Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

Genes and Development

Volumn 13, Issue 23, 1999, Pages 3070-3080

  Kim, Deok Ryong ^a,c   Dai, Yan ^a   Mundy, Cynthia L ^a   Yang, Wei ^b   Oettinger, Marjorie A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c University of Ulsan   (South Korea)

Author keywords

RAG1; RAG2; Recombination signal sequence; T cell receptor; V(D)J recombination

Indexed keywords

AMINO ACID; DNA; IRON; METAL ION; PROTEIN; RECOMBINASE; T LYMPHOCYTE RECEPTOR;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; DNA CLEAVAGE; DNA RECOMBINATION; ENZYME ACTIVE SITE; GENE MUTATION; METAL BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DNA BINDING;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ASPARTIC ACID; BINDING SITES; CATALYTIC DOMAIN; DNA NUCLEOTIDYLTRANSFERASES; DNA-BINDING PROTEINS; GENE REARRANGEMENT; HELA CELLS; HOMEODOMAIN PROTEINS; HUMANS; HYDROXYL RADICAL; IRON; MANGANESE; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEAR PROTEINS; PHENOTYPE; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; VDJ RECOMBINASES;

BACTERIA (MICROORGANISMS);

EID: 0000675571     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.13.23.3070     Document Type: Article

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