A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

Science

Volumn 285, Issue 5434, 1999, Pages 1733-1737

  Komarov, Pavel G ^a,b   Komarova, Elena A ^a   Kondratov, Roman V ^a,d   Christov Tselkov, Konstantin ^a   Coon, John S ^b   Chernov, Mikhail V ^c   Gudkov, Andrei V ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d Quark Biotech Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; PIFITHRIN ALPHA; PROTEIN INHIBITOR; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER RADIOTHERAPY; CANCER THERAPY; CELL FUNCTION; DRUG INDUCED DISEASE; DRUG MECHANISM; GENOTOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOTHIAZOLES; CELL DIVISION; CELL LINE; CELL NUCLEUS; CYTOPLASM; DNA; DNA DAMAGE; G2 PHASE; GAMMA RAYS; HUMANS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, NUDE; NEOPLASMS; RADIATION TOLERANCE; THIAZOLES; TIME FACTORS; TOLUENE; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

ANIMALIA;

EID: 0033543728     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.285.5434.1733     Document Type: Article

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35. We thank A. Polinsky for his generous help and R. Davidson for helpful comments on the manuscript. Supported in part by grants from NIH (CA75179 and CA60730) and Quark Biotech.