메뉴 건너뛰기




Volumn 16, Issue 11, 1997, Pages 3133-3144

IκBα is a target for the mitogen-activated 90 kDa ribosomal S6 kinase

Author keywords

Adenovirus EIA; I B ; NF B; Phosphorylation; RSK

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGENIC AGENT; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE INHIBITOR; SERINE; TRANSCRIPTION FACTOR; DNA BINDING PROTEIN; I KAPPA B; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN PRECURSOR; PROTEIN SERINE THREONINE KINASE; S6 KINASE;

EID: 0031007867     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.11.3133     Document Type: Article
Times cited : (209)

References (97)
  • 1
    • 0024439162 scopus 로고
    • Sequence and expression of chicken and mouse rsk: Homologs of Xenopus laevis ribosomal S6 kinase
    • Alcorta, D.A., Crews, C.M., Sweet, L.J., Bankston, L., Jones, S.W. and Erikson, R.L. (1989) Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase. Mol. Cell. Biol., 9, 3850-3859.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 3850-3859
    • Alcorta, D.A.1    Crews, C.M.2    Sweet, L.J.3    Bankston, L.4    Jones, S.W.5    Erikson, R.L.6
  • 2
    • 0028967819 scopus 로고
    • Inducible nuclear expression of newly synthesized IκBα negatively regulates DNA-binding and transcriptional activities of NFκB
    • Arenzana-Seisdedos, F., Thompson, J., Rodriguez, M.S., Bachelerie, F., Thomas, D. and Hay, R. (1995) Inducible nuclear expression of newly synthesized IκBα negatively regulates DNA-binding and transcriptional activities of NFκB. Mol. Cell. Biol., 15, 2689-2696.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2689-2696
    • Arenzana-Seisdedos, F.1    Thompson, J.2    Rodriguez, M.S.3    Bachelerie, F.4    Thomas, D.5    Hay, R.6
  • 3
    • 0028174061 scopus 로고
    • Function and activation of NFκB in the immune system
    • Baeuerle, P.A. and Henkel, T. (1994) Function and activation of NFκB in the immune system. Annu. Rev. Immunol., 12, 141-179.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 141-179
    • Baeuerle, P.A.1    Henkel, T.2
  • 6
    • 0029976817 scopus 로고    scopus 로고
    • An essential role tor NFκB in preventing TNF-α-induced cell death
    • Beg, A.A. and Baltimore, D. (1996) An essential role tor NFκB in preventing TNF-α-induced cell death. Science, 274, 782-784.
    • (1996) Science , vol.274 , pp. 782-784
    • Beg, A.A.1    Baltimore, D.2
  • 7
    • 0026783210 scopus 로고
    • IκB interacts with the nuclear localization sequences of the subunits of NFκB: A mechanism for cytoplasmic retention
    • Beg, A.A., Ruben, S.M., Scheinman, R.I., Haskill, S., Rosen, C.A. and Baldwin, A.S., Jr (1992) IκB interacts with the nuclear localization sequences of the subunits of NFκB: a mechanism for cytoplasmic retention. Genes Dev., 6, 1899-1913.
    • (1992) Genes Dev. , vol.6 , pp. 1899-1913
    • Beg, A.A.1    Ruben, S.M.2    Scheinman, R.I.3    Haskill, S.4    Rosen, C.A.5    Baldwin Jr., A.S.6
  • 8
    • 0025875225 scopus 로고
    • N-myc disrupts protein kinase C-mediated signal transduction in neuroblastoma
    • Bernards, R. (1991) N-myc disrupts protein kinase C-mediated signal transduction in neuroblastoma. EMBO J., 10, 1119-1125.
    • (1991) EMBO J. , vol.10 , pp. 1119-1125
    • Bernards, R.1
  • 9
    • 0028810979 scopus 로고
    • Insulin activates nuclear factor κB in mammalian cells through a Raf-1-mediated pathway
    • Bertrand, F., Philippe, C., Antoine, P.J., Baud, L., Groyer, A., Cepeau, J. and Cherqui, G. (1995) Insulin activates nuclear factor κB in mammalian cells through a Raf-1-mediated pathway. J. Biol. Chem., 270, 24435-24441.
    • (1995) J. Biol. Chem. , vol.270 , pp. 24435-24441
    • Bertrand, F.1    Philippe, C.2    Antoine, P.J.3    Baud, L.4    Groyer, A.5    Cepeau, J.6    Cherqui, G.7
  • 11
    • 0027233448 scopus 로고
    • Signal transduction via the MAP kinases: Proceed at your own RSK
    • Blenis, J. (1993) Signal transduction via the MAP kinases: proceed at your own RSK. Proc. Natl Acad. Sci. USA, 90, 5889-5892.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 5889-5892
    • Blenis, J.1
  • 12
    • 0027404184 scopus 로고
    • Mutational analysis of the p50 subunit of NFκB and inhibition of NFκB activity by trans-dominant p50 mutants
    • Bressler, P., Brown, K., Timmer, W., Bours, V., Siebenlist, U. and Fauci, A.S. (1993) Mutational analysis of the p50 subunit of NFκB and inhibition of NFκB activity by trans-dominant p50 mutants. J. Virol. 67, 288-293.
    • (1993) J. Virol. , vol.67 , pp. 288-293
    • Bressler, P.1    Brown, K.2    Timmer, W.3    Bours, V.4    Siebenlist, U.5    Fauci, A.S.6
  • 14
    • 0027462682 scopus 로고
    • Mutual regulation of the transcriptional activator NFκB and its inhibitor, IκBα
    • Brown, K., Park, S., Kanno, T., Fransozo, G. and Siebenlist, U. (1993) Mutual regulation of the transcriptional activator NFκB and its inhibitor, IκBα. Proc. Natl Acad. Sci. USA, 90, 2532-2536.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 2532-2536
    • Brown, K.1    Park, S.2    Kanno, T.3    Fransozo, G.4    Siebenlist, U.5
  • 15
    • 0028986075 scopus 로고
    • Control of IκBα proteolysis by site-specific, signal-induced phosphorylation
    • Brown, K., Gerstberger, S., Carlson, L., Fransozo, G. and Siebenlist, U. (1995) Control of IκBα proteolysis by site-specific, signal-induced phosphorylation. Science, 267, 1485-1488.
    • (1995) Science , vol.267 , pp. 1485-1488
    • Brown, K.1    Gerstberger, S.2    Carlson, L.3    Fransozo, G.4    Siebenlist, U.5
  • 16
    • 0026656506 scopus 로고
    • p105; the NFκB p50 precursor protein, is one of the cellular proteins complexed with the v-Rel oncoprotein in transformed chicken spleen cells
    • Capobianco, A.J., Chang, D., Mosialos, G. and Gilmore, T.D. (1992) p105; the NFκB p50 precursor protein, is one of the cellular proteins complexed with the v-Rel oncoprotein in transformed chicken spleen cells. J. Virol., 66, 3758-3767.
    • (1992) J. Virol. , vol.66 , pp. 3758-3767
    • Capobianco, A.J.1    Chang, D.2    Mosialos, G.3    Gilmore, T.D.4
  • 17
    • 0025282334 scopus 로고
    • Identification of Xenopus S6 protein kinase homologs (pp90rsk) in somatic cells: Phosphorylation and activation during initiation of cell proliferation
    • Chen, R.-H. and Blenis, J. (1990) Identification of Xenopus S6 protein kinase homologs (pp90rsk) in somatic cells: phosphorylation and activation during initiation of cell proliferation. Mol. Cell. Biol., 10, 3204-3215.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 3204-3215
    • Chen, R.-H.1    Blenis, J.2
  • 18
    • 0025924683 scopus 로고
    • Regulation of pp90rsk phosphorylation and S6 phosphotransferase activity in Swiss 3T3 cells by growth factor-, phorbol ester-, and cyclic AMP-mediated signal transduction
    • Chen, R.-H., Chung, J. and Blenis, J. (1991) Regulation of pp90rsk phosphorylation and S6 phosphotransferase activity in Swiss 3T3 cells by growth factor-, phorbol ester-, and cyclic AMP-mediated signal transduction. Mol. Cell. Biol., 11, 1861-1867.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 1861-1867
    • Chen, R.-H.1    Chung, J.2    Blenis, J.3
  • 19
    • 0026608787 scopus 로고
    • Nuclear localization and regulation of erk- and rsk-encoded protein kinases
    • Chen, R.-H., Sarnecki, C. and Blenis, J. (1992) Nuclear localization and regulation of erk- and rsk-encoded protein kinases. Mol. Cell. Biol., 12, 915-927.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 915-927
    • Chen, R.-H.1    Sarnecki, C.2    Blenis, J.3
  • 20
    • 0027361017 scopus 로고
    • Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase
    • Chen, R.-H., Abate, C. and Blenis, J. (1993) Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase. Proc. Natl Acad. Sci. USA, 90, 10952-10956.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 10952-10956
    • Chen, R.-H.1    Abate, C.2    Blenis, J.3
  • 21
    • 0029146930 scopus 로고
    • Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway
    • Chen, Z.J., Hagler, J., Palombella, V.J., Melandri, F., Scherer, D., Ballard, D. and Maniatis, T. (1995) Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway. Genes Dev., 9, 1586-1597.
    • (1995) Genes Dev. , vol.9 , pp. 1586-1597
    • Chen, Z.J.1    Hagler, J.2    Palombella, V.J.3    Melandri, F.4    Scherer, D.5    Ballard, D.6    Maniatis, T.7
  • 22
    • 0030004897 scopus 로고    scopus 로고
    • Site specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity
    • Chen, Z.J., Parent, L. and Maniatis, T. (1996) Site specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell, 84, 853-862.
    • (1996) Cell , vol.84 , pp. 853-862
    • Chen, Z.J.1    Parent, L.2    Maniatis, T.3
  • 23
    • 0025819209 scopus 로고
    • Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mkp from sea star oocytes and participate in the regulation of pp90 rsk activity
    • Chung, J., Pelech, S.L. and Blenis, J. (1991) Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mkp from sea star oocytes and participate in the regulation of pp90 rsk activity. Proc. Natl Acad. Sci. USA, 88, 4981-4985.
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 4981-4985
    • Chung, J.1    Pelech, S.L.2    Blenis, J.3
  • 24
    • 0026659046 scopus 로고
    • Rapamycin-FKBP specifically blocks growth-dependent activation of and signalling by the 70kd S6 protein kinases
    • Chung, J., Kuo, C.J., Crabtree, G.R. and Blenis, J. (1992) Rapamycin-FKBP specifically blocks growth-dependent activation of and signalling by the 70kd S6 protein kinases. Cell. 69, 1227-1236.
    • (1992) Cell. , vol.69 , pp. 1227-1236
    • Chung, J.1    Kuo, C.J.2    Crabtree, G.R.3    Blenis, J.4
  • 25
    • 0027363407 scopus 로고
    • NFκB activation by ultraviolet light not dependent on a nuclear signal
    • Devary, Y., Rosette, C., DiDonato, J.A. and Karin, M. (1993) NFκB activation by ultraviolet light not dependent on a nuclear signal. Science, 261, 1442-1445.
    • (1993) Science , vol.261 , pp. 1442-1445
    • Devary, Y.1    Rosette, C.2    DiDonato, J.A.3    Karin, M.4
  • 26
    • 0027295420 scopus 로고
    • A dominant negative protein kinase C ζ subspecies blocks NFκB activation
    • Diaz-Meco, M.T. et al. (1993) A dominant negative protein kinase C ζ subspecies blocks NFκB activation. Mol. Cell. Biol., 13, 4770-4775.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4770-4775
    • Diaz-Meco, M.T.1
  • 27
    • 0028176502 scopus 로고
    • ζ PKC induces phosphorylation and inactivation of IκBα in vitro
    • Diaz-Meco, M.T. et al. (1994) ζ PKC induces phosphorylation and inactivation of IκBα in vitro. EMBO J., 13, 1842-1848.
    • (1994) EMBO J. , vol.13 , pp. 1842-1848
    • Diaz-Meco, M.T.1
  • 28
    • 0028985190 scopus 로고
    • Phosphorylation of IκBα precedes but is not sufficient for its dissociation from NFκB
    • DiDonato, J., Mercurio, F. and Karin, M. (1995) Phosphorylation of IκBα precedes but is not sufficient for its dissociation from NFκB. Mol. Cell. Biol., 15, 1302-1311.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1302-1311
    • DiDonato, J.1    Mercurio, F.2    Karin, M.3
  • 29
    • 0029670083 scopus 로고    scopus 로고
    • Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation
    • DiDonato, J., Mercurio, F., Rosette, C., Wu-Li, J., Suyang, H., Ghosh, S. and Karin, M. (1996) Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation. Mol. Cell. Biol., 16, 1295-1304.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1295-1304
    • DiDonato, J.1    Mercurio, F.2    Rosette, C.3    Wu-Li, J.4    Suyang, H.5    Ghosh, S.6    Karin, M.7
  • 30
    • 0028170255 scopus 로고
    • Differential interactions of Rel-NFκB complexes with IκBα determine pools of constitutive and inducible NFκB activity
    • Dobrzanski, P., Ryseck, R.P. and Bravo, R. (1994) Differential interactions of Rel-NFκB complexes with IκBα determine pools of constitutive and inducible NFκB activity. EMBO J., 13, 4608-4616.
    • (1994) EMBO J. , vol.13 , pp. 4608-4616
    • Dobrzanski, P.1    Ryseck, R.P.2    Bravo, R.3
  • 31
    • 0022649274 scopus 로고
    • Purification and characterization of a protein kinase from Xenopus eggs highly specific for ribosomal protein S6
    • Erikson, E. and Maller, J.L. (1986) Purification and characterization of a protein kinase from Xenopus eggs highly specific for ribosomal protein S6. J. Biol. Chem., 261, 350-355.
    • (1986) J. Biol. Chem. , vol.261 , pp. 350-355
    • Erikson, E.1    Maller, J.L.2
  • 32
    • 0024240741 scopus 로고
    • Substrate specificity of ribosomal protein S6 kinase II from Xenopus eggs
    • Erikson, E. and Maller, J.L. (1988) Substrate specificity of ribosomal protein S6 kinase II from Xenopus eggs. Second Messenger Phosphoproteins, 2, 135-143.
    • (1988) Second Messenger Phosphoproteins , vol.2 , pp. 135-143
    • Erikson, E.1    Maller, J.L.2
  • 33
    • 0022340978 scopus 로고
    • Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product
    • Evan, G.I., Lewis, G.K., Ramsay, G. and Bishop, J.M. (1985) Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol. Cell. Biol:, 5, 3610-3616.
    • (1985) Mol. Cell. Biol , vol.5 , pp. 3610-3616
    • Evan, G.I.1    Lewis, G.K.2    Ramsay, G.3    Bishop, J.M.4
  • 34
    • 0026066613 scopus 로고
    • Generation of p50 subunit of NFκB by processing of p105 through an ATP-dependent pathway
    • Fan, C.M. and Maniatis, T. (1991) Generation of p50 subunit of NFκB by processing of p105 through an ATP-dependent pathway. Nature. 354, 395-398.
    • (1991) Nature , vol.354 , pp. 395-398
    • Fan, C.M.1    Maniatis, T.2
  • 35
    • 0027219329 scopus 로고
    • κB site-dependent induction of gene expression by diverse inducers of nuclear factor κB requires Raf-1
    • Finco, T.S. and Baldwin, A.S., Jr (1993) κB site-dependent induction of gene expression by diverse inducers of nuclear factor κB requires Raf-1. J. Biol. Chem., 268, 17676-17679.
    • (1993) J. Biol. Chem. , vol.268 , pp. 17676-17679
    • Finco, T.S.1    Baldwin Jr., A.S.2
  • 36
    • 0028172869 scopus 로고
    • Inducible phosphorylation of IκBα is not sufficient for its dissociation from NFκB and is inhibited by protease inhibitors
    • Finco, T.S., Beg, A.A. and Baldwin, A.S., Jr (1994) Inducible phosphorylation of IκBα is not sufficient for its dissociation from NFκB and is inhibited by protease inhibitors. Proc. Natl Acad. Sci. USA, 91, 11884-11888.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 11884-11888
    • Finco, T.S.1    Beg, A.A.2    Baldwin Jr., A.S.3
  • 37
    • 0030063435 scopus 로고    scopus 로고
    • Evidence for two catalytically active kinase domains in pp90rsk
    • Fisher, T.L. and Blenis, J. (1996) Evidence for two catalytically active kinase domains in pp90rsk. Mol. Cell. Biol., 16, 1212-1219.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1212-1219
    • Fisher, T.L.1    Blenis, J.2
  • 38
    • 0029984529 scopus 로고    scopus 로고
    • The ras-raf pathway is activated in human immunodeficiency virus-infected monocytes and participates in the activation of NFκB
    • Folgueira, L., Algeciras, A., MacMorran, W.S., Bren, G.D. and Paya, C.V. (1996) The ras-raf pathway is activated in human immunodeficiency virus-infected monocytes and participates in the activation of NFκB. J. Virol., 70, 2332-2338.
    • (1996) J. Virol. , vol.70 , pp. 2332-2338
    • Folgueira, L.1    Algeciras, A.2    MacMorran, W.S.3    Bren, G.D.4    Paya, C.V.5
  • 39
    • 0026758170 scopus 로고
    • The candidate oncoprotein Bcl-3 is an antagonist of p50/NFκB-mediated inhibition
    • Franzoso, G., Bours, V. Park, S., Tomita-Yamaguchi, M., Kelly, K. and Siebenlist, U. (1992) The candidate oncoprotein Bcl-3 is an antagonist of p50/NFκB-mediated inhibition. Nature, 359, 339-342.
    • (1992) Nature , vol.359 , pp. 339-342
    • Franzoso, G.1    Bours, V.2    Park, S.3    Tomita-Yamaguchi, M.4    Kelly, K.5    Siebenlist, U.6
  • 40
    • 0027232067 scopus 로고
    • NFκB and rel - Participants in a multiform transcriptional regulatory system
    • Grilli, M., Chiu, J.J.S. and Lenardo, M.J. (1993) NFκB and rel - participants in a multiform transcriptional regulatory system. Int. Rev. Cytol., 143, 1-62.
    • (1993) Int. Rev. Cytol. , vol.143 , pp. 1-62
    • Grilli, M.1    Chiu, J.J.S.2    Lenardo, M.J.3
  • 41
    • 0027328572 scopus 로고
    • Regulation of an epitope-tagged recombinant Rsk-1 S6 kinase by phorbol ester and erk/MAP kinase
    • Grove, J.R., Price, D.J., Banerjee, P., Balasubramanyam, A., Ahmad, M.F. and Avruch, J. (1993) Regulation of an epitope-tagged recombinant Rsk-1 S6 kinase by phorbol ester and erk/MAP kinase. Biochemistry, 32, 7727-7738.
    • (1993) Biochemistry , vol.32 , pp. 7727-7738
    • Grove, J.R.1    Price, D.J.2    Banerjee, P.3    Balasubramanyam, A.4    Ahmad, M.F.5    Avruch, J.6
  • 43
    • 0027165587 scopus 로고
    • Common structural constituents confer IκB activity to NFκB p105 and IκB/MAD-3
    • Hatada, E.N., Naumann, M. and Scheidereit, C. (1993) Common structural constituents confer IκB activity to NFκB p105 and IκB/MAD-3. EMBO J., 12, 2781-2788.
    • (1993) EMBO J. , vol.12 , pp. 2781-2788
    • Hatada, E.N.1    Naumann, M.2    Scheidereit, C.3
  • 44
    • 0027176524 scopus 로고
    • Rapid proteolysis of IκBα is necessary for activation of transcription factor NFκB
    • Henkel, T., Machleidt, T., Alkalay, I., Kronke, M., Ben-Neriah, Y. and Baeuerle, P.A. (1993) Rapid proteolysis of IκBα is necessary for activation of transcription factor NFκB. Nature, 365, 182-185.
    • (1993) Nature , vol.365 , pp. 182-185
    • Henkel, T.1    Machleidt, T.2    Alkalay, I.3    Kronke, M.4    Ben-Neriah, Y.5    Baeuerle, P.A.6
  • 45
    • 16044365828 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of IκBα activates NFκB without proteolytic degradation of IκBα
    • Imbert, V. et al. (1996) Tyrosine phosphorylation of IκBα activates NFκB without proteolytic degradation of IκBα. Cell, 86, 787-798.
    • (1996) Cell , vol.86 , pp. 787-798
    • Imbert, V.1
  • 46
    • 0026590966 scopus 로고
    • IκB-γ, a 70kD protein identical to the C-terminal half of p110 NFκB: A new member of the IκB-family
    • Inoue, J., Kerr, L.D., Kakizuka, A. and Verma, I.M. (1992) IκB-γ, a 70kD protein identical to the C-terminal half of p110 NFκB: a new member of the IκB-family. Cell. 68,1109-1120.
    • (1992) Cell , vol.68 , pp. 1109-1120
    • Inoue, J.1    Kerr, L.D.2    Kakizuka, A.3    Verma, I.M.4
  • 47
    • 0029002899 scopus 로고
    • A role for phosphorylation and degradation in the control of NFκB activity
    • Israël, A. (1995) A role for phosphorylation and degradation in the control of NFκB activity. Trends Genet., 11, 203-205.
    • (1995) Trends Genet. , vol.11 , pp. 203-205
    • Israël, A.1
  • 49
    • 0025945893 scopus 로고
    • The Rel-associated pp40 protein prevents DNA binding of rel and NFκB - Relationship with IκBβ and regulation by phosphorylation
    • Kerr, L.D., Inoue, J.I., Davis, N., Link, E., Baeuerle, P.A., Bose, H.R., Jr and Verma, I.M. (1991) The Rel-associated pp40 protein prevents DNA binding of rel and NFκB - relationship with IκBβ and regulation by phosphorylation. Genes Dev., 5, 1464-1476.
    • (1991) Genes Dev. , vol.5 , pp. 1464-1476
    • Kerr, L.D.1    Inoue, J.I.2    Davis, N.3    Link, E.4    Baeuerle, P.A.5    Bose Jr., H.R.6    Verma, I.M.7
  • 50
    • 0028332026 scopus 로고
    • Double-stranded RNA-dependent protein kinase activates transcription factor NFκB by phosphorylating IκB
    • Kumar, A., Haque, J., Lacoste, J., Hiscott, J. and Williams, B.R. (1994) Double-stranded RNA-dependent protein kinase activates transcription factor NFκB by phosphorylating IκB. Proc. Natl Acad. Sci. USA, 91, 6288-6292.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 6288-6292
    • Kumar, A.1    Haque, J.2    Lacoste, J.3    Hiscott, J.4    Williams, B.R.5
  • 51
    • 0027970168 scopus 로고
    • CD28 signaling causes a sustained down-regulation of IκBα which can be prevented by the immunosuppressant rapamycin
    • Lai, J.H. and Tan, T.H. (1994) CD28 signaling causes a sustained down-regulation of IκBα which can be prevented by the immunosuppressant rapamycin. J. Biol. Chem., 269, 30077-30080.
    • (1994) J. Biol. Chem. , vol.269 , pp. 30077-30080
    • Lai, J.H.1    Tan, T.H.2
  • 52
    • 0027482547 scopus 로고
    • Raf-1 protein kinase activates the NFκB transcription factor by dissociating the cytoplasmic NFκB-IκB complex
    • Li, S. and Sedivy, J.M. (1993) Raf-1 protein kinase activates the NFκB transcription factor by dissociating the cytoplasmic NFκB-IκB complex. Proc. Natl Acad. Sci. USA, 90, 9247-9251.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 9247-9251
    • Li, S.1    Sedivy, J.M.2
  • 53
    • 0029670085 scopus 로고    scopus 로고
    • Phosphorylation of IκBα in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability
    • Lin, R., Beauparlant, P., Makris, C., Meloche, S. and Hiscott, J. (1996) Phosphorylation of IκBα in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability. Mol. Cell. Biol., 16, 1401-1409.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1401-1409
    • Lin, R.1    Beauparlant, P.2    Makris, C.3    Meloche, S.4    Hiscott, J.5
  • 54
    • 0028981050 scopus 로고
    • Activation of NFκB requires proteolysis of the inhibitor IκBα: Signal-induced phosphorylation of IκBα alone does not release active NFκB
    • Lin, Y.C., Brown, K. and Siebenlist, U. (1995) Activation of NFκB requires proteolysis of the inhibitor IκBα: signal-induced phosphorylation of IκBα alone does not release active NFκB. Proc. Natl Acad. Sci. USA, 92, 552-556.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 552-556
    • Lin, Y.C.1    Brown, K.2    Siebenlist, U.3
  • 56
    • 0026740422 scopus 로고
    • The NFκB p50 precursor, p105, contains an internal IκB like inhibitor that preferentially inhibits p50
    • Liou, H.C., Nolan, G.P., Ghosh, S., Fujita, T. and Baltimore, D. (1992) The NFκB p50 precursor, p105, contains an internal IκB like inhibitor that preferentially inhibits p50. EMBO J., 11, 3003-3009.
    • (1992) EMBO J. , vol.11 , pp. 3003-3009
    • Liou, H.C.1    Nolan, G.P.2    Ghosh, S.3    Fujita, T.4    Baltimore, D.5
  • 57
    • 0030298294 scopus 로고    scopus 로고
    • Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NFκB activation prevents cell death
    • Liu, Z.-G., Hsu, H., Goeddel, D.V. and Karin, M. (1996) Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NFκB activation prevents cell death. Cell, 87, 565-576.
    • (1996) Cell , vol.87 , pp. 565-576
    • Liu, Z.-G.1    Hsu, H.2    Goeddel, D.V.3    Karin, M.4
  • 58
    • 0025732842 scopus 로고
    • Inhibition of transcription factors belonging to the rel/NFκB family by a transdominant negative mutant
    • Logeat, F., Israël, N., Ten, R., Blank, V., Le Bail, O., Kourilsky, P. and Israël, A. (1991) Inhibition of transcription factors belonging to the rel/NFκB family by a transdominant negative mutant. EMBO J., 10, 1827-1832.
    • (1991) EMBO J. , vol.10 , pp. 1827-1832
    • Logeat, F.1    Israël, N.2    Ten, R.3    Blank, V.4    Le Bail, O.5    Kourilsky, P.6    Israël, A.7
  • 59
    • 0029866197 scopus 로고    scopus 로고
    • Phosphorylation of p105 PEST sequence via a redox-insensitive pathway up-regulates processing of p50-NFκB
    • MacKichan, M.L., Logeat, F. and Israël, A. (1996) Phosphorylation of p105 PEST sequence via a redox-insensitive pathway up-regulates processing of p50-NFκB. J. Biol. Chem., 271, 6084-6091.
    • (1996) J. Biol. Chem. , vol.271 , pp. 6084-6091
    • MacKichan, M.L.1    Logeat, F.2    Israël, A.3
  • 61
    • 0030022860 scopus 로고    scopus 로고
    • Casein kinase II phosphorylates IκBα at S-283, S-289, S-293, and T-291 and is required for its degradation
    • McElhinny, J.A., Trushin, S.A., Bren, G.D., Chester, N. and Paya, C.V. (1996) Casein kinase II phosphorylates IκBα at S-283, S-289, S-293, and T-291 and is required for its degradation. Mol. Cell. Biol., 16, 899-906.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 899-906
    • McElhinny, J.A.1    Trushin, S.A.2    Bren, G.D.3    Chester, N.4    Paya, C.V.5
  • 62
    • 0027520473 scopus 로고
    • Proteolytic degradation of MAD3 (IκBα) and enhanced processing of the NFκB precursor p105 are obligatory steps in the activation of NFκB
    • Mellits, K.H., Hay, R.T. and Goodbourn, S. (1993) Proteolytic degradation of MAD3 (IκBα) and enhanced processing of the NFκB precursor p105 are obligatory steps in the activation of NFκB. Nucleic Acids Res., 21, 5059-5066.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 5059-5066
    • Mellits, K.H.1    Hay, R.T.2    Goodbourn, S.3
  • 63
    • 0027095797 scopus 로고
    • Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44 mapk
    • Meloche, S., Pages, G. and Pouysségur, J. (1992) Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44 mapk. Mol. Biol. Cell, 3, 63-71.
    • (1992) Mol. Biol. Cell , vol.3 , pp. 63-71
    • Meloche, S.1    Pages, G.2    Pouysségur, J.3
  • 64
    • 0027243576 scopus 로고
    • p105 and p98 proteins play an active role in NFκB-mediated signal transduction
    • Mercurio, F., DiDonato, J.A., Rosette, C. and Karin, M. (1993) p105 and p98 proteins play an active role in NFκB-mediated signal transduction. Genes Dev., 7, 705-718.
    • (1993) Genes Dev. , vol.7 , pp. 705-718
    • Mercurio, F.1    DiDonato, J.A.2    Rosette, C.3    Karin, M.4
  • 65
    • 0028557348 scopus 로고
    • Qualitative changes in the subunit composition of κB binding complexes during murine B cell differentiation
    • Miyamoto, S., Maki, M., Schmitt, M.J., Hatanaka, M. and Verma, I.M. (1994) Qualitative changes in the subunit composition of κB binding complexes during murine B cell differentiation. Proc. Natl Acad. Sci. USA, 91, 12740-12744.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 12740-12744
    • Miyamoto, S.1    Maki, M.2    Schmitt, M.J.3    Hatanaka, M.4    Verma, I.M.5
  • 66
    • 0028217280 scopus 로고
    • Human rsk isoforms: Cloning and characterization of tissue-specific expression
    • Moller, D.E., Xia, C.-H., Tang, W., Zhu, A.X. and Jakubowski, M. (1994) Human rsk isoforms: cloning and characterization of tissue-specific expression. Am. J. Physiol., 266, 351-359.
    • (1994) Am. J. Physiol. , vol.266 , pp. 351-359
    • Moller, D.E.1    Xia, C.-H.2    Tang, W.3    Zhu, A.X.4    Jakubowski, M.5
  • 67
    • 0028170265 scopus 로고
    • Activation of NFκB in vivo is regulated by multiple phosphorylations
    • Naumann, M. and Scheidereit, C. (1994) Activation of NFκB in vivo is regulated by multiple phosphorylations. EMBO J., 13, 4597-1607.
    • (1994) EMBO J. , vol.13 , pp. 4597-11607
    • Naumann, M.1    Scheidereit, C.2
  • 68
    • 0027472317 scopus 로고
    • The NFκB precursor p105 and the proto-oncogene product Bcl-3 are IκB molecules and control nuclear translocation of NFκB
    • Naumann, M., Wulczyn, F.G. and Scheidereit, C. (1993) The NFκB precursor p105 and the proto-oncogene product Bcl-3 are IκB molecules and control nuclear translocation of NFκB. EMBO J., 12, 213-222.
    • (1993) EMBO J. , vol.12 , pp. 213-222
    • Naumann, M.1    Wulczyn, F.G.2    Scheidereit, C.3
  • 70
    • 0027980321 scopus 로고
    • The ubiquitin-proteasome pathway is required for processing the NFκB1 precursor protein and the activation of NFκB
    • Palombella, V.J., Rando, O.J., Goldberg, A.L. and Maniatis, T. (1994) The ubiquitin-proteasome pathway is required for processing the NFκB1 precursor protein and the activation of NFκB. Cell, 78, 773-785.
    • (1994) Cell , vol.78 , pp. 773-785
    • Palombella, V.J.1    Rando, O.J.2    Goldberg, A.L.3    Maniatis, T.4
  • 71
    • 0025113220 scopus 로고
    • Casein kinase 2: An 'eminence grise' in cellular regulation? Biochim
    • Pinna, L.A. (1990) Casein kinase 2: an 'eminence grise' in cellular regulation? Biochim. Biophys. Acta, 1054, 267-284.
    • (1990) Biophys. Acta , vol.1054 , pp. 267-284
    • Pinna, L.A.1
  • 72
    • 0026759874 scopus 로고
    • Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase
    • Price, D.J., Grove, J.R., Calvo, V., Avruch, J. and Bierer, B.E. (1992) Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Science, 257, 973-977.
    • (1992) Science , vol.257 , pp. 973-977
    • Price, D.J.1    Grove, J.R.2    Calvo, V.3    Avruch, J.4    Bierer, B.E.5
  • 73
    • 0027451924 scopus 로고
    • In vivo control of NFκB activation by IκBα
    • Rice, N.R. and Ernst, M.K. (1993) In vivo control of NFκB activation by IκBα. EMBO J., 12, 4685-4695.
    • (1993) EMBO J. , vol.12 , pp. 4685-4695
    • Rice, N.R.1    Ernst, M.K.2
  • 74
    • 0026742527 scopus 로고
    • The precursor of NFκB p50 has IκBα-like functions
    • Rice, N.R., MacKichan, M.L. and Israël, A. (1992) The precursor of NFκB p50 has IκBα-like functions. Cell, 71, 243-253.
    • (1992) Cell , vol.71 , pp. 243-253
    • Rice, N.R.1    MacKichan, M.L.2    Israël, A.3
  • 75
    • 0027385031 scopus 로고
    • A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA binding activity
    • Rivera, V.M., Miranti, C.K., Misra, R.P., Ginty, D.D., Chen, R.-H., Blenis, J. and Greenberg, M.E. (1993) A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA binding activity. Mol. Cell. Biol., 13, 6260-6273.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 6260-6273
    • Rivera, V.M.1    Miranti, C.K.2    Misra, R.P.3    Ginty, D.D.4    Chen, R.-H.5    Blenis, J.6    Greenberg, M.E.7
  • 77
    • 0027439305 scopus 로고
    • NFκB p100 (lyt-10) is a component of H2TF1 and can function as an IκBα-like molecule
    • Scheinman, R.I., Beg, A.A. and Baldwin, A.S., Jr (1993) NFκB p100 (lyt-10) is a component of H2TF1 and can function as an IκBα-like molecule. Mol. Cell. Biol., 13, 6089-6101.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 6089-6101
    • Scheinman, R.I.1    Beg, A.A.2    Baldwin Jr., A.S.3
  • 78
    • 0028938175 scopus 로고
    • Downregulation of MHC class I expression due to interference with p105-NFκB1 processing by Ad12E1A
    • Schouten, G.J., van der Eb, A.J. and Zantema, A. (1995) Downregulation of MHC class I expression due to interference with p105-NFκB1 processing by Ad12E1A. EMBO J., 14, 1498-1507.
    • (1995) EMBO J. , vol.14 , pp. 1498-1507
    • Schouten, G.J.1    Van Der Eb, A.J.2    Zantema, A.3
  • 79
    • 0029665597 scopus 로고    scopus 로고
    • Constitutive phosphorylation of IκBα by casein kinase II occurs preferentially at serine 293: Requirement for degradation of free IκBα
    • Schwarz, E.M., van Antwerp, D. and Verma, I.M. (1996) Constitutive phosphorylation of IκBα by casein kinase II occurs preferentially at serine 293: requirement for degradation of free IκBα. Mol. Cell. Biol., 16, 3554-3559.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3554-3559
    • Schwarz, E.M.1    Van Antwerp, D.2    Verma, I.M.3
  • 82
    • 0023766145 scopus 로고
    • Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II
    • Sturgill, T.W., Ray, L.B., Erikson, E. and Maller, J.L. (1988) Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II. Nature, 334, 715-718.
    • (1988) Nature , vol.334 , pp. 715-718
    • Sturgill, T.W.1    Ray, L.B.2    Erikson, E.3    Maller, J.L.4
  • 83
    • 0026725026 scopus 로고
    • Rapid induction in regenerating liver of RL/IF-1 (an IκB that inhibits NFκB, Rel B-p50, and c-Rel-p50) and PHF, a novel κB site-binding complex
    • Tewari, M., Dobrzanski, P., Mohn, K., Cressman, D.E., Hsu, J.C., Bravo, R. and Taub, R. (1992) Rapid induction in regenerating liver of RL/IF-1 (an IκB that inhibits NFκB, Rel B-p50, and c-Rel-p50) and PHF, a novel κB site-binding complex. Mol. Cell. Biol., 12, 2898-2908.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 2898-2908
    • Tewari, M.1    Dobrzanski, P.2    Mohn, K.3    Cressman, D.E.4    Hsu, J.C.5    Bravo, R.6    Taub, R.7
  • 84
    • 0028986193 scopus 로고
    • NFκB: A lesson in family values
    • Thanos, D. and Maniatis, T. (1995) NFκB: a lesson in family values. Cell, 80, 529-532.
    • (1995) Cell , vol.80 , pp. 529-532
    • Thanos, D.1    Maniatis, T.2
  • 85
    • 0027786823 scopus 로고
    • p70 S6K/p85 S6K: Mechanism of activation, effects of rapamycin and role in mitogenesis
    • Thomas, G. (1993) p70 S6K/p85 S6K: mechanism of activation, effects of rapamycin and role in mitogenesis. Biochem. Soc. Trans., 21, 901-904.
    • (1993) Biochem. Soc. Trans. , vol.21 , pp. 901-904
    • Thomas, G.1
  • 86
    • 0028986194 scopus 로고
    • IκBβ regulates the persistent response in a biphasic activation of NFκB
    • Thompson, J.E., Phillips, R.J., Erdjument-Bromage, H., Tempst, P. and Ghosh, S. (1995) IκBβ regulates the persistent response in a biphasic activation of NFκB. Cell, 80, 573-582.
    • (1995) Cell , vol.80 , pp. 573-582
    • Thompson, J.E.1    Phillips, R.J.2    Erdjument-Bromage, H.3    Tempst, P.4    Ghosh, S.5
  • 87
    • 0028148227 scopus 로고
    • A proteasome inhibitor prevents activation of NFκB and stabilizes a newly phosphorylated form of IκBα that is still bound to NFκB
    • Traenckner, E.B.M., Wilk, S. and Baeuerle, P.A. (1994) A proteasome inhibitor prevents activation of NFκB and stabilizes a newly phosphorylated form of IκBα that is still bound to NFκB. EMBO J., 13, 5433-5441.
    • (1994) EMBO J. , vol.13 , pp. 5433-5441
    • Traenckner, E.B.M.1    Wilk, S.2    Baeuerle, P.A.3
  • 88
    • 0028978032 scopus 로고
    • Phosphorylation of human IκBα on serines 32 and 36 controls IκBα proteolysis and NFκB activation in response to diverse stimuli
    • Traenckner, E.B.M., Pahl, H.L., Henkel, T., Schmidt, K.N., Wilk, S. and Baeuerle, P.A. (1995) Phosphorylation of human IκBα on serines 32 and 36 controls IκBα proteolysis and NFκB activation in response to diverse stimuli. EMBO J., 14, 2876-2883.
    • (1995) EMBO J. , vol.14 , pp. 2876-2883
    • Traenckner, E.B.M.1    Pahl, H.L.2    Henkel, T.3    Schmidt, K.N.4    Wilk, S.5    Baeuerle, P.A.6
  • 89
    • 0027742184 scopus 로고
    • Distinct roles for cyclin dependent kinases in cell cycle control
    • van den Heuvel, S. and Harlow, E. (1993) Distinct roles for cyclin dependent kinases in cell cycle control. Science, 262, 2050-2054.
    • (1993) Science , vol.262 , pp. 2050-2054
    • Van Den Heuvel, S.1    Harlow, E.2
  • 90
    • 0018815076 scopus 로고
    • Assay of transforming activity of tumor virus DNA
    • van der Eb, A.J. and Graham, F.L. (1980) Assay of transforming activity of tumor virus DNA. Methods Enzymol., 65, 826-839.
    • (1980) Methods Enzymol. , vol.65 , pp. 826-839
    • Van Der Eb, A.J.1    Graham, F.L.2
  • 92
    • 0029122799 scopus 로고
    • N- and C-terminal sequences control degradation of MAD3/IκBα in response to inducers of NFκB activity
    • Whiteside, S.T., Ernst, M.K., LeBail, O., Laurent-Winter, C., Rice, N. and Israël, A. (1995) N- and C-terminal sequences control degradation of MAD3/IκBα in response to inducers of NFκB activity. Mol. Cell. Biol., 15, 5339-5345.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 5339-5345
    • Whiteside, S.T.1    Ernst, M.K.2    LeBail, O.3    Laurent-Winter, C.4    Rice, N.5    Israël, A.6
  • 94
    • 0029814063 scopus 로고    scopus 로고
    • Inhibiton of NFκB/Rel induces apoptosis of murine B cells
    • Wu, M. et al. (1996) Inhibiton of NFκB/Rel induces apoptosis of murine B cells. EMBO J., 15, 4682-4690.
    • (1996) EMBO J. , vol.15 , pp. 4682-4690
    • Wu, M.1
  • 95
    • 0026783677 scopus 로고
    • Candidate protooncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NFκB
    • Wulczyn, F.G., Naumann, M. and Scheidereit, C. (1992) Candidate protooncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NFκB. Nature, 358, 597-599.
    • (1992) Nature , vol.358 , pp. 597-599
    • Wulczyn, F.G.1    Naumann, M.2    Scheidereit, C.3
  • 96
    • 0029789643 scopus 로고    scopus 로고
    • Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase
    • Xing, J., Ginty, D.D. and Greenberg, M.E. (1996) Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science, 273, 959-963.
    • (1996) Science , vol.273 , pp. 959-963
    • Xing, J.1    Ginty, D.D.2    Greenberg, M.E.3
  • 97
    • 0029007314 scopus 로고
    • RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: Growth factor-stimulated kinase function and nuclear translocation
    • Zhao, Y., Bjorbaek, C., Weremowicz, S., Morton, C. and Moller, D.E. (1995) RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation. Mol. Cell. Biol., 15, 4353-4363.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 4353-4363
    • Zhao, Y.1    Bjorbaek, C.2    Weremowicz, S.3    Morton, C.4    Moller, D.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.