Hematopoietic malignancies demonstrate loss-of-function mutations of BAX

Blood

Volumn 91, Issue 8, 1998, Pages 2991-2997

  Meijerink, Jules P P ^b   Mensink, Ewald J B M ^b   Wang, Kun ^b   Sedlak, Thomas W ^b   Slöetjes, Annet W ^b   De Witte, Theo ^b   Waksman, Gabriel ^b   Korsmeyer, Stanley J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; PROTEIN BAX; PROTEIN BCL 2;

ACUTE LYMPHOBLASTIC LEUKEMIA; AMINO ACID SUBSTITUTION; APOPTOSIS; ARTICLE; GENE MUTATION; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC SYSTEM TUMOR; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 0032522953     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.8.2991.2991_2991_2997     Document Type: Article

References (42)

1. Thompson CB: Apoptosis in the pathogenesis and treatment of disease. Science 267:1456, 1995
2. Yang E, Korsmeyer SJ: Molecular thanatopsis: A discourse on the Bcl-2 family and cell death. Blood 88:386, 1996
3. Oltvai ZN, Milliman CL, Korsmeyer SJ: Bcl-2 heterodimerizes in-vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609, 1993
4. Sato T, Hanada M, Bodrug S, Irie SJ, Iwama N, Boise LH, Thompson CB, Golemis E, Fong L, Wang HG, Reed JC: Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc Natl Acad Sci USA 91:9238, 1994
5. Sedlak TW, Oltvai ZN, Yang E, Wang K, Boise LH, Thompson CB, Korsmeyer SJ: Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc Natl Acad Sci USA 92:7834, 1995
6. Yin XM, Oltvai ZN, Korsmeyer SJ: BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 369:321, 1994
7. Chittenden T, Remington C, Houghton AB, Ebb RG, Gallo GJ, Elangovan B, Chinnadurai G, Lutz RJ: A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. EMBO J 14:5589, 1995
8. Zha H, Aime Sempe C, Sato T, Reed JC: Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2. J Biol Chem 271:7440, 1996
9. Muchmore SW, Sattler M, Liang H, Meadows RP, Harlan JE, Yoon HS, Nettesheim D, Chang BS, Thompson CB, Wong SL, Ng SC, Fesik SW: X-ray and NMR structure of human Bcl-xl, an inhibitor of programmed cell death. Nature 381:335, 1996
10. Boyd JM, Gallo GJ, Subramanian T, Chittenden T, Lutz RJ, Chinnadurai G: Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. Oncogene 11:1921, 1995
11. Han J, Sabbatini P, White E: Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K. Mol Cell Biol 16:5857, 1996
12. Wang K, Yin XM, Chao DT, Milliman CL, Korsmeyer SJ: Bid: A novel BH3 domain-only death agonist. Genes Dev 10:2859, 1996
13. Borner C, Martinou I, Mattmann C, Irmler M, Schaerer E, Martinou JC, Tschopp J: The protein Bcl-2α does not require membrane attachment, but two conserved domains to suppress apoptosis. J Cell Biol 126:1059, 1994
14. Hunter JJ, Bond BL, Parslow TG: Functional dissection of the human Bcl-2 protein: Sequence requirements for inhibition of apoptosis. Mol Cell Biol 16:877, 1996
15. Reed JC: Bcl-2 and the regulation of programmed cell death. Cell Biol 124:1, 1994
16. Bargou RC, Daniel PT, Mapara MY, Bommert K, Wagener C, Kallinich B, Royer HD, Dorken B: Expression of the bcl-2 gene family in normal and malignant breast tissue: Low bax-alpha expression in tumor cells correlates with resistance towards apoptosis. Int J Cancer 60:854, 1995
17. Krajewski S, Blomqvist C, Franssila K, Krajewska M, Wasenius VM, Niskanen E, Nordling S, Reed JC: Reduced expression of proapoptotic gene Bax is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. Cancer Res 55:4471, 1995
18. Aguilar-Santelises M, Rottenberg ME, Lewin N, Mellstedt H, Jondal M: Bcl-2, Bax and P53 expression in B-CLL in relation to in-vitro survival and clinical progression. Int J Cancer 69:114, 1996
19. Gazzaniga P, Gradilone A, Vercillo R, Gandini O, Silvestri I, Napolitano M, Albonici L, Vincenzoni A, Gallucci M, Frati L, Agliano AM: Bcl-2/Bax mRNA expression ratio as prognostic factor in lowgrade urinary bladder cancer. Int J Cancer 69:100, 1996
20. Knudson CM, Tung KSK, Tourtellotte WG, Brown GAJ, Korsmeyer SJ: Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270:96, 1995
21. Deckwerth TL, Elliott JL, Knudson CM, Johnson EM Jr, Snider WD, Korsmeyer SJ: Bax is required for neuronal death after trophic factor deprivation and during development. Neuron 17:401, 1996
22. Xiang J, Chao DT, Korsmeyer SJ: Bax-induced cell death may not require interleukin 1β-converting enzyme-like proteases. Proc Natl Acad Sci USA 93:14559, 1996
23. Alnemri ES, Livingston DJ, Nicholson DW, Salveson G, Thornberry NA, Wong WW, Yuan J: Human ICE-CED-3 protease nomenclature. Cell 87:171, 1996
24. Zamzami N, Susin SA, Marchetti P, Hirsch T, Gomez-Monterrey I, Castedo M, Kroemer G: Mitochondrial control of nuclear apoptosis. J Exp Med 183:1533, 1996
25. Yin C, Knudson CM, Korsmeyer SJ, Van Dyke T: Bax suppresses tumorigenesis and stimulates apoptosis in-vivo. Nature 385:637, 1997
26. McCurrach ME, Conner TMF, Knudson CM, Korsmeyer SJ, Lowe SW: Bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. Proc Natl Acad Sci USA 1997:2345, 1997
27. Meijerink JPP, Smetsers TFCM, Slöetjes AW, Linders EHP, Mensink EJBM: Bax mutations in cell lines derived from hematological malignancies. Leukemia 9:1828, 1995
28. Rampino N, Yamamoto H, lonov Y, Li Y, Sawai H, Reed JC, Perucho M: Somatic frameshift mutations in the Bax gene in colon cancers of the microsatellite mutator phenotype. Science 275:967, 1997
29. Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334, 1990
30. Kolodziej PA, Young RA: Epitope tagging and protein surveillance. Methods Enzymol 194:508, 1991
31. Rose MD, Winston F, Hieter P: Methods in Yeast Genetics: A Laboratory Course Manual. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 1990
32. Pawelec G, Borowitz P, Krammer H, Wernet P: Constitutive interleukin 2 production by the JURKAT human leukemic T cell line. Eur J Immunol 12:387, 1982
33. McDonnell TJ, Deane N, Platt FM, Nunez G, Jaeger U, McKearn JP, Korsmeyer SJ: Bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 57:79, 1989
34. Lowe SW, Ruley HE, Jacks T, Housman DE: p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74:954, 1993
35. Symonds H, Krall L, Remington L, Saenz-Robles M, Lowe S, Jacks T, Van Dyke T: p53-dependent apoptosis suppresses tumor growth and progression in-vivo. Cell 78:703, 1994
36. Liu B, Parsons R, Papadopoulos N, Nicolaides NC, Lynch HT, Watson P, Jass JR, Dunlop M, Wyllie A, Peltomäki P, De La Chapelle A, Hamilton SR, Vogelstein B, Kinzler KW: Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nat Med 2:169, 1996
37. Lowsky R, DeCoteau JF, Reitmair AH, Ichinohasama R, Dong W-F, Xu Y, Mak TW, Kadin ME, Minden MD: Defects of the mismatch repair gene MSH2 are implicated in the development of murine and human lymphoblastic lymphomas and are associated with the aberrant expression of Rhombotin-2 (Lmo-2) and Tal-1 (SCL). Blood 89:2276, 1997
38. Hangaishi A, Ogawa S, Mitani K, Hosoya N, Chiba S, Yazaki Y, Hirai H: Mutations and loss of expression of a mismatch repair gene, hMLH1, in leukemia and lymphoma cell lines. Blood 89:1740, 1997
39. L-Bak peptide complex: Recognition between regulators of apoptosis. Science 275:983, 1997
40. L forms an ion channel in synthetic lipid membranes. Nature 385:353, 1997
41. Antonsson B, Conti F, Ciavatta AM, Montessuit S, Lewis S, Martinou I, Bernasconi L, Bernard A, Mermod J-J, Mazzei G, Maundrell K, Gambale RS, Martinou J-C: Inhibition of Bax channel-forming activity by Bcl-2. Science 277:370, 1997
42. Schlesinger PH, Gross A, Yin X-M, Yamamoto K, Saito M, Waksman G, Korsmeyer SJ: Comparison of the ion channel characteristics of pro-apoptotic BAX and anti-apoptotic BCL-2. Proc Natl Acad Sci USA 94:11357, 1997