The 90-kDa ribosomal S6 kinase (pp90(rsk)) phosphorylates the N-terminal regulatory domain of IκBα and stimulates its degradation in vitro

Journal of Biological Chemistry

Volumn 272, Issue 34, 1997, Pages 21281-21288

  Ghoda, Lucy ^a   Lin, Xin ^b   Greene, Warner C ^b,c  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c GLADSTONE INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHORBOL ESTER; PHOSPHOTRANSFERASE; TRANSCRIPTION FACTOR;

AMINO TERMINAL SEQUENCE; ANTIBODY SPECIFICITY; ARTICLE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME PHOSPHORYLATION; GENE TARGETING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; RIBOSOME; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION REGULATION;

ANIMALS; DNA-BINDING PROTEINS; ENZYME ACTIVATION; ENZYME INDUCTION; GENE PRODUCTS, TAX; HUMANS; I-KAPPA B PROTEINS; NF-KAPPA B; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; RATS; RIBOSOMAL PROTEIN S6 KINASES; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR RELA; TUMOR CELLS, CULTURED;

EUKARYOTA;

EID: 0030851775     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.34.21281     Document Type: Article

References (47)

1. Beg, A. A., and Baldwin, A. J. (1993) Genes Dev. 7, 2064-2070
2. Verma, I. M., Stevenson, J. K., Schwarz, E. M., Van Antwerp, D., and Miyamoto, S. (1995) Genes Dev. 9, 2723-2725
3. Haskill, S., Beg, A. A., Tompkins, S. M., Morris, J. S., Yurochko, A. D., Sampson-Johannes, A., Mondal, K., Ralph, P., and Baldwin, A. S., Jr. (1991) Cell 65, 1281-1289
4. Baeuerle, P. A., and Baltimore, D. (1988) Cell 53, 211-217
5. Ganchi, P., Sun, S. C., Greene, W. C., and Ballard, D. W. (1992) Mol. Biol. Cell 3, 1339-1352
6. Beg, A. A., Ruben, S. M., Scheinman, R. I., Haskill, S., Rosen, C. A., and Baldwin, A. S., Jr. (1992) Genes Dev. 6, 1899-1913
7. Brown, K., Gerstberger, S., Carlson, L., Franzoso, G., and Siebenlist, U. (1995) Science 267, 1485-1488
8. Brockman, J. A., Scherer, D. C., McKinsey, T. A., Hall, S. M., Qi, X., Lee, W. Y., and Ballard, D. W. (1995) Mol. Cell. Biol. 15, 2809-2818
9. Traenckner, E. B., Pahl, H. L., Henkel, T., Schmidt, K. N., Wilk, S., and Baeuerle, P. A. (1995) EMBO J. 14, 2876-2883
10. Sun, S. C., Elwood, J., Béraud, C., and Greene, W. C. (1994) Mol. Cell. Biol. 14, 7377-7384
11. Chen, Z., Hagler, J., Palombella, V. J., Melandri, F., Scherer, D., Ballard, D., and Maniatis, T. (1995) Genes Dev. 9, 1586-1597
12. Baldi, L., Brown, K., Franzoso, G., and Siebenlist, U. (1996) J. Biol. Chem. 271, 376-379
13. Scherer, D. C., Brockman, J. A., Chen, Z., Maniatis, T., and Ballard, D. W. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 11259-11263
14. DiDonato, J. A., Mercurio, F., and Karin, M. (1995) Mol. Cell. Biol. 15, 1302-1311
15. Finco, T. S., Beg, A. A., and Baldwin, A. J. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 11884-11888
16. Lin, Y. C., Brown, K., and Siebenlist, U. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 552-556
17. Traenckner, E. B., Wilk, S., and Baeuerle, P. A. (1994) EMBO J. 13, 5433-5441
18. Whiteside, S. T., Ernst, M. K., LeBail, O., Laurent, W. C., Rice, N., and Israel, A. (1995) Mol. Cell. Biol. 15, 5339-5345
19. Steward, R., and Govind, S. (1993) Curr. Opin. Genet. Dev. 3, 556-561
20. Belvin, M. P., Jin, Y., and Anderson, K. V. (1995) Genes Dev. 9, 783-793
21. Cao, Z., Henzel, W. J., and Gao, X. (1996) Science 271, 1128-1131
22. Barroga, C. F., Stevenson, J. K., Schwarz, E. M., and Verma, I. M. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 7637-7641
23. Lin, R., Beauparlant, P., Makris, C., Meloche, S., and Hiscott, J. (1996) Mol. Cell. Biol. 16, 1401-1409
24. McElhinny, J. A., Trushin, S. A., Bren, G. D., Chester, N., and Paya, C. V. (1996) Mol. Cell. Biol. 16, 899-906
25. Chen, Z. J., Parent, L., and Maniatis, T. (1996) Cell 84, 853-862
26. Blenis, J. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 5889-5892
27. Sturgill, T. W., Ray, L. B., Erikson, E., and Mailer, J. L. (1988) Nature 334, 715-718
28. Schägger, H., and von Jagow, J. G. (1987) Anal. Biochem. 166, 368-379
29. Pearson, R. B., and Kemp, B. E. (1991) Methods Enzymol. 200, 62-81
30. Sun, S. C., Ganchi, P., Ballard, D. W., and Greene, W. C. (1993) Science 259, 1912-1915
31. Coux, O., Tanaka, K., and Goldberg, A. L. (1996) Annu. Rev. Biochem. 65, 801-848
32. Hermida-Matsumoto, M.-L., Chock, P. B., Curran, T., and Yang, D. C. H. (1996) J. Biol. Chem. 271, 4930-4936
33. Li, X., and Coffino, P. (1994) Mol. Cell. Biol. 14, 87-92
34. Loetscher, P., Pratt, G., and Rechsteiner, M. (1991) J. Biol. Chem. 266, 11213-11220
35. Lu, L., Stanley, B. A., and Pegg, A. E. (1991) Biochem. J. 277, 671-675
36. Papavassiliou, A. G., Treier, M., Chavrier, C., and Bohmann, D. (1992) Science 258, 1941-1944
37. Rosenberg, H. Y., Bercovich, Z., and Kahana, C. (1991) Biochem. J. 277, 683-685
38. Rosenberg, H. Y., Strumpf, D., and Kahana, C. (1991) Eur. J. Biochem. 197, 419-424
39. Gross, M. (1980) Mol. Cell. Biochem. 31, 25-36
40. Chen, R. H., Tung, R., Abate, C., and Blenis, J. (1993) Biochem. Soc. Trans. 21, 895-900
41. Hsiao, K. M., Chou, S. Y., Shih, S. J., and Ferrell, J. E., Jr. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 5480-5484
42. Davis, I. J., Hazel, T. G., Chen, R. H., Blenis, J., and Lau, L. F. (1993) Mol. Endocrinol. 7, 953-964
43. Fisher, T. L., and Blenis, J. (1996) Mol. Cell. Biol. 16, 1212-1219
44. Xing, J., Ginty, D. D., and Greenberg, M. E. (1996) Science 273, 959-963
45. Nakajima, T., Fukamizu, A., Takahashi, J., Gage, F. H., Fisher, T., Blenis, J., and Montminy, M. R. (1996) Cell 86, 465-474
46. DiDonato, J., Mercurio, F., Rosette, C., Wu, L. J., Suyang, H., Ghosh, S., and Karin M. (1996) Mol. Cell. Biol. 16, 1295-3104
47. Wettenhall, R. E. H., Erikson, E., and Maller, J. L. (1992) J. Biol. Chem. 287, 9021-9027