The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination

Cell

Volumn 85, Issue 1, 1996, Pages 107-113

  Van Gent, Dik C ^a   Ramsden, Dale A ^a   Gellert, Martin ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ARTICLE; BASE PAIRING; GENE EXPRESSION REGULATION; GENE SEQUENCE; GENETIC RECOMBINATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION;

EID: 0030009253     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81086-7     Document Type: Article

References (17)

1. Baker, T.A., Mizuuchi, M., Savilahti, H., and Mizuuchi, K. (1993). Division of laboramong monomers within the Mu transposase tetramer. Cell 74, 723-733.
2. Bushman, F.D., and Craigie, R. (1991). Activities of human immuno-deficiency virus (HIV) integration protein in vitro: specific cleavage and integration of HIV DNA. Proc. Natl. Acad. Sci. USA 88, 1339-1343.
3. Gellert, M. (1992). Molecular analysis of V(D)J recombination. Annu. Rev. Genet. 22, 425-446.
4. Hesse, J.E., Lieber, M.R., Mizuuchi, K., and Gellert, M. (1989). V(D)J recombination: a functional definition of the joining signals. Genes Dev. 3, 1053-1061.
5. Jackson, S.P., and Jeggo, P.A. (1995). DNA double-strand break repair and V(D)J recombination. Trends Biochem. Sci. 20, 412-415.
6. Lewis, S.M. (1994). The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Adv. Immunol. 56, 27-150.
7. McBlane, J.F., van Gent, D.C., Ramsden, D.A., Romeo, C., Cuomo, C.A., Gellert, M., and Oettinger, M.A. (1995). Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83, 387-395.
8. Ramsden, D.A., and Gellert, M. (1995). Formation and resolution of double strand break intermediates in V(D)J rearrangement. Genes Dev. 9, 2409-2420.
9. Ramsden, D.A., McBlane, J.F., van Gent, D.C., and Gellert, M. (1996). Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage. EMBO J., in press.
10. Roberts, R.J., and Halford, S.E. (1993).Type II restriction endonucleases. In Nucleases, S.M. Linn, R.S. Lloyd, and R.J. Roberts, eds. (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press), pp. 35-88.
11. Roth, D.B., Nakajima, P.B., Menetski, J.P., Bosma, M.J., and Gellert, M. (1992a). V(D)J recombination in mouse thymocytes: double-strand breaks near T cell receptor 8 rearrangement signals. Cell 69, 41-53.
12. Roth, D.B., Menetski, J.P., Nakajima, P.B., Bosma, M.J., and Gellert, M. (1992b). V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in seid mouse thymocytes. Cell 70, 983-991.
13. Sadofsky, M., Hesse, J.E., van Gent, D.C., and Gellert, M. (1995). RAG-1 mutations that affect the target specificity of V(D)J recombination: a possible direct role of RAG-1 in site recognition. Genes Dev. 9, 2193-2199.
14. Schlissel, M., Constantinescu, A., Morrow, T., Baxter, M., and Peng, A. (1993). Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent, and cell-cycle-regulated. Genes Dev. 7, 2520-2532.
15. Tonegawa, S. (1983). Somatic generation of antibody diversity. Nature 302, 575-581.
16. van Gent, D.C., McBlane, J.F., Ramsden, D.A., Sadofsky, M.J., Hesse, J.E., and Gellert, M. (1995). Initiation of V(D)J recombination in a cell-free system. Cell 81, 925-934.
17. van Gent, D.C., Mizuuchi, K., and Gellert, M. (1996). Similarities between initiation of V(D)J recombination and retroviral integration. Science, 271, 1592-1594.