DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences

Molecular and Cellular Biology

Volumn 16, Issue 10, 1996, Pages 5683-5690

  Cuomo, Christina A ^a   Mundy, Cynthia L ^a   Oettinger, Marjorie A ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DNA CLEAVAGE; DNA SEQUENCE; DNA STRUCTURE; GENETIC RECOMBINATION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 0029814965     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.10.5683     Document Type: Article

References (31)

1. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1989. Current protocols in molecular biology. Greene Publishing Associates and Wiley-Interscience, New York.
2. Boubnov, N. V., Z. P. Wills, and D. T. Weaver. 1993. Coding sequence composition flanking either signal element alters V(D)J recombination efficiency. Nucleic Acids Res. 23:1060-1067.
3. Burlingame, R. P., M. G. Obukowicz, D. L. Lynn, and M. M. Howe. 1986. Isolation of point mutations in bacteriophage Mu attachment regions cloned in a lambda::mini-Mu phage. Proc. Natl. Acad. Sci. USA 83:6012-6016.
4. Cheung, S., K. Arndt, and P. Lu. 1984. Correlation of lac operator DNA imino proton exchange kinetics with its function. Proc. Natl. Acad. Sci. USA 81:3665-3669.
5. Eastman, Q. M., T. M. Leu, and D. G. Schatz. 1996. Initiation of V(D)J recombination in vitro obeying the 12/23 rule. Nature (London) 380:85-88.
6. Ezekiel, U. R., P. Engler, D. Stern, and U. Storb. 1995. Asymmetric processing of coding ends and the effect of coding end nuclentide composition on V(D)J recombination. Immunity 2:381-389.
7. Gellert, M. 1992. Molecular analysis of V(D)J recombination. Annu. Rev. Genet. 22:425-446.
8. Gerstein, R. M., and M. R. Lieber. 1993. Coding end sequence can markedly affect the initiation of V(D)J recombination. Genes Dev. 7:1459-1469.
9. Hesse, J. E., M. R. Lieber, K. Mizuuchi, and M. Gellert. 1989. V(D)J recombination: a functional definition of the joining signals. Genes Dev. 3:1053-1061.
10. Kirch, S. A., P. Sudarsanam, and M. A. Oettinger. 1996. Regions of RAG1 protein critical for V(D)J recombination. Eur. J. Immunol. 26:886-891.
11. La Femina, R. L., P. L. Callahan, and M. G. Cordingley. 1991. Substrate specificity of recombinant human immunodeficiency virus integrase protein. J. Virol. 65:5624-5630.
12. Lewis, S. M. 1994. The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Adv. Immunol. 56:27-150.
13. McBlane, J. F., D. C. van Gent, D. A. Ramsden, C. Romeo, C. A. Cuomo, M. Gellert, and M. A. Oettinger. 1995. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83:387-395.
14. Mizuuchi, K. 1992. Transpositional recombination: mechanistic insights from studies of Mu and other elements. Annu. Rev. Biochem. 61:1011-1051.
15. Mombaerts, P., J. Iacomini, R. S. Johnson, K. Herrup, S. Tonegawa, and V. E. Papaioannou. 1992. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68:869-877.
16. Oettinger, M. A., D. G. Schatz, C. Gorka, and D. Baltimore. 1990. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248:1517-1523.
17. Patel, D. J., L. Shapiro, and D. Hare. 1987. NMR-distance geometry studies of helical errors and sequence dependent conformations of DNA in solution, p. 115-161. In R. D. Wells and S. C. Harvey (ed.), Unusual DNA structures. Springer, New York.
18. Ramsden, D. A., K. Baetz, and G. E. Wu. 1994. Conservation of sequence in recombination signal sequence spacers. Nucleic Acids Res. 22:1785-1796.
19. Roth, D. B., J. P. Menetski, P. B. Nakajima, M. J. Bosma, and M. Gellert. 1992. V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes. Cell 70:983-991.
20. Roth, D. B., P. B. Nakajima, J. P. Menetski, M. J. Bosma, and M. Gellert. 1992. V(D)J recombination in mouse thymocytes: double-strand breaks near T cell receptor δ rearrangement signals. Cell 69:41-53.
21. Sadofsky, M., J. E. Hesse, D. C. van Gent, and M. Gellert. 1995. RAG-1 mutations that affect the target specificity of V(D)J recombination: a possible direct role of RAG-1 in site recognition. Genes Dev. 9:2193-2199.
22. Savilahti, H., P. A. Rice, and K. Mizuuchi. 1995. The phage Mu transpososome core: DNA requirements for assembly and function. EMBO J. 14: 4893-4903.
23. Schatz, D. G., M. A. Oettinger, and D. Baltimore. 1989. The V(D)J recombination activating gene (RAG-1). Cell 59:1035-1048.
24. Schlissel, M., A. Constantinescu, T. Morrow, M. Baxter, and A. Peng. 1993. Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent, and cell cycle regulated. Genes Dev. 7:2520-2532.
25. Shinkai, Y., G. Rathbun, K.-P. Lam, E. M. Oltz, V. Stewart, M. Mendelsohn, J. Charron, M. Datta, F. Young, A. M. Stall, and F. W. Alt. 1992. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68:855-867.
26. Steen, S. B., L. Gomelsky, and D. B. Roth. The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo. Genes Cells, in press.
27. Surette, M. G., T. Harkness, and G. Chaconas. 1991. Stimulation of the Mu A protein-mediated strand cleavage reaction by the Mu B protein, and the requirement of DNA nicking for stable type 1 transpososome formation. J. Biol. Chem. 266:3118-3124.
28. n tracts by B-DNA crystal structures. Nature (London) 354: 167-170.
29. van Gent, D. C., J. F. McBlane, D. A. Ramsden, M. J. Sadofsky, J. E. Hesse, and M. Gellert. 1995. Initiation of V(D)J recombination in a cell-free system. Cell 81:925-934.
30. van Gent, D. C., K. Mizuuchi, and M. Gellert. 1996. Initiation of V(D)J recombination: similarities to transposition and retroviral integration. Science 271:1592-1594.
31. van Gent, D. C., D. A. Ramsden, and M. Gellert. 1996. The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination. Cell 85: 107-113.