Cell-cycle arrest versus cell death in cancer therapy

Nature Medicine

Volumn 3, Issue 9, 1997, Pages 1034-1036

  Waldman, Todd ^a,b   Zhang, Yonggang ^a   Dillehay, Larry ^a   Yu, Jian ^a,b   Kinzler, Kenneth ^a   Vogelstein, Bert ^a,c   Williams, Jerry ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b Program in Human Genetics   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P21;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL DEATH; CELL SURVIVAL; COLON CARCINOMA; CONTROLLED STUDY; DNA DAMAGE; GAMMA RADIATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL DEATH; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; GAMMA RAYS; GENES, P53; HUMANS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; RADIATION TOLERANCE; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY;

ANIMALIA;

EID: 0030842655     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0997-1034     Document Type: Article

References (17)

1. Waldman, T., Lengauer, C., Kinzler, K.W. & Vogelstein, B. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 381, 713-716 (1996).
2. Kastan, M.B., Onyekwere, O., Sidransky, D., Vogelstein, B. & Craig, R.W. Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51, 6304-6311 (1991).
3. Cross, S.M. et al. A p53-dependent mouse spindle checkpoint. Science 267, 1353-1356 (1995).
4. Tishler, R.B., Lamppu, D.B., Park, S. & Price, B.D. Microtubule active drugs Taxol, vinblastine, and nocodazole increase the levels of transcriptionally active p53. Cancer Res. 55, 6021-6025 (1995).
5. 1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev. 10, 934-947 (1996).
6. Lowe, S.W., Ruley, H.E., lacks, T. & Housman, D.E. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74, 957-967 (1993).
7. Hartwell, L.H. & Kastan, M.B. Cell cycle control and cancer. Science 266, 1821-1828 (1994).
8. El-Deiry, W. et al. WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817-825 (1993).
9. Xiong, Y. et al. p21 is a universal inhibitor of cyclin kinases. Nature 366, 701-704 (1993)
10. Harper, J.W., Adami, G.R., Wei, N., Keyomarsi, K. & Elledge, S.J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75, 805-816 (1993).
11. Waldman, T., Kinzler, K. & Vogelstein, B. p21 is necessary for the p53-mediated C1 arrest in human cancer cells. Cancer Res. 55, 5187-5190 (1995).
12. CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82, 675-684 (1995).
13. Brugarolas, J. et al. Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377, 552-557 (1995).
14. Di Leonardo, A., Linke, S.P., Clarkin, K. & Wahl, C.M. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 8, 2540-2551 (1994).
15. 1 block is abolished in human diploid fibroblasts transfected with human papilloma virus E6 gene: Implications of the p53-Cip1/WAF1 pathway. Int. J. Oncol. 6, 233-236 (1995).
16. Revesz, L. Effect of tumour cells killed by x-rays upon the growth of admixed viable cells. Nature 178, 1391-1392 (1956).
17. Revesz, L. Effect of lethally damaged tumor cells upon the development of admixea viable cells. J. Natl. Cancer Inst. 20, 1157-1186 (1958).