Nerve growth factor signaling, neuroprotection, and neural repair

Annual Review of Neuroscience

Volumn 24, Issue , 2001, Pages 1217-1281

  Sofroniew, M V ^a   Howe, C L ^a   Mobley, W C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Excitotoxicity; Neurodegeneration; Neuroregeneration; Neurotrophins; NGF; P75NTR; TrkA; Tyrosine kinase

Indexed keywords

NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR;

AGING; GLIA CELL; HUMAN; NERVE CELL DIFFERENTIATION; NERVE GROWTH; NERVE REGENERATION; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; SYMPATHETIC NERVE CELL;

ANIMALS; HUMANS; NERVE DEGENERATION; NERVE GROWTH FACTOR; NERVE REGENERATION; NERVOUS SYSTEM PHYSIOLOGY; NEUROGLIA; NEURONS; SIGNAL TRANSDUCTION;

EID: 0034941330     PISSN: 0147006X     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.neuro.24.1.1217     Document Type: Review

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181. Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins
182. NGF induces the expression of the VGF gene through a cAMP response element
183. Modulation of ethanol neurotoxicity by nerve growth factor
184. NF-κB modulates lipopolysaccharide-induced microglial nerve growth factor expression
185. Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
186. NMDA potentiates NGF-induced sprouting of septal cholinergic neurons
187. Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection
188. Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: Role of macrophages
189. Functional analysis of a growth factor-responsive transcription factor complex
190. A Grb2-associated docking protein in EGF- and insulin-receptor signalling
191. Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor
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193. p140trk mRNA marks NGF-responsive forebrain neurons: Evidence that trk gene expression is induced by NGF
194. Nerve growth factor protects the neonatal brain against hypoxicischemic injury
195. Local and target-derived nerve growth factor protect basal forebrain cholinergic neurons from glutamate receptor-mediated toxicity
196. Analysis of the trk NGF receptor tyrosine kinase using recombinant fusion proteins
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198. Nerve growth factor signaling in caveolae-like domains at the plasma membrane
199. A potential interaction of p75 and trkA NGF receptors revealed by affinity crosslinking and immunoprecipitation
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201. In vitro glial responses to nerve growth factor
202. Structure function relationships in the neurotrophin family
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204. Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells
205. Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase
206. The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras
207. Activation of ternary complex factor Elk-1 by MAP kinases
208. Voltage-sensitive calcium currents are acutely increased by nerve growth factor in PC12 cells
209. Nerve growth factor (NGF)-induced calcium influx and intracellular calcium mobilization in 3T3 cells expressing NGF receptors
210. pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167
211. Molecular mechanisms of developmental neuronal death
212. The role of NGF in sensory neurons in vivo
213. The trk proto-oncogene product: A signal transducing receptor for nerve growth factor
214. Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF
215. Signal transduction by the neurotrophin receptors
216. Nerve growth factor receptor TrkA is expressed by horizontal and amacrine cells during chicken retinal development
217. Reactive astrocytes are substrates for the growth of adult CNS axons in the presence of elevated levels of nerve growth factor
218. +
219. A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice
220. Association of the p75 neurotrophin receptor with TRAF6
221. The trk proto-oncogene encodes a receptor for nerve growth factor
222. p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons
223. A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain
224. Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived growth factor in the rat hippocampus
225. Expression of a constitutively active phosphatidylinositol 3-kinase induces process formation in rat PC12 cells. Use of Cre/loxP recombination system
226. Differential regulation of the low-affinity nerve growth factor receptor during postnatal development of the rat brain
227. Protein kinase C alpha activates RAF-1 by direct phosphorylation
228. Stability of septohippocampal neurons following excitotoxic lesions of the rat hippocampus
229. The aged monkey basal forebrain: Rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor
230. Gab1 mediates neurite outgrowth, DNA synthesis, and survival in PC12 cells
231. Activation of nuclear factor kappa B in human neuroblastoma cell lines
232. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
233. Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions
234. Neutralizing intraspinal nerve growth factor blocks autonomic dysreflexia caused by spinal cord injury
235. The proto-oncogene Bcl-2 and its role in regulating apoptosis
236. Neurotrophins induce release of neurotrophins by the regulated secretory pathway
237. CNS glial cells express neurotrophin receptors whose levels are regulated by NGF
238. Differentiation of central nervous system neuronal cells by fibroblast-derived growth factor requires at least two signaling pathways: Roles for Ras and Src
239. Distribution of NGF receptors in normal and pathologic human lymphoid tissues
240. p75 neurotrophin receptor expression on adult human oligodendrocytes: Signaling without cell death in response to NGF
241. Cloning and expression of a novel neurotrophin, NT-7, from carp
242. Nerve growth factor rapidly suppresses basal, NMDA-evoked, and AMPA-evoked nitric oxide synthase activity in rat hippocampus in vivo
243. Human CD4+ T cell clones produce and release nerve growth factor and express high-affinity nerve growth factor receptors
244. Nerve growth factor receptors on PC12 cells: Ligand-induced conversion from low- to high-affinity states
245. Ras-dependent growth factor regulation of MEK kinase in PC 12 cells
246. Structure and developmental expression of the nerve growth factor receptor in the chicken central nervous system
247. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
248. Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene
249. Dependence on p75 for innervation of some sympathetic targets
250. p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF
251. Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system
252. Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes
253. Inactivation of rho signaling pathway promotes CNS axon regeneration
254. Axons regulate Schwann cell expression of the major myelin and NGF receptor genes
255. Mast cells synthesize, store, and release nerve growth factor
256. Small molecule nerve growth factor analogues image receptors in vivo
257. Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of chick embryo
258. A diffusible agent of mouse sarcoma, producing hyperplasia of sympathetic ganglia and hyperneurotization of viscera in the chick embryo
259. Nerve growth factor: From neurotrophin to neurokine
260. Update of the NGF saga
261. Signal transduction through MAP kinase cascades
262. Regulation of TrkA and ChAT expression in developing rat basal forebrain: Evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons
263. NMR structure of the death domain of the p75 neurotrophin receptor
264. Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve
265. Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons
266. Neurotrophins and brain insults
267. Nerve growth factor upregulates the transcriptional activity of CBP through activation of the p42/p44(MAPK) cascade
268. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death
269. Neurotrophic factors regulate cathepsin S in macrophages and microglia: A role in the degradation of myelin basic protein and amyloid beta peptide
270. Protein kinase C group B members PKC-delta, -epsilon, -zeta and PKC-L(eta). Comparison of properties of recombinant proteins in vitro and in vivo
271. The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines
272. A Trk nerve growth factor (NGF) receptor point mutation affecting interaction with phospholipase C-gamma 1 abolishes NGF-promoted peripherin induction but not neurite outgrowth
273. Nerve growth factor: Actions in the peripheral and central nervous systems
274. Minimized hormones grow in stature
275. TrkA activation is sufficient to rescue axotomized cholinergic neurons
276. Nerve growth factor and basic fibroblast growth factor protect rat cerebellar granule cells in culture against ethanol-induced cell death
277. An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ
278. Direct binding of the signaling adapter protein Grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase, TrkA
279. Brain-derived neurotrophic factor binding to the p75 neurotrophin receptor reduces TrkA signaling while increasing serine phosphorylation in the TrkA intracellular domain
280. Point sources of Schwann cells result in growth into a nerve entubulation repair site in the absence of axons: Effects of freeze-thawing
281. High affinity nerve growth factor binding displays a faster rate of association than p140trk binding. Implications for multi-subunit polypeptide receptors
282. Nerve growth factor-dependent activation of NF-kappaB contributes to survival of sympathetic neurons
283. Transgenic mice expressing the intracellular domain of the p75 neurotrophin receptor undergo neuronal apoptosis
284. Nerve growth factor treatment increases stimulus-evoked release of sensory neuropeptides in the rat spinal cord
285. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1
286. A new superfamily of cell surface proteins related to the nerve growth factor receptor
287. Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C
288. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
289. Nerve growth factor modifies the expression of inflammatory cytokines by mast cells via a prostanoid-dependent mechanism
290. A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences
291. Molecular characterization of the human trk oncogene
292. Molecular and biochemical characterization of the human trk proto-oncogene
293. Protection of the neostriatum against excitotoxic damage by neurotrophin-producing, genetically modified neural stem cells
294. Subcellular localization of low-affinity nerve growth factor receptor-immunoreactive protein in adult rat purkinje cells following traumatic injury
295. CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells
296. Calcium and free radicals: Mediators of neurotrophic factor and excitatory transmitter-regulated developmental plasticity and cell death
297. Excitotoxicity and excitoprotection in vitro
298. Neuroprotective signal transduction: Relevance to stroke
299. Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration
300. 2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons
301. Neurotrophins and synaptic plasticity
302. Activators and effectors of ras p21 proteins
303. New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor
304. The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule
305. Effect of age on axoplasmic transport of cholinesterase in rat sciatic nerves
306. The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation
307. The nerve growth factor family of receptors
308. The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor
309. Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function
310. Neurotrophins and sensory neurons: Role in development, maintenance and injury. A thematic summary
311. Neurotrophins, nociceptors, and pain
312. Inositol phosphates and cell signaling: Sew views of InsP5 and InsP6
313. cl-2 gene family in the nervous system
314. Changes of NGF presence in nonneuronal cells in response to experimental allergic encephalomyelitis in lewis rats
315. TrkA immunoreactive neurones in the rat spinal cord
316. Identification of TrkB autophosphorylation sites and evidence that phospholipase C-gamma 1 is a substrate of the TrkB receptor
317. Regulation of nerve growth factor receptor gene expression by nerve growth factor in the developing peripheral nervous system
318. Nerve growth factor derived from terminals selectively increases the ratio of p75 to trkA NGF receptors on mature sympathetic neurons
319. 2+/calmodulin-dependent kinase
320. The neurobiology of Schwann cells
321. Microsphere embolism-induced elevation of nerve growth factor level and appearance of nerve growth factor immunoreactivity in activated T-lymphocytes in the rat brain
322. Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor
323. Human rsk isoforms: Cloning and characterization of tissue-specific expression
324. Granule neuron regulation of purkinje cell development: Striking a balance between neurotrophin and glutamate signaling
325. A protein domain conserved between yeast MCM1 and human SRF directs ternary complex formation
326. Reduction in p140-TrkA receptor protein within the nucleus basalis and cortex in Alzheimer's disease
327. Nerve growth factor induces apoptosis in human medulloblastoma cell lines that express TrkA receptors
328. Nerve growth factor induces rapid accumulation of the GTP-bound form of p21ras in rat pheochromocytoma PC12 cells
329. The signal-dependent coactivator CBP is a nuclear target for pp90RSK
330. Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury
331. The molecular heterogeneity of protein kinase C and its implications for cellular regulation
332. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
333. Sarcoma viruses carrying ras oncogenes induce differentiation- associated properties in a neuronal cell line
334. Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma
335. The Ras and protein kinase C signaling pathways are functionally antagonistic in GH4 neuroendocrine cells
336. Loss of True blue labelling from the medial septum following transection of the fimbria-fornix: Evidence for the death of cholinergic and noncholinergic neurons
337. FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors
338. The structure, expression, and properties of additional members of the protein kinase C family
339. A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin
340. A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle
341. The phosphorylation and activation of B-raf in PC12 cells stimulated by nerve growth factor
342. Neurotrophins: Signals between the nervous and immune systems
343. Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor
344. Expression of nerve growth factor and neurotrophin-3 mRNAs in hippocampal interneurons: Morphological characterization, levels of expression, and colocalization of nerve growth factor and neurotrophin-3
345. Development of sensory neurons in the absence of NGF/TrkA signaling in vivo
346. Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)
347. Persistance of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase
348. Glutamate induces the growth factors NGF and bFGF, the receptors FGF-R1 and c-fos mRNA expression in rat astrocyte culture
349. Free radicals induce gene expression of NGF and bFGF in rat astrocyte culture
350. Central neuronal loss and behavioral impairment in mice lacking neurotrophin receptor p75
351. The effect of sytemically administered recombinant human nerve growth factor in healthy human subjects
352. Expression of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 in the somatosensory cortex of the mature rat: Coexpression with high-affinity neurotrophin receptors
353. TrkA activation in the rat visual cortex by antirat trkA IgG prevents the effect of monocular deprivation
354. Rapid and opposite effects of BDNF and NGF on the functional organization of the adult cortex in vivo
355. Identification and characterization of novel substrates of Trk receptors in developing neurons
356. PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity
357. SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells
358. Induction of apoptosis by the low-affinity NGF receptor
359. Functional regeneration of sensory axons into the adult spinal cord
360. The CREB-binding protein (CBP) cooperates with the serum response factor for transactivation of the c-fos serum response element
361. Nerve growth factor stimulates the tyrosine phosphorylation of endogenous Crk-II and augments its association with p130Cas in PC-12 cells
362. Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons
363. An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons
364. Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR
365. Nerve growth factor enhances regeneration through silicone chambers
366. Peripheral injury enhances entral regeneration of primary sensory neurones
367. The structures of the neurotrophin 4 homodimer and the brain-drived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site
368. Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer
369. The neurotrophin receptor, gp75, forms a complex with the receptor tyrosine kinase TrkA
370. Reciprocal modulation of TrkA and p75NTR affinity states is mediated by direct receptor interactions
371. TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40
372. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate
373. Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases
374. Nerve growth factor regulates sympathetic ganglion cell morphology and survival in the adult mouse
375. A second determinant of binding to the p75 neurotrophin receptor revealed by alanine-scanning mutagenesis of a conserved loop in nerve growth factor
376. Axonal and transneuronal transport in the transmission of neurological disease: Potential role in systems degeneration
377. Nerve growth factor receptors on PC12 cells: Evidence for two receptor classes with differing cytoskeletal association
378. NF-kappaB is activated and promotes cell death in focal cerebral ischemia
379. Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes
380. IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase
381. Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids
382. Bradykinin induces interleukin-6 expression in astrocytes through activation of nuclear factor-kappaB
383. Nerve growth factor in Alzheimer's disease: Increased levels throughout the brain coupled with declines in nucleus basalis
384. Identification of Src as a novel atypical protein kinase C-interacting protein
385. Cilliary neurotrophic factor enhances the expression of NGF and p75 low-affinity NGF receptor in astrocytes
386. The regulation and function of c-fos and other immediate early genes in the nervous system
387. Amelioration of delayed neuronal death in the hippocampus by nerve growth factor
388. Neurotrophins and hyperalgesia
389. Nerve growth factor promotes functional recovery of retinal ganglion cells after ischemia
390. Nerve growth factor: A survey of activity on immune and hematopoietic cells
391. The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons
392. Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: Convergence of estrogen and neurotrophin signaling pathways
393. Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene
394. The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death
395. Functions of the neurotrophins during nervous system development: What the knockouts are teaching us
396. Neuronal responses to axotomy
397. Atrophy but not death of adult septal cholinergic neurons after ablation of target capacity to produce mRNAs for NGF, BDNF and NT-3
398. Survival of adult basal forebrain cholinergic neurons after loss of target neurons
399. On the possibility of positive feedback in trophic interactions between afferent and target neurons
400. Retrograde changes in the basal forebrain of the rat following cortical damage
401. Aggregation of the intracellular domain of the type 1 tumor necrosis factor receptor defined by the two-hybrid system
402. Activation of the c-Raf protein kinase by protein kinase C phosphorylation
403. Mechanisms and genes of cellular suicide
404. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
405. Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses
406. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
407. Increased levels of nerve growth factor (NGF) protein and mRNA and reactive gliosis following kainic acid injection into the rat striatum
408. Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: Involvement of nerve growth factor
409. Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II
410. Functional properties of murine macrophages promoted by nerve growth factor
411. Nerve growth factor modulates Fc gamma receptor expression on murine macrophage J774A.1 cells
412. Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells
413. Death of developing septal cholinergic neurons following NGF withdrawal in vitro: Protection by protein synthesis inhibition
414. Hyperalgesia induced in the rat by the amino-terminal octapeptide of nerve growth factor
415. Induction of nerve growth factor receptor in Schwann cells after axotomy
416. Expression of nerve growth factor receptors by Schwann cells of axotomized peripheral nerves: Ultrastructural location, suppression by axonal contact, and binding properties
417. A novel domain within the 55 kd TNF receptor signals cell death
418. v-Crk modulation of growth factor-induced PC12 cell differentiation involves the Src homology 2 domain of v-Crk and sustained activation of the Ras/mitogen-activated protein kinase pathway
419. Cellular functions regulated by Src family kinases
420. Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation
421. iyk, a novel intracellular protein tyrosine kinase differentially expressed in the mouse mammary gland and intestine
422. Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain
423. Nerve growth factor is an autocrine survival factor for memory B lymphocytes
424. Nerve growth factor induces a multimeric TrkA receptor complex in neuronal cells that includes Crk, SHC and PLC-gamma 1 but excludes P130CAS
425. Identification of a latent MAP kinase kinase kinase in PC12 cells as B-raf
426. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor
427. The serum response element
428. Hepatic stellate cells express the low affinity nerve growth factor receptor p75 and undergo apoptosis in response to nerve growth factor stimulation
429. Characterization of an NGF-P-TrkA retrograde-signaling complex and age-dependent regulation of TrkA phosphorylation in sympathetic neurons
430. Basal forebrain cell loss following fimbria/fornix transection
431. Bridging grafts and transient nerve growth factor infusions promote long-term central nervous system neuronal rescue and partial functional recovery
432. Maintaining the neuronal phenotype after injury in the adult CNS. Neurotrophic factors, axonal growth substrates, and gene therapy
433. Neurotrophins rapidly modulate growth cone response to the axon guidance molecule, collapsin-1
434. Nerve growth factor promotes neurite regeneration in PC12 cells by translational control
435. Protein kinase C-epsilon associates with the Raf-1 kinase and induces the production of growth factors that stimulate Raf-1 activity
436. 125I-nerve growth factor in rat sympathetic neurons in compartmented cultures
437. The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin
438. B-Raf-dependent regulation of the MEK-1/mitogen-activated protein kinase pathway in PC12 cells and regulation by cyclic AMP
439. Depolarization and neurotrophins converge on the phosphatidylinositol 3-kinase-Akt pathway to synergistically regulate neuronal survival
440. Complex formation between RAS and RAF and other protein kinases
441. Suppression of TNF-alpha-induced apoptosis by NF-kappaB
442. 14-3-3 Isotypes facilitate coupling of protein kinase C-zeta to Raf-1: Negative regulation by 14-3-3 phosphorylation
443. Platelet-derived growth factor activation of mitogen-activated protein kinase depends on the sequential activation of phosphatidylcholine-specific phospholipase C, protein kinase C-zeta and Raf-1
444. Expression of neurotrophin and trk receptor genes in adult rats with fimbria transections: Effect of intraventricular nerve growth factor and brain-derived neurotrophic factor administration
445. Neurotrophins regulate sequential changes in neurotrophin receptor expression by sympathetic neuroblasts
446. Neurotrophins and nerve injury in the adult
447. Colocalization of NGF binding sites, trk mRNA, and low-affinity NGF receptor mRNA in primary sensory neurons: Responses to injury and infusion of NGF
448. Histochemical characterization of sensory neurons with high-affinity receptors for nerve growth factor
449. Differential influence of nerve growth factor on neuropeptide expression in vivo: A novel role in peptide suppression in adult sensory neurons
450. Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene
451. NTR by adult motor neurons after axotomy is triggered by retrograde transport of a positive signal from regenerating peripheral nerve
452. Nerve growth factor induces resistance of PC12 cells to nitric oxide cytotoxicity
453. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-kappaB
454. En passant neurotrophic action of an intermediate axonal target in the developing mammalian CNS
455. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
456. Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complex
457. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis
458. Lyn and Fgr are activated in distinct membrane fractions of human granulocytic cells
459. Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain
460. Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor
461. Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection
462. Profilin and the Abl tyrosine kinase are required for motor axon outgrowth in the Drosophila embryo
463. Antioxidant defense of the brain: A role for astrocytes
464. Nerve growth factor (NGF) augments cortical and hippocampal cholinergic functioning after p75NGF receptor-mediated deafferentation but impairs inhibitory avoidance and induces fear-related behaviors
465. Interaction with TrkA immobilizes gp75 in the high affinity nerve growth factor receptor complex
466. Regulation of NF-kappa B activity in rat dorsal root ganglia and PC12 cells by tumour necrosis factor and nerve growth factor
467. Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK
468. Re-expression of nerve growth factor receptor after axonal injury recapitulates a developmental event in motor neurons: Differential regulation when regeneration is allowed or prevented
469. Beta nerve growth factor binding to PC12 cells. Association kinetics and cooperative interactions
470. Peripheral cell types contributing to the hyperalgesic action of nerve growth factor in inflammation
471. Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity
472. Mapping of atypical protein kinase C within the nerve growth factor signaling cascade: Relationship to differentiation and survival of PC12 cells
473. Overexpression of atypical PKC in PC12 cells enhances NGF- responsiveness and survival through an NF-kappaB dependent pathway
474. A role for zeta protein kinase C in nerve growth factor-induced differentiation of PC12 cells
475. Transport of protein kinase C isoforms to the nucleus of PC12 cells by nerve growth factor: Association of atypical zeta-PKC with the nuclear matrix
476. Expression of the NGF receptor gene in sensory neurons and their cutaneous targets prior to and during innervation
477. BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases
478. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase
479. Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation
480. The Ras/phosphatidylinositol 3-kinase and Ras/ERK pathways function as independent survival modules each of which inhibits a distinct apoptotic signaling pathway in sympathetic neurons
481. The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells
482. Neurotrophin binding to the p75 receptor modulates rho activity and axonal outgrowth
483. Association of the Abl tyrosine kinase with the Trk nerve growth factor receptor
484. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
485. TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction
486. Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation
487. Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival
488. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor
489. Fibroblast growth factors stimulate nerve growth factor synthesis and secretion by astrocytes
490. Cooperative regulation of nerve growth factor synthesis and secretion in fibroblasts and astrocytes by fibroblast growth factor and other cytokines
491. Therapeutic potential of neurotrophic factors for neurological disorders
492. Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor in hippocampal neurons
493. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
494. Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases
495. RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: Growth factor-stimulated kinase function and nuclear translocation