메뉴 건너뛰기




Volumn 394, Issue 6695, 1998, Pages 744-751

Transposition mediated by RAG-1 and RAG2 and its implications for the evolution of the immune system

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; T LYMPHOCYTE RECEPTOR; ANTIBODY; CIRCULAR DNA; DNA; DNA BINDING PROTEIN; HIGH MOBILITY GROUP PROTEIN; HOMEODOMAIN PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; RAG 1 PROTEIN; RAG-1 PROTEIN; RAG2 PROTEIN, MOUSE; TRANSPOSASE; V(D)J RECOMBINATION ACTIVATING PROTEIN 2;

EID: 0032551829     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/29457     Document Type: Article
Times cited : (623)

References (44)
  • 1
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • Tonegawa, S. Somatic generation of antibody diversity. Nature 302, 575-581 (1983).
    • (1983) Nature , vol.302 , pp. 575-581
    • Tonegawa, S.1
  • 2
    • 0028048275 scopus 로고
    • The mechanism of V(D)J joining: Lessons from molecular, immunological, and comparative analyses
    • Lewis, S. M. The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Adv. Immunol. 56, 27-150 (1994).
    • (1994) Adv. Immunol. , vol.56 , pp. 27-150
    • Lewis, S.M.1
  • 3
    • 0024846088 scopus 로고
    • The V(D)J recombination activating gene (RAG-1)
    • Schatz, D. G., Oettinger, M. A. & Baltimore, D. The V(D)J recombination activating gene (RAG-1). Cell 59, 1035-1048 (1989).
    • (1989) Cell , vol.59 , pp. 1035-1048
    • Schatz, D.G.1    Oettinger, M.A.2    Baltimore, D.3
  • 4
    • 0025301095 scopus 로고
    • RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
    • Oettinger, M. A., Schatz, D. G., Gorka, C. & Baltimore, D. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248, 1517-1523 (1990).
    • (1990) Science , vol.248 , pp. 1517-1523
    • Oettinger, M.A.1    Schatz, D.G.2    Gorka, C.3    Baltimore, D.4
  • 5
    • 0028805853 scopus 로고
    • Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps
    • McBlane, I. F. et al. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83, 387-395 (1995).
    • (1995) Cell , vol.83 , pp. 387-395
    • McBlane, I.F.1
  • 6
    • 0029864993 scopus 로고    scopus 로고
    • Initiation of V(D)J recombination in vitro obeying the 12/23 rule
    • Eastman, Q. M., Leu, T. M. J. & Schatz, D. G. Initiation of V(D)J recombination in vitro obeying the 12/23 rule. Nature 380, 85-88 (1996).
    • (1996) Nature , vol.380 , pp. 85-88
    • Eastman, Q.M.1    Leu, T.M.J.2    Schatz, D.G.3
  • 7
    • 0030009253 scopus 로고    scopus 로고
    • The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination
    • van Gent, D.C., Ramsden, D.A. & Gellert, M. The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination. Cell 85, 107-113 (1996).
    • (1996) Cell , vol.85 , pp. 107-113
    • Van Gent, D.C.1    Ramsden, D.A.2    Gellert, M.3
  • 8
    • 0030980386 scopus 로고    scopus 로고
    • V(D)J recombination: Modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA bending proteins
    • Sawchuk, D. J. et al. V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA bending proteins. J. Exp. Med. 185, 2025-2032 (1997).
    • (1997) J. Exp. Med. , vol.185 , pp. 2025-2032
    • Sawchuk, D.J.1
  • 9
    • 0030994385 scopus 로고    scopus 로고
    • Stimulation of V(D)J cleavage by high mobility group proteins
    • van Gent, D. C., Hiom, K., Paull, T. T. & Gellert, M. Stimulation of V(D)J cleavage by high mobility group proteins. EMBO J. 16, 2665-2670 (1997).
    • (1997) EMBO J. , vol.16 , pp. 2665-2670
    • Van Gent, D.C.1    Hiom, K.2    Paull, T.T.3    Gellert, M.4
  • 10
    • 0029967722 scopus 로고    scopus 로고
    • Similarities between initiation of V(D)J recombination and retroviral integration
    • van Gent, D. C., Mizuuchi, K. & Gellert, M. Similarities between initiation of V(D)J recombination and retroviral integration. Science 271, 1592-1594 (1996).
    • (1996) Science , vol.271 , pp. 1592-1594
    • Van Gent, D.C.1    Mizuuchi, K.2    Gellert, M.3
  • 11
    • 0029117310 scopus 로고
    • What to do at an end - DNA double-strand-break repair
    • Weaver, D. T. What to do at an end - DNA double-strand-break repair. Trends Genet. 11, 388-392 (1995).
    • (1995) Trends Genet. , vol.11 , pp. 388-392
    • Weaver, D.T.1
  • 12
    • 0030783087 scopus 로고    scopus 로고
    • Double strand break repair
    • Chu, G. Double strand break repair. J. Biol. Chem. 272, 24097-24100 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 24097-24100
    • Chu, G.1
  • 14
    • 0028867419 scopus 로고
    • New insights into V(D)J recombination and its role in the evolution of the immune system
    • Thompson, C. B. New insights into V(D)J recombination and its role in the evolution of the immune system. Immunity 3, 531-539 (1995).
    • (1995) Immunity , vol.3 , pp. 531-539
    • Thompson, C.B.1
  • 15
    • 0344936724 scopus 로고    scopus 로고
    • The origins of V(D)J recombination
    • Lewis, S. M. & Wu, G. E. The origins of V(D)J recombination. Cell 88, 159-162 (1997).
    • (1997) Cell , vol.88 , pp. 159-162
    • Lewis, S.M.1    Wu, G.E.2
  • 16
    • 0027404163 scopus 로고
    • Phylogenetic diversification of immunoglobulin genes and the antibody repertoire
    • Litman, G. W. et al. Phylogenetic diversification of immunoglobulin genes and the antibody repertoire. Mol. Biol. Evol. 10, 60-72 (1993).
    • (1993) Mol. Biol. Evol. , vol.10 , pp. 60-72
    • Litman, G.W.1
  • 17
    • 0030966099 scopus 로고    scopus 로고
    • Recent advances in understanding V(D)J recombination
    • Gellert, M. Recent advances in understanding V(D)J recombination. Adv. Immunol. 64, 39-64 (1996).
    • (1996) Adv. Immunol. , vol.64 , pp. 39-64
    • Gellert, M.1
  • 18
    • 0028886688 scopus 로고
    • Unity in transposition reactions
    • Craig, N. L. Unity in transposition reactions. Science 270, 253-254(1995).
    • (1995) Science , vol.270 , pp. 253-254
    • Craig, N.L.1
  • 19
    • 0030887862 scopus 로고    scopus 로고
    • RAG1 and RAG2 form a stable post-cleavage synaptic complex with DNA containing signal ends in V(D)J recombination
    • Agrawal, A. & Schatz, D. G. RAG1 and RAG2 form a stable post-cleavage synaptic complex with DNA containing signal ends in V(D)J recombination. Cell 89, 43-53 (1997).
    • (1997) Cell , vol.89 , pp. 43-53
    • Agrawal, A.1    Schatz, D.G.2
  • 20
    • 0026637325 scopus 로고
    • Transpositional recombination: Mechanistic insights from studies of Mu and other elements
    • Mizuuchi, K. Transpositional recombination: mechanistic insights from studies of Mu and other elements. Annu. Rev. Biochem. 61, 1011-1051 (1992).
    • (1992) Annu. Rev. Biochem. , vol.61 , pp. 1011-1051
    • Mizuuchi, K.1
  • 21
    • 0032502886 scopus 로고    scopus 로고
    • Rejoining of DNA by the RAG1 and RAG2 proteins
    • Melek, M., Gellert, M. & van gent, D. C. Rejoining of DNA by the RAG1 and RAG2 proteins. Science 280, 301-303 (1998).
    • (1998) Science , vol.280 , pp. 301-303
    • Melek, M.1    Gellert, M.2    Van Gent, D.C.3
  • 22
    • 0030592523 scopus 로고    scopus 로고
    • The homeodomain of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination
    • Spanopoulou, E. et al. The homeodomain of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination. Cell 87, 263-276 (1996).
    • (1996) Cell , vol.87 , pp. 263-276
    • Spanopoulou, E.1
  • 24
    • 0024407545 scopus 로고
    • Intramolecular transposition by Tn10
    • Benjamin, H. W. & Kleckner, N. Intramolecular transposition by Tn10. Cell 59, 373-383 (1989).
    • (1989) Cell , vol.59 , pp. 373-383
    • Benjamin, H.W.1    Kleckner, N.2
  • 25
    • 0022419168 scopus 로고
    • Tn5 transposes independently of cointegrate resolution. Evidence for an alternative model for transposition
    • Isberg, R. R. & Syvanen, M. Tn5 transposes independently of cointegrate resolution. Evidence for an alternative model for transposition. J. Mol. Biol. 182, 69-78 (1985).
    • (1985) J. Mol. Biol. , vol.182 , pp. 69-78
    • Isberg, R.R.1    Syvanen, M.2
  • 26
    • 0019786361 scopus 로고
    • Intramolecular integration within Moloney Murine Leukemia Virus DNA
    • Shoemaker, C., Hoffmann, J., Goff, S. P. & Baltimore, D. Intramolecular integration within Moloney Murine Leukemia Virus DNA. J. Virol. 40, 164-172 (1981).
    • (1981) J. Virol. , vol.40 , pp. 164-172
    • Shoemaker, C.1    Hoffmann, J.2    Goff, S.P.3    Baltimore, D.4
  • 27
    • 0025221829 scopus 로고
    • Efficient autointegration of avian retrovirus DNA in vitro
    • Lee, Y. M. H. & Coffin, I. M. Efficient autointegration of avian retrovirus DNA in vitro. J. Virol. 64, 5958-5965 (1990).
    • (1990) J. Virol. , vol.64 , pp. 5958-5965
    • Lee, Y.M.H.1    Coffin, I.M.2
  • 28
    • 0023687763 scopus 로고
    • Retroviral DNA integration: Structure of an integration intermediate
    • Fujiware, T. & Mizuuchi, K. Retroviral DNA integration: structure of an integration intermediate. Cell 54, 497-504 (1988).
    • (1988) Cell , vol.54 , pp. 497-504
    • Fujiware, T.1    Mizuuchi, K.2
  • 29
    • 0040896601 scopus 로고
    • Retroviral integration: Structure of the initial covalent product and its precursor, and a role for the viral in protein
    • Brown, P. O., Bowerman, B., Varmus, H. E. & Bishop, J. M. Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein. Proc. Natl Acad. Sci. USA 86, 2525-2529 (1989).
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 2525-2529
    • Brown, P.O.1    Bowerman, B.2    Varmus, H.E.3    Bishop, J.M.4
  • 30
    • 0004224917 scopus 로고
    • Am. Soc. Microbiol., Washington DC
    • Berg, D. E. & Howe, M. M. Mobile DNA (Am. Soc. Microbiol., Washington DC, 1989).
    • (1989) Mobile DNA
    • Berg, D.E.1    Howe, M.M.2
  • 31
    • 0026799383 scopus 로고
    • Polynucleotidyl transfer reactions in transpositional DNA recombination
    • Mizuuchi, K. Polynucleotidyl transfer reactions in transpositional DNA recombination. J. Biol. Chem. 267, 21273-21276 (1992).
    • (1992) J. Biol. Chem. , vol.267 , pp. 21273-21276
    • Mizuuchi, K.1
  • 32
    • 0029655788 scopus 로고    scopus 로고
    • Tn10 and IS10 transposition and chromosome rearrangements: Mechanism and regulation in vivo and in vitro
    • Kleckner, N., Chalmers, R. M., Kwon, D., Sakai, J. & Bolland, S. Tn10 and IS10 transposition and chromosome rearrangements: mechanism and regulation in vivo and in vitro. Curr. Top. Microbiol. Immunol. 204, 49-82 (1996).
    • (1996) Curr. Top. Microbiol. Immunol. , vol.204 , pp. 49-82
    • Kleckner, N.1    Chalmers, R.M.2    Kwon, D.3    Sakai, J.4    Bolland, S.5
  • 33
    • 0032084698 scopus 로고    scopus 로고
    • Assembly of a 12/23 paired signal complex: A critical control point in V(D)J recombination
    • Hiom, K. & Gellert, M. Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination. Mol. Cell 1, 1011-1019 (1998).
    • (1998) Mol. Cell , vol.1 , pp. 1011-1019
    • Hiom, K.1    Gellert, M.2
  • 34
    • 0028584269 scopus 로고
    • Crystal structure of the catalytic domain of HIV-1 integrase: Similarity to other polynucleotidyl transferases
    • Dyda, F. et al. Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases. Science 266, 1981-1986 (1994).
    • (1994) Science , vol.266 , pp. 1981-1986
    • Dyda, F.1
  • 35
    • 0029129435 scopus 로고
    • Structure of the bacteriophage Mu transposase core: A common structural motif for DNA transposition and retroviral integration
    • Rice, P., & Mizuuchi, K. Structure of the bacteriophage Mu transposase core: a common structural motif for DNA transposition and retroviral integration. Cell 82, 209-220 (1995).
    • (1995) Cell , vol.82 , pp. 209-220
    • Rice, P.1    Mizuuchi, K.2
  • 36
    • 0028865574 scopus 로고
    • High-resolution structure of the catalytic domain of avian sarcoma virus integrase
    • Bujacz, G. et al. High-resolution structure of the catalytic domain of avian sarcoma virus integrase. J. Mol. Biol. 253, 333-346 (1995).
    • (1995) J. Mol. Biol. , vol.253 , pp. 333-346
    • Bujacz, G.1
  • 37
    • 0032577448 scopus 로고    scopus 로고
    • IHF modulation of Tn10 transposition: Sensory transduction of supercoiling status via a proposed protein/DNA molecular spring
    • Chalmers, R., Guhathakurta, A., Benjamin, H. & Kleckner, N. IHF modulation of Tn10 transposition: sensory transduction of supercoiling status via a proposed protein/DNA molecular spring. Cell 93, 897-908 (1998).
    • (1998) Cell , vol.93 , pp. 897-908
    • Chalmers, R.1    Guhathakurta, A.2    Benjamin, H.3    Kleckner, N.4
  • 38
    • 0031006969 scopus 로고    scopus 로고
    • Target site selection in transposition
    • Craig, N. L. Target site selection in transposition. Annu.. Rev. Biochem. 66, 437-474 (1997).
    • (1997) Annu.. Rev. Biochem. , vol.66 , pp. 437-474
    • Craig, N.L.1
  • 39
    • 0030967281 scopus 로고    scopus 로고
    • The Tn10 synaptic complex can capture a target DNA only after transposon excision
    • Sakai, J. & Kleckner, N. The Tn10 synaptic complex can capture a target DNA only after transposon excision. Cell 89, 205-214 (1997).
    • (1997) Cell , vol.89 , pp. 205-214
    • Sakai, J.1    Kleckner, N.2
  • 40
    • 0030890117 scopus 로고    scopus 로고
    • α, β, γ and δ T cell antigen receptor genes arose early in vertebrate phylogeny
    • Rast, J. P. et al. α, β, γ and δ T cell antigen receptor genes arose early in vertebrate phylogeny. Immunity 6, 1-11 (1997).
    • (1997) Immunity , vol.6 , pp. 1-11
    • Rast, J.P.1
  • 41
    • 0018627375 scopus 로고
    • Sequences at the somatic recombination sites of immunoglobulin light-chain genes
    • Sakano, H., Hüppi, K., Heinrich, G. & Tonegawa, S. Sequences at the somatic recombination sites of immunoglobulin light-chain genes. Nature 280, 288-294 (1979).
    • (1979) Nature , vol.280 , pp. 288-294
    • Sakano, H.1    Hüppi, K.2    Heinrich, G.3    Tonegawa, S.4
  • 42
    • 0028921810 scopus 로고
    • High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors
    • Zwilling, S., König, H. & Wirth, T. High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors. EMBO J. 14, 1198-1208 (1995).
    • (1995) EMBO J. , vol.14 , pp. 1198-1208
    • Zwilling, S.1    König, H.2    Wirth, T.3
  • 43
    • 0026052160 scopus 로고
    • Cutting and closing without recombination in V(D)J joining
    • Lewis, S. M. & Hesse, J. E. Cutting and closing without recombination in V(D)J joining. EMBO J. 10, 3631-3639 (1991).
    • (1991) EMBO J. , vol.10 , pp. 3631-3639
    • Lewis, S.M.1    Hesse, J.E.2
  • 44
    • 0025817040 scopus 로고
    • V(D)J recombination: Evidence that a replicative mechanism is not required
    • Hsieh, C., McCloskey, R. P., Radany, E. & Lieber, M. R. V(D)J recombination: evidence that a replicative mechanism is not required. Mol. Cell. Biol. 11, 3972-3977 (1991).
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 3972-3977
    • Hsieh, C.1    McCloskey, R.P.2    Radany, E.3    Lieber, M.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.