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Volumn 55, Issue 1, 1999, Pages 64-75

Clinical implications of p53 mutations

Author keywords

Apoptosis; Cancer genetics; Chemotherapy; Clinical outcome; Prognosis; Tumor suppressor

Indexed keywords

CYTOTOXIC AGENT; PROTEIN P53;

EID: 0033054908     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000180050270     Document Type: Review
Times cited : (197)

References (140)
  • 1
    • 0027983669 scopus 로고
    • Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
    • 1 Cho Y., Gorina S., Jeffrey P. D. and Pavletich N. P. (1994) Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science 265: 346-355
    • (1994) Science , vol.265 , pp. 346-355
    • Cho, Y.1    Gorina, S.2    Jeffrey, P.D.3    Pavletich, N.P.4
  • 2
    • 0030951637 scopus 로고    scopus 로고
    • Tumor suppressors: A developing role for p53?
    • 2 Hall P. A. and Lane D. P. (1997) Tumor suppressors: a developing role for p53? Curr. Biol. 7: R144-147
    • (1997) Curr. Biol. , vol.7
    • Hall, P.A.1    Lane, D.P.2
  • 3
    • 0030828044 scopus 로고    scopus 로고
    • p53 and apoptosis
    • 3 Bellamy C. O. (1997) p53 and apoptosis. Br. Med. Bull. 53: 522-538
    • (1997) Br. Med. Bull. , vol.53 , pp. 522-538
    • Bellamy, C.O.1
  • 4
    • 0028672529 scopus 로고
    • The p53 tumor suppressor gene inhibits angiogenesis by stimulating the production of thrombospondin
    • 4 Dameron K. M., Volpert O. V., Tainsky M. A. and Bouck N. (1994) The p53 tumor suppressor gene inhibits angiogenesis by stimulating the production of thrombospondin. Cold Spring Harb. Symp. Quant. Biol. 59: 483-489
    • (1994) Cold Spring Harb. Symp. Quant. Biol. , vol.59 , pp. 483-489
    • Dameron, K.M.1    Volpert, O.V.2    Tainsky, M.A.3    Bouck, N.4
  • 5
    • 0031465731 scopus 로고    scopus 로고
    • p21/p53, cellular growth control and genomic integrity
    • 5 El-Deiry W. (1998) p21/p53, cellular growth control and genomic integrity. Curr. Top. Microbiol. Immunol. 227: 121-137
    • (1998) Curr. Top. Microbiol. Immunol. , vol.227 , pp. 121-137
    • El-Deiry, W.1
  • 6
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • 6 Levine A. J. (1997) p53, the cellular gatekeeper for growth and division. Cell 88: 323-331
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 8
    • 0030612166 scopus 로고    scopus 로고
    • Mammalian G1 and G2 phase checkpoints
    • 8 O'Connor P. M. (1997) Mammalian G1 and G2 phase checkpoints. Cancer Surv. 29: 151-182
    • (1997) Cancer Surv. , vol.29 , pp. 151-182
    • O'Connor, P.M.1
  • 9
    • 0029801598 scopus 로고    scopus 로고
    • p53: Guardian of cellular senescence
    • 9 Wynford T. D. (1996) p53: guardian of cellular senescence. J. Pathol. 180: 118-121
    • (1996) J. Pathol. , vol.180 , pp. 118-121
    • Wynford, T.D.1
  • 10
    • 0028169994 scopus 로고
    • p53-dependent apoptosis suppresses tumor growth and progression in vivo
    • 10 Symonds H., Krall L., Remington L., Saenz-Robles M., Lowe S., Jacks T. et al. (1994) p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell 78: 703-711
    • (1994) Cell , vol.78 , pp. 703-711
    • Symonds, H.1    Krall, L.2    Remington, L.3    Saenz-Robles, M.4    Lowe, S.5    Jacks, T.6
  • 11
    • 0028323294 scopus 로고
    • Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells
    • 11 Lowe S. W., Jacks T., Housman D. E. and Ruley H. E. (1994) Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells. Proc. Natl. Acad. Sci. USA 91: 2026-2030
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 2026-2030
    • Lowe, S.W.1    Jacks, T.2    Housman, D.E.3    Ruley, H.E.4
  • 12
    • 0028171968 scopus 로고
    • Mediation of c-Myc-induced apoptosis by p53
    • 12 Hermeking H. and Eick D. (1994) Mediation of c-Myc-induced apoptosis by p53. Science 265: 2091-2093
    • (1994) Science , vol.265 , pp. 2091-2093
    • Hermeking, H.1    Eick, D.2
  • 13
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptolic potential in solid tumours
    • 13 Graeber T. G., Osmanian C., Jacks T., Housman D. E., Koch C. J., Lowe S. W. et al. (1996) Hypoxia-mediated selection of cells with diminished apoptolic potential in solid tumours. Nature 379: 88-91
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3    Housman, D.E.4    Koch, C.J.5    Lowe, S.W.6
  • 15
    • 0028225536 scopus 로고
    • Prognostic significance of loss of a chromosome 17p and p53 gene mutations in blast crisis of chronic myelogenous leukaemia
    • 15 Nakai H., Misawa S., Taniwaki M., Horiike S., Takashima T., Seriu T. et al. (1994) Prognostic significance of loss of a chromosome 17p and p53 gene mutations in blast crisis of chronic myelogenous leukaemia. Br. J. Haematol. 87: 425-427
    • (1994) Br. J. Haematol. , vol.87 , pp. 425-427
    • Nakai, H.1    Misawa, S.2    Taniwaki, M.3    Horiike, S.4    Takashima, T.5    Seriu, T.6
  • 16
    • 0028295419 scopus 로고
    • Nonhereditary p53 mutations in T-cell acute lymphoblastic leukemia are associated with the relapse phase
    • 16 Hsiao M. H., Yu A. L., Yeargin J., Ku D. and Haas M. (1994) Nonhereditary p53 mutations in T-cell acute lymphoblastic leukemia are associated with the relapse phase. Blood 83: 2922-2930
    • (1994) Blood , vol.83 , pp. 2922-2930
    • Hsiao, M.H.1    Yu, A.L.2    Yeargin, J.3    Ku, D.4    Haas, M.5
  • 17
    • 0027436745 scopus 로고
    • p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDRI/MDR3 gene expression
    • 17 El Rouby S., Thomas A., Costin D., Rosenberg C. R., Potmesil M., Silber R. et al. (1993) p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDRI/MDR3 gene expression. Blood 82: 3452-3459
    • (1993) Blood , vol.82 , pp. 3452-3459
    • El Rouby, S.1    Thomas, A.2    Costin, D.3    Rosenberg, C.R.4    Potmesil, M.5    Silber, R.6
  • 18
    • 0026608857 scopus 로고
    • p53 allele losses, mutations and expression in breast cancer and their relationship to clinico-pathological parameters
    • 18 Thompson A. M., Anderson T. J., Condie A., Prosser J., Chetty U., Carter D. C. et al. (1992) p53 allele losses, mutations and expression in breast cancer and their relationship to clinico-pathological parameters. Int. J. Cancer 50: 528-532
    • (1992) Int. J. Cancer , vol.50 , pp. 528-532
    • Thompson, A.M.1    Anderson, T.J.2    Condie, A.3    Prosser, J.4    Chetty, U.5    Carter, D.C.6
  • 19
    • 0027481931 scopus 로고
    • Somatic p53 mutations in human breast carcinomas in an Icelandic population: A prognostic factor
    • 19 Thorlacius S., Borresen A. L. and Eyfjord J. E. (1993) Somatic p53 mutations in human breast carcinomas in an Icelandic population: a prognostic factor. Cancer Res. 53: 1637-1641
    • (1993) Cancer Res. , vol.53 , pp. 1637-1641
    • Thorlacius, S.1    Borresen, A.L.2    Eyfjord, J.E.3
  • 21
    • 0030071853 scopus 로고    scopus 로고
    • Mutation detection by highly sensitive methods indicates that p53 gene mutations in breast cancer can have important prognostic value
    • 21 Kovach J. S., Hartmann A., Blaszyk H., Cunningham J., Schaid D. and Sommer S. S. (1996) Mutation detection by highly sensitive methods indicates that p53 gene mutations in breast cancer can have important prognostic value. Proc. Natl. Acad. Sci. USA 93: 1093-1096
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 1093-1096
    • Kovach, J.S.1    Hartmann, A.2    Blaszyk, H.3    Cunningham, J.4    Schaid, D.5    Sommer, S.S.6
  • 22
    • 0028875410 scopus 로고
    • Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy
    • 22 Bergh J., Norberg T., Sjogren S., Lindgren A. and Holmberg L. (1995) Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy. Nature Med. 1: 1029-1034
    • (1995) Nature Med. , vol.1 , pp. 1029-1034
    • Bergh, J.1    Norberg, T.2    Sjogren, S.3    Lindgren, A.4    Holmberg, L.5
  • 23
    • 0029956081 scopus 로고    scopus 로고
    • Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients
    • 23 Aas T., Borresen A. L., Geisler S., Smith-Sorensen B., Johnsen H., Varhaug J. E. et al. (1996) Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients. Nature Med. 2: 811-814
    • (1996) Nature Med. , vol.2 , pp. 811-814
    • Aas, T.1    Borresen, A.L.2    Geisler, S.3    Smith-Sorensen, B.4    Johnsen, H.5    Varhaug, J.E.6
  • 24
    • 0030657740 scopus 로고    scopus 로고
    • Original p53 status predicts for pathological response in locally advanced breast cancer patients treated preoperatively with continuous infusion 5-fluorouracil and radiation therapy
    • 24 Formenti S. C., Dunnington G., Uzieli B., Lenz H., Keren-Rosenberg S., Silberman H. et al. (1997) Original p53 status predicts for pathological response in locally advanced breast cancer patients treated preoperatively with continuous infusion 5-fluorouracil and radiation therapy. Int. J. Radial. Oncol. Biol. Phys. 39: 1059-1068
    • (1997) Int. J. Radial. Oncol. Biol. Phys. , vol.39 , pp. 1059-1068
    • Formenti, S.C.1    Dunnington, G.2    Uzieli, B.3    Lenz, H.4    Keren-Rosenberg, S.5    Silberman, H.6
  • 25
    • 15144343103 scopus 로고    scopus 로고
    • p53 mutation is a poor prognostic indicator for survival in patients with hepatocellular carcinoma undergoing surgical tumour ablation
    • 25 Honda K., Sbisa E., Tullo A., Papeo P. A., Saccone C., Poole S. et al. (1998) p53 mutation is a poor prognostic indicator for survival in patients with hepatocellular carcinoma undergoing surgical tumour ablation. Br. J. Cancer 77: 776-782
    • (1998) Br. J. Cancer , vol.77 , pp. 776-782
    • Honda, K.1    Sbisa, E.2    Tullo, A.3    Papeo, P.A.4    Saccone, C.5    Poole, S.6
  • 26
    • 0030934802 scopus 로고    scopus 로고
    • Mutated p53 gene is an independent adverse predictor of survival in colon carcinoma
    • 26 Pricolo V. E., Finkelstein S. D., Hansen K., Cole B. F. and Bland K. I. (1997) Mutated p53 gene is an independent adverse predictor of survival in colon carcinoma. Arch. Surg. 132: 371-374; discussion 374-375
    • (1997) Arch. Surg. , vol.132 , pp. 371-374
    • Pricolo, V.E.1    Finkelstein, S.D.2    Hansen, K.3    Cole, B.F.4    Bland, K.I.5
  • 27
    • 0030865134 scopus 로고    scopus 로고
    • p53 protein in endometrial cancer is related to proliferative activity and prognosis but not to expression of p21 protein
    • 27 Backe J., Gassel A. M., Hauber K., Krebs S., Bartek J., Caffier H. et al. (1997) p53 protein in endometrial cancer is related to proliferative activity and prognosis but not to expression of p21 protein. Int. J. Gynecol. Pathol. 16: 361-368
    • (1997) Int. J. Gynecol. Pathol. , vol.16 , pp. 361-368
    • Backe, J.1    Gassel, A.M.2    Hauber, K.3    Krebs, S.4    Bartek, J.5    Caffier, H.6
  • 28
    • 0027137816 scopus 로고
    • Mutations of the p53 gene as a predictor of poor prognosis in patients with non-small-cell lung cancer
    • 28 Mitsudomi T., Oyama T., Kusano T., Osaki T., Nakanishi R. and Shirakusa T. (1993) Mutations of the p53 gene as a predictor of poor prognosis in patients with non-small-cell lung cancer. J. Natl. Cancer Inst. 85: 2018-2023
    • (1993) J. Natl. Cancer Inst. , vol.85 , pp. 2018-2023
    • Mitsudomi, T.1    Oyama, T.2    Kusano, T.3    Osaki, T.4    Nakanishi, R.5    Shirakusa, T.6
  • 29
    • 0031908238 scopus 로고    scopus 로고
    • Mutations of p53 and K-ras genes as prognostic factors for non-small cell lung cancer
    • 29 Huang C. L., Taki T., Adachi M., Konishi T., Higashiyama M., Kinoshita M. et al. (1998) Mutations of p53 and K-ras genes as prognostic factors for non-small cell lung cancer. Int. J. Oncol. 12: 553-563
    • (1998) Int. J. Oncol. , vol.12 , pp. 553-563
    • Huang, C.L.1    Taki, T.2    Adachi, M.3    Konishi, T.4    Higashiyama, M.5    Kinoshita, M.6
  • 31
    • 0028168146 scopus 로고
    • Anaplastic Wilms' tumour, a subtype displaying poor prognosis, harbours p53 gene mutations
    • 31 Bardeesy N., Falkoff D., Petruzzi M. J., Nowak N., Zabel B., Adam M. et al. (1994) Anaplastic Wilms' tumour, a subtype displaying poor prognosis, harbours p53 gene mutations. Nature Genet. 7:91-97
    • (1994) Nature Genet. , vol.7 , pp. 91-97
    • Bardeesy, N.1    Falkoff, D.2    Petruzzi, M.J.3    Nowak, N.4    Zabel, B.5    Adam, M.6
  • 33
  • 34
    • 0031032368 scopus 로고    scopus 로고
    • The relationship between TP53 mutations and overexpression of p53 and prognosis in malignant gliomas of childhood
    • 34 Pollack I. F., Hamilton R. L., Finkelstein S. D., Campbell J. W., Martinez A. J., Sherwin R. N. et al. (1997) The relationship between TP53 mutations and overexpression of p53 and prognosis in malignant gliomas of childhood. Cancer Res. 57: 304-309
    • (1997) Cancer Res. , vol.57 , pp. 304-309
    • Pollack, I.F.1    Hamilton, R.L.2    Finkelstein, S.D.3    Campbell, J.W.4    Martinez, A.J.5    Sherwin, R.N.6
  • 35
    • 0032054823 scopus 로고    scopus 로고
    • Prognostic value of P53 gene mutations in a large series of node-negative breast cancer patients
    • 35 Falette N., Paperin M. P., Treilleux I., Gratadour A. C., Peloux N., Mignotte H. et al. (1998) Prognostic value of P53 gene mutations in a large series of node-negative breast cancer patients. Cancer Res. 58: 1451-1455
    • (1998) Cancer Res. , vol.58 , pp. 1451-1455
    • Falette, N.1    Paperin, M.P.2    Treilleux, I.3    Gratadour, A.C.4    Peloux, N.5    Mignotte, H.6
  • 36
    • 0028850813 scopus 로고
    • Clonal expansion and attenuated apoptosis in Wilms' tumors are associated with p53 gene mutations
    • 36 Bardeesy N., Beckwith J. B., and Pelletier J. (1995) Clonal expansion and attenuated apoptosis in Wilms' tumors are associated with p53 gene mutations. Cancer Res. 55: 215-219
    • (1995) Cancer Res. , vol.55 , pp. 215-219
    • Bardeesy, N.1    Beckwith, J.B.2    Pelletier, J.3
  • 37
    • 0029563159 scopus 로고
    • p53 mediated tumour cell response to chemotherapeutic DNA damage: A preliminary study in matched pairs of breast cancer biopsies
    • 37 Moll U. M., Ostermeyer A. G., Ahomadegbe J. C., Mathieu M. C. and Riou G (1995) p53 mediated tumour cell response to chemotherapeutic DNA damage: a preliminary study in matched pairs of breast cancer biopsies. Hum. Pathol. 26: 1293-1301
    • (1995) Hum. Pathol. , vol.26 , pp. 1293-1301
    • Moll, U.M.1    Ostermeyer, A.G.2    Ahomadegbe, J.C.3    Mathieu, M.C.4    Riou, G.5
  • 38
    • 8244233169 scopus 로고    scopus 로고
    • Neoangiogenesis and p53 protein in lung cancer: Their prognostic role and their relation with vascular endothelial growth factor (VEGF) expression
    • 38 Fontanini G., Vignati S., Lucchi M., Mussi A., Calcinai A., Boldrini L. et al. (1997) Neoangiogenesis and p53 protein in lung cancer: their prognostic role and their relation with vascular endothelial growth factor (VEGF) expression. Br. J. Cancer 75: 1295-1301
    • (1997) Br. J. Cancer , vol.75 , pp. 1295-1301
    • Fontanini, G.1    Vignati, S.2    Lucchi, M.3    Mussi, A.4    Calcinai, A.5    Boldrini, L.6
  • 39
    • 0032548970 scopus 로고    scopus 로고
    • p53, vessel count, and vascular endothelial growth factor expression in human colon cancer
    • 39 Takahashi Y., Bucana C. D., Cleary K. R. and Ellis L. M. (1998) p53, vessel count, and vascular endothelial growth factor expression in human colon cancer. Int. J. Cancer 79: 34-38
    • (1998) Int. J. Cancer , vol.79 , pp. 34-38
    • Takahashi, Y.1    Bucana, C.D.2    Cleary, K.R.3    Ellis, L.M.4
  • 40
    • 0029808229 scopus 로고    scopus 로고
    • Clonality and stability of the p53 gene in human astrocytic tumor cells: Quantitative analysis of p53 gene mutations by yeast functional assay
    • 40 Tada M., Iggo R. D., Ishii N., Shinohe Y., Sakuma S., Estreicher A. et al. (1996) Clonality and stability of the p53 gene in human astrocytic tumor cells: quantitative analysis of p53 gene mutations by yeast functional assay. Int. J. Cancer 67: 447-450
    • (1996) Int. J. Cancer , vol.67 , pp. 447-450
    • Tada, M.1    Iggo, R.D.2    Ishii, N.3    Shinohe, Y.4    Sakuma, S.5    Estreicher, A.6
  • 41
    • 0029964158 scopus 로고    scopus 로고
    • A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
    • 41 Linke S. P., Clarkin K. C., Di Leonardo A., Tsou A. and Wahl G. M. (1996) A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev. 10: 934-947
    • (1996) Genes Dev. , vol.10 , pp. 934-947
    • Linke, S.P.1    Clarkin, K.C.2    Di Leonardo, A.3    Tsou, A.4    Wahl, G.M.5
  • 42
    • 0029834677 scopus 로고    scopus 로고
    • Cellular oxidative stress and the control of apoptosis by wild-type p53, cytotoxic compounds and cytokines
    • 42 Lotem J., Peled-Kamar M., Groner Y. and Sachs L. (1996) Cellular oxidative stress and the control of apoptosis by wild-type p53, cytotoxic compounds and cytokines. Proc. Natl. Acad. Sci. USA 93: 9166-9171
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9166-9171
    • Lotem, J.1    Peled-Kamar, M.2    Groner, Y.3    Sachs, L.4
  • 43
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • 43 Serrano M., Lin A. W., McCurrach M. E., Beach D. and Lowe S. W. (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88: 593-602
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 44
    • 0027319521 scopus 로고
    • p53 is required for radiation-induced apoptosis in mouse thymocytes
    • 44 Lowe S. W., Schmilt E. M., Smith S. W., Osborne B. A. and Jacks T. (1993) p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362: 847-849
    • (1993) Nature , vol.362 , pp. 847-849
    • Lowe, S.W.1    Schmilt, E.M.2    Smith, S.W.3    Osborne, B.A.4    Jacks, T.5
  • 46
    • 0026496885 scopus 로고
    • A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxiatelangiectasia
    • 46 Kastan M. B., Zhan Q., El Deiry W., Carrier F., Jacks T., Walsh W. V. et al. (1992) A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxiatelangiectasia. Cell 71: 587-597
    • (1992) Cell , vol.71 , pp. 587-597
    • Kastan, M.B.1    Zhan, Q.2    El Deiry, W.3    Carrier, F.4    Jacks, T.5    Walsh, W.V.6
  • 47
    • 0027893001 scopus 로고
    • Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage
    • 47 Slichenmyer W. J., Nelson W. G., Slebos R. J. and Kastan M. B. (1993) Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage. Cancer Res. 53: 4164-4168
    • (1993) Cancer Res. , vol.53 , pp. 4164-4168
    • Slichenmyer, W.J.1    Nelson, W.G.2    Slebos, R.J.3    Kastan, M.B.4
  • 48
    • 0029001624 scopus 로고
    • p53 involvement in control of G2 exit of the cell cycle: Role in DNA damage-induced apoptosis
    • 48 Guillouf C., Rosselli F., Krishnaraju K., Moustacchi E., Hoffman B. and Liebermann D. A. (1995) p53 involvement in control of G2 exit of the cell cycle: role in DNA damage-induced apoptosis. Oncogene 10: 2263-2270
    • (1995) Oncogene , vol.10 , pp. 2263-2270
    • Guillouf, C.1    Rosselli, F.2    Krishnaraju, K.3    Moustacchi, E.4    Hoffman, B.5    Liebermann, D.A.6
  • 49
    • 0030929838 scopus 로고    scopus 로고
    • DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function
    • 49 Di Leonardo A., Khan S. H., Linke S. P., Greco V., Seidita G. and Wahl G. M. (1997) DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function. Cancer Res. 57: 1013-1019
    • (1997) Cancer Res. , vol.57 , pp. 1013-1019
    • Di Leonardo, A.1    Khan, S.H.2    Linke, S.P.3    Greco, V.4    Seidita, G.5    Wahl, G.M.6
  • 51
    • 0029658664 scopus 로고    scopus 로고
    • Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage
    • 51 Minn A. J., Boise L. H. and Thompson C. B. (1996) Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage. Genes Dev. 10: 2621-2631
    • (1996) Genes Dev. , vol.10 , pp. 2621-2631
    • Minn, A.J.1    Boise, L.H.2    Thompson, C.B.3
  • 52
    • 0031931414 scopus 로고    scopus 로고
    • Characterization of the p53-dependent postmitotic checkpoint following spindle disruption
    • 52 Lanni J. S. and Jacks T. (1998) Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol. Cell. Biol. 18: 1055-1064
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1055-1064
    • Lanni, J.S.1    Jacks, T.2
  • 54
    • 0028047723 scopus 로고
    • The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice
    • 54 Merritt A. J., Potten C. S., Kemp C. J., Hickman J. A., Balmain A., Lane D. P. et al. (1994) The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res. 54: 614-617
    • (1994) Cancer Res. , vol.54 , pp. 614-617
    • Merritt, A.J.1    Potten, C.S.2    Kemp, C.J.3    Hickman, J.A.4    Balmain, A.5    Lane, D.P.6
  • 55
    • 0027196547 scopus 로고
    • Control of programmed cell death in normal and leukemic cells: New implications for therapy
    • 55 Sachs L. and Lotem J. (1993) Control of programmed cell death in normal and leukemic cells: new implications for therapy. Blood 82: 15-21
    • (1993) Blood , vol.82 , pp. 15-21
    • Sachs, L.1    Lotem, J.2
  • 56
    • 0028301094 scopus 로고
    • p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation
    • 56 Clarke A. R., Gledhill S., Hooper M. L., Bird C. C. and Wyllie A. H. (1994) p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation. Oncogene 9: 1767-1773
    • (1994) Oncogene , vol.9 , pp. 1767-1773
    • Clarke, A.R.1    Gledhill, S.2    Hooper, M.L.3    Bird, C.C.4    Wyllie, A.H.5
  • 57
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • 57 Lowe S. W., Ruley H. E., Jacks T. and Housman D. E. (1993) p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74: 957-967
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 58
    • 0028849274 scopus 로고
    • p21 is necessary for the p53-mediated G1 arrest in human cancer cells
    • 58 Waldman T., Kinzler K. W. and Vogelstein B. (1995) p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res. 55: 5187-5190
    • (1995) Cancer Res. , vol.55 , pp. 5187-5190
    • Waldman, T.1    Kinzler, K.W.2    Vogelstein, B.3
  • 59
    • 0028978183 scopus 로고
    • Mice lacking p21CIP1/WAFI undergo normal development, but are defective in G1 checkpoint control
    • 59 Deng C., Zhang P., Harper J. W., Elledge S. J. and Leder P. (1995) Mice lacking p21CIP1/WAFI undergo normal development, but are defective in G1 checkpoint control. Cell 82: 675-684
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.W.3    Elledge, S.J.4    Leder, P.5
  • 61
    • 0030609861 scopus 로고    scopus 로고
    • Bypass of senescence after disruption of p21CIP1/WAFI gene in normal diploid human fibroblasts
    • 61 Brown J. P., Wei W., and Sedivy J. M. (1997) Bypass of senescence after disruption of p21CIP1/WAFI gene in normal diploid human fibroblasts. Science 277: 831-834
    • (1997) Science , vol.277 , pp. 831-834
    • Brown, J.P.1    Wei, W.2    Sedivy, J.M.3
  • 62
    • 0030011128 scopus 로고    scopus 로고
    • Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
    • 62 Waldman T., Lengauer C., Kinzler K. W. and Vogelstein B. (1996) Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 381: 713-716
    • (1996) Nature , vol.381 , pp. 713-716
    • Waldman, T.1    Lengauer, C.2    Kinzler, K.W.3    Vogelstein, B.4
  • 65
    • 0028171454 scopus 로고
    • p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents
    • 65 Fan S., el-Deiry W. S., Bae I., Freeman J., Jondle D., Bhatia K. et al. (1994) p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents. Cancer Res. 54: 5824-5830
    • (1994) Cancer Res. , vol.54 , pp. 5824-5830
    • Fan, S.1    El-Deiry, W.S.2    Bae, I.3    Freeman, J.4    Jondle, D.5    Bhatia, K.6
  • 66
    • 0031985148 scopus 로고    scopus 로고
    • Mutation of the p53 gene in human astrocytic tumours correlates with increased resistance to DNA-damaging agents but not to anti-microtubule anti-cancer agents
    • 66 Iwadate Y., Tagawa M., Fujimoto S., Hirose M., Namba H., Sueyoshi K. et al. (1998) Mutation of the p53 gene in human astrocytic tumours correlates with increased resistance to DNA-damaging agents but not to anti-microtubule anti-cancer agents. Br. J. Cancer 77: 547-551
    • (1998) Br. J. Cancer , vol.77 , pp. 547-551
    • Iwadate, Y.1    Tagawa, M.2    Fujimoto, S.3    Hirose, M.4    Namba, H.5    Sueyoshi, K.6
  • 68
    • 0028944890 scopus 로고
    • Altered p53 status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related human lymphoblast lines
    • 68 Xia F., Wang X., Wang Y. H., Tsang N. M., Yandell D. W., Kelsey K. T. et al. (1995) Altered p53 status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related human lymphoblast lines. Cancer Res. 55: 12-15
    • (1995) Cancer Res. , vol.55 , pp. 12-15
    • Xia, F.1    Wang, X.2    Wang, Y.H.3    Tsang, N.M.4    Yandell, D.W.5    Kelsey, K.T.6
  • 69
    • 0028172868 scopus 로고
    • p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies
    • 69 Wattel E., Preudhomme C., Hecquet B., Vanrumbeke M., Quesnel B., Dervite I. et al. (1994) p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies. Blood 84: 3148-3157
    • (1994) Blood , vol.84 , pp. 3148-3157
    • Wattel, E.1    Preudhomme, C.2    Hecquet, B.3    Vanrumbeke, M.4    Quesnel, B.5    Dervite, I.6
  • 70
    • 0031018994 scopus 로고    scopus 로고
    • Relationship of p53, bcl-2 and tumour proliferation to clinical drug resistance in non-Hodgkin's lymphomas
    • 70 Wilson W. H., Teruya-Feldstein J., Fest T., Harris C., Steinberg S. M., Jaffe E. S. et al. (1997) Relationship of p53, bcl-2 and tumour proliferation to clinical drug resistance in non-Hodgkin's lymphomas. Blood 89: 601-609
    • (1997) Blood , vol.89 , pp. 601-609
    • Wilson, W.H.1    Teruya-Feldstein, J.2    Fest, T.3    Harris, C.4    Steinberg, S.M.5    Jaffe, E.S.6
  • 71
    • 0028091651 scopus 로고
    • Clinical significance of p53 mutations in relapsed T-cell acute lymphoblastic leukemia
    • 71 Diccianni M. B., Yu J., Hsiao M., Mukherjee S., Shao L. E. and Yu A. L. (1994) Clinical significance of p53 mutations in relapsed T-cell acute lymphoblastic leukemia. Blood 84: 3105-3112
    • (1994) Blood , vol.84 , pp. 3105-3112
    • Diccianni, M.B.1    Yu, J.2    Hsiao, M.3    Mukherjee, S.4    Shao, L.E.5    Yu, A.L.6
  • 72
    • 0031919283 scopus 로고    scopus 로고
    • p53 protein accumulation and response to adjuvant chemotherapy in premenopausal women with node-negative early breast cancer
    • 72 Clahsen P. C., van de Velde C. J., Duval C., Pallud C., Mandard A. M., Delobelle D. A. et al. (1998) p53 protein accumulation and response to adjuvant chemotherapy in premenopausal women with node-negative early breast cancer. J. Clin. Oncol. 16: 470-479
    • (1998) J. Clin. Oncol. , vol.16 , pp. 470-479
    • Clahsen, P.C.1    Van De Velde, C.J.2    Duval, C.3    Pallud, C.4    Mandard, A.M.5    Delobelle, D.A.6
  • 73
    • 0031982783 scopus 로고    scopus 로고
    • p53 protein accumulation predicts poor response to tamoxifen therapy of patients with recurrent breast cancer
    • 73 Berns E. M., Klijn J. G., van Putten W. L., de Witte H. H., Look M. P., Meijer-van Gelder M. E. et al. (1998) p53 protein accumulation predicts poor response to tamoxifen therapy of patients with recurrent breast cancer. J. Clin. Oncol. 16: 121-127
    • (1998) J. Clin. Oncol. , vol.16 , pp. 121-127
    • Berns, E.M.1    Klijn, J.G.2    Van Putten, W.L.3    De Witte, H.H.4    Look, M.P.5    Meijer-van Gelder, M.E.6
  • 75
    • 0032548879 scopus 로고    scopus 로고
    • No significant predictive value of c-erbB-2 or p53 expression regarding sensitivity to primary chemotherapy or radiotherapy in breast cancer
    • 75 Rozan S., Vincent-Salomon A., Zafrani B., Validire P., De Cremoux P., Bernoux A. et al. (1998) No significant predictive value of c-erbB-2 or p53 expression regarding sensitivity to primary chemotherapy or radiotherapy in breast cancer. Int. J. Cancer 79: 27-33
    • (1998) Int. J. Cancer , vol.79 , pp. 27-33
    • Rozan, S.1    Vincent-Salomon, A.2    Zafrani, B.3    Validire, P.4    De Cremoux, P.5    Bernoux, A.6
  • 76
    • 0032549081 scopus 로고    scopus 로고
    • Bax immunohistochemical expression in breast carcinoma: A study with long term follow-up
    • 76 Veronese S., Mauri F. A., Caffo O., Scaioli M., Aldovini D., Perrone G. et al. (1998) Bax immunohistochemical expression in breast carcinoma: a study with long term follow-up. Int. J. Cancer 79: 13-18
    • (1998) Int. J. Cancer , vol.79 , pp. 13-18
    • Veronese, S.1    Mauri, F.A.2    Caffo, O.3    Scaioli, M.4    Aldovini, D.5    Perrone, G.6
  • 77
    • 0029045784 scopus 로고
    • Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma
    • 77 Krajewski S., Blomqvist C., Franssila K., Krajewska M., Wasenius V. M., Niskanen E. et al. (1995) Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. Cancer Res. 55: 4471-4478
    • (1995) Cancer Res. , vol.55 , pp. 4471-4478
    • Krajewski, S.1    Blomqvist, C.2    Franssila, K.3    Krajewska, M.4    Wasenius, V.M.5    Niskanen, E.6
  • 78
    • 0030843744 scopus 로고    scopus 로고
    • Prognostic significance of apoptosis related proteins Bcl-2 and Bax in node-negative breast cancer patients
    • 78 Kapranos N., Karaiosifidi H., Valavanis C., Kouri E. and Vasilaros S. (1997) Prognostic significance of apoptosis related proteins Bcl-2 and Bax in node-negative breast cancer patients. Anticancer Res. 17: 2499-2505
    • (1997) Anticancer Res. , vol.17 , pp. 2499-2505
    • Kapranos, N.1    Karaiosifidi, H.2    Valavanis, C.3    Kouri, E.4    Vasilaros, S.5
  • 79
    • 0028944271 scopus 로고
    • Expression of the bcl-2 gene family in normal and malignant breast tissue: Low bax-alpha expression in tumor cells correlates with resistance towards apoptosis
    • 79 Bargou R. C., Daniel P. T., Mapara M. Y., Bommert K., Wagener C., Kallinich B. et al. (1995) Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-alpha expression in tumor cells correlates with resistance towards apoptosis. Int. J. Cancer 60: 854-859
    • (1995) Int. J. Cancer , vol.60 , pp. 854-859
    • Bargou, R.C.1    Daniel, P.T.2    Mapara, M.Y.3    Bommert, K.4    Wagener, C.5    Kallinich, B.6
  • 81
    • 8944244998 scopus 로고    scopus 로고
    • Overexpression of bax sensitizes human breast cancer MCF-7 cells to radiation-induced apoptosis
    • 81 Sakakura C., Sweeney E. A., Shirahamu T., Igarashi Y., Hakomori S., Nakatani H. et al. (1996) Overexpression of bax sensitizes human breast cancer MCF-7 cells to radiation-induced apoptosis. Int. J. Cancer 67: 101-105
    • (1996) Int. J. Cancer , vol.67 , pp. 101-105
    • Sakakura, C.1    Sweeney, E.A.2    Shirahamu, T.3    Igarashi, Y.4    Hakomori, S.5    Nakatani, H.6
  • 82
    • 0030062205 scopus 로고    scopus 로고
    • Induction of the death-promoting gene bax-alpha sensitizes cultured breast-cancer cells to drug-induced apoptosis
    • 82 Wagener C., Bargou R. C., Daniel P. T., Bommert K., Mapara M. Y., Royer H. D. et al. (1996) Induction of the death-promoting gene bax-alpha sensitizes cultured breast-cancer cells to drug-induced apoptosis. Int. J. Cancer 67: 138-141
    • (1996) Int. J. Cancer , vol.67 , pp. 138-141
    • Wagener, C.1    Bargou, R.C.2    Daniel, P.T.3    Bommert, K.4    Mapara, M.Y.5    Royer, H.D.6
  • 83
    • 0029899837 scopus 로고    scopus 로고
    • Oddball p53 in testicular tumors
    • 83 Chresta C. M. and Hickman J. A. (1996) Oddball p53 in testicular tumors. Nature Med. 2: 745-746
    • (1996) Nature Med. , vol.2 , pp. 745-746
    • Chresta, C.M.1    Hickman, J.A.2
  • 84
    • 0029929672 scopus 로고    scopus 로고
    • Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax:Bcl-2 ratio
    • 84 Chresta C. M., Masters J. R. and Hickman J. A. (1996) Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax:Bcl-2 ratio. Cancer Res. 56: 1834-1841
    • (1996) Cancer Res. , vol.56 , pp. 1834-1841
    • Chresta, C.M.1    Masters, J.R.2    Hickman, J.A.3
  • 85
    • 0026555717 scopus 로고
    • Modulation of activity of the promoter of the human MDR1 gene by Ras and p53
    • 85 Chin K. V., Ueda K., Pastan I. and Gottesman M. M. (1992) Modulation of activity of the promoter of the human MDR1 gene by Ras and p53. Science 255: 459-462
    • (1992) Science , vol.255 , pp. 459-462
    • Chin, K.V.1    Ueda, K.2    Pastan, I.3    Gottesman, M.M.4
  • 86
    • 0027364051 scopus 로고
    • Relationship between p53 gene mutations and multidrug resistance (mdrl) gene expression in myelodysplastic syndromes
    • 86 Preudhomme C., Lepelley P., Vachee A., Soenen V., Quesnel B., Cosson A. et al. (1993) Relationship between p53 gene mutations and multidrug resistance (mdrl) gene expression in myelodysplastic syndromes. Leukemia 7: 1888-1890
    • (1993) Leukemia , vol.7 , pp. 1888-1890
    • Preudhomme, C.1    Lepelley, P.2    Vachee, A.3    Soenen, V.4    Quesnel, B.5    Cosson, A.6
  • 88
    • 0028910555 scopus 로고
    • The mutational status of p53 protein in gastric and esophageal adenocarcinoma cell lines predicts sensitivity to chemotherapeutic agents
    • 88 Nabeya Y., Loganzo F. Jr., Maslak P., Lai L., de Oliveira A. R., Schwartz G. K. et al. (1995) The mutational status of p53 protein in gastric and esophageal adenocarcinoma cell lines predicts sensitivity to chemotherapeutic agents. Int. J. Cancer 64: 37-46
    • (1995) Int. J. Cancer , vol.64 , pp. 37-46
    • Nabeya, Y.1    Loganzo F., Jr.2    Maslak, P.3    Lai, L.4    De Oliveira, A.R.5    Schwartz, G.K.6
  • 89
    • 0027421045 scopus 로고
    • Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines
    • 89 O'Connor P. M., Jackman J., Jondle D., Bhatia K., Magrath I. and Kohn K. W. (1993) Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines. Cancer Res. 53: 4776-4780
    • (1993) Cancer Res. , vol.53 , pp. 4776-4780
    • O'Connor, P.M.1    Jackman, J.2    Jondle, D.3    Bhatia, K.4    Magrath, I.5    Kohn, K.W.6
  • 90
    • 0028069906 scopus 로고
    • Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus
    • 90 Liu T. J., Zhang W. W., Taylor D. L., Roth J. A., Goepfert H. and Clayman G. L. (1994) Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus. Cancer Res. 54: 3662-3667
    • (1994) Cancer Res. , vol.54 , pp. 3662-3667
    • Liu, T.J.1    Zhang, W.W.2    Taylor, D.L.3    Roth, J.A.4    Goepfert, H.5    Clayman, G.L.6
  • 91
    • 9544244796 scopus 로고    scopus 로고
    • Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer
    • 91 Roth J. A., Nguyen D., Lawrence D. D., Kemp B. L., Carrasco C. H., Ferson D. Z. et al. (1996) Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nature Med. 2: 985-991
    • (1996) Nature Med. , vol.2 , pp. 985-991
    • Roth, J.A.1    Nguyen, D.2    Lawrence, D.D.3    Kemp, B.L.4    Carrasco, C.H.5    Ferson, D.Z.6
  • 92
    • 0030783796 scopus 로고    scopus 로고
    • p53 nuclear immunoreactivity as a predictor of response and outcome following chemotherapy for metastatic bladder cancer
    • 92 Sengelov L., Horn T. and Steven K. (1997) p53 nuclear immunoreactivity as a predictor of response and outcome following chemotherapy for metastatic bladder cancer. J. Cancer Res. Clin. Oncol. 123: 565-570
    • (1997) J. Cancer Res. Clin. Oncol. , vol.123 , pp. 565-570
    • Sengelov, L.1    Horn, T.2    Steven, K.3
  • 95
    • 0027054864 scopus 로고
    • Immunohistochemical detection of mutant p53-suppressor gene product in patients with breast cancer: Influence on metastasis-free survival
    • 95 Hanzal E., Gitsch G., Kohlberger P., Dadak C., Miechowiecka N. and Breitenecker G. (1992) Immunohistochemical detection of mutant p53-suppressor gene product in patients with breast cancer: influence on metastasis-free survival. Anticancer Res. 12: 2325-2329
    • (1992) Anticancer Res. , vol.12 , pp. 2325-2329
    • Hanzal, E.1    Gitsch, G.2    Kohlberger, P.3    Dadak, C.4    Miechowiecka, N.5    Breitenecker, G.6
  • 96
    • 0025802994 scopus 로고
    • p53 expression in human breast cancer related to survival and prognostic factors: An immunohistochemical study
    • 96 Ostrowski J. L., Sawan A., Henry L., Wright C., Henry J. A., Hennessy C. et al. (1991) p53 expression in human breast cancer related to survival and prognostic factors: an immunohistochemical study. J. Pathol. 164: 75-81
    • (1991) J. Pathol. , vol.164 , pp. 75-81
    • Ostrowski, J.L.1    Sawan, A.2    Henry, L.3    Wright, C.4    Henry, J.A.5    Hennessy, C.6
  • 97
    • 0031564954 scopus 로고    scopus 로고
    • p73 is a human p53-related protein that can induce apoptosis
    • 97 Jost C. A., Murin M. C. and Kaelin W. J. (1997) p73 is a human p53-related protein that can induce apoptosis. Nature 389: 191-194
    • (1997) Nature , vol.389 , pp. 191-194
    • Jost, C.A.1    Murin, M.C.2    Kaelin, W.J.3
  • 98
    • 0030812331 scopus 로고    scopus 로고
    • Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
    • 98 Kaghad M., Bonnet H., Yang A., Creancier L., Biscan J. C., Valent A. et al. (1997) Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 90: 809-819
    • (1997) Cell , vol.90 , pp. 809-819
    • Kaghad, M.1    Bonnet, H.2    Yang, A.3    Creancier, L.4    Biscan, J.C.5    Valent, A.6
  • 99
    • 0031464286 scopus 로고    scopus 로고
    • p53CP, a putative p53 competing protein that specifically binds to the consensus p53 DNA binding sites: A third member of the p53 family?
    • 99 Bian J. and Sun Y. (1997) p53CP, a putative p53 competing protein that specifically binds to the consensus p53 DNA binding sites: a third member of the p53 family? Proc. Natl. Acad. Sci. USA 94: 14753-14758
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 14753-14758
    • Bian, J.1    Sun, Y.2
  • 101
    • 0029857892 scopus 로고    scopus 로고
    • DNA sequence analysis of exons 2 through 11 and immunohistochemical staining are required to detect all known p53 alterations in human malignancies
    • 101 Casey G., Lopez M. E., Ramos J. C., Plummer S. J., Arboleda M. J., Shaughnessy M. et al. (1996) DNA sequence analysis of exons 2 through 11 and immunohistochemical staining are required to detect all known p53 alterations in human malignancies. Oncogene 13: 1971-1981
    • (1996) Oncogene , vol.13 , pp. 1971-1981
    • Casey, G.1    Lopez, M.E.2    Ramos, J.C.3    Plummer, S.J.4    Arboleda, M.J.5    Shaughnessy, M.6
  • 102
    • 0028346606 scopus 로고
    • p53 immunohistochemical analysis in breast cancer with four monoclonal antibodies: Comparison of staining and PCR-SSCP results
    • 102 Jacquemier J., Moles J. P., Penault-Llorca F., Adelaide J., Torrente M., Viens P. et al. (1994) p53 immunohistochemical analysis in breast cancer with four monoclonal antibodies: comparison of staining and PCR-SSCP results. Br. J. Cancer 69: 846-852
    • (1994) Br. J. Cancer , vol.69 , pp. 846-852
    • Jacquemier, J.1    Moles, J.P.2    Penault-Llorca, F.3    Adelaide, J.4    Torrente, M.5    Viens, P.6
  • 103
    • 0026632997 scopus 로고
    • Abnormal expression of wild type p53 protein in normal cells of a cancer family patient
    • 103 Barnes D. M., Hanby A. M., Gillett C. E., Mohammed S., Hodgson S., Bobrow L. G. et al. (1992) Abnormal expression of wild type p53 protein in normal cells of a cancer family patient. Lancet 340: 259-263
    • (1992) Lancet , vol.340 , pp. 259-263
    • Barnes, D.M.1    Hanby, A.M.2    Gillett, C.E.3    Mohammed, S.4    Hodgson, S.5    Bobrow, L.G.6
  • 104
    • 0030058617 scopus 로고    scopus 로고
    • The p53 gene in breast cancer: Prognostic value of complementary DNA sequencing versus immunohistochemistry
    • 104 Sjogren S., Inganas M., Norberg T., Lindgren A., Nordgren H., Holmberg L. et al. (1996) The p53 gene in breast cancer: prognostic value of complementary DNA sequencing versus immunohistochemistry. J. Natl. Cancer Inst. 88: 173-182
    • (1996) J. Natl. Cancer Inst. , vol.88 , pp. 173-182
    • Sjogren, S.1    Inganas, M.2    Norberg, T.3    Lindgren, A.4    Nordgren, H.5    Holmberg, L.6
  • 106
    • 0028071555 scopus 로고
    • Mutations in the p53 tumour suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • 106 Greenblatt M. S., Bennett W. P., Hollstein M. and Harris C. C. (1994) Mutations in the p53 tumour suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. 54: 4855-4878
    • (1994) Cancer Res. , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 107
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • 107 Fearon E. R. and Vogelstein B. (1990) A genetic model for colorectal tumorigenesis. Cell 61: 759-767
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 108
    • 0027283604 scopus 로고
    • Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents
    • 108 Lotem J. and Sachs L. (1993) Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents. Blood 82: 1092-1096
    • (1993) Blood , vol.82 , pp. 1092-1096
    • Lotem, J.1    Sachs, L.2
  • 109
    • 0029810442 scopus 로고    scopus 로고
    • Prognosis is correlated with p53 mutation type for soft tissue sarcoma patients
    • 109 Taubert H., Meye A. and Wurl P. (1996) Prognosis is correlated with p53 mutation type for soft tissue sarcoma patients. Cancer Res. 56: 4134-4136
    • (1996) Cancer Res. , vol.56 , pp. 4134-4136
    • Taubert, H.1    Meye, A.2    Wurl, P.3
  • 110
    • 8244225811 scopus 로고    scopus 로고
    • p53 exon 5 mutations as a prognostic indicator of shortened survival in non-small-cell lung cancer
    • 110 Vega F. J., Iniesta P., Caldes T., Sanchez A., Lopez J. A., de Juan C. et al. (1997) p53 exon 5 mutations as a prognostic indicator of shortened survival in non-small-cell lung cancer. Br. J. Cancer 76: 44-51
    • (1997) Br. J. Cancer , vol.76 , pp. 44-51
    • Vega, F.J.1    Iniesta, P.2    Caldes, T.3    Sanchez, A.4    Lopez, J.A.5    De Juan, C.6
  • 111
    • 0028901763 scopus 로고
    • Clinical significance of p53 mutations in newly diagnosed Burkitt's lymphoma and acute lymphoblastic leukemia: A report of 48 cases
    • 111 Preudhomme C., Dervite I., Wattel E., Vanrumbeke M., Flactif M., Lai J. L. et al. (1995) Clinical significance of p53 mutations in newly diagnosed Burkitt's lymphoma and acute lymphoblastic leukemia: a report of 48 cases. J. Clin. Oncol. 13: 812-820
    • (1995) J. Clin. Oncol. , vol.13 , pp. 812-820
    • Preudhomme, C.1    Dervite, I.2    Wattel, E.3    Vanrumbeke, M.4    Flactif, M.5    Lai, J.L.6
  • 115
    • 0031398767 scopus 로고    scopus 로고
    • Prognostic factors in astrocytomas: Relationship of p53, MDM-2, BCL-2 and PCNA immunohistochemical expression to tumor grade and overall patient survival
    • 115 Ehrmann J. J., Kolar Z., Vojtesek B., Kala M., Komenda S. and Oulton A. (1997) Prognostic factors in astrocytomas: relationship of p53, MDM-2, BCL-2 and PCNA immunohistochemical expression to tumor grade and overall patient survival. Neoplasma 44: 299-304
    • (1997) Neoplasma , vol.44 , pp. 299-304
    • Ehrmann, J.J.1    Kolar, Z.2    Vojtesek, B.3    Kala, M.4    Komenda, S.5    Oulton, A.6
  • 116
    • 0030667191 scopus 로고    scopus 로고
    • p21/waf1/cip1 and mdm-2 expression in breast carcinoma patients as related to prognosis
    • 116 Jiang M., Shao Z. M., Wu J., Lu J. S., Yu L. M., Yuan J. D. et al. (1997) p21/waf1/cip1 and mdm-2 expression in breast carcinoma patients as related to prognosis. Int. J. Cancer 74: 529-534
    • (1997) Int. J. Cancer , vol.74 , pp. 529-534
    • Jiang, M.1    Shao, Z.M.2    Wu, J.3    Lu, J.S.4    Yu, L.M.5    Yuan, J.D.6
  • 118
    • 0028937653 scopus 로고
    • Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene
    • 118 Zhou M., Yeager A. M., Smith S. D. and Findley H. W. (1995) Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene. Blood 85: 1608-1614
    • (1995) Blood , vol.85 , pp. 1608-1614
    • Zhou, M.1    Yeager, A.M.2    Smith, S.D.3    Findley, H.W.4
  • 119
    • 0026425686 scopus 로고
    • Role of the human papillomaviruses in human cancer
    • 119 Howley P. M. (1991) Role of the human papillomaviruses in human cancer. Cancer Res. 51: 5019s-5022s
    • (1991) Cancer Res. , vol.51
    • Howley, P.M.1
  • 121
    • 0030728468 scopus 로고    scopus 로고
    • Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
    • 121 Kamijo T., Zindy F., Roussel M. F., Quelle D. E., Downing J. R., Ashmun R. A. et al. (1997) Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91: 649-659
    • (1997) Cell , vol.91 , pp. 649-659
    • Kamijo, T.1    Zindy, F.2    Roussel, M.F.3    Quelle, D.E.4    Downing, J.R.5    Ashmun, R.A.6
  • 122
    • 0032191393 scopus 로고    scopus 로고
    • Tumor surveillance via the ARG-p53 pathway
    • 122 Sherr C. (1998) Tumor surveillance via the ARG-p53 pathway. Genes Dev. 12: 2984-2991
    • (1998) Genes Dev. , vol.12 , pp. 2984-2991
    • Sherr, C.1
  • 124
    • 0031018674 scopus 로고    scopus 로고
    • Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
    • 124 Rampino N., Yamamoto H., Ionov Y., Li Y., Sawai H., Reed J. C. et al. (1997) Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 275: 967-969
    • (1997) Science , vol.275 , pp. 967-969
    • Rampino, N.1    Yamamoto, H.2    Ionov, Y.3    Li, Y.4    Sawai, H.5    Reed, J.C.6
  • 125
    • 0032032682 scopus 로고    scopus 로고
    • Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer
    • 125 Yamamoto H., Sawai H., Weber T. K., Rodriguez B. M. and Perucho M. (1998) Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer. Cancer Res. 58: 997-1003
    • (1998) Cancer Res. , vol.58 , pp. 997-1003
    • Yamamoto, H.1    Sawai, H.2    Weber, T.K.3    Rodriguez, B.M.4    Perucho, M.5
  • 126
    • 0030938089 scopus 로고    scopus 로고
    • Bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis
    • 126 McCurrach M. E., Connor T. M., Knudson C. M., Korsmeyer S. J. and Lowe S. W. (1997) bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. Proc. Natl. Acad. Sci. USA 94: 2345-2349
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2345-2349
    • McCurrach, M.E.1    Connor, T.M.2    Knudson, C.M.3    Korsmeyer, S.J.4    Lowe, S.W.5
  • 127
    • 0028210781 scopus 로고
    • Detection of oncogene mutations in sputum precedes diagnosis of lung cancer
    • 127 Mao L., Hruban R. H., Boyle J. O., Tockman M. and Sidransky D. (1994) Detection of oncogene mutations in sputum precedes diagnosis of lung cancer. Cancer Res. 54: 1634-1637
    • (1994) Cancer Res. , vol.54 , pp. 1634-1637
    • Mao, L.1    Hruban, R.H.2    Boyle, J.O.3    Tockman, M.4    Sidransky, D.5
  • 129
    • 0027981340 scopus 로고
    • Prevalence of serum antibodies against the p53 tumor suppressor gene protein in various cancers
    • 129 Angelopoulou K., Diamandis E. P., Sutherland D. J., Kellen J. A. and Bunting P. S. (1994) Prevalence of serum antibodies against the p53 tumor suppressor gene protein in various cancers. Int. J. Cancer 58: 480-487
    • (1994) Int. J. Cancer , vol.58 , pp. 480-487
    • Angelopoulou, K.1    Diamandis, E.P.2    Sutherland, D.J.3    Kellen, J.A.4    Bunting, P.S.5
  • 131
    • 0026523778 scopus 로고
    • Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line
    • 131 Shaw P., Bovey R., Tardy S., Sahli R., Sordat B. and Costa J. (1992) Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc. Natl. Acad. Sci. USA 89: 4495-4499
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 4495-4499
    • Shaw, P.1    Bovey, R.2    Tardy, S.3    Sahli, R.4    Sordat, B.5    Costa, J.6
  • 132
    • 0028143201 scopus 로고
    • Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model
    • 132 Fujiwara T., Cai D. W., Georges R. N., Mukhopadhyay T., Grimm E. A. and Roth J. A. (1994) Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model. J. Natl. Cancer Inst. 86: 1458-1462
    • (1994) J. Natl. Cancer Inst. , vol.86 , pp. 1458-1462
    • Fujiwara, T.1    Cai, D.W.2    Georges, R.N.3    Mukhopadhyay, T.4    Grimm, E.A.5    Roth, J.A.6
  • 133
    • 0028519273 scopus 로고
    • Allosteric activation of latent p53 tetramers
    • 133 Hupp T. R. and Lane D. P. (1994) Allosteric activation of latent p53 tetramers. Curr. Biol. 4: 865-875
    • (1994) Curr. Biol. , vol.4 , pp. 865-875
    • Hupp, T.R.1    Lane, D.P.2
  • 134
    • 0030961889 scopus 로고    scopus 로고
    • Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain
    • 134 Selivanova G., Iotsova V., Okan I., Fritsche M., Strom M., Groner B. et al. (1997) Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain. Nature Med. 3: 632-638
    • (1997) Nature Med. , vol.3 , pp. 632-638
    • Selivanova, G.1    Iotsova, V.2    Okan, I.3    Fritsche, M.4    Strom, M.5    Groner, B.6
  • 135
    • 0030865104 scopus 로고    scopus 로고
    • Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents
    • 135 O'Connor P. M., Jackman J., Bae I., Myers T. G., Fan S., Mutoh M. et al. (1997) Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. Cancer Res. 57: 4285-4300
    • (1997) Cancer Res. , vol.57 , pp. 4285-4300
    • O'Connor, P.M.1    Jackman, J.2    Bae, I.3    Myers, T.G.4    Fan, S.5    Mutoh, M.6
  • 137
    • 0030322318 scopus 로고    scopus 로고
    • IL-12 and mutant P53 peptide-pulsed dendritic cells for the specific immunotherapy of cancer
    • 137 Gabrilovich D. I., Cunningham H. T. and Carbone D. P. (1996) IL-12 and mutant P53 peptide-pulsed dendritic cells for the specific immunotherapy of cancer. J. Immunother. Emphasis Tumor Immunol. 19: 414-418
    • (1996) J. Immunother. Emphasis Tumor Immunol. , vol.19 , pp. 414-418
    • Gabrilovich, D.I.1    Cunningham, H.T.2    Carbone, D.P.3
  • 139
    • 0031006629 scopus 로고    scopus 로고
    • Progress of the smart bomb cancer virus
    • 139 Lowe S. W. (1997) Progress of the smart bomb cancer virus. Nature Med. 3: 606-608
    • (1997) Nature Med. , vol.3 , pp. 606-608
    • Lowe, S.W.1
  • 140
    • 0030917202 scopus 로고    scopus 로고
    • ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents
    • 140 Heise C., Sampson-Johannes A., Williams A., McCormick F., Von Hoff D. D. and Kirn D. H. (1997) ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nature Med. 3: 639-645
    • (1997) Nature Med. , vol.3 , pp. 639-645
    • Heise, C.1    Sampson-Johannes, A.2    Williams, A.3    McCormick, F.4    Von Hoff, D.D.5    Kirn, D.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.