Biochemical and functional interactions between the neurotrophin receptors trk and p75(NTR)

EMBO Journal

Volumn 18, Issue 3, 1999, Pages 616-622

  Bibel, Miriam ^a   Hoppe, Edmund ^a,b   Barde, Yves Alain ^a  

^a MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^b SANOFI   (France)

Author keywords

BDNF; Neurotrophins; NT3; NT4; Receptors

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MEMBRANE RECEPTOR; NEUROTROPHIN 3; NEUROTROPHIN 4; NEUROTROPHIN RECEPTOR;

ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; DELETION MUTANT; GENE CONSTRUCT; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRECIPITATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION;

ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE; CHO CELLS; CRICETINAE; DNA PRIMERS; LIGANDS; MICE; PHOSPHORYLATION; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, CILIARY NEUROTROPHIC FACTOR; RECEPTOR, TRKA; RECEPTOR, TRKC; RECEPTORS, NERVE GROWTH FACTOR; SEQUENCE DELETION;

EID: 0033081042     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.3.616     Document Type: Article

References (42)

1. Bamji, S.X., Majdan, M., Pozniak, C.D., Belliveau, D.J., Aloyz, R., Kohn, J., Causing, C.G. and Miller, F.D. (1998) The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death. J. Cell Biol., 140, 911-923.
2. Barbacid, M. (1994) The trk family of neurotrophin receptors. J. Neurobiol., 25, 1386-1403.
3. LNTR reduces NGF binding to TrkA on PC12 cells. Neuron, 13, 203-215.
4. Benedetti, M., Levi, A. and Chao, M.V. (1993) Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness. Proc. Natl Acad. Sci. USA, 90, 7859-7863.
5. Bothwell, M. (1991) Keeping track of neurotrophin receptors. Cell, 65, 915-918.
6. Casaccia-Bonnefil, P., Carter, B.D., Dobrowsky, R.T. and Chao, M.V. (1996) Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Nature, 383, 716-719.
7. Chao, M.V. (1992) Neurotrophin receptors: a window into neuronal differentiation. Neuron, 9, 583-593.
8. Chao, M.V. and Hempstead, B.L. (1995) p75 and Trk: a two-receptor system. Trends Neurosci., 18, 321-326.
9. Chen, C. and Okayama, H. (1987) High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol., 7, 2745-2752.
10. Davey, F. and Davies, A.M. (1998) TrkB signalling inhibits p75-mediated apoptosis induced by nerve growth factor in embryonic proprioceptive neurons. Curr. Biol., 8, 915-918.
11. Davies, A.M., Lee, K.-F. and Jaenisch, R. (1993) p75-delicient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins. Neuron, 11, 565-574.
12. Dechant, G., Biffo, S., Okazawa, H., Kolbeck, R., Pottgiesser, J. and Barde, Y.-A. (1993) Expression and binding characteristics of the BDNF receptor chick trkB. Development, 119, 545-558.
13. NTR with Trk receptors. J. Biol. Chem., 270, 22135-22142.
14. Frade, J.M. and Barde, Y.-A. (1998) Microglia-derived nerve growth factor causes cell death in the developing retina. Neuron, 20, 35-41.
15. Frade, J.M. and Barde, Y.-A. (1999) Genetic evidence for cell death mediated by nerve growth factor and the neurotrophin receptor p75 in the developing mouse retina and spinal cord. Development, in press.
16. Frade, J.M., Rodríguez-Tébar, A. and Barde, Y.-A. (1996) Induction of cell death by endogenous nerve growth factor through its p75 receptor. Nature, 383, 166-168.
17. Gargano, N., Levi, A. and Alema, S. (1997) Modulation of nerve growth factor internalization by direct interaction between p75 and TrkA receptors. J. Neurosci. Res., 50, 1-12.
18. Graham, F.L., Smiley, J., Russell, W.C. and Nairn, R. (1977) Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol., 36, 59-72.
19. Hackett, S.F., Friedman, Z., Freund, J., Schoenfeld, C., Curtis, R., DiStefano, P.S. and Campochiaro, P.A. (1998) A splice variant of trkB and brain-derived neurotrophic factor are co-expressed in retinal pigmented epithelial cells and promote differentiated characteristics. Brain Res., 789, 201-212.
20. Hantzopoulos, P.A., Suri, C., Glass, D.J., Goldfarb, M.P. and Yancopoulos, G.D. (1994) The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins. Neuron, 13, 187-201.
21. Hempstead, B.L., Martin-Zanca, D., Kaplan, D.R., Parada, L.F. and Chao, M.V. (1991) High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor. Nature, 350, 678-683.
22. Horton, A., Laramee, G., Wyatt, S., Shih, A., Winslow, J. and Davies, A.M. (1997) NGF binding to p75 enhances the sensitivity of sensory and sympathetic neurons to NGF at different stages of development. Mol. Cell. Neurosci., 10, 162-172.
23. Huber, L.J. and Chao, M.V. (1995) A potential interaction of p75 and trkA NGF receptors revealed by affinity crosslinking and immunoprecipitation. J. Neurosci. Res., 40, 557-563.
24. Kaplan, D.R. and Miller, F.D. (1997) Signal transduction by the neurotrophin receptors. Curr. Opin. Cell Biol., 9, 213-221.
25. Kris, R.M., Lax, I., Gullick, W., Waterfield, M.D., Ullrich, A., Fridkin, M. and Schlessinger, J. (1985) Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbB protein. Cell, 40, 619-625.
26. Lee, K.-F., Li, E., Huber, L.J., Landis, S.C., Sharpe, A.H., Chao, M.V. and Jaenisch, R. (1992) Targeted mutation of the p75 low affinity NGF receptor gene leads to deficits in the peripheral sensory nervous system. Cell, 69, 737-749.
27. Lee, K.-F., Davies, A.M. and Jaenisch, R. (1994) p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF. Development, 120, 1027-1033.
28. Lewin, G.R. and Barde, Y.-A. (1996) Physiology of the neurotrophins. Annu. Rev. Neurosci., 19, 289-317.
29. MacPhee, I.J. and Barker, P.A. (1997) Brain-derived neurotrophic factor binding to the p75 neurotrophin receptor reduces TrkA signaling whereas increasing serine phosphorylation in the TrkA intracellular domain. J. Biol. Chem., 272, 23547-23551.
30. trk binding. Implications for multi-subunit polypeptide receptors. J. Biol. Chem., 269, 6884-6891.
31. Mayer, U., Pöschl, E., Nischt, R., Specks, U., Pan, T.-C., Chu, M.-L. and Timpl, R. (1994) Recombinant expression and properties of the Kunitz-type protease-inhibitor module from human type VI collagen α3 (VI) chain. Eur. J. Biochem., 225, 573-580.
32. Meakin, S.O. and Shooter, E.M. (1992) The nerve growth factor family of receptors. Trends Neurosci., 15, 323-331.
33. Rodriguez-Tébar, A. and Barde, Y.-A. (1988) Binding characteristics of brain-derived neurotrophic factor to its receptors on neurons from the chick embryo. J. Neurosci., 8, 3337-3342.
34. Ross, A.H., Daou, M.C., McKinnon, C.A., Condon, P.J., Lachyankar, M.B., Stephens, R.M., Kaplan, D.R. and Wolf, D.E. (1996) The neurotrophin receptor, gp75, forms a complex with the receptor tyrosine kinase TrkA. J. Cell Biol., 132, 945-953.
35. Rydén, M., Hempstead, B. and Ibáñez, C.F. (1997) Differential modulation of neuron survival during development by nerve growth factor binding to the p75 neurotrophin receptor. J. Biol. Chem., 272, 16322-16328.
36. Schröpel, A., von Schack, D., Dechant, G. and Barde, Y.-A. (1995) Early expression of the nerve growth factor receptor ctrkA in chick sympathetic and sensory ganglia. Mol. Cell. Neurosci., 6, 544-556.
37. Snider, W.D. (1994) Functions of the neurotrophins during nervous system development: What the knockouts are teaching us. Cell, 77, 627-638.
38. Strohmaier, C., Carter, B.D., Urfer, R., Barde, Y.-A. and Dechant, G. (1996) A splice variant of the neurotrophin receptor trkB with increased specificity for brain-derived neurotrophic factor. EMBO J., 15, 3332-3337.
39. Sutter, A., Riopelle, R.J., Harris-Warrick, R.M. and Shooter, E.M. (1979) Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells. J. Biol. Chem., 254, 5972-5982.
40. LNGFR regulates trk signal transduction and NGF-induced neuronal differentiation in MAH cells. Neuron, 12, 733-745.
41. Waterfield, M.D., Mayes, E.L., Stroobant, P., Bennet, P.L., Young, S., Goodfellow, P.N., Banting, G.S. and Ozanne, B. (1982) A monoclonal antibody to the human epidermal growth factor receptor. J. Cell. Biochem., 20, 149-161.
42. Wolf, D.E., McKinnon, C.A., Daou, M.-C., Stephens, R.M., Kaplan, D.R. and Ross, A.H. (1995) Interaction with TrkA immobilizes gp75 in the high affinity nerve growth factor receptor complex. J. Biol. Chem., 270, 2133-2138.