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Volumn 94, Issue 4, 1998, Pages 463-470

DNA transposition by the RAG1 and RAG2 proteins: A possible source of oncogenic translocations

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HYBRID PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; SIGNAL PEPTIDE;

EID: 0032555758     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81587-1     Document Type: Article
Times cited : (441)

References (40)
  • 1
    • 0030887862 scopus 로고    scopus 로고
    • RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination
    • Agrawal, A., and Schatz, D.G. (1997). RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination. Cell 89, 43-53.
    • (1997) Cell , vol.89 , pp. 43-53
    • Agrawal, A.1    Schatz, D.G.2
  • 2
    • 0025642707 scopus 로고
    • Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity
    • Aplan, P.D., Lombardi, D.P., Ginsberg, A.M., Cossman, J., Bertness, V.L., and Kirsch, I.R. (1990). Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity. Science 250, 1426-1429.
    • (1990) Science , vol.250 , pp. 1426-1429
    • Aplan, P.D.1    Lombardi, D.P.2    Ginsberg, A.M.3    Cossman, J.4    Bertness, V.L.5    Kirsch, I.R.6
  • 3
    • 0027491030 scopus 로고
    • The hobo transposable element of Drosophila can be cross-mobilized in houseflies and excises like the Ac element of maize
    • Atkinson, P.W., Warren, W.D., and O'Brochta, D.A. (1993). The hobo transposable element of Drosophila can be cross-mobilized in houseflies and excises like the Ac element of maize. Proc. Natl. Acad. Sci. USA 90, 9693-9697.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 9693-9697
    • Atkinson, P.W.1    Warren, W.D.2    O'Brochta, D.A.3
  • 6
    • 0024423882 scopus 로고
    • The human T cell receptor genes are targets for chromosomal abnormalities in T cell tumors
    • Boehm, T., and Rabbitts, T.H. (1989). The human T cell receptor genes are targets for chromosomal abnormalities in T cell tumors. FASEB J. 3, 2344-2359.
    • (1989) FASEB J. , vol.3 , pp. 2344-2359
    • Boehm, T.1    Rabbitts, T.H.2
  • 7
    • 0029886929 scopus 로고    scopus 로고
    • Mechanism of V(D)J recombination
    • Bogue, M., and Roth, D.B. (1996). Mechanism of V(D)J recombination. Curr. Opin. Immunol. 8, 175-180.
    • (1996) Curr. Opin. Immunol. , vol.8 , pp. 175-180
    • Bogue, M.1    Roth, D.B.2
  • 8
    • 0030837472 scopus 로고    scopus 로고
    • V(D)J recombination in Ku86-deficient mice: Distinct effects on coding, signal, and hybrid joint formation
    • Bogue, M.A., Wang, C., Zhu, C., and Roth, D.B. (1997). V(D)J recombination in Ku86-deficient mice: distinct effects on coding, signal, and hybrid joint formation. Immunity 7, 37-47.
    • (1997) Immunity , vol.7 , pp. 37-47
    • Bogue, M.A.1    Wang, C.2    Zhu, C.3    Roth, D.B.4
  • 9
    • 0026549933 scopus 로고
    • Reversal of integration and DNA splicing mediated by integrase of human immunodeficiency virus
    • Chow, S.A., Vincent, K.A., Ellison, V., and Brown, P.O. (1992). Reversal of integration and DNA splicing mediated by integrase of human immunodeficiency virus. Science 255, 723-726.
    • (1992) Science , vol.255 , pp. 723-726
    • Chow, S.A.1    Vincent, K.A.2    Ellison, V.3    Brown, P.O.4
  • 11
    • 0031860891 scopus 로고    scopus 로고
    • Extensive, nonrandom diversity of excision footprints generated by Ds-like transposon ascot-1 suggests new parallels with V(D)J recombination
    • Colot, V., Haedens, V., and Rossignol, J.L. (1998). Extensive, nonrandom diversity of excision footprints generated by Ds-like transposon ascot-1 suggests new parallels with V(D)J recombination. Mol. Cell. Biol. 18, 4337-4346.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 4337-4346
    • Colot, V.1    Haedens, V.2    Rossignol, J.L.3
  • 12
    • 0030584463 scopus 로고    scopus 로고
    • V(D)J recombination and transposition: Closer than expected
    • Craig, N.L. (1996). V(D)J recombination and transposition: closer than expected. Science 271, 1512.
    • (1996) Science , vol.271 , pp. 1512
    • Craig, N.L.1
  • 13
    • 0031006969 scopus 로고    scopus 로고
    • Target site selection in transposition
    • Craig, N.L. (1997). Target site selection in transposition. Annu. Rev. Biochem. 66, 437-474.
    • (1997) Annu. Rev. Biochem. , vol.66 , pp. 437-474
    • Craig, N.L.1
  • 14
    • 0026330796 scopus 로고
    • HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer
    • Engelman, A., Mizuuchi, K., and Craigie, R. (1991). HIV-1 DNA integration: mechanism of viral DNA cleavage and DNA strand transfer. Cell 67, 1211-1221.
    • (1991) Cell , vol.67 , pp. 1211-1221
    • Engelman, A.1    Mizuuchi, K.2    Craigie, R.3
  • 15
    • 0030966099 scopus 로고    scopus 로고
    • Recent advances in understanding V(D)J recombination
    • Gellert, M. (1997). Recent advances in understanding V(D)J recombination. Adv. Immunol. 64, 39-64.
    • (1997) Adv. Immunol. , vol.64 , pp. 39-64
    • Gellert, M.1
  • 16
    • 0032478071 scopus 로고    scopus 로고
    • Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease
    • Goossens, T., Klein, U., and Küppers, R. (1998). Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease. Proc. Natl. Acad. Sci. USA. 95, 2463-2468.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 2463-2468
    • Goossens, T.1    Klein, U.2    Küppers, R.3
  • 17
    • 0030934860 scopus 로고    scopus 로고
    • Ku86 is not required for protection of signal ends or for formation of nonstandard V(D)J recombination products
    • Han, J.O., Steen, S.B., and Roth, D.B. (1997). Ku86 is not required for protection of signal ends or for formation of nonstandard V(D)J recombination products. Mol. Cell. Biol. 17, 2226-2234.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2226-2234
    • Han, J.O.1    Steen, S.B.2    Roth, D.B.3
  • 18
    • 0030964130 scopus 로고    scopus 로고
    • A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage
    • Hiom, K., and Gellert, M. (1997). A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage. Cell 88, 65-72.
    • (1997) Cell , vol.88 , pp. 65-72
    • Hiom, K.1    Gellert, M.2
  • 19
    • 0032084698 scopus 로고    scopus 로고
    • Assembly of a 12/23 paired signal complex: A critical control point in V(D)J recombination
    • Hiom, K., and Gellert, M. (1998). Assembly of a 12/23 paired signal complex: A critical control point in V(D)J recombination. Mol. Cell 1, 1011-1019.
    • (1998) Mol. Cell , vol.1 , pp. 1011-1019
    • Hiom, K.1    Gellert, M.2
  • 20
    • 0026721505 scopus 로고
    • Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes
    • Korsmeyer, S.J. (1992). Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes. Annu. Rev. Immunol. 10, 785-807.
    • (1992) Annu. Rev. Immunol. , vol.10 , pp. 785-807
    • Korsmeyer, S.J.1
  • 21
    • 0028048275 scopus 로고
    • The mechanism of V(D)J joining: Lessons from molecular, immunological, and comparative analyses
    • Lewis, S.M. (1994). The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Adv. Immunol. 56, 27-150.
    • (1994) Adv. Immunol. , vol.56 , pp. 27-150
    • Lewis, S.M.1
  • 22
    • 0028805853 scopus 로고
    • Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps
    • McBlane, J.F., van Gent, D.C., Ramsden, D.A., Romeo, C., Cuomo, C.A., Gellert, M., and Oettinger, M.A. (1995). Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83, 387-395.
    • (1995) Cell , vol.83 , pp. 387-395
    • McBlane, J.F.1    Van Gent, D.C.2    Ramsden, D.A.3    Romeo, C.4    Cuomo, C.A.5    Gellert, M.6    Oettinger, M.A.7
  • 23
    • 0032502886 scopus 로고    scopus 로고
    • Rejoining of DNA by the RAG1 and RAG2 proteins
    • Melek, M., Gellert, M., and van Gent, D.C. (1998). Rejoining of DNA by the RAG1 and RAG2 proteins. Science 280, 301-303.
    • (1998) Science , vol.280 , pp. 301-303
    • Melek, M.1    Gellert, M.2    Van Gent, D.C.3
  • 24
    • 0026799383 scopus 로고
    • Polynucleotidyl transfer reactions in transpositional DNA recombination
    • Mizuuchi, K. (1992a). Polynucleotidyl transfer reactions in transpositional DNA recombination. J. Biol. Chem. 267, 21273-6.
    • (1992) J. Biol. Chem. , vol.267 , pp. 21273-21276
    • Mizuuchi, K.1
  • 25
    • 0026637325 scopus 로고
    • Transpositional recombination: Mechanistic insights from studies of Mu and other elements
    • Mizuuchi, K. (1992b). Transpositional recombination: mechanistic insights from studies of Mu and other elements. Annu. Rev. Biochem. 61, 1011-1051.
    • (1992) Annu. Rev. Biochem. , vol.61 , pp. 1011-1051
    • Mizuuchi, K.1
  • 26
    • 0030628279 scopus 로고    scopus 로고
    • Polynucleotidyl transfer reactions in site-specific DNA recombination
    • Mizuuchi, K. (1997). Polynucleotidyl transfer reactions in site-specific DNA recombination. Genes Cells 2, 1-12.
    • (1997) Genes Cells , vol.2 , pp. 1-12
    • Mizuuchi, K.1
  • 27
    • 0025899314 scopus 로고
    • Inversion of the phosphate chirality at the target site of Mu DNA strand transfer: Evidence for a one-step transesterification mechanism
    • Mizuuchi, K., and Adzuma, K. (1991). Inversion of the phosphate chirality at the target site of Mu DNA strand transfer: evidence for a one-step transesterification mechanism. Cell 66, 129-140.
    • (1991) Cell , vol.66 , pp. 129-140
    • Mizuuchi, K.1    Adzuma, K.2
  • 28
    • 0025301095 scopus 로고
    • RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
    • Oettinger, M.A., Schatz, D.G., Gorka, C., and Baltimore, D. (1990). RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248, 1517-1523.
    • (1990) Science , vol.248 , pp. 1517-1523
    • Oettinger, M.A.1    Schatz, D.G.2    Gorka, C.3    Baltimore, D.4
  • 29
    • 0025937091 scopus 로고
    • Structural and functional chimerism results from chromosomal ranslocation in lymphoid tumors
    • Rabbitts, T.H., and Boehm, T. (1991). Structural and functional chimerism results from chromosomal ranslocation in lymphoid tumors. Adv. Imunol. 50, 119-145.
    • (1991) Adv. Imunol. , vol.50 , pp. 119-145
    • Rabbitts, T.H.1    Boehm, T.2
  • 30
    • 0028801363 scopus 로고
    • Formation and resolution of double strand break intermediates in V(D)J rearrangement
    • Ramsden, D.A., and Gellrt, M. (1995). Formation and resolution of double strand break intermediates in V(D)J rearrangement. Genes Dev. 9, 2409-2420.
    • (1995) Genes Dev. , vol.9 , pp. 2409-2420
    • Ramsden, D.A.1    Gellert, M.2
  • 31
    • 0030753633 scopus 로고    scopus 로고
    • Cell-free V(D)J recombination
    • Ramsden, D.A., Paull, T.T., and Gellert, M. (1997). Cell-free V(D)J recombination. Nature 388,488-491.
    • (1997) Nature , vol.388 , pp. 488-491
    • Ramsden, D.A.1    Paull, T.T.2    Gellrt, M.3
  • 32
    • 0029092358 scopus 로고
    • RAG-1 mutations that affect the target specificity of V(D)J recombi-nation: A possible direct role of RAG-1 in site recognition
    • Sadofsky, M., Hesse, J.E., van Gent, D.C., and Geliert, M. (1995). RAG-1 mutations that affect the target specificity of V(D)J recombi-nation: a possible direct role of RAG-1 in site recognition. Genes Dev. 9,2193-2199.
    • (1995) Genes Dev. , vol.9 , pp. 2193-2199
    • Sadofsky, M.1    Hesse, J.E.2    Van Gent, D.C.3    Gellert, M.4
  • 33
    • 0018627375 scopus 로고
    • Sequences at the somatic recombination sites of immunoglobulin light-chain genes
    • Sakano, H., Huppi, K., Heinrich, G., and Tonegawa, S. (1979). Sequences at the somatic recombination sites of immunoglobulin light-chain genes. Nature 280, 288-294.
    • (1979) Nature , vol.280 , pp. 288-294
    • Sakano, H.1    Huppi, K.2    Heinrich, G.3    Tonegawa, S.4
  • 34
    • 0029986753 scopus 로고    scopus 로고
    • Mu transpositional recombination: Donor DNA cleavage and strand transfer in trans by the Mu transposase
    • Savilahti, H., and Mizuuchi, K. (1996). Mu transpositional recombination: donor DNA cleavage and strand transfer in trans by the Mu transposase. Cell 85, 271-280.
    • (1996) Cell , vol.85 , pp. 271-280
    • Savilahti, H.1    Mizuuchi, K.2
  • 35
    • 0030155949 scopus 로고    scopus 로고
    • The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo
    • Steen, S.B., Gomelsky, L., and Roth, D.B. (1996). The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo. Genes Cells 1, 543-553.
    • (1996) Genes Cells , vol.1 , pp. 543-553
    • Steen, S.B.1    Gomelsky, L.2    Roth, D.B.3
  • 36
    • 0028867419 scopus 로고
    • New insights into V(D)J recombination and its role in the evolution of the immune system
    • Thompson, C.B. (1995). New insights into V(D)J recombination and its role in the evolution of the immune system. Immunity 3, 531-539.
    • (1995) Immunity , vol.3 , pp. 531-539
    • Thompson, C.B.1
  • 37
    • 0022379447 scopus 로고
    • The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining
    • Tsujimoto, Y., Gorham, J., Cossman, J., Jaffe, E., and Croce, C.M. (1985). The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science 229, 1390-1393.
    • (1985) Science , vol.229 , pp. 1390-1393
    • Tsujimoto, Y.1    Gorham, J.2    Cossman, J.3    Jaffe, E.4    Croce, C.M.5
  • 38
    • 0025324784 scopus 로고
    • Chromosomal translocations in lymphoid neoplasia: A reappraisal of the recombinase model
    • Tycko, B., and Sklar, J. (1990). Chromosomal translocations in lymphoid neoplasia: a reappraisal of the recombinase model. Can-cer Cells 2, 1-8.
    • (1990) Can-cer Cells , vol.2 , pp. 1-8
    • Tycko, B.1    Sklar, J.2
  • 39
    • 0029967722 scopus 로고    scopus 로고
    • Similarities between initiation of V(D)J recombination and retroviral integration
    • van Gent, D.C., Mizuuchi, K., and Geliert, M. (1996a). Similarities between initiation of V(D)J recombination and retroviral integration. Science 271, 1592-1594.
    • (1996) Science , vol.271 , pp. 1592-1594
    • Van Gent, D.C.1    Mizuuchi, K.2    Geliert, M.3
  • 40
    • 0030009253 scopus 로고    scopus 로고
    • The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination
    • van Gent, D.C., Ramsden, D.A., and Geliert, M. (1996b). The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination. Cell 85, 107-113.
    • (1996) Cell , vol.85 , pp. 107-113
    • Van Gent, D.C.1    Ramsden, D.A.2    Gellert, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.