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Volumn 21, Issue 3, 2000, Pages 485-495

Apoptosis in cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; FAS ANTIGEN; PROTEIN P53; TUMOR NECROSIS FACTOR RECEPTOR;

EID: 0034057320     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/21.3.485     Document Type: Review
Times cited : (1710)

References (169)
  • 1
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr, J.F., Wyllie, A.H. and Currie, A.R. (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer, 26, 239-257.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 2
    • 0019225636 scopus 로고
    • Cell death: The significance of apoptosis
    • Wyllie, A.H., Kerr, J.F. and Currie, A.R. (1980) Cell death: the significance of apoptosis. Int. Rev. Cytol., 68, 251-306.
    • (1980) Int. Rev. Cytol. , vol.68 , pp. 251-306
    • Wyllie, A.H.1    Kerr, J.F.2    Currie, A.R.3
  • 3
    • 0028329172 scopus 로고
    • Apoptosis - Its significance in cancer and cancer therapy
    • Published erratum appears in Cancer (1994) 73, 3108
    • Kerr, J.F.R., Winterford, C.M. and Harmon, B.V. (1994) Apoptosis - its significance in cancer and cancer therapy. Cancer, 73, 2013-2026, [Published erratum appears in Cancer (1994) 73, 3108.]
    • (1994) Cancer , vol.73 , pp. 2013-2026
    • Kerr, J.F.R.1    Winterford, C.M.2    Harmon, B.V.3
  • 4
    • 0028943734 scopus 로고
    • Apoptosis in the pathogenesis and treatment of disease
    • Thompson, C.B. (1995) Apoptosis in the pathogenesis and treatment of disease. Science, 267, 1456-1462.
    • (1995) Science , vol.267 , pp. 1456-1462
    • Thompson, C.B.1
  • 5
    • 0021679848 scopus 로고
    • Cloning of the chromosome breakpoint of neoplastic B cells with the t(14:18) chromosome translocation
    • Tsujimoto, Y. Finger, L.R., Yunis, J., Nowell, P.C. and Croce, C.M. (1984) Cloning of the chromosome breakpoint of neoplastic B cells with the t(14:18) chromosome translocation. Science, 226, 1097-1099.
    • (1984) Science , vol.226 , pp. 1097-1099
    • Tsujimoto, Y.1    Finger, L.R.2    Yunis, J.3    Nowell, P.C.4    Croce, C.M.5
  • 6
    • 0021821903 scopus 로고
    • Involvement of the Bcl-2 gene in human follicular lymphoma
    • Tsujimoto, Y., Cossman, J., Jaffe, E. and Croce, C.M. (1985) Involvement of the bcl-2 gene in human follicular lymphoma. Science, 228, 1440-1443.
    • (1985) Science , vol.228 , pp. 1440-1443
    • Tsujimoto, Y.1    Cossman, J.2    Jaffe, E.3    Croce, C.M.4
  • 7
    • 0023786047 scopus 로고
    • Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-b cells
    • Vaux, D.L., Cory, S. and Adams, J.M. (1988) Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature, 335, 440-442.
    • (1988) Nature , vol.335 , pp. 440-442
    • Vaux, D.L.1    Cory, S.2    Adams, J.M.3
  • 8
    • 0024521441 scopus 로고
    • Bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation
    • McDonnell, T.J., Deane, N., Platt, F.M., Nunez, G., Jaeger, U., McKearn, J.P. and Korsmeyer, S.J. (1989) bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell, 57, 79-88.
    • (1989) Cell , vol.57 , pp. 79-88
    • McDonnell, T.J.1    Deane, N.2    Platt, F.M.3    Nunez, G.4    Jaeger, U.5    McKearn, J.P.6    Korsmeyer, S.J.7
  • 9
    • 0025204548 scopus 로고
    • Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
    • Hockenbery, D., Nunez, G., Milliman, C., Schreiber, R.D. and Korsmeyer, S.J. (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature, 348, 334-336.
    • (1990) Nature , vol.348 , pp. 334-336
    • Hockenbery, D.1    Nunez, G.2    Milliman, C.3    Schreiber, R.D.4    Korsmeyer, S.J.5
  • 10
    • 0025251664 scopus 로고
    • Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
    • Strasser, A., Harris, A.W., Bath, M.L. and Cory, S. (1990) Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature, 348, 331-333.
    • (1990) Nature , vol.348 , pp. 331-333
    • Strasser, A.1    Harris, A.W.2    Bath, M.L.3    Cory, S.4
  • 11
    • 0033179760 scopus 로고    scopus 로고
    • BCL-2 family members and the mitochondria in apoptosis
    • Gross, A., McDonnell, J.M. and Korsmeyer, S.J. (1999) BCL-2 family members and the mitochondria in apoptosis. Genes Dev., 13, 1899-1911.
    • (1999) Genes Dev. , vol.13 , pp. 1899-1911
    • Gross, A.1    McDonnell, J.M.2    Korsmeyer, S.J.3
  • 12
    • 0032409781 scopus 로고    scopus 로고
    • Bcl-2 family proteins
    • Reed, J.C. (1998) Bcl-2 family proteins. Oncogene. 17, 3225-3236.
    • (1998) Oncogene , vol.17 , pp. 3225-3236
    • Reed, J.C.1
  • 13
    • 0031018674 scopus 로고    scopus 로고
    • Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
    • Rampino, N., Yamamoto, H., Ionov, Y., Li, Y., Sawai, H., Reed, J.C. and Perucho, M. (1997) Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science, 275, 967-969.
    • (1997) Science , vol.275 , pp. 967-969
    • Rampino, N.1    Yamamoto, H.2    Ionov, Y.3    Li, Y.4    Sawai, H.5    Reed, J.C.6    Perucho, M.7
  • 16
    • 0025784539 scopus 로고
    • Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
    • Yonish-Rouach, E., Resnitzky, D., Lotem, J., Sachs, L., Kimchi, A. and Oren, M. (1991) Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature, 352, 345-347.
    • (1991) Nature , vol.352 , pp. 345-347
    • Yonish-Rouach, E.1    Resnitzky, D.2    Lotem, J.3    Sachs, L.4    Kimchi, A.5    Oren, M.6
  • 17
    • 0027319521 scopus 로고
    • P53 is required for radiation-induced apoptosis in mouse thymocytes
    • Lowe, S.W., Schmitt, E.M., Smith, S.W., Osborne, B.A. and Jacks, T. (1993) p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature, 362, 847-849.
    • (1993) Nature , vol.362 , pp. 847-849
    • Lowe, S.W.1    Schmitt, E.M.2    Smith, S.W.3    Osborne, B.A.4    Jacks, T.5
  • 19
    • 0031829822 scopus 로고    scopus 로고
    • The role of CD95 (APO-1/Fas) mutations in lymphoproliferative and malignant lymphatic diseases
    • Beltinger, C., Bohler, T., Schrappe, M., Ludwig, W.D. and Debatin, K.M. (1998) The role of CD95 (APO-1/Fas) mutations in lymphoproliferative and malignant lymphatic diseases. Klin. Padiatr., 210, 153-158.
    • (1998) Klin. Padiatr. , vol.210 , pp. 153-158
    • Beltinger, C.1    Bohler, T.2    Schrappe, M.3    Ludwig, W.D.4    Debatin, K.M.5
  • 20
    • 0030884103 scopus 로고    scopus 로고
    • PKB/Akt: Connecting phosphoinositide 3-kinase to cell survival and beyond
    • Marte, B.M. and Downward, J. (1997) PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biochem. Sci., 22, 355-358.
    • (1997) Trends Biochem. Sci. , vol.22 , pp. 355-358
    • Marte, B.M.1    Downward, J.2
  • 21
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    • Cantley, L.C. and Neel, B.G. (1999) New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. Natl Acad. Sci. USA, 96, 4240-4245.
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 22
    • 0030669560 scopus 로고    scopus 로고
    • Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice
    • Jager, R., Herzer, U., Schenkel, J. and Weiher, H. (1997) Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice. Oncogene, 15, 1787-1795.
    • (1997) Oncogene , vol.15 , pp. 1787-1795
    • Jager, R.1    Herzer, U.2    Schenkel, J.3    Weiher, H.4
  • 23
    • 0033028043 scopus 로고    scopus 로고
    • The role of p53 in tumour suppression: Lessons from mouse models
    • Attardi, L.D. and Jacks, T. (1999) The role of p53 in tumour suppression: lessons from mouse models. Cell Mol. Life Sci., 55, 48-63.
    • (1999) Cell Mol. Life Sci. , vol.55 , pp. 48-63
    • Attardi, L.D.1    Jacks, T.2
  • 24
    • 0028356419 scopus 로고
    • A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis
    • Christofori, G., Naik, P. and Hanahan, D. (1994) A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis. Nature, 369, 414-418.
    • (1994) Nature , vol.369 , pp. 414-418
    • Christofori, G.1    Naik, P.2    Hanahan, D.3
  • 25
    • 0031038137 scopus 로고    scopus 로고
    • Bax suppresses tumorigenesis and stimulates apoptosis in vivo
    • Yin, C., Knudson, C.M., Korsmeyer, S.J. and Van Dyke, T. (1997) Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature, 385, 637-640.
    • (1997) Nature , vol.385 , pp. 637-640
    • Yin, C.1    Knudson, C.M.2    Korsmeyer, S.J.3    Van Dyke, T.4
  • 26
    • 0033577766 scopus 로고    scopus 로고
    • Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: Reduction in protective apoptotic response at the preneoplastic stage
    • Shibata, M.A., Liu, M.L., Knudson, M.C., Shibata, E., Yoshidome, K., Bandey, T., Korsmeyer, S.J. and Green, J.E. (1999) Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage. EMBO J., 18, 2692-2701.
    • (1999) EMBO J. , vol.18 , pp. 2692-2701
    • Shibata, M.A.1    Liu, M.L.2    Knudson, M.C.3    Shibata, E.4    Yoshidome, K.5    Bandey, T.6    Korsmeyer, S.J.7    Green, J.E.8
  • 27
    • 0028850813 scopus 로고
    • Clonal expansion and attenuated apoptosis in Wilms' tumors are associated with p53 gene mutations
    • Bardeesy, N., Beckwith, J.B. and Pelletier, J. (1995) Clonal expansion and attenuated apoptosis in Wilms' tumors are associated with p53 gene mutations. Cancer Res., 55, 215-219.
    • (1995) Cancer Res. , vol.55 , pp. 215-219
    • Bardeesy, N.1    Beckwith, J.B.2    Pelletier, J.3
  • 28
    • 0030938089 scopus 로고    scopus 로고
    • Bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis
    • McCurrach, M.E., Connor, T.M., Knudson, C.M., Korsmeyer, S.J. and Lowe, S.W. (1997) bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. Proc. Natl Acad. Sci. USA, 94, 2345-2349.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 2345-2349
    • McCurrach, M.E.1    Connor, T.M.2    Knudson, C.M.3    Korsmeyer, S.J.4    Lowe, S.W.5
  • 31
    • 0028846176 scopus 로고
    • Inhibitors of cyclin-dependent kinase and cancer
    • Biggs, J.R. and Kraft, A.S. (1995) Inhibitors of cyclin-dependent kinase and cancer. J. Mol. Med., 73, 509-514.
    • (1995) J. Mol. Med. , vol.73 , pp. 509-514
    • Biggs, J.R.1    Kraft, A.S.2
  • 32
    • 0030021748 scopus 로고    scopus 로고
    • Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant
    • Rowan, S., Ludwig, R.L., Haupt, Y., Bates, S., Lu, X., Oren, M. and Vousden, K.H. (1996) Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant. EMBO J., 15, 827-838.
    • (1996) EMBO J. , vol.15 , pp. 827-838
    • Rowan, S.1    Ludwig, R.L.2    Haupt, Y.3    Bates, S.4    Lu, X.5    Oren, M.6    Vousden, K.H.7
  • 33
    • 0029783722 scopus 로고    scopus 로고
    • A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis
    • Friedlander, P., Haupt, Y., Prives, C. and Oren, M. (1996) A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis. Mol. Cell Biol., 16, 4961-4971.
    • (1996) Mol. Cell Biol. , vol.16 , pp. 4961-4971
    • Friedlander, P.1    Haupt, Y.2    Prives, C.3    Oren, M.4
  • 35
    • 0026504147 scopus 로고
    • Social controls on cell survival and cell death
    • Raff, M.C. (1992) Social controls on cell survival and cell death. Nature, 356, 397-400.
    • (1992) Nature , vol.356 , pp. 397-400
    • Raff, M.C.1
  • 36
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human box gene
    • Miyashita, T. and Reed, J.C. (1995) Tumor suppressor p53 is a direct transcriptional activator of the human box gene. Cell, 80, 293-299.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 38
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • Graeber, T.G., Osmanian, C., Jacks, T., Housman, D.E., Koch, C.J., Lowe, S.W. and Giaccia, A.J. (1996) Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature, 379, 88-91.
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3    Housman, D.E.4    Koch, C.J.5    Lowe, S.W.6    Giaccia, A.J.7
  • 39
    • 0033605145 scopus 로고    scopus 로고
    • P53-and ATM-dependent apoptosis induced by telomeres lacking TRF2
    • Karlseder, J., Broccoli, D., Dai, Y., Hardy, S. and de Lange, T. (1999) p53-and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science, 283, 1321-1325.
    • (1999) Science , vol.283 , pp. 1321-1325
    • Karlseder, J.1    Broccoli, D.2    Dai, Y.3    Hardy, S.4    De Lange, T.5
  • 40
    • 0033553516 scopus 로고    scopus 로고
    • P53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
    • Chin, L., Artandi, S.E., Shen, Q., Tam, A., Lee, S.L., Gottlieb, G.J., Greider, C.W. and DePinho, R.A. (1999) p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell, 97, 527-538.
    • (1999) Cell , vol.97 , pp. 527-538
    • Chin, L.1    Artandi, S.E.2    Shen, Q.3    Tam, A.4    Lee, S.L.5    Gottlieb, G.J.6    Greider, C.W.7    DePinho, R.A.8
  • 41
    • 0028057613 scopus 로고
    • Disruption of epithelial cell-matrix interactions induces apoptosis
    • Frisch, S.M. and Francis, H. (1994) Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol., 124, 619-626.
    • (1994) J. Cell Biol. , vol.124 , pp. 619-626
    • Frisch, S.M.1    Francis, H.2
  • 42
    • 0033551899 scopus 로고    scopus 로고
    • Integrin signaling
    • Giancotti, F.G. and Ruoslahti, E. (1999) Integrin signaling. Science, 285, 1028-1032.
    • (1999) Science , vol.285 , pp. 1028-1032
    • Giancotti, F.G.1    Ruoslahti, E.2
  • 45
    • 0032127861 scopus 로고    scopus 로고
    • Bcl-2 expression is reciprocal to p53 and c-myc expression in metastatic human colorectal cancer
    • Popescu, R.A., Lohri, A., de Kant, E., Thiede, C., Reuter, J., Herrmann, R. and Rochlitz, C.F. (1998) bcl-2 expression is reciprocal to p53 and c-myc expression in metastatic human colorectal cancer. Eur. J. Cancer, 34, 1268-1273.
    • (1998) Eur. J. Cancer , vol.34 , pp. 1268-1273
    • Popescu, R.A.1    Lohri, A.2    De Kant, E.3    Thiede, C.4    Reuter, J.5    Herrmann, R.6    Rochlitz, C.F.7
  • 46
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • Ashkenazi, A. and Dixit, V.M. (1998) Death receptors: signaling and modulation. Science, 281, 1305-1308.
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 47
    • 0029786304 scopus 로고    scopus 로고
    • Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins
    • Takeuchi, M., Rothe, M. and Goeddel, D.V. (1996) Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins. J. Biol. Chem., 271, 19935-19942.
    • (1996) J. Biol. Chem. , vol.271 , pp. 19935-19942
    • Takeuchi, M.1    Rothe, M.2    Goeddel, D.V.3
  • 49
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green, D.R. and Reed, J.C. (1998) Mitochondria and apoptosis. Science, 281, 1309-1312.
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 51
    • 0032418092 scopus 로고    scopus 로고
    • Role of Bcl-2 family proteins in apoptosis: Apoptosomes or mitochondria?
    • Tsujimoto, Y. (1998) Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria?' Genes Cells, 3, 697-707.
    • (1998) Genes Cells , vol.3 , pp. 697-707
    • Tsujimoto, Y.1
  • 52
    • 0030745646 scopus 로고    scopus 로고
    • Apaf-1, a human protein homologous to C. Elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
    • Zou, H., Henzel, W.J., Liu, X., Lulschg, A. and Wang, X. (1997) Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell, 90, 405-413.
    • (1997) Cell , vol.90 , pp. 405-413
    • Zou, H.1    Henzel, W.J.2    Liu, X.3    Lulschg, A.4    Wang, X.5
  • 53
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome e and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S.M., Ahmad, M., Alnemri, E.S. and Wang, X. (1997) Cytochrome e and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell, 91, 479-489.
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3    Srinivasula, S.M.4    Ahmad, M.5    Alnemri, E.S.6    Wang, X.7
  • 54
  • 55
    • 0032575750 scopus 로고    scopus 로고
    • Caspases: Enemies within
    • Thornberry, N.A. and Lazebnik, Y. (1998) Caspases: enemies within. Science, 281, 1312-1316.
    • (1998) Science , vol.281 , pp. 1312-1316
    • Thornberry, N.A.1    Lazebnik, Y.2
  • 56
    • 0032515874 scopus 로고    scopus 로고
    • Bel-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation
    • HU, Y., Benedict, M.A., Wu, D., Inohara, N. and Nunez, G. (1998) Bel-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Proc. Natl Acad. Sci. USA, 95, 4386-4391.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 4386-4391
    • Hu, Y.1    Benedict, M.A.2    Wu, D.3    Inohara, N.4    Nunez, G.5
  • 58
    • 0032575723 scopus 로고    scopus 로고
    • Essential role of CED-4 oligomerization in CED-3 activation and apoptosis
    • Yang, X., Chang, H.Y. and Baltimore, D. (1998) Essential role of CED-4 oligomerization in CED-3 activation and apoptosis. Science, 281, 1355-1357.
    • (1998) Science , vol.281 , pp. 1355-1357
    • Yang, X.1    Chang, H.Y.2    Baltimore, D.3
  • 59
    • 0029906828 scopus 로고    scopus 로고
    • BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases
    • Xiang, J., Chao, D.T. and Korsmeyer, S.J. (1996) BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases. Proc. Natl Acad. Sci. USA, 93, 14559-14563.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 14559-14563
    • Xiang, J.1    Chao, D.T.2    Korsmeyer, S.J.3
  • 60
    • 0031033274 scopus 로고    scopus 로고
    • Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak
    • McCarthy, N.J., Whyte, M.K., Gilbert, C.S. and Evan, G.I. (1997) Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak. J. Cell Biol., 136, 215-227.
    • (1997) J. Cell Biol. , vol.136 , pp. 215-227
    • McCarthy, N.J.1    Whyte, M.K.2    Gilbert, C.S.3    Evan, G.I.4
  • 65
    • 0032544449 scopus 로고    scopus 로고
    • Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
    • Cecconi, F., Alvarez-Bolado, G., Meyer, B.I., Roth, K.A. and Gruss, P. (1998) Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell, 94, 727-737.
    • (1998) Cell , vol.94 , pp. 727-737
    • Cecconi, F.1    Alvarez-Bolado, G.2    Meyer, B.I.3    Roth, K.A.4    Gruss, P.5
  • 66
    • 0033538475 scopus 로고    scopus 로고
    • Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II
    • Wang, J., Zheng, L., Lobito, A., Chan, F.K., Dale, J., Sneller, M., Yao, X., Puck, J.M., Straus, S.E. and Lenardo, M.J. (1999) Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. Cell, 98, 47-58.
    • (1999) Cell , vol.98 , pp. 47-58
    • Wang, J.1    Zheng, L.2    Lobito, A.3    Chan, F.K.4    Dale, J.5    Sneller, M.6    Yao, X.7    Puck, J.M.8    Straus, S.E.9    Lenardo, M.J.10
  • 67
    • 0344417114 scopus 로고    scopus 로고
    • Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype
    • Schwartz, S.Jr, Yamamoto, H., Navarro, M., Maestro, M., Reventos, J. and Perucho, M. (1999) Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype. Cancer Res., 59, 2995-3002.
    • (1999) Cancer Res. , vol.59 , pp. 2995-3002
    • Schwartz S., Jr.1    Yamamoto, H.2    Navarro, M.3    Maestro, M.4    Reventos, J.5    Perucho, M.6
  • 68
    • 0030201118 scopus 로고    scopus 로고
    • Characterization of the mouse cyclin D3 gene: Exon/intron organization and promoter activity
    • Wang, Z., Sicinski,P., Weinberg, R.A., Zhang, Y. and Ravid, K. (1996) Characterization of the mouse cyclin D3 gene: exon/intron organization and promoter activity. Genomics, 35, 156-163.
    • (1996) Genomics , vol.35 , pp. 156-163
    • Wang, Z.1    Weinberg, R.A.2    Zhang, Y.3    Ravid, K.4
  • 69
    • 1842333237 scopus 로고    scopus 로고
    • Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
    • del Peso, L., Gonzalez-Garcia, M., Page, C., Herrera, R. and Nunez, G. (1997) Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science, 278, 687-689.
    • (1997) Science , vol.278 , pp. 687-689
    • Del Peso, L.1    Gonzalez-Garcia, M.2    Page, C.3    Herrera, R.4    Nunez, G.5
  • 72
    • 0032904432 scopus 로고    scopus 로고
    • PTEN: A tumour suppressor that functions as a phospholipid phosphatase
    • Maehama, T. and Dixon, J.E. (1999) PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell. Biol., 9, 125-128.
    • (1999) Trends Cell. Biol. , vol.9 , pp. 125-128
    • Maehama, T.1    Dixon, J.E.2
  • 75
    • 0032555697 scopus 로고    scopus 로고
    • Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
    • Li, H., Zhu, H., Xu, C.J. and Yuan, J. (1998) Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell. 94, 491-501.
    • (1998) Cell. , vol.94 , pp. 491-501
    • Li, H.1    Zhu, H.2    Xu, C.J.3    Yuan, J.4
  • 78
    • 0021684759 scopus 로고
    • Mutations in the gene encoding the adenovirus early region IB 19,000-molecular-weight tumor antigen cause the degradation of chromosomal DNA
    • White, E., Grodzicker, T. and Stillman, B.W. (1984) Mutations in the gene encoding the adenovirus early region IB 19,000-molecular-weight tumor antigen cause the degradation of chromosomal DNA. J. Virol., 52, 410-419.
    • (1984) J. Virol. , vol.52 , pp. 410-419
    • White, E.1    Grodzicker, T.2    Stillman, B.W.3
  • 79
    • 0023134272 scopus 로고
    • Expression of adenovirus E1B mutant phenotypes is dependent on the host cell and on synthesis of E1A proteins
    • White, E. and Stillman, B. (1987) Expression of adenovirus E1B mutant phenotypes is dependent on the host cell and on synthesis of E1A proteins. J. Virol., 61, 426-435.
    • (1987) J. Virol. , vol.61 , pp. 426-435
    • White, E.1    Stillman, B.2
  • 80
    • 0026639932 scopus 로고
    • The adenovirus E1A proteins induce apoptosis which is inhibited by the E1B 19K and Bcl-2 proteins
    • Rao, L., Debbas, M., Sabbatini, P., Hockenbery, D., Korsmeyer, S. and White, E. (1992) The adenovirus E1A proteins induce apoptosis which is inhibited by the E1B 19K and Bcl-2 proteins. Proc. Natl Acad. Sci. USA, 89, 7742-7746.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 7742-7746
    • Rao, L.1    Debbas, M.2    Sabbatini, P.3    Hockenbery, D.4    Korsmeyer, S.5    White, E.6
  • 81
    • 0032575705 scopus 로고    scopus 로고
    • A matter of life and cell death
    • Evan, G. and Littlewood, T. (1998) A matter of life and cell death. Science, 281, 1317-1322.
    • (1998) Science , vol.281 , pp. 1317-1322
    • Evan, G.1    Littlewood, T.2
  • 83
    • 0028263811 scopus 로고
    • C-myc-induced apoptosis in fibroblasts is inhibited by specific cylokines
    • Harrington, E.A., Bennett, M.R., Fanidi, A. and Evan, G.I. (1994) c-myc-induced apoptosis in fibroblasts is inhibited by specific cylokines. EMBO J., 13, 3286-3295.
    • (1994) EMBO J. , vol.13 , pp. 3286-3295
    • Harrington, E.A.1    Bennett, M.R.2    Fanidi, A.3    Evan, G.I.4
  • 84
    • 0026688162 scopus 로고
    • Apoptotic cell death induced by c-myc is inhibited by bcl-2
    • Bissonnette, R.P., Echeverri, F., Mahboubi, A. and Green, D.R. (1992) Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature, 359, 552-554.
    • (1992) Nature , vol.359 , pp. 552-554
    • Bissonnette, R.P.1    Echeverri, F.2    Mahboubi, A.3    Green, D.R.4
  • 85
    • 0026722655 scopus 로고
    • Cooperative interaction between c-myc and bcl-2 proto-oncogenes
    • Fanidi, A., Harrington, E.A. and Evan, G.I. (1992) Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature, 359, 554-556.
    • (1992) Nature , vol.359 , pp. 554-556
    • Fanidi, A.1    Harrington, E.A.2    Evan, G.I.3
  • 86
    • 0027364326 scopus 로고
    • The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max
    • Amati, B., Littlewood, T.D., Evan, G.I. and Land, H. (1993) The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max. EMBO J. 12, 5083-5087.
    • (1993) EMBO J. , vol.12 , pp. 5083-5087
    • Amati, B.1    Littlewood, T.D.2    Evan, G.I.3    Land, H.4
  • 87
    • 0030726461 scopus 로고    scopus 로고
    • Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins
    • Samuelson, A.V. and Lowe, S.W. (1997) Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins. Proc. Natl Acad Sci. USA, 94, 12094-12099.
    • (1997) Proc. Natl Acad Sci. USA , vol.94 , pp. 12094-12099
    • Samuelson, A.V.1    Lowe, S.W.2
  • 88
    • 0027934570 scopus 로고
    • P53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
    • Morgenbesser, S.D., Williams, B.O., Jacks, T. and DePinho, R.A. (1994) p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature, 371, 72-74.
    • (1994) Nature , vol.371 , pp. 72-74
    • Morgenbesser, S.D.1    Williams, B.O.2    Jacks, T.3    Depinho, R.A.4
  • 89
    • 0029910628 scopus 로고    scopus 로고
    • Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system
    • Macleod, K.F., Hu, Y. and Jacks, T. (1996) Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J., 15, 6178-6188.
    • (1996) EMBO J. , vol.15 , pp. 6178-6188
    • Macleod, K.F.1    Hu, Y.2    Jacks, T.3
  • 90
    • 0028999429 scopus 로고
    • P53-mediated apoptosis in HeLa cells can be overcome by excess pRB
    • Haupt, Y. Rowan, S. and Oren, M. (1995) p53-mediated apoptosis in HeLa cells can be overcome by excess pRB. Oncogene, 10, 1563-1571.
    • (1995) Oncogene , vol.10 , pp. 1563-1571
    • Haupt, Y.1    Rowan, S.2    Oren, M.3
  • 91
    • 0028222124 scopus 로고
    • P53 and E2F-1 cooperate to mediate apoptosis
    • Wu, X. and Levine, A.J. (1994) p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad Sci. USA, 91, 3602-3606.
    • (1994) Proc. Natl. Acad Sci. USA , vol.91 , pp. 3602-3606
    • Wu, X.1    Levine, A.J.2
  • 92
    • 0028061670 scopus 로고
    • Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
    • Shan, B. and Lee, W.H. (1994) Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol. Cell Biol., 14, 8166-8173.
    • (1994) Mol. Cell Biol. , vol.14 , pp. 8166-8173
    • Shan, B.1    Lee, W.H.2
  • 93
    • 0027947383 scopus 로고
    • Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
    • Qin, X.Q., Livingston, D.M., Kaelin, W.G.Jr and Adams, P.D. (1994) Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl Acad Sci. USA. 91, 10918-10922.
    • (1994) Proc. Natl Acad Sci. USA , vol.91 , pp. 10918-10922
    • Qin, X.Q.1    Livingston, D.M.2    Kaelin W.G., Jr.3    Adams, P.D.4
  • 94
    • 0027262606 scopus 로고
    • Stabilization of the p53 tumor suppressor is induced by adenovirus E1A and accompanies apoptosis
    • Lowe, S.W. and Ruley, H.E. (1993) Stabilization of the p53 tumor suppressor is induced by adenovirus E1A and accompanies apoptosis. Genes Dev., 7, 535-545.
    • (1993) Genes Dev. , vol.7 , pp. 535-545
    • Lowe, S.W.1    Ruley, H.E.2
  • 95
    • 0028323294 scopus 로고
    • Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells
    • Lowe, S.W., Jacks, T., Housman, D.E. and Ruley, H.E. (1994) Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells. Proc. Natl Acad. Sci. USA, 91, 2026-2030.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 2026-2030
    • Lowe, S.W.1    Jacks, T.2    Housman, D.E.3    Ruley, H.E.4
  • 96
    • 0027251720 scopus 로고
    • Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B
    • Debbas, M. and White, E. (1993) Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes Dev., 7, 546-554.
    • (1993) Genes Dev. , vol.7 , pp. 546-554
    • Debbas, M.1    White, E.2
  • 97
    • 0028171968 scopus 로고
    • Mediation of c-myc induced apoptosis by p53
    • Hermeking, H. and Eick, D. (1994) Mediation of c-myc induced apoptosis by p53. Science, 265, 2091-2093.
    • (1994) Science , vol.265 , pp. 2091-2093
    • Hermeking, H.1    Eick, D.2
  • 99
    • 0028334011 scopus 로고
    • Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: Implications for tumor suppressor gene function in development
    • Pan, H.C. and Griep, A.E. (1994) Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: Implications for tumor suppressor gene function in development. Genes Dev., 8, 1285-1299.
    • (1994) Genes Dev. , vol.8 , pp. 1285-1299
    • Pan, H.C.1    Griep, A.E.2
  • 100
    • 0028227260 scopus 로고
    • Apoptosis or retinoblastoma: Alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53
    • Howes, K.A., Ransom, L.N., Papermaster, D.S., Lasudry, J.G.H., Albert, D.M. and Windle, J.J. (1994) Apoptosis or retinoblastoma: Alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53. Genes Dev., 8, 1300-1310.
    • (1994) Genes Dev. , vol.8 , pp. 1300-1310
    • Howes, K.A.1    Ransom, L.N.2    Papermaster, D.S.3    Lasudry, J.G.H.4    Albert, D.M.5    Windle, J.J.6
  • 103
    • 0032191393 scopus 로고    scopus 로고
    • Tumor surveillance via the ARF-p53 pathway
    • Sherr, C.J. (1998) Tumor surveillance via the ARF-p53 pathway. Genes Dev., 12, 2984-2991.
    • (1998) Genes Dev. , vol.12 , pp. 2984-2991
    • Sherr, C.J.1
  • 104
    • 0032905924 scopus 로고    scopus 로고
    • C-Myc target genes involved in cell growth, apoptosis and metabolism
    • Dang, C.V. (1999) c-Myc target genes involved in cell growth, apoptosis and metabolism. Mol. Cell Biol., 19, 1-11.
    • (1999) Mol. Cell Biol. , vol.19 , pp. 1-11
    • Dang, C.V.1
  • 105
    • 0032145569 scopus 로고    scopus 로고
    • Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
    • Zindy, F., Eischen, C.M., Randle, D.H., Kamijo, T., Cleveland, J.L., Sherr, C.J. and Roussel, M.F. (1998) Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev., 12, 2424-2433.
    • (1998) Genes Dev. , vol.12 , pp. 2424-2433
    • Zindy, F.1    Eischen, C.M.2    Randle, D.H.3    Kamijo, T.4    Cleveland, J.L.5    Sherr, C.J.6    Roussel, M.F.7
  • 108
    • 0033152390 scopus 로고    scopus 로고
    • C-myc-induced sensitization to apoptosis is mediated through cytochrome c release
    • Juin, P., Hueber, A.O., Littlewood, T. and Evan, G. (1999) c-myc-induced sensitization to apoptosis is mediated through cytochrome c release. Genes Dev., 13, 1367-1381.
    • (1999) Genes Dev. , vol.13 , pp. 1367-1381
    • Juin, P.1    Hueber, A.O.2    Littlewood, T.3    Evan, G.4
  • 112
    • 0016774373 scopus 로고
    • An electron-microscope study of the mode of cell death induced by cancer-chemotherapeutic agents in populations of proliferating normal and neoplastic cells
    • Searle, J., Lawson, T.A., Abbott, P.J., Harmon, B. and Kerr, J.F.R. (1975) An electron-microscope study of the mode of cell death induced by cancer-chemotherapeutic agents in populations of proliferating normal and neoplastic cells. J. Pathol., 116, 129-138.
    • (1975) J. Pathol. , vol.116 , pp. 129-138
    • Searle, J.1    Lawson, T.A.2    Abbott, P.J.3    Harmon, B.4    Kerr, J.F.R.5
  • 113
    • 0025880971 scopus 로고
    • Drug-target interactions: Only the first step in the commitment to a programmed cell death?
    • Dive, C. and Hickman, J.A. (1991) Drug-target interactions: only the first step in the commitment to a programmed cell death? Br. J. Cancer, 64, 192-196.
    • (1991) Br. J. Cancer , vol.64 , pp. 192-196
    • Dive, C.1    Hickman, J.A.2
  • 114
    • 0024470862 scopus 로고
    • Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, amplothecin and other cytotoxic anticancer drugs: A cautionary note
    • Kaufmann, S.H. (1989) Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, amplothecin and other cytotoxic anticancer drugs: a cautionary note. Cancer Res., 49, 5870-5878.
    • (1989) Cancer Res. , vol.49 , pp. 5870-5878
    • Kaufmann, S.H.1
  • 115
    • 0024988359 scopus 로고
    • Activation of programmed cell death by anticancer agents: Cisplatin as a model system
    • Eastman, A. (1990) Activation of programmed cell death by anticancer agents: cisplatin as a model system. Cancer Cells, 2, 275-280.
    • (1990) Cancer Cells , vol.2 , pp. 275-280
    • Eastman, A.1
  • 116
    • 0032962588 scopus 로고    scopus 로고
    • Apoptosis and therapy
    • Schmitt, C.A. and Lowe, S.W. (1999) Apoptosis and therapy. J. Pathol., 187, 127-137.
    • (1999) J. Pathol. , vol.187 , pp. 127-137
    • Schmitt, C.A.1    Lowe, S.W.2
  • 117
    • 0027451668 scopus 로고
    • P53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe, S.W., Ruley, H.E., Jacks, T. and Housman, D.E. (1993) p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell, 74, 954-967.
    • (1993) Cell , vol.74 , pp. 954-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 119
    • 0028231586 scopus 로고
    • Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene
    • Fujiwara, T., Grimm, E.A., Mukhopadhyay, T., Zhang, W.W., Owenschaub, L.B. and Roth, J.A. (1994) Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene. Cancer Res., 54, 2287-2291.
    • (1994) Cancer Res. , vol.54 , pp. 2287-2291
    • Fujiwara, T.1    Grimm, E.A.2    Mukhopadhyay, T.3    Zhang, W.W.4    Owenschaub, L.B.5    Roth, J.A.6
  • 122
    • 0027389763 scopus 로고
    • Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line
    • Miyashita, T. and Reed, J.C. (1993) Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood, 81, 151-157.
    • (1993) Blood , vol.81 , pp. 151-157
    • Miyashita, T.1    Reed, J.C.2
  • 123
    • 0027279128 scopus 로고
    • Bcl-2 modulation of apoptosis induced by anticancer drugs: Resistance to thymidylate stress is independent of classical resistance pathways
    • Fisher, T.C., Milner, A.E., Gregory, C.D., Jackman, A.L., Aherne, G.W., Hartley, J.A., Dive, C. and Hickman, J.A. (1993) bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways. Cancer Res., 53, 3321-3326.
    • (1993) Cancer Res. , vol.53 , pp. 3321-3326
    • Fisher, T.C.1    Milner, A.E.2    Gregory, C.D.3    Jackman, A.L.4    Aherne, G.W.5    Hartley, J.A.6    Dive, C.7    Hickman, J.A.8
  • 124
    • 0028072523 scopus 로고
    • DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by bcl-2
    • Strasser, A., Harris, A.W., Jacks, T. and Cory, S. (1994) DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by bcl-2. Cell, 79, 329-339.
    • (1994) Cell , vol.79 , pp. 329-339
    • Strasser, A.1    Harris, A.W.2    Jacks, T.3    Cory, S.4
  • 125
    • 0029935682 scopus 로고    scopus 로고
    • Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells
    • Friesen, C., Herr, J., Krammer, P.H. and Debatin, K.M. (1996) Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nature Med., 2, 574-577.
    • (1996) Nature Med. , vol.2 , pp. 574-577
    • Friesen, C.1    Herr, J.2    Krammer, P.H.3    Debatin, K.M.4
  • 126
    • 0032233488 scopus 로고    scopus 로고
    • Does 'death receptor' signaling play a role in tumorigenesis and cancer therapy?
    • Villunger, A. and Strasser, A. (1998) Does 'death receptor' signaling play a role in tumorigenesis and cancer therapy? Oncol. Res., 10, 541-550.
    • (1998) Oncol. Res. , vol.10 , pp. 541-550
    • Villunger, A.1    Strasser, A.2
  • 128
    • 0033118475 scopus 로고    scopus 로고
    • Apoptosis, p53 and tumor cell sensitivity to anticancer agents
    • Brown, J.M. and Wouters, B.G. (1999) Apoptosis, p53 and tumor cell sensitivity to anticancer agents. Cancer Res., 59. 1391-1399.
    • (1999) Cancer Res. , vol.59 , pp. 1391-1399
    • Brown, J.M.1    Wouters, B.G.2
  • 130
    • 0031004077 scopus 로고    scopus 로고
    • Germinal center-derived signals act with Bcl-2 to decrease apoptosis and increase clonogenicity of drug-treated human B lymphoma cells
    • Walker, A., Taylor, S.T., Hickman, J.A. and Dive, C. (1997) Germinal center-derived signals act with Bcl-2 to decrease apoptosis and increase clonogenicity of drug-treated human B lymphoma cells. Cancer Res., 57, 1939-1945.
    • (1997) Cancer Res. , vol.57 , pp. 1939-1945
    • Walker, A.1    Taylor, S.T.2    Hickman, J.A.3    Dive, C.4
  • 131
    • 0027246692 scopus 로고
    • Regulation by bcl-2, c-myc and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and -defective myeloid leukemic cells
    • Lotem, J. and Sachs, L. (1993) Regulation by bcl-2, c-myc and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and -defective myeloid leukemic cells. Cell Growth Differ., 4, 41-47.
    • (1993) Cell Growth Differ , vol.4 , pp. 41-47
    • Lotem, J.1    Sachs, L.2
  • 132
    • 0028301094 scopus 로고
    • P53 dependence or early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation
    • Clarke, A.R., Gledhill, S., Hooper, M.L., Bird, C.C. and Wyllie, A.H. (1994) p53 dependence or early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation. Oncogene, 9, 1767-1773.
    • (1994) Oncogene , vol.9 , pp. 1767-1773
    • Clarke, A.R.1    Gledhill, S.2    Hooper, M.L.3    Bird, C.C.4    Wyllie, A.H.5
  • 133
    • 0028047723 scopus 로고
    • The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice
    • Merritt, A.J., Potten, C.S., Kemp, C.J., Hickman, J.A., Balmain, A., Lane, D.P. and Hall, P.A. (1994) The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res., 54, 614-617.
    • (1994) Cancer Res. , vol.54 , pp. 614-617
    • Merritt, A.J.1    Potten, C.S.2    Kemp, C.J.3    Hickman, J.A.4    Balmain, A.5    Lane, D.P.6    Hall, P.A.7
  • 134
    • 0032404145 scopus 로고    scopus 로고
    • The relationships between p53-dependent apoptosis, inhibition of proliferation and 5-fluorouracil-induced histopathology in murine intestinal epithelia
    • Pritchard, D.M., Potten, C.S. and Hickman, J.A. (1998) The relationships between p53-dependent apoptosis, inhibition of proliferation and 5-fluorouracil-induced histopathology in murine intestinal epithelia. Cancer Rec., 58, 5453-5465.
    • (1998) Cancer Rec. , vol.58 , pp. 5453-5465
    • Pritchard, D.M.1    Potten, C.S.2    Hickman, J.A.3
  • 135
    • 0030879563 scopus 로고    scopus 로고
    • ATM and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity
    • Westphal, C.H., Rowan, S., Schmaltz, C., Elson, A., Fisher, D.E. and Leder, P. (1997) atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity. Nature Genet., 16, 397-401.
    • (1997) Nature Genet. , vol.16 , pp. 397-401
    • Westphal, C.H.1    Rowan, S.2    Schmaltz, C.3    Elson, A.4    Fisher, D.E.5    Leder, P.6
  • 136
    • 0032055166 scopus 로고    scopus 로고
    • Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation
    • Domen, J., Gandy, K.L. and Weissman, I.L. (1998) Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation. Blood, 91, 2272-2282.
    • (1998) Blood , vol.91 , pp. 2272-2282
    • Domen, J.1    Gandy, K.L.2    Weissman, I.L.3
  • 137
    • 0032080807 scopus 로고    scopus 로고
    • Direct evidence that apoptosis enhances tumor responses to fractionated radiotherapy
    • Rupnow, B.A., Murtha, A.D., Alarcon, R.M., Giaccia, A.J. and Knox, S.J. (1998) Direct evidence that apoptosis enhances tumor responses to fractionated radiotherapy. Cancer Res., 58, 1779-1784.
    • (1998) Cancer Res. , vol.58 , pp. 1779-1784
    • Rupnow, B.A.1    Murtha, A.D.2    Alarcon, R.M.3    Giaccia, A.J.4    Knox, S.J.5
  • 138
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • Graeber, T.G., Osmanian, C., Jacks, T., Housman, D.E., Koch, C.J., Lowe, S.W. and Giaccia.A.J. (1996) Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature, 379, 88-91.
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3    Housman, D.E.4    Koch, C.J.5    Lowe, S.W.6
  • 139
    • 0032907528 scopus 로고    scopus 로고
    • Cellular senescence and cancer
    • Wynford-Thomas, D. (1999) Cellular senescence and cancer. J. Pathol., 187, 100-111.
    • (1999) J. Pathol. , vol.187 , pp. 100-111
    • Wynford-Thomas, D.1
  • 142
    • 0032190629 scopus 로고    scopus 로고
    • Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
    • Lin, A.W., Barradas, M., Stone, J.C., van Aelst, L., Serrano, M. and Lowe, S.W. (1998) Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev., 12, 3008-3019.
    • (1998) Genes Dev. , vol.12 , pp. 3008-3019
    • Lin, A.W.1    Barradas, M.2    Stone, J.C.3    Van Aelst, L.4    Serrano, M.5    Lowe, S.W.6
  • 143
    • 0032192153 scopus 로고    scopus 로고
    • Senescence of human fibroblasts induced by oncogenic raf
    • Zhu, J., Woods, D., McMahon, M. and Bishop, J.M. (1998) Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev., 12, 2997-3007.
    • (1998) Genes Dev. , vol.12 , pp. 2997-3007
    • Zhu, J.1    Woods, D.2    McMahon, M.3    Bishop, J.M.4
  • 145
    • 17444388849 scopus 로고    scopus 로고
    • A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents
    • Chang, B.D., Broude, E.V., Dokmanovic, M., Zhu, H., Ruth, A., Xuan, Y., Kandel, E.S., Lausch, E., Christov, K. and Roninson, J.B. (1999) A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res., 59, 3761-3767.
    • (1999) Cancer Res. , vol.59 , pp. 3761-3767
    • Chang, B.D.1    Broude, E.V.2    Dokmanovic, M.3    Zhu, H.4    Ruth, A.5    Xuan, Y.6    Kandel, E.S.7    Lausch, E.8    Christov, K.9    Roninson, J.B.10
  • 146
    • 0033135041 scopus 로고    scopus 로고
    • Vivo cytotoxicity of ovarian cancer cells through tumor-selective expression of the BAX gene
    • Tai, Y.T., Strobel, T., Kufe, D. and Cannistra, S.A. (1999) In vivo cytotoxicity of ovarian cancer cells through tumor-selective expression of the BAX gene. Cancer Res., 59, 2121-2126.
    • (1999) Cancer Res. , vol.59 , pp. 2121-2126
    • Tai, Y.T.1    Strobel, T.2    Kufe, D.3    Cannistra, S.A.4
  • 147
    • 0028979438 scopus 로고
    • Overexpression of bcl-x(S), sensitizes MCF-7 cells to chemotherapy-induced apoptosis
    • Sumantran, V.N., Ealovega, M.W., Nunez, G., Clarke, M.F. and Wicha, M.S. (1995) Overexpression of bcl-x(S), sensitizes MCF-7 cells to chemotherapy-induced apoptosis. Cancer Res., 55, 2507-2510.
    • (1995) Cancer Res. , vol.55 , pp. 2507-2510
    • Sumantran, V.N.1    Ealovega, M.W.2    Nunez, G.3    Clarke, M.F.4    Wicha, M.S.5
  • 148
    • 0029664990 scopus 로고    scopus 로고
    • Bcl-xs gene therapy induces apoptosis of human mammary tumors in nude mice
    • Ealovega, M.W., McGinnis, P.K., Sumantran, V.N., Clarke, M.F. and Wicha, M.S. (1996) bcl-xs gene therapy induces apoptosis of human mammary tumors in nude mice. Cancer Res., 56, 1965-1969.
    • (1996) Cancer Res. , vol.56 , pp. 1965-1969
    • Ealovega, M.W.1    McGinnis, P.K.2    Sumantran, V.N.3    Clarke, M.F.4    Wicha, M.S.5
  • 151
    • 0029858387 scopus 로고    scopus 로고
    • TNF-and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-kappaB
    • Wang, C.Y., Mayo, M.W. and Baldwin, A.S.Jr (1996) TNF-and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science, 274, 784-787.
    • (1996) Science , vol.274 , pp. 784-787
    • Wang, C.Y.1    Mayo, M.W.2    Baldwin A.S., Jr.3
  • 152
    • 0032905030 scopus 로고    scopus 로고
    • Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB
    • Wang, C.Y., Cusack, J.C.Jr. Liu, R. and Baldwin, A.S.Jr (1999) Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB. Nature Med., 5, 412-417.
    • (1999) Nature Med. , vol.5 , pp. 412-417
    • Wang, C.Y.1    Cusack J.C., Jr.2    Liu, R.3    Baldwin A.S., Jr.4
  • 154
    • 0032054248 scopus 로고    scopus 로고
    • Therapeutic intervention and signaling
    • Heimbrook, D.C. and Oliff, A. (1998) Therapeutic intervention and signaling. Curr. Opin. Cell Biol., 10, 284-288.
    • (1998) Curr. Opin. Cell Biol. , vol.10 , pp. 284-288
    • Heimbrook, D.C.1    Oliff, A.2
  • 155
    • 0033606961 scopus 로고    scopus 로고
    • Ras-GTPase activating protein inhibition specifically induces apoptosis of tumour cells
    • Leblanc, V., Delumeau, I. and Tocque, B. (1999) Ras-GTPase activating protein inhibition specifically induces apoptosis of tumour cells. Oncogene, 18, 4884-4889.
    • (1999) Oncogene , vol.18 , pp. 4884-4889
    • Leblanc, V.1    Delumeau, I.2    Tocque, B.3
  • 156
  • 157
    • 0031906110 scopus 로고    scopus 로고
    • Adenovirus-mediated p53 gene delivery potentiates the radiation-induced growth inhibition of experimental brain tumors
    • Badie, B., Kramar, M.H., Lau, R., Boothman, D.A., Economou, J.S. and Black, K.L. (1998) Adenovirus-mediated p53 gene delivery potentiates the radiation-induced growth inhibition of experimental brain tumors. J. Neurooncol., 37, 217-222.
    • (1998) J. Neurooncol. , vol.37 , pp. 217-222
    • Badie, B.1    Kramar, M.H.2    Lau, R.3    Boothman, D.A.4    Economou, J.S.5    Black, K.L.6
  • 159
    • 0027741247 scopus 로고
    • Adenovirus genes that modulate the sensitivity of virus-infected cells to lysis by TNF
    • Wold, W.S. (1993) Adenovirus genes that modulate the sensitivity of virus-infected cells to lysis by TNF. J. Cell Biochem., 53, 329-335.
    • (1993) J. Cell Biochem. , vol.53 , pp. 329-335
    • Wold, W.S.1
  • 160
    • 0030843522 scopus 로고    scopus 로고
    • C-Myc plays a role in cellular susceptibility to death receptor-mediated and chemotherapy-induced apoptosis in human monocytic leukemia U937 cells
    • Dong, J., Naito, M. and Tsuruo, T. (1997) c-Myc plays a role in cellular susceptibility to death receptor-mediated and chemotherapy-induced apoptosis in human monocytic leukemia U937 cells. Oncogene, 15, 639-647.
    • (1997) Oncogene , vol.15 , pp. 639-647
    • Dong, J.1    Naito, M.2    Tsuruo, T.3
  • 161
    • 0030762815 scopus 로고    scopus 로고
    • An antagonist decoy receptor and a death domain-containing receptor for TRAIL
    • Pan, G., Ni, J., Wei, Y.F., Yu, G., Gentz, R. and Dixit, V.M. (1997) An antagonist decoy receptor and a death domain-containing receptor for TRAIL Science, 277, 815-818.
    • (1997) Science , vol.277 , pp. 815-818
    • Pan, G.1    Ni, J.2    Wei, Y.F.3    Yu, G.4    Gentz, R.5    Dixit, V.M.6
  • 165
    • 0032565444 scopus 로고    scopus 로고
    • Apoptin(R) specifically causes apoptosis in tumor cells and after UV-treatment in untransformed cells from cancer-prone individuals: A review
    • Noteborn, M.H.M., Zhang, Y. and van der Eb, A.J. (1998) Apoptin(R) specifically causes apoptosis in tumor cells and after UV-treatment in untransformed cells from cancer-prone individuals: A review. Mutat. Res., 400, 447-455.
    • (1998) Mutat. Res. , vol.400 , pp. 447-455
    • Noteborn, M.H.M.1    Zhang, Y.2    Van Der Eb, A.J.3
  • 167
    • 0029559027 scopus 로고
    • Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint
    • Krek, W., Xu, G. and Livingston, D.M. (1995) Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint. Cell, 83, 1149-1158.
    • (1995) Cell , vol.83 , pp. 1149-1158
    • Krek, W.1    Xu, G.2    Livingston, D.M.3


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