Mechanistic basis for coding end sequence effects in the initiation of V(D)J recombination

Molecular and Cellular Biology

Volumn 19, Issue 12, 1999, Pages 8094-8102

  Yu, Kefei ^a   Lieber, Michael R ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; ARTICLE; EXON; GENE REARRANGEMENT; GENETIC RECOMBINATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

EID: 0033512850     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.12.8094     Document Type: Article

References (30)

1. Besmer, E., J. Mansilla-Soto, S. Cassard, D. J. Sawchuk, G. Brown, M. Sadofsky, S. M. Lewis, M. C. Nussenzweig, and P. Cortes. 1998. Hairpin coding end opening is mediated by the recombination activating genes RAG1 and RAG2. Mol. Cell 2:817-828.
2. Boubnov, N. V., Z. P. Wills, and D. T. Weaver. 1993. V(D)J recombination coding junction formation without DNA homology: processing of coding end termini. Mol. Cell. Biol. 13:6957-6968.
3. Boubnov, N. V., Z. P. Wills, and D. T. Weaver. 1995. Coding sequence composition flanking either signal element alters V(D)J recombination efficiency. Nucleic Acids Res. 13:1060-1067.
4. Cuomo, C. A., C. L. Mundy, and M. A. Oettinger. 1996. DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences. Mol. Cell. Biol. 16:5683-5690.
5. Eastman, Q. M., and D. G. Schatz. 1997. Nicking is asynchronous and stimulated by synapsis in 12/23 rule-regulated V(D)J cleavage. Nucleic Acids Res. 25:4370-4378.
6. Ezekiel, U. R., P. Engler, D. Stern, and U. Storb. 1995. Asymmetric processing of coding ends and the effect of coding end nucleotide composition on V(D)J recombination. Immunity 2:381-389.
7. Ezekiel, U. R., T. Sun, G. Bozek, and U. Storb. 1997. The composition of coding joints formed in V(D)J recombination is strongly affected by the nucleotide sequence of the coding ends and their relationship to the recombination signal sequences. Mol. Cell. Biol. 17:4191-4197.
8. Gellert, M. 1997. Recent advances in understanding V(D)J recombination. Adv. Immunol. 64:39-64.
9. Gerstein, R. M., and M. R. Lieber. 1993. Coding end sequence can markedly affect the initiation of V(D)J recombination. Genes Dev. 7:1459-1469.
10. Hesse, J. E., M. R. Lieber, K. Mizuuchi, and M. Gellert. 1989. V(D)J recombination: a functional definition of the joining signals. Genes Dev. 3:1053-1067.
11. Hiom, K., and M. Gellert. 1997. A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage. Cell 88:65-72.
12. Hiom, K., and M. Gellert. 1998. Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination. Mol. Cell 1:1011-1019.
13. Kim, D. R., and M. A. Oettinger. 1998. Functional analysis of coordinated cleavage in V(D)J recombination. Mol. Cell. Biol. 18:4679-4688.
14. Lieber, M. R. 1998. Pathologic and physiologic double-strand breaks: roles in cancer, aging, and the immune system. Am. J. Pathol. 153:1323-1332.
15. McBlane, J. F., D. C. van Gent, D. A. Ramsden, C. Romeo, C. A. Cuomo, M. Gellert, and M. A. Oettinger. 1995. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83:387-395.
16. Oettinger, M. A., D. G. Schatz, C. Gorka, and D. Baltimore. 1990. Rag-1 and Rag-2, adjacent genes that synergistically activate V(D)J recombination. Science 248:1517-1523.
17. Sadofsky, M. J., J. E. Hesse, D. C. van Gent, and M. Gellert. 1995. RAG-1 mutations that affect the target specificity of V(D)J recombination: a possible direct role of RAG-1 in site recognition. Genes Dev. 9:2193-2199.
18. 2+ cofactors at the initial stages of V(D)J recombination. J. Biol. Chem. 273: 16325-16331.
19. Sawchuk, D., F. Weis-Garcia, S. Malik, E. Besmer, M. Bustin, M. Nussenzweig, and P. Cortes. 1997. V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins. J. Exp. Med. 185:2025-2032.
20. Schatz, D. G. 1997. V(D)J recombination moves in vitro. Semin. Immunol. 9:149-160.
21. Schatz, D. G., and D. Baltimore. 1988. Stable expression of immunoglobulin gene V(D)J recombinase activity by gene transfer into 3T3 fibroblasts. Cell 53:107-115.
22. Schatz, D. G., M. A. Oettinger, and D. Baltimore. 1989. The V(D)J recombination activating gene, RAG-1. Cell 59:1035-1048.
23. Swanson, P. C., and S. Desiderio. 1998. V(D)J recombination signal recognition: distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2. Immunity 9:115-125.
24. Swanson, P. C., and S. Desiderio. 1999. RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex. Mol. Cell. Biol. 19:3674-3683.
25. Tonegawa, S. 1983. Somatic generation of antibody diversity. Nature 302: 575-581.
26. vanGent, D. C., K. Mizuuchi, and M. Gellert. 1996. Similarities between initiation of V(D)J recombination and retroviral integration. Science 271: 1592-1594.
27. vanGent, D. C., D. A. Ramsden, and M. Gellert. 1996. The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination. Cell 85:107-113.
28. Weis-Garcia, F., E. Besmer, D. J. Sawchuk, W. Yu, Y. Hu, S. Cassard, M. Nussenzweig, and P. Cortes. 1997. V(D)J recombination: in vitro coding joint formation. Mol. Cell. Biol. 17:6379-6385.
29. West, R. B., and M. R. Lieber. 1998. The RAG-HMG1 complex enforces the 12/23 rule of V(D)J recombination specifically at the double-hairpin formation step. Mol. Cell. Biol. 18:6408-6415.
30. Yu, K., M. R. Lieber. Unpublished data.