-98
    • Rogerson, B.J.1
  • 49
    • 0031041632 scopus 로고    scopus 로고
    • The transcriptional promoter regulates hypermutation of the antibody heavy chain locus
    • K. Tumas-Brundage, T. Manser, The transcriptional promoter regulates hypermutation of the antibody heavy chain locus, J. Exp. Med. 185 (1997) 239-250.
    • (1997) J. Exp. Med. , vol.185 , pp. 239-250
    • Tumas-Brundage, K.1    Manser, T.2
  • 50
    • 0030063726 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
    • A. Peters, U. Storb, Somatic hypermutation of immunoglobulin genes is linked to transcription initiation, Immunity 4 (1996) 57-65.
    • (1996) Immunity , vol.4 , pp. 57-65
    • Peters, A.1    Storb, U.2
  • 51
    • 0029888843 scopus 로고    scopus 로고
    • The molecular basis of somatic hypermutation of immunoglobulin genes
    • U. Storb, The molecular basis of somatic hypermutation of immunoglobulin genes, Curr. Opin. Immunol. 8 (1996) 206-214.
    • (1996) Curr. Opin. Immunol. , vol.8 , pp. 206-214
    • Storb, U.1
  • 54
    • 0032127810 scopus 로고    scopus 로고
    • Somatic hypermutation in the heavy chain locus correlates with transcription
    • Y. Fukita, H. Jacobs, K. Rajewsky, Somatic hypermutation in the heavy chain locus correlates with transcription, Immunity 9 (1998) 105-114.
    • (1998) Immunity , vol.9 , pp. 105-114
    • Fukita, Y.1    Jacobs, H.2    Rajewsky, K.3
  • 55
    • 0029108605 scopus 로고
    • Targeting and regulation of immunoglobulin gene somatic hypermutation and isotype switch recombination
    • M. HengstschlŠger, N. Maizels, H. Leung, Targeting and regulation of immunoglobulin gene somatic hypermutation and isotype switch recombination, Prog. Nucleic Acid Res. Mol. Biol. 50 (1995) 67-99.
    • (1995) Prog. Nucleic Acid Res. Mol. Biol. , vol.50 , pp. 67-99
    • Hengstschlšger, M.1    Maizels, N.2    Leung, H.3
  • 56
    • 0028270307 scopus 로고
    • Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region
    • A.G. Betz, C. Milstein, A. González-Fernández, R. Pannell, T. Larson, M.S. Neuberger, Elements regulating somatic hypermutation of an immunoglobulin κ gene: critical role for the intron enhancer/matrix attachment region, Cell 77 (1994) 239-248.
    • (1994) Cell , vol.77 , pp. 239-248
    • Betz, A.G.1    Milstein, C.2    González-Fernández, A.3    Pannell, R.4    Larson, T.5    Neuberger, M.S.6
  • 57
    • 0031009483 scopus 로고    scopus 로고
    • Cells strongly expressing Ig κ transgenes show clonal recruitment of hypermutation: A role for both MAR and the enhancers
    • B. Goyenechea, N. Klix, J. Yelamos, G.T. Williams, A. Riddell, M.S. Neuberger, C. Milstein, Cells strongly expressing Ig κ transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers, EMBO J. 16 (1997) 3987-3994.
    • (1997) EMBO J. , vol.16 , pp. 3987-3994
    • Goyenechea, B.1    Klix, N.2    Yelamos, J.3    Williams, G.T.4    Riddell, A.5    Neuberger, M.S.6    Milstein, C.7
  • 58
    • 0027510316 scopus 로고
    • Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer
    • T. Azuma, N. Motoyama, L.E. Fields, D.Y. Loh, Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer, Int. Immunol. 5 (1993) 121-130.
    • (1993) Int. Immunol. , vol.5 , pp. 121-130
    • Azuma, T.1    Motoyama, N.2    Fields, L.E.3    Loh, D.Y.4
  • 59
    • 0029965649 scopus 로고    scopus 로고
    • Enhancers of hypermutation
    • J. Bachl, M. Wabl, Enhancers of hypermutation, Immunogenetics 45 (1996) 59-64.
    • (1996) Immunogenetics , vol.45 , pp. 59-64
    • Bachl, J.1    Wabl, M.2
  • 63
    • 0021088187 scopus 로고
    • Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma
    • T.H. Rabbitts, P.H. Hamlyn, R. Baer, Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma, Nature 306 (1983) 760-765.
    • (1983) Nature , vol.306 , pp. 760-765
    • Rabbitts, T.H.1    Hamlyn, P.H.2    Baer, R.3
  • 64
    • 0029661825 scopus 로고    scopus 로고
    • L gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection
    • L gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection, Blood 88 (1996) 3562-3568.
    • (1996) Blood , vol.88 , pp. 3562-3568
    • Chapman, C.J.1    Zhou, J.X.2    Gregory, C.3    Rickinson, A.B.4    Stevenson, F.K.5
  • 65
    • 0027960893 scopus 로고
    • Locus-specific somatic hypermutation in germinal centre T cells
    • B. Zheng, W. Xue, G. Kelsoe, Locus-specific somatic hypermutation in germinal centre T cells, Nature 372 (1994) 556-559.
    • (1994) Nature , vol.372 , pp. 556-559
    • Zheng, B.1    Xue, W.2    Kelsoe, G.3
  • 66
    • 0031897134 scopus 로고    scopus 로고
    • Somatic hypermutation of the T cell receptor Vβ gene in microdissected splenic white pulps from HIV-1-positive patients
    • R. Cheynier, S. Henrichwark, S. Wain-Hobson, Somatic hypermutation of the T cell receptor Vβ gene in microdissected splenic white pulps from HIV-1-positive patients, Eur. J. Immunol. 28 (1998) 1604-1610.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 1604-1610
    • Cheynier, R.1    Henrichwark, S.2    Wain-Hobson, S.3
  • 67
    • 0028927653 scopus 로고
    • Antigen-specific development of primary and memory T cells in vivo
    • M.G. McHeyzer-Williams, M.M. Davis, Antigen-specific development of primary and memory T cells in vivo, Science 268 (1995) 106-111.
    • (1995) Science , vol.268 , pp. 106-111
    • McHeyzer-Williams, M.G.1    Davis, M.M.2
  • 68
    • 0027306091 scopus 로고
    • LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas
    • J.P. Kerckaert, C. Deweindt, H. Tilly, S. Quief, G. Lecocq, C. Bastard, LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas, Nat. Genet. 5 (1993) 66-70.
    • (1993) Nat. Genet. , vol.5 , pp. 66-70
    • Kerckaert, J.P.1    Deweindt, C.2    Tilly, H.3    Quief, S.4    Lecocq, G.5    Bastard, C.6
  • 72
    • 2642623612 scopus 로고    scopus 로고
    • Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes
    • H.M. Shen, A. Peters, B. Baron, X. Zhu, U. Storb, Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes, Science 280 (1998) 1750-1752.
    • (1998) Science , vol.280 , pp. 1750-1752
    • Shen, H.M.1    Peters, A.2    Baron, B.3    Zhu, X.4    Storb, U.5
  • 73
    • 0032079749 scopus 로고    scopus 로고
    • RadA protein is an archaeal RecA protein homolog that catalyzes DNA strand exchange
    • E.M. Seitz, J.P. Brockman, S.J. Sandier, A.J. Clark, S.C. Kowalczykowski, RadA protein is an archaeal RecA protein homolog that catalyzes DNA strand exchange, Genes Dev. 12 (1998) 1248-1253.
    • (1998) Genes Dev. , vol.12 , pp. 1248-1253
    • Seitz, E.M.1    Brockman, J.P.2    Sandier, S.J.3    Clark, A.J.4    Kowalczykowski, S.C.5
  • 74
    • 0032053857 scopus 로고    scopus 로고
    • Identification, characterization, and genetic mapping of RadSld, a new mouse and human RAD51/RecA-related gene
    • D.L. Pittman, L.R. Weinberg, J.C. Schimenti, Identification, characterization, and genetic mapping of RadSld, a new mouse and human RAD51/RecA-related gene, Genomics 49 (1998) 103-111.
    • (1998) Genomics , vol.49 , pp. 103-111
    • Pittman, D.L.1    Weinberg, L.R.2    Schimenti, J.C.3
  • 75
    • 0032499970 scopus 로고    scopus 로고
    • Sequence analysis and expression of a novel mouse homolog of Escherichia coli recA gene
    • M. Kawabata, K. Saeki, Sequence analysis and expression of a novel mouse homolog of Escherichia coli recA gene, Biochim. Biophys. Acta 1398 (1998) 353-358.
    • (1998) Biochim. Biophys. Acta , vol.1398 , pp. 353-358
    • Kawabata, M.1    Saeki, K.2
  • 76
    • 0032530155 scopus 로고    scopus 로고
    • A phylogenomic study of the MutS family of proteins
    • J.A. Eisen, A phylogenomic study of the MutS family of proteins, Nucleic Acids Res. 26 (1998) 4291-4300.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 4291-4300
    • Eisen, J.A.1
  • 77
    • 0027292427 scopus 로고
    • Linear DNA of Borrelia species and antigenie variation
    • A.G. Barbour, Linear DNA of Borrelia species and antigenie variation, Trends Microbiol. 1 (1993) 236-239.
    • (1993) Trends Microbiol. , vol.1 , pp. 236-239
    • Barbour, A.G.1
  • 79
    • 0027965079 scopus 로고
    • Antigen diversity in the bacterium B. hermsii through 'somatic' mutations in rearranged vmp genes
    • B.I. Restrepo, A.G. Barbour, Antigen diversity in the bacterium B. hermsii through 'somatic' mutations in rearranged vmp genes, Cell 78 (1994) 867-876.
    • (1994) Cell , vol.78 , pp. 867-876
    • Restrepo, B.I.1    Barbour, A.G.2
  • 80
    • 0030904280 scopus 로고    scopus 로고
    • Antigenic variation in Lyme disease Borreliae by promiscuous recombination of VMP-like sequence cassettes
    • J.R. Zhang, J.M. Hardham, A.G. Barbour, S.J. Norris, Antigenic variation in Lyme disease Borreliae by promiscuous recombination of VMP-like sequence cassettes, Cell 89 (1997) 275-285.
    • (1997) Cell , vol.89 , pp. 275-285
    • Zhang, J.R.1    Hardham, J.M.2    Barbour, A.G.3    Norris, S.J.4
  • 82
    • 0031128325 scopus 로고    scopus 로고
    • DNA turnover and mutation in resting cells
    • B.A. Bridges, DNA turnover and mutation in resting cells, Bioessays 19 (1997) 347-352.
    • (1997) Bioessays , vol.19 , pp. 347-352
    • Bridges, B.A.1
  • 83
    • 0027487613 scopus 로고
    • Adaptive mutation: The uses of adversity
    • P.L. Foster, Adaptive mutation: the uses of adversity, Annu. Rev. Microbiol. 47 (1993) 467-504.
    • (1993) Annu. Rev. Microbiol. , vol.47 , pp. 467-504
    • Foster, P.L.1
  • 84
    • 0026094779 scopus 로고
    • Adaptive reversion of a frameshift mutation in Escherichia coli
    • J. Cairns, P.L. Foster, Adaptive reversion of a frameshift mutation in Escherichia coli, Genetics 128 (1991) 695-701.
    • (1991) Genetics , vol.128 , pp. 695-701
    • Cairns, J.1    Foster, P.L.2
  • 85
    • 0030924613 scopus 로고    scopus 로고
    • Genome-wide hypermutation in a subpopulation of stationary-phase cells underlies recombination-dependent adaptive mutation
    • J. Torkelson, R.S. Harris, M.J. Lombardo, J. Nagendran, C. Thulin, S.M. Rosenberg, Genome-wide hypermutation in a subpopulation of stationary-phase cells underlies recombination-dependent adaptive mutation, EMBO J. 16 (1997) 3303-3311.
    • (1997) EMBO J. , vol.16 , pp. 3303-3311
    • Torkelson, J.1    Harris, R.S.2    Lombardo, M.J.3    Nagendran, J.4    Thulin, C.5    Rosenberg, S.M.6
  • 87
    • 0027938589 scopus 로고
    • Adaptive reversion of a frameshift mutation in Escherichia coli by simple base deletions in homopolymeric runs
    • P.L. Foster, J.M. Trimarchi, Adaptive reversion of a frameshift mutation in Escherichia coli by simple base deletions in homopolymeric runs, Science 265 (1994) 407-409.
    • (1994) Science , vol.265 , pp. 407-409
    • Foster, P.L.1    Trimarchi, J.M.2
  • 89
    • 0030988977 scopus 로고    scopus 로고
    • A direct role for DNA polymerase III in adaptive reversion of a frameshift mutation in Escherichia coli
    • R.S. Harris, H.J. Bull, S.M. Rosenberg, A direct role for DNA polymerase III in adaptive reversion of a frameshift mutation in Escherichia coli, Mutat. Res. 375 (1997) 19-24.
    • (1997) Mutat. Res. , vol.375 , pp. 19-24
    • Harris, R.S.1    Bull, H.J.2    Rosenberg, S.M.3
  • 90
    • 0027941501 scopus 로고
    • Adaptive mutation by deletions in small mononucleotide repeats
    • S.M. Rosenberg, S. Longerich, P. Gee, R.S. Harris, Adaptive mutation by deletions in small mononucleotide repeats, Science 265 (1994) 405-407.
    • (1994) Science , vol.265 , pp. 405-407
    • Rosenberg, S.M.1    Longerich, S.2    Gee, P.3    Harris, R.S.4
  • 92
    • 0030582673 scopus 로고    scopus 로고
    • Meiotic recombination in yeast: Coronation of the double-strand-break repair model
    • F. Stahl, Meiotic recombination in yeast: coronation of the double-strand-break repair model, Cell 87 (1996) 965-968.
    • (1996) Cell , vol.87 , pp. 965-968
    • Stahl, F.1
  • 93
    • 0029024834 scopus 로고
    • DNA synthesis errors associated with double-strand-break repair
    • J.N. Strathern, B.K. Shafer, C.B. McGill, DNA synthesis errors associated with double-strand-break repair, Genetics 140 (1995) 965-972.
    • (1995) Genetics , vol.140 , pp. 965-972
    • Strathern, J.N.1    Shafer, B.K.2    McGill, C.B.3
  • 94
    • 0030700468 scopus 로고    scopus 로고
    • A role for REV3 in mutagenesis during double-strand break repair in Saccharomyces cerevisiae
    • S.L. Holbeck, J.N. Strathern, A role for REV3 in mutagenesis during double-strand break repair in Saccharomyces cerevisiae, Genetics 147 (1997) 1017-1024.
    • (1997) Genetics , vol.147 , pp. 1017-1024
    • Holbeck, S.L.1    Strathern, J.N.2
  • 95
    • 0030443024 scopus 로고    scopus 로고
    • DNA polymerase ζ and the control of DNA damage induced mutagenesis in eukaryotes
    • C.W. Lawrence, D.C. Hinkle, DNA polymerase ζ and the control of DNA damage induced mutagenesis in eukaryotes, Cancer Surv. 28 (1996) 21-31.
    • (1996) Cancer Surv. , vol.28 , pp. 21-31
    • Lawrence, C.W.1    Hinkle, D.C.2
  • 96
    • 0029952294 scopus 로고    scopus 로고
    • Thyminethymine dimer bypass by yeast DNA polymerase ζ
    • J.R. Nelson, C.W. Lawrence, D.C. Hinkle, Thyminethymine dimer bypass by yeast DNA polymerase ζ, Science 272 (1996) 1646-1649.
    • (1996) Science , vol.272 , pp. 1646-1649
    • Nelson, J.R.1    Lawrence, C.W.2    Hinkle, D.C.3
  • 97
    • 0029787108 scopus 로고    scopus 로고
    • Deoxycytidyl transferase activity of yeast REV1 protein
    • J.R. Nelson, C.W. Lawrence, D.C. Hinkle, Deoxycytidyl transferase activity of yeast REV1 protein, Nature 382 (1996) 729-731.
    • (1996) Nature , vol.382 , pp. 729-731
    • Nelson, J.R.1    Lawrence, C.W.2    Hinkle, D.C.3
  • 98
    • 0031907155 scopus 로고    scopus 로고
    • Analysis of damage tolerance pathways in Saccharomyces cerevisiae: A requirement for Rev3 DNA polymerase in translesion synthesis
    • K. Baynton, A. Bresson-Roy, R.P. Fuchs, Analysis of damage tolerance pathways in Saccharomyces cerevisiae: a requirement for Rev3 DNA polymerase in translesion synthesis, Mol. Cell. Biol. 18 (1998) 960-966.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 960-966
    • Baynton, K.1    Bresson-Roy, A.2    Fuchs, R.P.3
  • 99
    • 0032499748 scopus 로고    scopus 로고
    • A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase ζ
    • P.E. Gibbs, W.G. McGregor, V.M. Maher, P. Nisson, C.W. Lawrence, A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase ζ Proc. Natl. Acad. Sci. USA 95 (1998) 6876-6880.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6876-6880
    • Gibbs, P.E.1    McGregor, W.G.2    Maher, V.M.3    Nisson, P.4    Lawrence, C.W.5
  • 100
    • 0031845115 scopus 로고    scopus 로고
    • Identification, chromosomal mapping and tissue-specific expression of hREV3 encoding a putative human DNA polymerase ζ
    • W. Xiao, T. Lechler, B.L. Chow, T. Fontanie, M. Agustus, K.C. Carter, Y.F. Wei, Identification, chromosomal mapping and tissue-specific expression of hREV3 encoding a putative human DNA polymerase ζ, Carcinogenesis 19 (1998) 945-949.
    • (1998) Carcinogenesis , vol.19 , pp. 945-949
    • Xiao, W.1    Lechler, T.2    Chow, B.L.3    Fontanie, T.4    Agustus, M.5    Carter, K.C.6    Wei, Y.F.7
  • 101
    • 0029654349 scopus 로고
    • Editing DNA replication and recombination by mismatch repair: From bacterial genetics to mechanisms of predisposition to cancer in humans
    • M. Radman, I. Matic, J.A. Halliday, F. Taddei, Editing DNA replication and recombination by mismatch repair: from bacterial genetics to mechanisms of predisposition to cancer in humans, Philos. Trans. R. Soc. Lond. B: Biol. Sci. 347 (1995) 97-103.
    • (1995) Philos. Trans. R. Soc. Lond. B: Biol. Sci. , vol.347 , pp. 97-103
    • Radman, M.1    Matic, I.2    Halliday, J.A.3    Taddei, F.4
  • 102
    • 0029943449 scopus 로고    scopus 로고
    • Mismatch repair in replication fidelity, genetic recombination, and cancer biology
    • P. Modrich, R. Lahue, Mismatch repair in replication fidelity, genetic recombination, and cancer biology, Annu. Rev. Biochem. 65 (1996) 101-133.
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 101-133
    • Modrich, P.1    Lahue, R.2
  • 103
    • 0029784320 scopus 로고    scopus 로고
    • Biochemistry and genetics of eukaryotic mismatch repair
    • R. Kolodner, Biochemistry and genetics of eukaryotic mismatch repair, Genes Dev. 10 (1996) 1433-1442.
    • (1996) Genes Dev. , vol.10 , pp. 1433-1442
    • Kolodner, R.1
  • 104
    • 0026355962 scopus 로고
    • Mechanisms and biological effects of mismatch repair
    • P. Modrich, Mechanisms and biological effects of mismatch repair, Annu. Rev. Genet. 25 (1991) 229-253.
    • (1991) Annu. Rev. Genet. , vol.25 , pp. 229-253
    • Modrich, P.1
  • 106
    • 0029101616 scopus 로고
    • Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer
    • N. de Wind, M. Dekker, A. Berns, M. Radman, H. te Riele, Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer, Cell 82 (1995) 321-330.
    • (1995) Cell , vol.82 , pp. 321-330
    • De Wind, N.1    Dekker, M.2    Berns, A.3    Radman, M.4    Te Riele, H.5
  • 108
    • 0040746316 scopus 로고
    • Gene conversion
    • I.M. Roitt, P.J. Delves (Eds.), Academic Press
    • P.J. Hastings, S.M. Rosenberg, Gene conversion, in: I.M. Roitt, P.J. Delves (Eds.), Encyclopedia of Immunology, Academic Press, 1992, pp. 602-605.
    • (1992) Encyclopedia of Immunology , pp. 602-605
    • Hastings, P.J.1    Rosenberg, S.M.2
  • 110
    • 0032549125 scopus 로고    scopus 로고
    • Mismatch repair co-opted by hypermutation
    • M. Cascalho, J. Wong, C. Steinberg, M. Wabl, Mismatch repair co-opted by hypermutation, Science 279 (1998) 1207-1210.
    • (1998) Science , vol.279 , pp. 1207-1210
    • Cascalho, M.1    Wong, J.2    Steinberg, C.3    Wabl, M.4
  • 112
    • 0032127811 scopus 로고    scopus 로고
    • Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process
    • S. Frey, B. Bertocci, F. Delbos, L. Quint, J.C. Weill, C.A. Reynaud, Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process, Immunity 9 (1998) 127-134.
    • (1998) Immunity , vol.9 , pp. 127-134
    • Frey, S.1    Bertocci, B.2    Delbos, F.3    Quint, L.4    Weill, J.C.5    Reynaud, C.A.6
  • 113
    • 0032101611 scopus 로고    scopus 로고
    • Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein
    • Q.H. Phung, D.B. Winter, A. Cranston, R.E. Tarone, V.A. Bohr, R. Fishel, P.J. Gearhart, Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein, J. Exp. Med. 187 (1998) 1745-1751.
    • (1998) J. Exp. Med. , vol.187 , pp. 1745-1751
    • Phung, Q.H.1    Winter, D.B.2    Cranston, A.3    Tarone, R.E.4    Bohr, V.A.5    Fishel, R.6    Gearhart, P.J.7
  • 114
    • 0032127804 scopus 로고    scopus 로고
    • Hot spot focusing of somatic hyermutation in MSH2-deficient mice suggests two stages of mutational targeting
    • C. Rada, M.R. Ehrenstein, M.S. Neuberger, C. Milstein, Hot spot focusing of somatic hyermutation in MSH2-deficient mice suggests two stages of mutational targeting, Immunity 9 (1998) 135-141.
    • (1998) Immunity , vol.9 , pp. 135-141
    • Rada, C.1    Ehrenstein, M.R.2    Neuberger, M.S.3    Milstein, C.4
  • 116
    • 0032499751 scopus 로고    scopus 로고
    • V(D)J hypermutation and DNA mismatch repair: Vexed by fixation
    • G. Kelsoe, V(D)J hypermutation and DNA mismatch repair: vexed by fixation, Proc. Natl. Acad. Sci. USA 95 (1998) 6576-6577.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6576-6577
    • Kelsoe, G.1
  • 117
    • 0032100485 scopus 로고    scopus 로고
    • The role of DNA repair in somatic hypermutation of immunoglobulin genes
    • N. Kim, U. Storb, The role of DNA repair in somatic hypermutation of immunoglobulin genes, J. Exp. Med. 187 (1998) 1729-1733.
    • (1998) J. Exp. Med. , vol.187 , pp. 1729-1733
    • Kim, N.1    Storb, U.2
  • 118
    • 0032555715 scopus 로고    scopus 로고
    • Somatic hypermutation, transcription, and DNA mismatch repair
    • M. Wiesendanger, M.D. Scharff, W. Edelmann, Somatic hypermutation, transcription, and DNA mismatch repair, Cell 94 (1998) 415-418.
    • (1998) Cell , vol.94 , pp. 415-418
    • Wiesendanger, M.1    Scharff, M.D.2    Edelmann, W.3
  • 119
    • 0029892790 scopus 로고    scopus 로고
    • DNA excision repair
    • A. Sancar, DNA excision repair, Annu. Rev. Biochem. 65 (1996) 43-81.
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 43-81
    • Sancar, A.1
  • 121
    • 0023663101 scopus 로고
    • Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene
    • I. Mellon, G. Spivak, P.C. Hanawalt, Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene, Cell 51 (1987) 241-249.
    • (1987) Cell , vol.51 , pp. 241-249
    • Mellon, I.1    Spivak, G.2    Hanawalt, P.C.3
  • 122
    • 0030768038 scopus 로고    scopus 로고
    • Nucleotide excision repair in mammalian cells
    • R.D. Wood, Nucleotide excision repair in mammalian cells, J. Biol. Chem. 272 (1997) 23465-23468.
    • (1997) J. Biol. Chem. , vol.272 , pp. 23465-23468
    • Wood, R.D.1
  • 123
    • 0032558691 scopus 로고    scopus 로고
    • DNA repair: Knockouts still mutating after first round
    • R.D. Wood, DNA repair: knockouts still mutating after first round, Curr. Biol. 8 (1998) 757-760.
    • (1998) Curr. Biol. , vol.8 , pp. 757-760
    • Wood, R.D.1
  • 125
    • 0000542120 scopus 로고    scopus 로고
    • The inactivation of the XPC gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes
    • H.M. Shen, D.L. Cheo, E. Friedberg, U. Storb, The inactivation of the XPC gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes, Mol. Immunol. 34 (1997) 527-533.
    • (1997) Mol. Immunol. , vol.34 , pp. 527-533
    • Shen, H.M.1    Cheo, D.L.2    Friedberg, E.3    Storb, U.4
  • 126
    • 0029871507 scopus 로고    scopus 로고
    • Somatic hypermutation of Ig genes in patients with Xeroderma pigmentosum (XP-D)
    • S.D. Wagner, J.G. Elvin, P. Norris, J.M. McGregor, M.S. Neuberger, Somatic hypermutation of Ig genes in patients with Xeroderma pigmentosum (XP-D), Int. Immunol. 8 (1996) 701-705.
    • (1996) Int. Immunol. , vol.8 , pp. 701-705
    • Wagner, S.D.1    Elvin, J.G.2    Norris, P.3    McGregor, J.M.4    Neuberger, M.S.5
  • 127
    • 0030761761 scopus 로고    scopus 로고
    • B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes
    • N. Kim, K. Kage, F. Matsuda, M.P. Lefranc, U. Storb, B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes, J. Exp. Med. 186 (1997) 413-419.
    • (1997) J. Exp. Med. , vol.186 , pp. 413-419
    • Kim, N.1    Kage, K.2    Matsuda, F.3    Lefranc, M.P.4    Storb, U.5
  • 128
    • 0030861915 scopus 로고    scopus 로고
    • DNA glycosylases in the base excision repair of DNA
    • H.E. Krokan, R. Standal, G. Slupphaug, DNA glycosylases in the base excision repair of DNA, Biochem. J. 325 (1997) 1-16.
    • (1997) Biochem. J. , vol.325 , pp. 1-16
    • Krokan, H.E.1    Standal, R.2    Slupphaug, G.3
  • 129
    • 0030698057 scopus 로고    scopus 로고
    • Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers
    • F.C. Kuo, J. Sklar, Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers, J. Exp. Med. 186 (1997) 1547-1556.
    • (1997) J. Exp. Med. , vol.186 , pp. 1547-1556
    • Kuo, F.C.1    Sklar, J.2
  • 130
    • 0000590741 scopus 로고
    • Genes and antibodies
    • J. Lederberg, Genes and antibodies, Science 129 (1959) 1649-1653.
    • (1959) Science , vol.129 , pp. 1649-1653
    • Lederberg, J.1
  • 131
    • 0014019617 scopus 로고
    • Origin of antibody variation
    • S. Brenner, C. Milstein, Origin of antibody variation, Nature 211 (1966) 242-243.
    • (1966) Nature , vol.211 , pp. 242-243
    • Brenner, S.1    Milstein, C.2
  • 132
    • 0019391404 scopus 로고
    • H gene segment encodes the immune response to phosphorylcholine: Somatic mutation is correlated with the class of the antibody
    • H gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody, Cell 25 (1981) 59-66.
    • (1981) Cell , vol.25 , pp. 59-66
    • Crews, S.1    Griffin, J.2    Huang, H.3    Calame, K.4    Hood, L.5
  • 134
    • 0032169576 scopus 로고    scopus 로고
    • Skiing the black diamond slope: Progress on the biochemistry of translesion DNA synthesis
    • G.C. Walker, Skiing the black diamond slope: progress on the biochemistry of translesion DNA synthesis, Proc. Natl. Acad. Sci. USA 95 (1998) 10348-10350.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10348-10350
    • Walker, G.C.1
  • 135
    • 0030018123 scopus 로고    scopus 로고
    • Analysis of the mutagenic properties of the UmuDC, MucAB and RumAB proteins, using a site-specific abasic lesion
    • C.W. Lawrence, A. Borden, R. Woodgate, Analysis of the mutagenic properties of the UmuDC, MucAB and RumAB proteins, using a site-specific abasic lesion, Mol. Gen. Genet. 251 (1996) 493-498.
    • (1996) Mol. Gen. Genet. , vol.251 , pp. 493-498
    • Lawrence, C.W.1    Borden, A.2    Woodgate, R.3
  • 136
    • 0029916565 scopus 로고    scopus 로고
    • Substitution of mucAB or rumAB for umuDC alters the relative frequencies of the two classes of mutations induced by a site-specific T-T cyclobutane dimer and the efficiency of translesion DNA synthesis
    • E.S. Szekeres Jr., R. Woodgate, C.W. Lawrence, Substitution of mucAB or rumAB for umuDC alters the relative frequencies of the two classes of mutations induced by a site-specific T-T cyclobutane dimer and the efficiency of translesion DNA synthesis, J. Bacteriol. 178 (1996) 2559-2563.
    • (1996) J. Bacteriol. , vol.178 , pp. 2559-2563
    • Szekeres Jr., E.S.1    Woodgate, R.2    Lawrence, C.W.3
  • 137
    • 0023652339 scopus 로고
    • A hyperconversion mechanism generates the chicken light chain preimmune repertoire
    • C.A. Reynaud, V. Anquez, H. Grimai, J.C. Weill, A hyperconversion mechanism generates the chicken light chain preimmune repertoire, Cell 48 (1987) 379-388.
    • (1987) Cell , vol.48 , pp. 379-388
    • Reynaud, C.A.1    Anquez, V.2    Grimai, H.3    Weill, J.C.4
  • 138
    • 0023652303 scopus 로고
    • Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment
    • C.B. Thompson, P.E. Neiman, Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment, Cell 48 (1987) 369-378.
    • (1987) Cell , vol.48 , pp. 369-378
    • Thompson, C.B.1    Neiman, P.E.2
  • 139
    • 0025676044 scopus 로고
    • Somatic diversification of immunoglobulin heavy chain VDJ genes: Evidence for somatic gene conversion in rabbits
    • R.S. Becker, K.L. Knight, Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits, Cell 63 (1990) 987-997.
    • (1990) Cell , vol.63 , pp. 987-997
    • Becker, R.S.1    Knight, K.L.2
  • 140
    • 0030589235 scopus 로고    scopus 로고
    • Gene conversion contributes to Ig light chain diversity in cattle
    • C.L. Parng, S. Hansal, R.A. Goldsby, B.A. Osborne, Gene conversion contributes to Ig light chain diversity in cattle, J. Immunol. 157 (1996) 5478-5486.
    • (1996) J. Immunol. , vol.157 , pp. 5478-5486
    • Parng, C.L.1    Hansal, S.2    Goldsby, R.A.3    Osborne, B.A.4
  • 141
    • 0029938761 scopus 로고    scopus 로고
    • Gene conversion and homologous recombination in murine B cells
    • E. Selsing, B. Xu, D. Sigurdardottir, Gene conversion and homologous recombination in murine B cells, Semin. Immunol. 8 (1996) 151-158.
    • (1996) Semin. Immunol. , vol.8 , pp. 151-158
    • Selsing, E.1    Xu, B.2    Sigurdardottir, D.3
  • 142
    • 0028025489 scopus 로고
    • Analysis of sequence transfers resembling gene conversion in a mouse antibody transgene
    • B. Xu, E. Selsing, Analysis of sequence transfers resembling gene conversion in a mouse antibody transgene, Science 265 (1994) 1590-1593.
    • (1994) Science , vol.265 , pp. 1590-1593
    • Xu, B.1    Selsing, E.2
  • 143
    • 0021888368 scopus 로고
    • Structure of primary anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice
    • A. Cumano, K. Rajewsky, Structure of primary anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice, Eur. J. Immunol. 15 (1985) 512-520.
    • (1985) Eur. J. Immunol. , vol.15 , pp. 512-520
    • Cumano, A.1    Rajewsky, K.2
  • 144
    • 0029872907 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes
    • S.D. Wagner, M.S. Neuberger, Somatic hypermutation of immunoglobulin genes, Annu. Rev. Immunol. 14 (1996) 441-457.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 441-457
    • Wagner, S.D.1    Neuberger, M.S.2
  • 145
    • 0025970135 scopus 로고
    • Somatic generation of diversity in a mammalian primary lymphoid organ: The sheep ileal Peyer's patches
    • C.A. Reynaud, C.R. Mackay, R.G. Muller, J.C. Weill, Somatic generation of diversity in a mammalian primary lymphoid organ: the sheep ileal Peyer's patches, Cell 64 (1991) 995-1005.
    • (1991) Cell , vol.64 , pp. 995-1005
    • Reynaud, C.A.1    Mackay, C.R.2    Muller, R.G.3    Weill, J.C.4
  • 146
    • 0028818503 scopus 로고
    • Somatic hypermutation: How many mechanisms diversify V region sequences?
    • N. Maizels, Somatic hypermutation: how many mechanisms diversify V region sequences?, Cell 83 (1995) 9-12.
    • (1995) Cell , vol.83 , pp. 9-12
    • Maizels, N.1
  • 147
    • 0031944788 scopus 로고    scopus 로고
    • Recombination-based mechanisms for somatic hypermutation
    • Q. Kong, R.S. Harris, N. Maizels, Recombination-based mechanisms for somatic hypermutation, Immunol. Rev. 162 (1998) 67-76.
    • (1998) Immunol. Rev. , vol.162 , pp. 67-76
    • Kong, Q.1    Harris, R.S.2    Maizels, N.3
  • 148
    • 0031449639 scopus 로고    scopus 로고
    • Mammalian Rad51 protein: A RecA homologue with pleiotropic functions
    • S. Vispe, M. Defais, Mammalian Rad51 protein: a RecA homologue with pleiotropic functions, Biochimie 79 (1997) 587-592.
    • (1997) Biochimie , vol.79 , pp. 587-592
    • Vispe, S.1    Defais, M.2
  • 149
    • 0032127849 scopus 로고    scopus 로고
    • Role of the human RAD51 protein in homologous recombination and double-strand break repair
    • P. Baumann, S.C. West, Role of the human RAD51 protein in homologous recombination and double-strand break repair, Trends Biochem. Sci. 23 (1998) 247-251.
    • (1998) Trends Biochem. Sci. , vol.23 , pp. 247-251
    • Baumann, P.1    West, S.C.2
  • 150
    • 0032556898 scopus 로고    scopus 로고
    • Stimulation by Rad52 of yeast Rad51-mediated recombination
    • A. Shinohara, T. Ogawa, Stimulation by Rad52 of yeast Rad51-mediated recombination, Nature 391 (1998) 404-407.
    • (1998) Nature , vol.391 , pp. 404-407
    • Shinohara, A.1    Ogawa, T.2
  • 151
    • 0032556909 scopus 로고    scopus 로고
    • Genetic recombination. from competition to collaboration
    • R. Kanaar, J.H. Hoeijmakers, Genetic recombination. From competition to collaboration, Nature 391 (1998) 335, 337-338.
    • (1998) Nature , vol.391 , pp. 335
    • Kanaar, R.1    Hoeijmakers, J.H.2
  • 152
    • 0032556865 scopus 로고    scopus 로고
    • Synergistic actions of Rad51 and Rad52 in recombination and DNA repair
    • F.E. Benson, P. Baumann, S.C. West, Synergistic actions of Rad51 and Rad52 in recombination and DNA repair, Nature 391 (1998) 401-404.
    • (1998) Nature , vol.391 , pp. 401-404
    • Benson, F.E.1    Baumann, P.2    West, S.C.3
  • 153
    • 0028879965 scopus 로고
    • Homologous recombination and the roles of double-strand breaks
    • A. Shinohara, T. Ogawa, Homologous recombination and the roles of double-strand breaks, Trends Biochem. Sci. 20 (1995) 387-391.
    • (1995) Trends Biochem. Sci. , vol.20 , pp. 387-391
    • Shinohara, A.1    Ogawa, T.2
  • 155
    • 0032532322 scopus 로고    scopus 로고
    • Localization of splenic B cells activated for switch recombination by in situ hybridization with I-yl switch transcript and Rad51 probes
    • M.-C. Peakman, N. Maizels, Localization of splenic B cells activated for switch recombination by in situ hybridization with I-yl switch transcript and Rad51 probes, J. Immunol. 161 (1998) 4008-4015.
    • (1998) J. Immunol. , vol.161 , pp. 4008-4015
    • Peakman, M.-C.1    Maizels, N.2
  • 159
    • 0030052281 scopus 로고    scopus 로고
    • Rearrangement/hypermutation/gene conversion: When, where and why?
    • J.C. Weill, C.A. Reynaud, Rearrangement/hypermutation/gene conversion: when, where and why?, Immunol. Today 17 (1996) 92-97.
    • (1996) Immunol. Today , vol.17 , pp. 92-97
    • Weill, J.C.1    Reynaud, C.A.2
  • 160
    • 0031894290 scopus 로고    scopus 로고
    • Evolution of somatic hypermutation and gene conversion in adaptive immunity
    • M. Diaz, M.F. Flajnik, Evolution of somatic hypermutation and gene conversion in adaptive immunity, Immunol. Rev. 162 (1998) 13-24.
    • (1998) Immunol. Rev. , vol.162 , pp. 13-24
    • Diaz, M.1    Flajnik, M.F.2
  • 161
    • 0030845386 scopus 로고    scopus 로고
    • Rapid methods for the analysis of immunoglobulin gene hypermutation: Application to transgenic and gene targeted mice
    • C.J. Jolly, N. Klix, M.S. Neuberger, Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice, Nucleic Acids Res. 25 (1997) 1913-1919.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 1913-1919
    • Jolly, C.J.1    Klix, N.2    Neuberger, M.S.3
  • 163
  • 164
  • 166
    • 0031802496 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes is independent of the Bloom's syndrome DNA helicase
    • S.Z. Sack, Y. Liu, J. German, N.S. Green, Somatic hypermutation of immunoglobulin genes is independent of the Bloom's syndrome DNA helicase, Clin. Exp. Immunol. 112 (1998) 248-254.
    • (1998) Clin. Exp. Immunol. , vol.112 , pp. 248-254
    • Sack, S.Z.1    Liu, Y.2    German, J.3    Green, N.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.