Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: Reduction in protective apoptotic response at the preneoplastic stage

EMBO Journal

Volumn 18, Issue 10, 1999, Pages 2692-2701

  Shibata, Masa Aki ^a   Liu, Min Ling ^a   Knudson, Michael C ^b   Shibata, Eiko ^a   Yoshidome, Katsuhide ^a   Bandey, Tabassum ^c   Korsmeyer, Stanley J ^b   Green, Jeffrey E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b HARVARD UNIVERSITY   (United States)

^c SAIC FREDERICK INC   (United States)

Author keywords

Apoptosis; bax; Cell death; Mammary gland; Transgenic mice; Tumor progression

Indexed keywords

PROTEIN BAX; VIRUS LARGE T ANTIGEN;

ALLELE; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BREAST TUMOR; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENOTYPE; HAPLOIDY; INVASIVE CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENE; TRANSGENIC MOUSE; TUMOR GROWTH;

ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BREAST NEOPLASMS; CELL DIVISION; GENE DOSAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOTYPE; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; MUTATION; PLOIDIES; PRECANCEROUS CONDITIONS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MUS MUSCULUS;

EID: 0033577766     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.10.2692     Document Type: Article

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