Genetic evidence that the RAG1 protein directly participates in V(D)J recombination through substrate recognition

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 6, 1996, Pages 2333-2338

  Roman, Christopher A J ^a   Baltimore, David ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; LYMPHOCYTE ANTIGEN RECEPTOR;

AMINO ACID SUBSTITUTION; ARTICLE; GENE REARRANGEMENT; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN DNA INTERACTION;

BASE SEQUENCE; CELLS, CULTURED; GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, IMMUNOGLOBULIN; HOMEODOMAIN PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; OLIGODEOXYRIBONUCLEOTIDES; PROTEINS; RECOMBINATION, GENETIC; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 0029966374     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.6.2333     Document Type: Article

References (29)

1. Oettinger, M. A., Schatz, D. G., Gorka, C. & Baltimore, D. (1990) Science 248, 1517-1523.
2. Schatz, D. G., Oettinger, M. A. & Baltimore, D. (1989) Cell 59, 1035-1048.
3. Shinkai, Y., Rathbun, G., Lam, K.-P., Oltz, E. M., Stewart, V., Mendelsohn, M., Charron, J., Datta, M., Young, F., Stall, A. M. & Alt, F. W. (1992) Cell 68, 855-867.
4. Spanopoulou, E., Roman, C. A. J., Corcoran, L. M., Schlissel, M. S., Silver, D., Nussenzweig, M., Shinton, S., Hardy, R. & Baltimore, D. (1994) Genes Dev. 8, 1030-1042.
5. Mombaerts, P., lacomini, J., Johnson, R. S., Herrup, K., Tonegawa, S. & Papaioannou, V. (1992) Cell 68, 869-877.
6. Tonegawa, S. (1983) Nature (London) 302, 575-581.
7. Hesse, J. E., Lieber, M. R., Mizuuchi, K. & Gellert, M. (1989) Genes Dev. 3, 1053-1061.
8. Gerstein, R. M. & Lieber, M. R. (1993) Genes Dev. 7, 1459-1469.
9. Gauss, G. H. & Lieber, M. R. (1992) Genes Dev. 6, 1553-1561.
10. Ezekiel, U. R., Engler, P., Stern, D. & Storb, U. (1995) Immunity 2, 381-389.
11. Roth, D. B., Nakajima, P. B., Menetski, J. P., Bosma, M. J. & Gellert, M. (1992) Cell 69, 41-53.
12. Roth, D. B., Zhu, C. & Gellert, M. (1993) Proc. Natl. Acad. Sci. USA 90, 10788-10792.
13. Roth, D. B., Menetski, J. P., Nakajima, P. B. Bosma, M. J. & Gellert, M. (1992) Cell 70, 983-991.
14. Schlissel, M., Constantinescu, A., Morrow, T., Baxter, M. & Peng, A. (1993) Genes Dev. 7, 2520-2532.
15. Zhu, C. & Roth, D. B. (1995) Immunity 2, 101-112.
16. Taccioli, G., Rathhun, G., Shinkai, Y., Oltz, E. M., Cheng, H., Whitmore, G., Stamato, T., Jeggo, P. & Alt, F. W. (1992) Curr. Top. Microbiol. Immunol. 182, 107-114.
17. Gent, D. C. v., McBlane, J. F., Ramsden, D. A., Sadofsky, M. J., Hesse, J. E. & Gellert, M. (1995) Cell 81, 925-934.
18. Hesse, J. E., Lieber, M. R., Gellert, M. & Mizuuchi, K. (1987) Cell 49, 775-783.
19. Lieber, M. R., Hesse, J. E., Lewis, S., Bosma, G. C., Rosenberg, N., Mizuuchi, K., Bosma, M. J. & Gellert, M. (1988) Cell 55, 7-16.
20. Higuchi, R., Krummel, B. & Saiki, R. K. (1988) Nucleic Acids Res. 16, 7351-7367.
21. Pear, W. S., Nolan, G. P., Scott, M. L. & Baltimore, D. (1993) Proc. Natl. Acad. Sci. USA 90, 8392-8396.
22. Hirt, B. (1967) J. Exp. Biol. 26, 365-369.
23. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Lab. Press, Cold Spring Harbor, NY), 2nd Ed.
24. Schatz, D. G. & Baltimore, D. (1988) Cell 53, 107-115.
25. Landau, N., Schatz, D. G., Rosa, M. & Baltimore. D. (1987) Mol. Cell. Biol. 7, 3237-3243.
26. Sadofsky, M. J., Hesse, J. E., McBlane, J. F. & Gellert, M. (1993) Nucleic Acids Res. 21, 5644-5650.
27. Silver, D. P., Spanopoulou, E., Mulligan, R. C. & Baltimore, D. (1993) Proc. Natl. Acad. Sci. USA 90, 6100-6140.
28. Gerstein, R. M. & Lieber, M. R. (1992) Nature (London) 363, 625-627.
29. Sadofsky, M., Hesse, J. E., van Gent, D. C. & Gellert, M. (1995) Genes Dev. 9, 2193-2199.