Depolarization and neurotrophins converge on the phosphatidylinositol 3- kinase-Akt pathway to synergistically regulate neuronal survival

Journal of Cell Biology

Volumn 146, Issue 5, 1999, Pages 955-966

  Vaillant, A R ^a   Mazzoni, I ^a   Tudan, C ^a   Boudreau, M ^a   Kaplan, D R ^a   Miller, F D ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Calcium calmodulin dependent protein kinase II; Mitogen activated protein kinase; Nerve growth factor; Ras; Sympathetic neurons

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; POTASSIUM CHLORIDE; PROTEIN KINASE (CALCIUM,CALMODULIN); RAS PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; DEPOLARIZATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SYMPATHETIC NERVE CELL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL SURVIVAL; CELLS, CULTURED; DRUG SYNERGISM; ENZYME ACTIVATION; MEMBRANE POTENTIALS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NERVE GROWTH FACTORS; NEURONS; PHOSPHORYLATION; POTASSIUM CHLORIDE; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS P21(RAS); RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, TRKA; RECEPTORS, NERVE GROWTH FACTOR; SIGNAL TRANSDUCTION; SYMPATHETIC NERVOUS SYSTEM;

ADENOVIRIDAE; ANIMALIA;

EID: 0032864021     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.146.5.955     Document Type: Article

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