Neutralizing intraspinal nerve growth factor blocks autonomic dysreflexia caused by spinal cord injury

Journal of Neuroscience

Volumn 19, Issue 17, 1999, Pages 7405-7414

  Krenz, Natalie R ^a,b   Meakin, Susan O ^a,b   Krassioukov, Andrei V ^a,b   Weaver, Lynne C ^a,b  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Antibody to nerve growth factor; Autonomic dysreflexia; Calcitonin gene related peptide; Nerve growth factor; Primary afferent fiber sprouting; Spinal cord injury

Indexed keywords

NERVE GROWTH FACTOR;

ANIMAL TISSUE; ARTICLE; HYPERTENSION; MALE; NERVE SPROUTING; NERVE STIMULATION; NONHUMAN; PATHOGENESIS; PATHOLOGICAL REFLEX; PRIORITY JOURNAL; RAT; SENSORY NERVE; SPINAL CORD DORSAL HORN; SPINAL CORD INJURY;

EID: 0033198220     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-17-07405.1999     Document Type: Article

References (45)

1. Averill S, McMahon SB, Clary DO, Reichardt LF, Priestley JV (1995) Immunocytochemical localization of trkA receptors in chemically identified subgroups of adult rat sensory neurons. Eur J Neurosci 4:1484-1494.
2. Bakhit C, Armanini M, Wong WLT, Bennett GL, Wrathall JR (1991) Increase in nerve growth factor-like immunoreactivity and decrease in choline acetyltransferase following contusive spinal cord injury. Brain Res 554:264-271.
3. Botterell EH, Callaghan JC, Jousse AT (1953) Pain in paraplegia clinical management and surgical treatment. Proc R Soc Med 47:281-288.
4. Cheng H, Cao Y, Olson L (1996) Spinal cord repair in adult paraplegic rats: partial restoration of hind limb function. Science 273:510-513.
5. Christensen MD, Hulsebosch CE (1997) Spinal cord injury and anti-NGF treatment results in changes in CGRP density and distribution in the dorsal horn in the rat. Exp Neurol 147:463-475.
6. Christensen MD, Supowit SC, DiPette DJ, Hulsebosch CE (1997) A study of upregulation of gene expression of CGRP and GAP-43 in dorsal root ganglia by spinal hemisection and nerve growth factor. Soc Neurosci Abstr 23:1721.
7. Clarke HA, Dekaban GA, Weaver LC (1998) Identification of lamina V and VII interneurons presynaptic to adrenal sympathetic preganglionic neurons in rats using a recombinant herpes simplex virus type 1. Neuroscience 85:863-872.
8. Cohen MJ, McArthur DL, Vulpe M, Schandler SL, Gerber KE (1988) Comparing chronic pain from spinal cord injury to chronic pain of other origins. Pain 35:57-63.
9. Conner JM, Varon S (1992) Distribution of nerve growth factor-like immunoreactive neurons in the adult rat brain following colchicine treatment. J Comp Neurol 326:347-362.
10. Constantinou J, Reynolds ML, Woolf CJ, Safieh-Garabedian B, Fitzgerald M (1994) Nerve growth factor levels in developing rat skin: upregulation following skin wounding. NeuroReport 5:2281-2284.
11. Diamond J, Holmes M, Coughlin M (1992) Endogenous NGF and nerve impulses regulate the collateral sprouting of sensory axons in the skin of the adult rat. J Neurosci 12:1454-1466.
12. Green SH, Rydel RE, Connolly JL, Greene LA (1986) PC12 cell mutants that possess low-but not high-affinity nerve growth factor receptors neither respond to nor internalize nerve growth factor. J Cell Biol 102:830-843.
13. Grill R, Murai K, Blesch A, Gage FH, Tuszynski MH (1997a) Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury. J Neurosci 17:5560-5572.
14. Grill RJ, Blesch A, Tuszynski MH (1997b) Robust growth of chronically injured spinal cord axons induced by grafts of genetically modified NGF-secreting cells. Exp Neurol 148:444-452.
15. Heumann R, Lindholm D, Bandtlow C, Meyer M, Radeke MJ, Misko TP, Shooter E, Thoenen H (1987) Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: Role of macrophages. Proc Natl Acad Sci USA 84:8735-8739.
16. Janig W (1996) Neurobiology of visceral afferent neurons: neuroanatomy, functions organ regulations and sensations. Biol Psychol 42:29-51.
17. Joshi S, LeVatte MA, Dekaban GA, Weaver LC (1995) Identification of spinal interneurons antecedent to adrenal sympathetic preganglionic neurons using trans-synaptic transport of herpes simplex virus type 1. Neuroscience 65:893-903.
18. Koizumi K, Collin R, Kaufman A, Brooks CM (1970) Contribution of unmyelinated afferent excitation to sympathetic reflexes. Brain Res 20:99-106.
19. Korsching S, Thoenen H (1983) Nerve growth factor in sympathetic ganglia and corresponding target organs of the rat: correlation with density of sympathetic innervation. Proc Natl Acad Sci USA 80:3513-3516.
20. Korsching S, Thoenen H (1985) Nerve growth factor supply for sensory neurons: site of origin and competition with the sympathetic nervous system. Neurosci Lett 54:201-205.
21. Krassioukov AV, Weaver LC (1995) Episodic hypertension due to autonomic dysreflexia in acute and chronic spinal cord-injured rats. Am J Physiol 268:H2077-H2083.
22. Krenz NR, Weaver LC (1998a) Astrocytes and macrophages are immunoreactive for nerve growth factor following spinal cord injury in rats. Soc Neurosci Abstr 24:743-743.
23. Krenz NR, Weaver LC (1998b) Sprouting of primary afferent fibers after spinal cord transection in the rat. Neuroscience 85:443-458.
24. Kruse MN, Belton AL, De Groat WC (1993) Changes in bladder and external urethral sphincter function after spinal cord injury in the rat. Am J Physiol 264:R1157-R1163.
25. Lee BY, Karmakar MG, Herz BL, Sturgill RA (1994) Autonomic dysreflexia revisited. J Spinal Cord Med 18:75-87.
26. Ma W, Ribeiro-Da-Silva A, Noel G, Julien J-P, Cuello AC (1995) Ectopic substance P and calcitonin gene-related peptide immunoreactive fibres in the spinal cord of transgenic mice over-expressing nerve growth factor. Eur J Neurosci 7:2021-2035.
27. Maiorov DN, Krenz NR, Krassioukov AV, Weaver LC (1997a) Role of spinal NMDA and AMPA receptors in episodic hypertension in conscious spinal rats. Am J Physiol 273:H1266-H1274.
28. Maiorov DN, Weaver LC, Krassioukov AV (1997b) Relationship between sympathetic activity and arterial pressure in conscious spinal rats. Am J Physiol 272:H625-H631.
29. Maiorov DN, Fehlings MG, Krassioukov AV (1998) Relationship between severity of spinal cord injury and abnormalities in neurogenic cardiovascular control in conscious rats. J Neurotrauma 15:365-374.
30. Mathias CJ, Frankel HL (1992) The cardiovascular system in tetraplegia and paraplegia. In: Handbook of clinical neurology (Frankel HL, ed), pp 435-456. London: Elsevier Science.
31. Mathias CJ, Frankel HL (1993) Autonomie disturbances in spinal cord lesions. In: Autonomic failure. A textbook of clinical disorders of the autonomic nervous system (Bannister R, Mathias CJ, eds), pp 839-881. Oxford: Oxford Medical.
32. McGuire EJ, Brady S (1979) Detrusor-sphincter dyssynergia. J Urol 121:774-777.
33. Meakin SO, MacDonald JIS (1998) A novel juxtamembrane deletion in rat TrkA blocks differentiative but not mitogenic cell signaling in response to nerve growth factor. J Neurochem 71:1875-1888.
34. Menei P, Montero-Menei C, Whittemore SR, Bunge RP, Bunge MB (1998) Schwann cells genetically modified to secrete human BDNF promote enhanced axonal regrowth across transected adult rat spinal cord. Eur J Neurosci 10:607-621.
35. Middleton JW, Siddall PJ, Walker S, Molloy AR, Rutkowski SB (1996) Intrathecal clonidine and baclophen in the management of spasticity and neuropathic pain following spinal cord injury: a case study. Arch Phys Med Rehabil 77:824-826.
36. Osborn JW, Taylor RF, Schramm LP (1990) Chronic cervical spinal cord injury and autonomie hyperreflexia in rats. Am J Physiol 258:R169-R174.
37. Pittam BS, Ewart WR, Appia F, Wingate DL (1988) Physiological enteric stimulation elicits cardiovascular reflexes in the rat. Am J Physiol 255:G319-G328.
38. Sato A, Schmidt RF (1973) Somatosympathetic reflexes: afferent fibers, central pathways, discharge characteristics. Physiol Rev 53:916-947.
39. Sharkey KA, Sobrino JA, Cervero F, Varro A, Dockray GJ (1989) Visceral and somatic afferent origin of calcitonin gene-related peptide immunoreactivity in the lower thoracic spinal cord of the rat. Neuroscience 32:169-179.
40. Shelton DL, Reichardt LF (1994) Expression of the β-nerve growth factor gene correlates with the density of sympathetic innervation in effector organs. Proc Natl Acad Sci USA 81:7951-7955.
41. Sokol RR, Rohlf FJ (1981) Biometry: the principles and practice of statistics in biological research. San Francisco: W.H. Freeman.
42. Tuszynski MH, Peterson DA, Ray J, Baird A, Nakahara Y, Gage FH (1994) Fibroblasts genetically modified to produce nerve growth factor induce robust neuritic ingrowth after grafting to the spinal cord. Exp Neurol 126:1-14.
43. Tuszynski MH, Gabriel K, Gage FH, Suhr S, Meyer S, Rosetti A (1996) Nerve growth factor delivery by gene transfer induces differential outgrowth of sensory, motor, and noradrenergic neurites after adult spinal cord injury. Exp Neurol 137:157-173.
44. Xu X-J, Hao J-X, Aldskogius H, Seiger A, Wiesenfeld-Hallin Z (1992) Chronic pain-related syndrome in rats after ischemic spinal cord lesion: a possible animal model for pain in patients with spinal cord injury. Pain 48:279-290.
45. Yezierski RP (1996) Pain following spinal cord injury: the clinical problem and experimental studies. Pain 68:185-194.