Functional regeneration of sensory axons into the adult spinal cord

Nature

Volumn 403, Issue 6767, 2000, Pages 312-316

  Ramer, Matt S ^a   Priestley, John V ^b   McMahon, Stephen B ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SUBPOPULATION; CONTROLLED STUDY; DORSAL ROOT; ELECTROPHYSIOLOGY; NERVE FIBER REGENERATION; NERVE REGENERATION; NERVE ROOT INJURY; NERVE STIMULATION; NONHUMAN; PERIPHERAL NERVE; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SPINAL CORD; SPINAL CORD DORSAL HORN;

AFFERENT PATHWAYS; ANIMALS; AXONS; BRAIN-DERIVED NEUROTROPHIC FACTOR; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; NERVE CRUSH; NERVE FIBERS, MYELINATED; NERVE GROWTH FACTOR; NERVE GROWTH FACTORS; NERVE REGENERATION; NERVE TISSUE PROTEINS; NEURONS, AFFERENT; NEUROTROPHIN 3; PAIN; PERIPHERAL NERVES; POSTERIOR HORN CELLS; RATS; RHIZOTOMY; SPINAL CORD; SPINAL NERVE ROOTS; SYNAPTIC TRANSMISSION;

ANIMALIA;

EID: 0034688281     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35002084     Document Type: Article

References (27)

1. Ramon y Cajal, S. Degeneration and Regeneration in the Nervous System (Hafner, New York, 1928).
2. Bennett, D. L. H. et al. A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons following nerve injury. J. Neurosci. 18, 3059-3072 (1998).
3. Averill, S., McMahon, S. B., Clary, D. O., Reichardt, L. F. & Priestley, J. V. Immunocytochemical localization of trkA receptors in chemically identified subgroups of adult rat sensory neurons. Eur. J. Neurosci. 7, 1484-1494 (1995).
4. 3 purinoceptors in sensory neurons: effects of axotomy and glial-derived neurotrophic factor. Mol. Cell. Neurosci. 12, 256-268 (1998).
5. McMahon, S. B., Armanini, M. P., Ling, L. H. & Phillips, H. S. Expression and coexpression of Trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets. Neuron 12, 1161-1171 (1994).
6. Chong, M, S., Woolf, C. J., Haque, N. S. & Anderson, P. N. Axonal regeneration from injured dorsal roots into the spinal cord of adult rats. J. Comp. Neurol. 410, 42-54 (1999).
7. Kozlova, E. N., Stromberg, I., Bygdeman, M. & Aldskogius, H. Peripherally grafted human foetal dorsal root ganglion cells extend axons into the spinal cord of adult host rats by circumventing dorsal root entry zone astrocytes. Neuroreport 6, 269-272 (1995).
8. Thompson, S. W. N., Dray, A., McCarson, K. E., Krause, J. E. & Urban, L. Nerve growth factor induces mechanical allodynia associated with novel A fibre-evoked spinal reflex activity and enhanced neurokinin-1 receptor activation in the rat. Pain 62, 219-231 (1995).
9. Houle, J. D., Skinner, R. D., Garcia-Rill, E. & Turner, K. L. Synoptic evoked potentials from regenerating dorsal root axons within fetal spinal cord tissue transplants. Exp. Neurol 139, 278-290 (1996).
10. Oudega, M. & Hagg, T. Neurotrophins promote regeneration of sensory axons in the adult rat spinal cord. Brain Res. 818, 431-438 (1999).
11. Itoh, Y. & Tessler, A. Regeneration of adult dorsal root axons into transplants of fetal spinal cord and brain: a comparison of growth and synapse formation in appropriate and inappropriate targets. J. Comp. Neurol. 302, 272-293 (1990).
12. Tessler, A., Himes, B. T., Houle, J. D. & Reier, P. J. Regeneration of adult dorsal root axons into transplants of embryonic spinal cord. J. Comp. Neurol. 270, 537-548 (1988).
13. Rosario, C. M., Aldskogius, H., Carlstedt, T. & Sidman, R. L. Centrifugal growth in orthotopic grafts of allogenic dorsal root ganglia of adult rats: evidence for possible central ingrowth. Exp. Neurol. 115, 158-162 (1992).
14. Ramon-Cueto, A. & Nieto-Sampedro, M. Regeneration into the spinal cord of transected dorsal root axons is promoted by ensheathing glia transplants. Exp. Neurol. 127, 232-244 (1994).
15. Sims, T. J. & Gilmore, S. A. Regeneration of dorsal root axons into experimentally altered glial environments in the rat spinal cord. Exp. Brain Res. 99, 23-33 (1994).
16. Zhang, Y., Dijkhuizen, P. A., Anderson, P. N., Lieberman, A. R. & Verhaagen, J. NT-3 delivered by an adenoviral vector induces injured dorsal root axons to regenerate into the spinal cord of adult rats. J. Neurosci. Res. 15, 554-562 (1998).
17. Neumann, S. & Woolf, C. J. Regeneration of dorsal column fibres into and beyond the lesion site following adult spinal cord injury. Neuron 23, 83-91 (1999).
18. Iwaya, K., Mizni, K., Tessler, A. & Itoh, Y. Neurotrophic agents in fibrin glue mediate adult dorsal root regeneration into spinal cord. Neurosurgery 44, 589-596 (1999).
19. Cai, D., Shen, Y., DeBellard, M. E., Tang, S. & Filbin, M. T. Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism. Neuron 22, 89-101 (1999).
20. Schnell, L., Schneider, R., Kolbeck, R., Barde, Y. A. & Schwab, M. E. Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion. Nature 367, 170-173 (1994).
21. Dyer, J. K., Bourke, J. A. & Steeves, J. D. Regeneration of brainstem-spinal axons after lesion and immunological disruption of myelin in adult rat. Exp. Neurol. 154, 12-22 (1998).
22. Kalderon, N. & Fuks, Z. Structural recovery in lesioned adult mammalian spinal cord by x-irradiation of the lesion site. Proc. Natl Acad. Sci. USA 93, 11179-11184 (1996).
23. Davies, S. J. et al. Regeneration of adult axons in white matter tracts of the central nervous system. Nature 390, 680-683 (1997).
24. Bradbury, E. J., Khemani, S., King, V. R., Priestley, J. V. & McMahon, S. B. NT-3 promotes growth of lesioned adult rat sensory neurons ascending in the dorsal columns of the spinal cord. Eur. J. Neurosci. 11, 3873-3883 (1999).
25. Zhou, X. F. et al. Satellite cell-derived nerve growth factor and neurotrophin-3 are involved in noradrenergic sprouting in the dorsal root ganglia following peripheral nerve injury in the rat. Eur. J. Neurosci. 11, 1711-1722 (1999).
26. Winkler, J. et al. Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor. Ann. Neurol. 41, 32-93 (1997).
27. Fraher, J. P. The transitional zone and CNS regeneration. J. Anat. 194, 161-182 (1999).