A second determinant of binding to the p75 neurotrophin receptor revealed by alanine-scanning mutagenesis of a conserved loop in nerve growth factor

Journal of Biological Chemistry

Volumn 272, Issue 52, 1997, Pages 33085-33091

  Rydén, Mikael ^a   Ibáñez, Carlos F ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; NERVE GROWTH FACTOR; NEUROTROPHIN; NEUROTROPHIN RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; EMBRYO; HYDROPHOBICITY; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; RECEPTOR BINDING; SYMPATHETIC GANGLION;

ALANINE; AMINO ACID SEQUENCE; ANIMALS; BACTERIAL PROTEINS; COMPUTER SIMULATION; CONSERVED SEQUENCE; DIMERIZATION; GANGLIA, SYMPATHETIC; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NERVE GROWTH FACTORS; PC12 CELLS; PROTEIN CONFORMATION; RATS; RECEPTOR, NERVE GROWTH FACTOR; RECEPTOR, TRKA; RECEPTORS, NERVE GROWTH FACTOR;

ANIMALIA;

EID: 0031468623     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.52.33085     Document Type: Article

References (25)

1. Ibáñez, C. F., Hökfelt, T., Oison, L., Fuxe, K., Jörnvall, H., and Ottoson, D. (eds) (1995) Life and Death in the Nervous System: Role of Neurotrophic Factors and Their Receptors, Vol. 67, Elsevier, Oxford
2. McDonald, N., Lapatto, R., Murray-Rust, J., Gunning, J., Wlodawer, A., and Blundell, T. (1991) Nature 354, 411-414
3. Ibáñez, C. F., Ebendal, T., and Persson, H. (1991) EMBO J. 10, 2105-2110
4. Rodriguez-Tébar, A., Dechant, G., and Barde, Y.-A. (1990) Neuron 4, 487-492
5. Rodriguez-Tébar, A., Dechant, G., Gotz, R., and Barde, Y.-A. (1992) EMBO J. 11, 917-922
6. Kaplan, D. R., and Stephens, R. M. (1994) J. Neurobiol. 25, 1404-1417
7. Chao, M. V., and Hempstead, B. L. (1995) Trends Neurosci. 18, 321-326
8. Rabizadeh, S., Oh, J., Zhong, L. T., Yang, J., Bitler, C. M., Butcher, L. L., and Bredesen, D. E. (1993) Science 261, 345-348
9. Casaccia-Bonnefil, P., Carter, B. D., Dobrowsky, R. T., and Chao, M. V. (1996) Nature 383, 716-719
10. Frade, J. M., Rodriguez-Tébar, A., and Barde, Y.-A. (1996) Nature 383, 166-168
11. Dechant, G., and Barde, Y.-A. (1997) Curr. Opin. Neurobiol. 7, 413-418
12. Dobrowsky, R., Werner, M., Castellino, A., Chao, M., and Hannun, Y. (1994) Science 265, 1596-1599
13. Dobrowsky, R. T., Jenkins, G. M., and Hannun, Y. A. (1995) J. Biol. Chem. 270, 22135-22142
14. Carter, B. D., Kaltschmidt, C., Kaltschmidt, B., Offenhäuser, N., Böhm-Matthaei, R., Baeuerle, P. A., and Barde, Y.-A. (1996) Science 272, 542-545
15. Ibáñez, C. F., Ilag, L. L., Murray-Rust, J., and Persson, H. (1993) EMBO J. 12, 2281-2293
16. Ibáñez, C. F., Ebendal, T., Barbany, G., Murray-Rust, J., Blundell, T. L., and Persson, H. (1992) Cell 69, 329-341
17. Rydén, M., Murray-Rust, J., Glass, D., Ilag, L. L., Trupp, M., Yancopoulos, G. D., McDonald, N. Q., and Ibáñez, C. F. (1995) EMBO J. 14, 1979-1990
18. Ibáñez, C. F., Hallböök, F., Ebendal, T., and Persson, H. (1990) EMBO J. 9, 1477-1483
19. Woo, S. B., Timm, D. E., and Neet, K. E. (1995) J. Biol. Chem. 270, 6278-6285
20. Ip, N. Y., Stitt, T. N., Tapley, P., Klein, R., Glass, D. J., Fandl, J., Greene, L. A., Barbacid, M., and Yancopoulos, G. D. (1993) Neuron 10, 137-149
21. Rydén, M., and Ibáñez, C. F. (1996) J. Biol. Chem. 271, 5623-5637
22. Ebendal, T. ( 1989) in Nerve Growth Factors (Rush, R. A., ed) Vol. 12, pp. 81-93, John Wiley & Sons Ltd., Chichester, England
23. Loeb, D., Maragos, J., Martin-Zanca, D., Chao, M., Parada, L., and Greene, L. (1991) Cell 66, 961-966
24. Urfer, R., Tsoulfas, P., Soppet, D., Escandón, E., Parada, L., and Presta, L. (1994) EMBO J. 13, 5896-5909
25. Kunkel, T. A. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 488-492