메뉴 건너뛰기




Volumn 19, Issue 5, 1999, Pages 3674-3683

RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; PROTEIN RAG 1; PROTEIN RAG 2; UNCLASSIFIED DRUG;

EID: 0032908830     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.5.3674     Document Type: Article
Times cited : (90)

References (42)
  • 1
    • 0032551829 scopus 로고    scopus 로고
    • Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system
    • Agrawal, A., Q. M. Eastman, and D. G. Schatz. 1998. Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system. Nature 394:744-751.
    • (1998) Nature , vol.394 , pp. 744-751
    • Agrawal, A.1    Eastman, Q.M.2    Schatz, D.G.3
  • 2
    • 0030887862 scopus 로고    scopus 로고
    • RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination
    • Agrawal, A., and D. G. Schatz. 1997. RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination. Cell 89:43-53.
    • (1997) Cell , vol.89 , pp. 43-53
    • Agrawal, A.1    Schatz, D.G.2
  • 3
    • 0031826699 scopus 로고    scopus 로고
    • Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequence
    • Akamatsu, Y., and M. A. Oettinger. 1998. Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequence. Mol. Cell. Biol. 18: 4670-4678.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 4670-4678
    • Akamatsu, Y.1    Oettinger, M.A.2
  • 4
    • 0001265782 scopus 로고    scopus 로고
    • RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination
    • Difilippantonio, M. J., C. J. McMahan, Q. M. Eastman, E. Spanopoulou, and D. G. Schatz. 1996. RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination. Cell 87:253-262.
    • (1996) Cell , vol.87 , pp. 253-262
    • Difilippantonio, M.J.1    McMahan, C.J.2    Eastman, Q.M.3    Spanopoulou, E.4    Schatz, D.G.5
  • 5
    • 0029864993 scopus 로고    scopus 로고
    • Initiation of V(D)J recombination in vitro obeying the 12/23 rule
    • Eastman, Q. M., T. M. J. Leu, and D. G. Schatz. 1996. Initiation of V(D)J recombination in vitro obeying the 12/23 rule. Nature 380:85-88.
    • (1996) Nature , vol.380 , pp. 85-88
    • Eastman, Q.M.1    Leu, T.M.J.2    Schatz, D.G.3
  • 6
    • 0025040403 scopus 로고
    • The Hin invertasome: Protein-mediated joining of distant recombination sites at the enhancer
    • Heichman, K. A., and R. C. Johnson. 1990. The Hin invertasome: protein-mediated joining of distant recombination sites at the enhancer. Science 249:511-517.
    • (1990) Science , vol.249 , pp. 511-517
    • Heichman, K.A.1    Johnson, R.C.2
  • 7
    • 0032084698 scopus 로고    scopus 로고
    • Assembly of a 12/23 paired signal complex: A critical control point in V(D)J recombination
    • Hiom, K., and M. Gellert. 1998. Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination. Mol. Cell 1:1011-1019.
    • (1998) Mol. Cell , vol.1 , pp. 1011-1019
    • Hiom, K.1    Gellert, M.2
  • 8
    • 0030964130 scopus 로고    scopus 로고
    • A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage
    • Hiom, K., and M. Gellert. 1997. A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage. Cell 88:65-72.
    • (1997) Cell , vol.88 , pp. 65-72
    • Hiom, K.1    Gellert, M.2
  • 9
    • 0032555758 scopus 로고    scopus 로고
    • DNA transposition by the RAG1 and RAG2 proteins: A possible source of oncogenic translocations
    • Hiom, K., M. Melek, and M. Gellert. 1998. DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations. Cell 94:463-470.
    • (1998) Cell , vol.94 , pp. 463-470
    • Hiom, K.1    Melek, M.2    Gellert, M.3
  • 11
    • 0025850374 scopus 로고
    • Structural aspects of a higher order nucleoprotein complex: Induction of an altered DNA structure at the Mu-host junction of the Mu Type 1 transpososome
    • Lavoie, B. D., B. S. Chan, R. G. Allison, and G. Chaconas. 1991. Structural aspects of a higher order nucleoprotein complex: induction of an altered DNA structure at the Mu-host junction of the Mu Type 1 transpososome. EMBO J. 10:3051-3059.
    • (1991) EMBO J. , vol.10 , pp. 3051-3059
    • Lavoie, B.D.1    Chan, B.S.2    Allison, R.G.3    Chaconas, G.4
  • 12
    • 0029083695 scopus 로고
    • rag-1 and rag-2 are components of a high-molecular-weight complex, and association of rag-2 with this complex is rag-1 dependent
    • Leu, T. M. J., and D. G. Schatz. 1995. rag-1 and rag-2 are components of a high-molecular-weight complex, and association of rag-2 with this complex is rag-1 dependent. Mol. Cell. Biol. 15:5657-5670.
    • (1995) Mol. Cell. Biol , vol.15 , pp. 5657-5670
    • Leu, T.M.J.1    Schatz, D.G.2
  • 13
    • 0030707531 scopus 로고    scopus 로고
    • RAG-1- and RAG-2-dependent assembly of functional complexes with V(D)J recombination substrates in solution
    • Li, W., P. Swanson, and S. Desiderio. 1997. RAG-1- and RAG-2-dependent assembly of functional complexes with V(D)J recombination substrates in solution. Mol. Cell. Biol. 17:6932-6939.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 6932-6939
    • Li, W.1    Swanson, P.2    Desiderio, S.3
  • 14
    • 0028805853 scopus 로고
    • Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps
    • McBlane, J. F., D. C. van Gent, D. A. Ramsden, C. Romeo, C. A. Cuomo, M. Gellert, and M. A. Oettinger. 1995. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83:387-395.
    • (1995) Cell , vol.83 , pp. 387-395
    • McBlane, J.F.1    Van Gent, D.C.2    Ramsden, D.A.3    Romeo, C.4    Cuomo, C.A.5    Gellert, M.6    Oettinger, M.A.7
  • 15
    • 0031092628 scopus 로고    scopus 로고
    • Definition of a large region of RAG1 that is important for coimmunoprecipitation of RAG2
    • McMahan, C. J., M. J. Sadofsky, and D. G. Schatz. 1997. Definition of a large region of RAG1 that is important for coimmunoprecipitation of RAG2. J. Immunol. 158:2202-2210.
    • (1997) J. Immunol. , vol.158 , pp. 2202-2210
    • McMahan, C.J.1    Sadofsky, M.J.2    Schatz, D.G.3
  • 16
    • 0032502886 scopus 로고    scopus 로고
    • Rejoining of DNA by the RAG1 and RAG2 proteins
    • Melek, M., M. Gellert, and D. C. van Gent. 1998. Rejoining of DNA by the RAG1 and RAG2 proteins. Science 280:301-303.
    • (1998) Science , vol.280 , pp. 301-303
    • Melek, M.1    Gellert, M.2    Van Gent, D.C.3
  • 17
    • 0032167803 scopus 로고    scopus 로고
    • Communication between Hin recombinase and Fis regulatory subunits during coordinate activation of Hin-catalyzed site-specific DNA inversion
    • Merickel, S. K., M. J. Haykinson, and R. C. Johnson. 1998. Communication between Hin recombinase and Fis regulatory subunits during coordinate activation of Hin-catalyzed site-specific DNA inversion. Genes Dev. 12: 2803-2816.
    • (1998) Genes Dev. , vol.12 , pp. 2803-2816
    • Merickel, S.K.1    Haykinson, M.J.2    Johnson, R.C.3
  • 18
    • 0026708067 scopus 로고
    • Assembly of the active form of the transposase-Mu DNA complex: A critical control point in Mu transposition
    • Mizuuchi, M., T. A. Baker, and K. Mizuuchi. 1992. Assembly of the active form of the transposase-Mu DNA complex: a critical control point in Mu transposition. Cell 70:303-311.
    • (1992) Cell , vol.70 , pp. 303-311
    • Mizuuchi, M.1    Baker, T.A.2    Mizuuchi, K.3
  • 20
    • 85038179038 scopus 로고    scopus 로고
    • New England Biolabs. Unpublished data
    • New England Biolabs. Unpublished data.
  • 21
    • 0025301095 scopus 로고
    • RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
    • Oettinger, M. A., D. G. Schatz, C. Gorka, and D. Baltimore. 1990. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248:1517-1523.
    • (1990) Science , vol.248 , pp. 1517-1523
    • Oettinger, M.A.1    Schatz, D.G.2    Gorka, C.3    Baltimore, D.4
  • 22
    • 0029966374 scopus 로고    scopus 로고
    • Genetic evidence that the RAG1 protein directly participates in V(D)J recombination through substrate recognition
    • Roman, C., and D. Baltimore. 1996. Genetic evidence that the RAG1 protein directly participates in V(D)J recombination through substrate recognition. Proc. Natl. Acad. Sci. USA 93:2333-2338.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2333-2338
    • Roman, C.1    Baltimore, D.2
  • 23
    • 0027491330 scopus 로고
    • Characterization of broken DNA molecules associated with V(D)J recombination
    • Roth, D., C. Zhu, and M. Gellert. 1993. Characterization of broken DNA molecules associated with V(D)J recombination. Proc. Natl. Acad. Sci. USA 90:10788-10792.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10788-10792
    • Roth, D.1    Zhu, C.2    Gellert, M.3
  • 24
    • 0032555695 scopus 로고    scopus 로고
    • VDJ recombination: A transposase goes to work
    • Roth, D. B., and N. L. Craig. 1998. VDJ recombination: a transposase goes to work. Cell 94:411-414.
    • (1998) Cell , vol.94 , pp. 411-414
    • Roth, D.B.1    Craig, N.L.2
  • 25
    • 0026792892 scopus 로고
    • V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in seid mouse thymocytes
    • Roth, D. B., J. P. Menetski, P. B. Nakajima, M. J. Bosma, and M. Gellert. 1992. V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in seid mouse thymocytes. Cell 70:983-991.
    • (1992) Cell , vol.70 , pp. 983-991
    • Roth, D.B.1    Menetski, J.P.2    Nakajima, P.B.3    Bosma, M.J.4    Gellert, M.5
  • 26
    • 0029092358 scopus 로고
    • RAG-1 mutations that affect the target specificity of V(D)J recombination: A possible direct role of RAG-1 in site recognition
    • Sadofsky, M. J., J. E. Hesse, D. C. van Gent, and M. Gellert. 1995. RAG-1 mutations that affect the target specificity of V(D)J recombination: a possible direct role of RAG-1 in site recognition. Genes Dev. 9:2193-2199.
    • (1995) Genes Dev. , vol.9 , pp. 2193-2199
    • Sadofsky, M.J.1    Hesse, J.E.2    Van Gent, D.C.3    Gellert, M.4
  • 28
    • 0029858349 scopus 로고    scopus 로고
    • The Tn7 transposase is a heteromeric complex in which DNA breakage and joining activities are distributed between different gene products
    • Sarnovsky, R. J., E. W. May, and N. L. Craig. 1996. The Tn7 transposase is a heteromeric complex in which DNA breakage and joining activities are distributed between different gene products. EMBO J. 15:6348-6361.
    • (1996) EMBO J. , vol.15 , pp. 6348-6361
    • Sarnovsky, R.J.1    May, E.W.2    Craig, N.L.3
  • 29
    • 0029096898 scopus 로고
    • The phage Mu transpososome core: DNA requirements for assembly and function
    • Savilahti, H., P. A. Rice, and K. Mizuuchi. 1995. The phage Mu transpososome core: DNA requirements for assembly and function. EMBO J. 14: 4893-4903.
    • (1995) EMBO J. , vol.14 , pp. 4893-4903
    • Savilahti, H.1    Rice, P.A.2    Mizuuchi, K.3
  • 30
    • 0024846088 scopus 로고
    • The V(D)J recombination activating gene, RAG-1
    • Schatz, D. G., M. A. Oettinger, and D. Baltimore. 1989. The V(D)J recombination activating gene, RAG-1. Cell 59:1035-1048.
    • (1989) Cell , vol.59 , pp. 1035-1048
    • Schatz, D.G.1    Oettinger, M.A.2    Baltimore, D.3
  • 31
    • 0027769386 scopus 로고
    • Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent, and cell cycle regulated
    • Schlissel, M., A. Constantinescu, T. Morrow, M. Baxter, and A. Peng. 1993. Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent, and cell cycle regulated. Genes Dev. 7:2520-2532.
    • (1993) Genes Dev. , vol.7 , pp. 2520-2532
    • Schlissel, M.1    Constantinescu, A.2    Morrow, T.3    Baxter, M.4    Peng, A.5
  • 32
    • 0027410476 scopus 로고
    • V(D)J recombination: Signal and coding joint resolution are upcoupled and depend on parallel synapsis of the sites
    • Sheehan, K. M., and M. R. Lieber. 1993. V(D)J recombination: signal and coding joint resolution are upcoupled and depend on parallel synapsis of the sites. Mol. Cell. Biol. 13:1363-1370.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 1363-1370
    • Sheehan, K.M.1    Lieber, M.R.2
  • 33
    • 0029553231 scopus 로고
    • Localization, interaction, and RNA binding properties of the V(D)J recombination-activating proteins RAG1 and RAG2
    • Spanopoulou, E., P. Cortes, C. Shih, C.-M. Huang, D. P. Silver, P. Svec, and D. Baltimore. 1995. Localization, interaction, and RNA binding properties of the V(D)J recombination-activating proteins RAG1 and RAG2. Immunity 3:715-726.
    • (1995) Immunity , vol.3 , pp. 715-726
    • Spanopoulou, E.1    Cortes, P.2    Shih, C.3    Huang, C.-M.4    Silver, D.P.5    Svec, P.6    Baltimore, D.7
  • 34
    • 0030592523 scopus 로고    scopus 로고
    • The homeodomain region of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination
    • Spanopoulou, E., F. Zaitseva, F.-H. Wang, S. Santagata, D. Baltimore, and G. Panayotou. 1996. The homeodomain region of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination. Cell 87:263-276.
    • (1996) Cell , vol.87 , pp. 263-276
    • Spanopoulou, E.1    Zaitseva, F.2    Wang, F.-H.3    Santagata, S.4    Baltimore, D.5    Panayotou, G.6
  • 35
    • 0030155949 scopus 로고    scopus 로고
    • The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo
    • Steen, S. B., L. Gomelsky, and D. B. Roth. 1996. The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo. Genes Cells 1:543-553.
    • (1996) Genes Cells , vol.1 , pp. 543-553
    • Steen, S.B.1    Gomelsky, L.2    Roth, D.B.3
  • 36
    • 0032126295 scopus 로고    scopus 로고
    • V(D)J recombination signal recognition: Distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2
    • Swanson, P. C., and S. Desiderio. 1998. V(D)J recombination signal recognition: distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2. Immunity 9:115-125.
    • (1998) Immunity , vol.9 , pp. 115-125
    • Swanson, P.C.1    Desiderio, S.2
  • 37
    • 0030994385 scopus 로고    scopus 로고
    • Stimulation of V(D)J cleavage by high mobility group proteins
    • van Gent, D. C., K. Hiom, T. T. Paull, and M. Gellert. 1997. Stimulation of V(D)J cleavage by high mobility group proteins. EMBO J. 16:2665-2670.
    • (1997) EMBO J. , vol.16 , pp. 2665-2670
    • Van Gent, D.C.1    Hiom, K.2    Paull, T.T.3    Gellert, M.4
  • 39
    • 0029967722 scopus 로고    scopus 로고
    • Similarities between initiation of V(D)J recombination and retroviral integration
    • van Gent, D. C., K. Mizuuchi, and M. Gellert. 1996. Similarities between initiation of V(D)J recombination and retroviral integration. Science 271: 1592-1594.
    • (1996) Science , vol.271 , pp. 1592-1594
    • Van Gent, D.C.1    Mizuuchi, K.2    Gellert, M.3
  • 40
    • 0030009253 scopus 로고    scopus 로고
    • The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination
    • van Gent, D. C., D. A. Ramsden, and M. Gellert. 1996. The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination. Cell 85: 107-113.
    • (1996) Cell , vol.85 , pp. 107-113
    • Van Gent, D.C.1    Ramsden, D.A.2    Gellert, M.3
  • 41
    • 0029075461 scopus 로고
    • Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex
    • Werner, M. H., J. R. Hugh, A. M. Gronenborn, and G. M. Clore. 1995. Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex. Cell 81: 705-714.
    • (1995) Cell , vol.81 , pp. 705-714
    • Werner, M.H.1    Hugh, J.R.2    Gronenborn, A.M.3    Clore, G.M.4
  • 42
    • 0027973387 scopus 로고
    • Specific photocrosslinking of DNA-protein complexes: Identification of contacts between integration host factor and its target DNA
    • Yang, S.-W., and H. A. Nash. 1994. Specific photocrosslinking of DNA-protein complexes: identification of contacts between integration host factor and its target DNA. Proc. Natl. Acad. Sci. USA 91:12183-12187.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 12183-12187
    • Yang, S.-W.1    Nash, H.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.