Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

Genes and Development

Volumn 13, Issue 23, 1999, Pages 3059-3069

  Landree, Mark A ^a   Wibbenmeyer, Jamie A ^a,b   Roth, David B ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b University of Houston   (United States)

Author keywords

Immunoglobulin; RAG1; RAG2; V(D)J recombination

Indexed keywords

AMINO ACID; IMMUNOGLOBULIN; METAL ION; PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; DNA CLEAVAGE; DNA RECOMBINATION; HUMAN; METAL BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; CHO CELLS; CRICETINAE; CRICETULUS; CYSTEINE; DNA; DNA NUCLEOTIDYLTRANSFERASES; DNA-BINDING PROTEINS; GENE REARRANGEMENT; HOMEODOMAIN PROTEINS; HUMANS; LYMPHOCYTES; MANGANESE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEAR PROTEINS; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; VDJ RECOMBINASES; VERTEBRATES;

EID: 0033380368     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.13.23.3059     Document Type: Article

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