Rag1/2-mediated resolution of transposition intermediates: Two pathways and possible consequences

Cell

Volumn 101, Issue 6, 2000, Pages 625-633

  Melek, Meni ^a   Gellert, Martin ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MAGNESIUM; PROTEIN;

ARTICLE; CHROMOSOME TRANSLOCATION; GENETIC RECOMBINATION; PRIORITY JOURNAL;

MAMMALIA;

EID: 0034625261     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80874-0     Document Type: Article

References (36)

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3. Hairpin coding end opening is mediated by RAG1 and RAG2 proteins
4. Hairpin formation in Tn5 transposition
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6. Reversal of integration and DNA splicing mediated by integrase of human immunodeficiency virus
7. Initiation of V(D)J recombination in vitro obeying the 12/23 rule
8. HIV-1 DNA integration: Mechanism of viral cleavage and DNA strand transfer
9. Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/2 protein complex
10. Recent advances in understanding V(D)J recombination
11. Stereospecificity of reactions catalyzed by HIV-1 integrase
12. Assembly of a 12/23 paired signal complex: A critical control point in V(D)J recombination
13. DNA Transposition by the RAG1 and RAG2 proteins: A possible source of oncogenic translocations
14. A variant translocation places the lambda immunoglobulin genes 3' to the c-myc oncogene in Burkitt's lymphoma
15. Identification of genes involved in repair of DNA double-strand breaks in mammalian cells
16. Hairpin opening by single-strand-specific nucleases
17. Tn10 transposition via a DNA hairpin intermediate
18. Mutations of acidic residues in RAG1 define the active site of the V(D)J racombinase
19. Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of VDJ recombination
20. The mechanism of V(D)J joining: Lessons from molecular, immunological, and comparative analyses
21. Lymphoma-associated translocation t(14;18) in blood B cells of normal individuals
22. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps
23. Rejoining of DNA by the RAG1 and RAG2 proteins
24. Transpositional recombination: Mechanistic insights from studies of Mu and other elements
25. Inversion of phosphate chirality at the target site of DNA strand transfer: Evidence for a one-step transesterification mechanism
26. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
27. Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage
28. Sequences at the somatic recombination sites of immunoglobulin light-chain genes
29. The RAG1/RAG2 complex constitutes a 3' flap endonuclease: Implications for junctional diversity in V(D)J and transpositional recombination
30. DNA hairpin opening mediated by the RAG1 and RAG2 proteins
31. New insights into V(D)J recombination and its role in the evolution of the immune system
32. Somatic generation of antibody diversity
33. The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination
34. Similarities between initiation of V(D)J recombination and retroviral integration
35. Stimulation of V(D)J cleavage by high mobility group proteins