FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors

Molecular and Cellular Biology

Volumn 20, Issue 3, 2000, Pages 979-989

  Ong, S H ^a   Guy, G R ^a   Hadari, Y R ^b   Laks, S ^b   Gotoh, N ^b   Schlessinger, J ^b   Lax, I ^b  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOCKING PROTEIN; FIBROBLAST GROWTH FACTOR; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR RECEPTOR; PHOSPHOTYROSINE;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MUTAGENESIS; MYRISTYLATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL LINE; GRB2 ADAPTOR PROTEIN; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PHOSPHOPROTEINS; PROTEIN-TYROSINE-PHOSPHATASE; PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RECEPTORS, FIBROBLAST GROWTH FACTOR; RECEPTORS, NERVE GROWTH FACTOR; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE DELETION; SEQUENCE HOMOLOGY, AMINO ACID; SHP1 PROTEIN TYROSINE PHOSPHATASE; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; TRANSFECTION;

EID: 0033974109     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.3.979-989.2000     Document Type: Article

References (44)

1. Arighi, E., L. Alberti, F. Torriti, S. Ghizzoni, M. G. Rizzeti, G. Pelicci, B. Pasini, I. Bongarzone, C. Piutti, M. A. Pierotti, and M. G. Borrello. 1997. Identification of Shc docking site on Ret tyrosine kinase. Oncogene 14:773-782.
2. Barde, Y. 1989. Trophic factors and neuronal survival. Neuron 2:1525-1534.
3. Batzer, A., P. Blaikie, K. Nelson, J. Schlessinger, and B. Margolis. 1995. The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor. Mol. Cell. Biol. 15:4403-4409.
4. Borg, J. P., J. Ooi, E. Levy, and B. Margolis. 1996. The phosphotyrosine interaction domains of X11 and FE65 bind distinct sites on the YENPTY motif of amyloid precursor protein. Mol. Cell. Biol. 16:6229-6241.
5. Carpino, N., D. Wisniewski, A. Strife, D. Marshak, R. Kobayashi, B. Stillman, and B. Clarkson. 1997. p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. Cell 88:197-204.
6. Chien, C. T., S. Wang, M. Rothenberg, L. Y. Jan, and T. N. Jan. 1998. Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo. Mol. Cell. Biol. 18:598-607.
7. Cowburn, D. 1997. Peptide recognition by PTB and PDZ domains. Curr. Opin. Struct. Biol. 7:835-838.
8. Dho, S. E., S. Jacob, C. D. Wolting, M. B. French, L. R. Rohrschneider, and C. J. McGlade. 1998. The mammalian Numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing Numb binding protein, Lnx. J. Biol. Chem. 273: 9179-9187.
9. Dikic, I., A. G. Batzer, P. Blaikie, A. Obermeier, A. Ullrich, J. Schlessinger, and B. Margolis. 1995. Shc binding to nerve growth factor receptor is mediated by the phosphotyrosine interaction domains. J. Biol. Chem. 270: 15125-15129.
10. Easton, J. B., N. M. Moody, X. Zhu, and D. S. Middlemas. 1999. Brain-derived neurotrophic factor induces phosphorylation of fibroblast growth factor receptor substrate 2. J. Biol. Chem. 274:11321-11327.
11. Gillespie, L. L., G. Chen, and G. Paterno. 1995. Cloning of a fibroblast growth factor receptor 1 splice variant from Xenopus embryos that lacks a protein kinase C site important for the regulation of receptor activity. J. Biol. Chem. 270:22758-22763.
12. Goldfarb, M. 1996. Function of fibroblast growth factors in vertebrate development. Cytokine Growth Factor Rev. 7:311-325.
13. Gustafson, T. A., W. He, A. Craparo, C. D. Schaub, T. J. O'Neill. 1995. Phosphotyrosine-dependent interaction of Shc and insulin receptor substrate-I with the NPEY motif of the insulin receptor via a novel non-SH2 domain. Mol. Cell. Biol. 15:2500-2508.
14. Hadari, Y. R., H. Kouhara, I. Lax, and J. Schlessinger. 1998. Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation. Mol. Cell. Biol. 18:3966-3973.
15. Harrison, S. 1996. Peptide-surface association: the case of PDZ and PTB domains. Cell 86:341-343.
16. Holgado-Madruga, M., D. R. Emlet, D. K. Moscatello, A. K. Godwin, and A. J. Wong. 1996. A Grb2-associated docking protein in EGF- and insulin-receptor signaling. Nature 379:560-564.
17. Holland, S. J., N. W. Gale, G. D. Gish, R. A. Roth, Z. Songyang, L. C. Cantley, M. Henkemeyer, G. D. Yancopoulos, and T. Pawson. 1997. Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells. EMBO J. 16:3877-3888.
18. Kavanaugh, W. M., C. W. Turck, and L. T. Williams. 1995. PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine. Science 268:1177-1179.
19. Kouhara, H., Y. R. Hadari, T. Spivak-Kroizman, J. Schilling, D. Bar-Sagi, I. Lax, and J. Schlessinger. 1997. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell 89:693-702.
20. Lai, K. M. V., J. P. Olivier, G. D. Gish, M. Henkemeyer, J. McGlade, and T. Pawson. 1995. A Drosophila Shc gene product is implicated in signaling by the DER receptor tyrosine kinase. Mol. Cell. Biol. 15:4810-4818.
21. Laminet, A. A., G. Apel, L. Conroy, and W. M. Kavanaugh. 1996. Affinity, specificity and kinetics of the Shc phosphotyrosine binding domain with asparagine-X-X-phosphotyrosine motifs of growth factor receptors. J. Biol. Chem. 271:264-269.
22. Lange-Carter, C. A., and G. L. Johnson. 1994. Ras-dependent growth factor regulation of MEK kinase in PC12 cells. Science 265:1458-1461.
23. Li, S. C., C. Zwahlen, S. J. F. Vincent, C. J. McGlade, L. E. Kay, and T. Pawson. 1998. Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity. Nat. Struct. Biol. 5:1075-1083.
24. Li, S. C., Z. Songyang, S. J. F. Vincent, C. Zwahlen, S. Wiley, L. Cantley, L. E. Kay, J. Forman-Kay, and T. Pawson. 1997. High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif. Proc. Natl. Acad. Sci. USA 94:7204-7209.
25. Mandiyan, V., R. O'Brien, M. Zhou, B. Margolis, M. A. Lemmon, J. M. Sturtevant, J. Schlessinger. 1996. Thermodynamic studies of Shc phosphotyrosine-interaction-domain recognition of the NPXpY-motif. J. Biol. Chem. 271:4770-4775.
26. Meakin, S. O., J. I. S. MacDonald, E. A. Gryz, C. J. Kubu, and J. M. Verdi. 1999. The signaling adaptor FRS2 competes with Shc for binding to the nerve growth factor receptor TrkA. J. Biol. Chem. 274:9861-9870.
27. Mohammadi, M., C. A. Dionne, W. Li, T. Spivak-Kroizman, N. Li, M. A. Honegger, J. Schlessinger, and M. Jaye. 1992. Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis. Nature 358:681-684.
28. Obermeier, A., R. Lammers, K. H. Weismuller, G. Jung, J. Schlessinger, and A. Ullrich. 1993. Identification of Trk binding sites for Shc and phosphatidylinositol 3′-kinase and formation of a multimeric signaling complex. J. Biol. Chem. 268:22963-22966.
29. Ong, S. H., Y. P. Lim, B. C. Low, and G. R. Guy. 1997. Shp2 associates directly with tyrosine phosphorylated p90 (SNT) protein in FGF-stimulated cells. Biochem. Biophys. Res. Commun. 238:261-266.
30. Pawson, T., and J. D. Scott. 1997. Signaling through scaffolding, anchoring and adaptor proteins. Science 278:2075-2080.
31. Rabin, S., V. Cleghon, and D. R. Kaplan. 1993. SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells. Mol Cell. Biol. 13:2203-2213.
32. Rizzo, C., D. Califano, G. L. Colucci-D'Amato, G. De Vita, A. D'Alessio, N. A. Dathan, A. Fusco, C. Monaco, G. Santelli, G. Vecchio, N. Santoro, and V. de Franciscis. 1996. Ligand stimulation of a Ret chimeric receptor carrying the activating mutation responsible for the multiple endocrine neoplasia type 2B. J. Biol. Chem. 271:29497-29501.
33. Schlessinger, J., and A. Ullrich. 1992. Growth factor signaling by receptor tyrosine kinases. Cell 9:383-391.
34. Schlessinger, J. 1993. How receptor tyrosine kinases activate Ras. Trends Biochem. Sci. 18:273-275.
35. Takahashi-Tezuka, M., Y. Yoshida, T. Fukada, T. Ohtani, Y. Yamanaka, K. Nishida, K. Nakajima, M. Hibi, and T. Hirano. 1998. Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase. Mol. Cell. Biol. 18:4109-4117.
36. van der Geer, P., and T. Pawson. 1995. The PTB domain: a new protein module implicated in signal transduction. Trends Biochem. Sci. 20:277-280.
37. Weidner, K. M., S. Di Cesare, M. Sachs, V. Brinkmann, J. Behrens, and W. Birchmeier. 1996. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature 384:173-176.
38. Xu, H., K. Lee, and M. Goldfarb. 1998. Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adaptor proteins. J. Biol. Chem. 273:17987-17990.
39. Yamanashi, Y., and D. Baltimore. 1997. Identification of the Ab1- and ras-GAP-associated 62 kDa protein as a docking protein, Dok. Cell 88:205-211.
40. Yenush, L., and M. F. White. 1997. The IRS-signaling system during insulin and cytokine action. Bioessays 19:491-500.
41. Yoon, S. O., S. P. Soltoff, and M. V. Chao. 1997. A dominant role of the juxtamembrane region of the TrkA nerve growth factor receptor during neuronal cell differentiation. J. Biol. Chem. 272:23231-23238.
42. Zambrano, N, J. D. Buxbaum, G. Minopoll, F. Fiore, P. De Candia, S. De Renzis, R. Faranio, S. Sabo, J. Cheetham, M. Sudol, and T. Russo. 1997. Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild type and mutant Alzheimer's β-amyloid precursor protein. J. Biol. Chem. 272:6399-6405.
43. Zhang, Z., C. H. Lee, V. Mandiyan, J. P. Borg, B. Margolis, J. Schlessinger, and J. Kuriyan. 1997. Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain. EMBO J. 16:6141-6150.
44. Zhou, S., B. Margolis, M. Chaudhuri, S. E. Shoelson, and L. C. Cantley. 1995. The phosphotyrosine interaction domain of Shc recognizes tyrosine-phosphorylated NPXY motif. J. Biol. Chem. 270:14863-14866.