Ras-GTPase activating protein inhibition specifically induces apoptosis of tumour cells

Oncogene

Volumn 18, Issue 34, 1999, Pages 4884-4889

  Leblanc, Véronique ^a   Delumeau, Isabelle ^b   Tocqué, Bruno ^a  

^a ExonHit Therapeutics   (France)

^b SANOFI   (France)

Author keywords

Apoptosis; Ras GAP; RhoA; Tumour cells

Indexed keywords

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MONOCLONAL ANTIBODY; PHOSPHATIDYLINOSITOL 3 KINASE; RAS PROTEIN;

APOPTOSIS; ARTICLE; CELL SURVIVAL; HUMAN; HUMAN CELL; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TUMOR CELL; TUMOR SUPPRESSOR GENE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIBODIES, MONOCLONAL; APOPTOSIS; BREAST NEOPLASMS; CDC42 GTP-BINDING PROTEIN; CELL CYCLE PROTEINS; CELL SURVIVAL; COLONIC NEOPLASMS; FEMALE; FIBROBLASTS; GTP-BINDING PROTEINS; GTPASE-ACTIVATING PROTEINS; HELA CELLS; HUMANS; LUNG NEOPLASMS; MICROINJECTIONS; MICROSCOPY, VIDEO; ONCOGENE PROTEINS V-RAF; PROTEINS; RAS GTPASE-ACTIVATING PROTEINS; RETROVIRIDAE PROTEINS, ONCOGENIC; RHOA GTP-BINDING PROTEIN; SRC HOMOLOGY DOMAINS; TUMOR CELLS, CULTURED;

EID: 0033606961     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1202855     Document Type: Article

References (33)

1. Alonso T, Srivastava S and Santos E. (1990). Mol. Cell. Biol., 10, 3117-3124.
2. Arceci RJ. (1995). Curr. Opin. Hematol., 2, 268-274.
3. Bobak D, Moorman J, Guanzon A, Gilmer L and Hahn C. (1997). Oncogene, 2, 2179-2189.
4. Clark GJ, Westwick JK and Der CJ. (1997). J. Biol. Chem., 272, 1677-1681.
5. Cochet O, Kenigsberg M, Delumeau I, Virone-Oddos A, Multon MC, Fridman WH, Schweighoffer F, Teillaud JL and Tocque B. (1998). Cancer Res., 58, 1170-1176.
6. Coso OA, Chiariello M, Yu JC, Teramoto H, Crespo P, Xu N, Miki T and Gutkind JS. (1995). Cell, 81, 1137-1146.
7. Downward J. (1998). Curr. Opin. Cell. Biol., 10, 262-267.
8. Fenton RG, Hixon JA, Wright PW, Brooks AD and Sayers TJ. (1998). Cancer Res., 58, 3391-4003.
9. Fiorentini C, Matarrese P, Straface E, Falzano L, Fabbri A, Donelli G, Cossarizza A, Boquet P and Malorni W. (1998). Exp. Cell. Res., 242, 341-350.
10. Henkemeyer M, Rossi DJ, Holmyard DP, Puri MC, Mbamalu G, Harpal K, Shih T, Jacks T and Pawson T. (1995). Nature, 377, 695-701.
11. Henning SW, Galandrini R, Hall A and Cantrell DA. (1997). EMBO J., 16, 2397-2407.
12. Kauffmann-Zeh A, Rodriguez-Viciana P, Ulrich E, Gilbert C, Coffer P, Downward J and Evan G. (1997). Nature, 385, 544-548.
13. Leblanc V, Tocqué B and Delumeau I. (1998). Mol. Cell. Biol., 18, 5567-5578.
14. Medema RH, de Laat WL, Martin GA, McCormick F and Bos JL. (1992). Mol. Cell. Biol., 12, 3425-3430.
15. Minden A, Lin A, Claret FX, Abo A and Karin M. (1995). Cell, 81, 1147-1157.
16. Mollat P, Zhang GY, Frobert Y, Zhang YH, Fournier A, Grassi J and Thang MN. (1992). Biotechnology NY, 10, 1151-1156.
17. Moorman JP, Bobak DA und Hahn CS. (1996). J. Immunol., 156, 4146-4153.
18. Nobes CD and Hall A. (1995). Cell, 81, 53-62.
19. Nonaka H, Tanaka K, Hirano H, Fujiwara T, Kohno H, Umikawa M, Mino A and Takai Y. (1995). EMBO J., 14, 5931-5938.
20. Olson MF, Paterson HF and Marshall CJ. (1998). Nature, 394, 295-299.
21. Qiu RG, Chen J, Kirn D, McCormick F and Symons M. (1995a). Nature, 374, 457-459.
22. Qiu RG, Chen J, McCormick F and Symons M. (1995b). Proc. Natl. Acad. Sci. USA, 92, 11781-11785.
23. Rey I, Soubigou P, Debussehe L, David C, Morgat A, Bost PE, Mayaux JF and Tocque B. (1989). Mol. Cell. Biol., 9, 3904-3910.
24. Ridley AJ and Hall A. (1992). Cell, 70, 389-399.
25. Rodriguez-Viciana P, Warne PH, Vanhaesebroeck B, Waterfield MD and Downward J. (1996). EMBO J., 15, 2442-2451.
26. Salvesen GS and Dixit VM. (1997). Cell, 91, 443-446.
27. Schweighoffer F, Barlat I, Chevallier-Multon MC and Tocque B. (1992). Science, 256, 825-827.
28. Serrano M, Lin AW, McCurrach ME, Beach D and Lowe SW. (1997). Cell, 88, 593-602.
29. Teramoto H, Crespo P, Coso OA, Igishi T, Xu N and Gutkind JS. (1996). J. Biol. Chem., 271, 25731-25734.
30. Tocqué B, Delumeau I, Parker F, Maurier F, Multon MC and Schweighoffer F. (1997). Cell Signal, 9, 153-158.
31. Wang HG, Rapp UR and Reed JC. (1996). Cell, 87, 629-638.
32. Wasylyk C, Imler JL and Wasylyk B. (1988). EMBO J., 7, 2475-2483.
33. White MA, Nicolette C, Minden A, Polverino A, Van Aelst L, Karin M and Wigler MH. (1995). Cell, 80, 533-541.