Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease

Dementia and Geriatric Cognitive Disorders

Volumn 9, Issue 5, 1998, Pages 246-257

  Jönhagen, Maria Eriksdotter ^a   Nordberg, Agneta ^a   Amberla, Kaarina ^a   Bäckman, Lars ^a   Ebendal, Ted ^b   Meyerson, Björn ^a   Olson, Lars ^c   Seiger, Åke ^a   Shigeta, Masahiro ^e   Theodorsson, Elvar ^d   Viitanen, Malti ^a   Winblad, Bengt ^a   Wahlund, Lars Olof ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

^d LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^e JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Alzheimer's disease; Cognitive deficits; Electroencephalography; Nerve growth factor; Nicotinic receptors; Pain; Positron emission tomography; Weight loss

Indexed keywords

NERVE GROWTH FACTOR; NEUROTROPHIC FACTOR; NICOTINE;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BACKACHE; BRAIN REGION; CASE REPORT; CHOLINERGIC NERVE CELL; CLINICAL FEATURE; ELECTROENCEPHALOGRAPHY; FEMALE; HIPPOCAMPUS; HUMAN; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; LATERAL BRAIN VENTRICLE; MALE; NEUROPHYSIOLOGY; NEUROPSYCHOLOGICAL TEST; NEURORADIOLOGY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SIDE EFFECT; TIME; TREATMENT OUTCOME; WEIGHT GAIN; WEIGHT REDUCTION;

AGED; ALPHA RHYTHM; ALZHEIMER DISEASE; BRAIN; CARBON RADIOISOTOPES; CEREBROVASCULAR CIRCULATION; COGNITION DISORDERS; FEMALE; GLUCOSE; HUMANS; INJECTIONS, INTRAVENTRICULAR; MALE; MIDDLE AGED; NERVE GROWTH FACTORS; NEUROPSYCHOLOGICAL TESTS; NICOTINE; NICOTINIC AGONISTS; PILOT PROJECTS; THETA RHYTHM; TOMOGRAPHY, EMISSION-COMPUTED; WEIGHT LOSS;

EID: 0005868926     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000017069     Document Type: Article

References (56)

1. Levi-Montalcini R: The nerve growth factor 35 years later. Science 1987;237:1154-1162.
2. Olson L, Backlund EO, Ebendal T, Freedman R, Hamberger B, Hansson P, Hoffer B, Lindblom U, Meyerson B, Strömberg I, Sydow O, Seiger Å: Intraputaminal infusion of nerve growth factor to support adrenal medullary autografts in Parkinson's disease: One-year follow-up of first clinical trial. Arch Neurol 1991; 48:373-381.
3. Sydow O, Hansson P, Young D, Meyerson B, Backlund E-O, Ebendal T, Farnebo L-O, Freedman R, Hamberger B, Hoffer B, Seiger Å, Strömberg I, Olson L: Long-term beneficial effects of adrenal medullary autografts supported by nerve growth factor in Parkinson's disease. Eur J Neurol 1995;2:445-454.
4. Ebendal T: NGF in CNS: Experimental data and clinical implications. Prog Growth Factor Res 1989;1:143-159.
5. Kordower J, Gash D, Bothwell M, Hersh L, Mufson E: Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer patients. Neurobiol Aging 1989;10:67-74.
6. Fischer W, Wiktorin K, Björklund A, Williams LR, Varon S, Gage FH: Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature 1987;329:65-68.
7. Hefti F, Hartikka J, Knusel B: Function of neurotrophic factors in the adult and aging brain and their possible uses in the treatment of neurodegenerative diseases. Neurobiol Aging 1989;10:515-533.
8. Olson L: NGF and the treatment of Alzheimer's disease. Exp Neurol 1993;124:5-15.
9. Chen KS, Nishimura MC, Armanini MP, Crowley C, Spencer SD, Phillips HS: Disruption of a single allele of the nerve growth factor gene results in atrophy of basal forebrain cholinergic neurons and memory deficits. J Neurosci 1997;17:7288-7296.
10. Greitz D, Hannerz J: A proposed model for the CSF-circulation, based on observations with radionuclide cisternography and previous MRI studies. Am J Neuroradiol 1996;17:431-438.
11. 11C-nicotine binding, blood flow, EEG, and verbal episodic memory in an Alzheimer patient (case report). J Neural Transm 1992;4: 79-95.
12. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, ed 3, rev. Washington, American Psychiatric Association, 1987.
13. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 1984;34:939-944.
14. Folstein MF, Folstein SE, McHugh PR: Mini-mental state: A practical method for grading the cognitive state of the patient for the clinician. J Psychiatr Res 1975;12:189-198.
15. Ebendal T, Olson L, Seiger Å, Belew M: Nerve growth factor in chick and rat tissues: in Black IB (ed): Cellular and Molecular Biology of Neuronal Development. New York, Plenum Press, 1984, pp 231-242.
16. Söderström S, Hallböök F, Ibanez CF, Persson H, Ebendal T: Recombinant human β-nerve growth factor (NGF): Biological activity and properties in an enzyme immunoassay. J Neurosci Res 1990;27:665-667.
17. Theodorsson-Norheim E, Hemsén A, Brodin E, Lundberg JM: Sample handling techniques when analyzing regulatory peptides. Life Sci 1987;41:845-848.
18. Brodin E, Lindefors N, Theodorsson-Norheim E, Rosell S: Tachykinin multiplicity in rat central nervous system as studied using antisera raised against substance P and neurokinin A. Regul Peptides 1986;13:253-272.
19. Bäckman L: Adult age differences in cross-modal recoding and mental tempo and older adults utilization of compensatory task conditions. Exp Aging Res 1986;12:135-140.
20. Buschke H: Selective reminding for analysis of memory and learning. J Verb Learn Verb Behav 1973;12:543-550.
21. Bäckman L: Recognition memory across the adult life span: The role of prior knowledge. Mem Cogn 1991;19:63-71.
22. Sharps MJ, Gollin ES: Memory for object locations in young and elderly adults. J Gerontol 1987;42:336-341.
23. Wechsler D: WAIS-R manual. New York, Psych Corp, 1981.
24. Lezak MD: Neuropsychological assessment. New York, Oxford University Press, 1983.
25. Armitage SG: An analysis of certain psychological tests used for the evaluation of brain injury. Psychol Monogr 1946;60:277.
26. Kausler DH: Experimental Psychology and Human Aging. New York, Wiley, 1982.
27. 15O. J Nucl Med 1983;24:782-789.
28. 11C-nicotine in brain of Alzheimer patients as visualized by positron emission tomography. J Neural Transm 1990;2: 215-224.
29. 11C-nicotine binding in normal and Alzheimer brains - In vivo assessment using positron emission tomography. Alzheimer Dis Assoc Disord 1995;1:21-27.
30. Patlak CS, Blasberg JD, Fenstermacher JD: Graphical evaluation of blood to brain transfer constants from multiple tissue uptake data. J Cereb Blood Flow Metab 1983;3:1-7.
31. 3H]acetylcholine binding sites in the frontal cortex of Alzheimer brains. Neurosci Lett 1986;72:115-119.
32. Nordberg A, Lilja A, Lundqvist H, Hartvig P, Amberla K, Viitanen M, Warpman U, Johanson M, Hellström-Lindahl E, Bjurling P, Fasth KJ, Långström B, Winblad B: Tacrine restores cholinergic nicotinic receptors and glucose metabolism in Alzheimer patients as visualized by positron emission tomography. Neurobiol Aging 1992;13:747-758.
33. Nordberg A, Lundqvist H, Hartvig P, Andersson J, Johansson M, Hellström-Lindahl E, Långström B: Imaging of nicotinic and muscarinic receptors in Alzheimer's disease: Effect of tacrine treatment. Dement Geriatr Cogn Disord 1997;8:78-84.
34. 3H-acetylcholine efflux from Alzheimer brain slices to normal level. J Neural Transm 1986;67:275-285.
35. Svensson AL, Nordberg A: Tacrine interacts with an allosteric activator site on a4b2 nAChRs in MlO cells. Neuroreport 1996;7: 2201-2205.
36. 1H-nicotine binding to a nicotinic cholinergic receptor on PC12 cells. Endocrinology 1992;130:825-830.
37. Rogers SW, Mandelzys A, Deneris ES, Cooper E, Heinemann S: The expression of nicotinic receptors by PC12 cells treated with NGF. J Neurosci 1992;12:4611-4623.
38. Cuello CA: Toward the repair of cortical synapses in Alzheimer's disease: in Giacobini E. Becker R (eds): Alzheimer Disease: Therapeutic Strategies. Boston, Birkhäuser, 1996, pp 277-283.
39. Obrist W, Busse E, Eisdorfer R, Kleemeier R: Relation of the electroencephalogram to intellectual function in senescence. J Gerontol 1962;17:192-206.
40. Hartikainen P, Soininen H, Partanen J, Helkala E, Riekkinen P: Aging and spectral analysis of EEG in normal subjects: A link to memory and CSF AChE. Acta Neurol Scand 1992;86: 148-155.
41. Gordon E, Sim M: The EEG in presenile dementia. J Neurol Neurosurg Psychiatry 1967; 3:285-291.
42. Johannesson G, Brun A, Gustafson L, Ingvar D: EEG in presenile dementia related to blood flow and autopsy findings. Acta Neurol Scand 1982;65:59-70.
43. Coben L, Danziger W, Storandt M: A longitudinal EEG study of mild senile dementia of Alzheimer type: Changes at 1 year and at 2.5 years. Electroencephalogr Clin Neurophysiol 1985;61:101-112.
44. Palmer M, Eriksdotter-Nilsson M, Henschen A, Ebendal T, Olson L: Nerve growth factor-induced excitation of selected neurons in the brain which is blocked by a low-affinity receptor antibody. Exp Brain Res 1993;93:226-230.
45. Kobayashi S, Ögren SO, Ebendal T, Olson L: Intraventricular injection of NGF, but not BDNF, induces rapid motor activation that is inhibited by nicotinic receptor antagonists. Exp Brain Res 1997;116:315-325.
46. Kobayashi S, Ögren SO, Ebendal T, Olson L: Dopamine receptor antagonists block nerve growth factor-induced hyperactivity. Eur J Pharmacol 1997;12:1-5.
47. Lauterborn JC, Tran TM, Isackson PJ, Gall CM: Nerve growth factor mRNA is expressed by GABAergic neurons in rat hippocampus. Neuroreport 1993;5:273-276.
48. Petty BG, Cornblath DR, Adornato BT, Chaudry V, Flexner C, Wachsman M, Sinicropi D, Burton LE, Peroutka SJ: The effect of systemically administered recombinant human nerve growth factor in healthy human subjects. Ann Neurol 1994;36:244-246.
49. Lewin GR: Neurotrophic factors and pain. Scmin Neurosci 1995;7:227-232.
50. Lewin GR, Mendell LM: Nerve growth factor and nociception. Trends Ncurosci 1993;16: 353-358.
51. Shen KF, Crain SM: Nerve growth factor rapidly prolongs the action potential of mature sensory ganglion neurons in culture, and this effect requires activation of Gs-couples excitatory kappa-opioid receptors on these cells. J Neurosci 1994;14:5570-5579.
52. Williams LR, Oostveen JA: Sensitivity of Fisher 344 × brown Norway hybrid rats to exogenous NGF: Weight loss correlates with stimulation of striatal choline acetyltransferase. Neurosci Lett 1992;147:136-138.
53. White H, Pieper C, Schmader K, Fillenbaum G: Weight change in Alzheimer's disease. J Am Geriatr Soc 1996;44:265-272.
54. Venero JL, Hefti F, Knusel B: Trophic effect of exogenous nerve growth factor on rat striatal cholinergic neurons: Comparison between intraparenchymal and intraventricular administration. Mol Pharmacol 1996;49:303-310.
55. Chao MV, Hempstead BL: p75 and Trk: A two-receptor system. Trends Neurosci 1995;18: 321-326.
56. Snyder SH, Sabatini DM: Immunophilins and the nervous system. Nat Med 1995;1:32-37.