Genetic modulation of T cell receptor gene segment usage during somatic recombination

Journal of Experimental Medicine

Volumn 192, Issue 8, 2000, Pages 1191-1196

  Livak, Ferenc ^a,e   Burtrum, Douglas B ^b   Rowen, Lee ^d   Schatz, David G ^a   Petrie, Howard T ^b,c,f  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Obstetrics Gynecology   (United States)

^c Weill Cornell Graduate School of Biomedical Sciences   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

^e UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^f MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Recombination signal sequence; Repertoire selection; T cell receptor locus; Thymus; VDJ recombination

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR; RECOMBINASE; SIGNAL PEPTIDE; T LYMPHOCYTE RECEPTOR;

ARTICLE; GENETIC RECOMBINATION; GERM LINE; PRIORITY JOURNAL; SOMATIC CELL; SOMATIC CELL GENETICS; SYNAPSE; T LYMPHOCYTE SUBPOPULATION; THYMUS;

ANIMALS; BASE SEQUENCE; CONSENSUS SEQUENCE; DNA PRIMERS; DNA, RIBOSOMAL; GENES, T-CELL RECEPTOR; GENES, T-CELL RECEPTOR BETA; KIDNEY; MICE; MICE, INBRED C57BL; POLYMERASE CHAIN REACTION; RECOMBINATION, GENETIC; T-LYMPHOCYTES;

EID: 0034675843     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.8.1191     Document Type: Article

References (30)

1. Somatic generation of antibody diversity
2. Somatic recombination in a murine T-cell receptor gene
3. Ordered rearrangement of immunoglobulin heavy chain variable region segments
4. V(D)J recombination: Molecular biology and regulation
5. Regulation of TCR α and β gene allelic exclusion during T-cell development
6. V(D)J recombination moves in vitro
7. + thymocytes controlled by MHC class II gene products
8. Deletion of self-reactive T cells before entry into the thymus medulla
9. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules
10. Selection is not required to produce invariant T-cell receptor γ-gene junctional sequences
11. The MHC reactivity of the T cell repertoire prior to positive and negative selection
12. Quantitative impact of thymic clonal deletion on the T cell repertoire
13. The helper T-cell repertoire of mice expressing class II major histocompatibility complex β chains in the absence of α chains
14. Thymus-derived glucocorticoids set the thresholds for thymocyte selection by inhibiting TCR-mediated thymocyte activation
15. T cell receptor gene recombination patterns and mechanisms: Cell death, rescue, and T cell production
16. V(D)J recombination: A functional definition of the joining signals
17. 2+ cofactors at the initial stages of V(D)J recombination
18. Separate lineages of T cells expressing the αβ and γδ receptors
19. RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination
20. DNA hairpin opening mediated by the RAG1 and RAG2 proteins
21. Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking
22. V(D)J recombination in mouse thymocytes: Double-strand breaks near T cell receptor δ rearrangement signals
23. Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes
24. - thymocyte differentiation
25. T cell receptor (TCR)-β gene recombination: Dissociation from cell cycle regulation and developmental progression during T cell ontogeny
26. Junctional sequences of fetal T cell receptor β chains have few N regions
27. + cells
28. Mouse kappa lightchain recombination signal sequences mediate recombination more frequently than do those of lambda light chain
29. Analysis of direct and inverted DJH rearrangements in a human Ig heavy chain transgenic minilocus
30. Sequence of the spacer in the recombination signal sequence affects V(D)J rearrangement frequency and correlates with nonrandom Vκ usage in vivo