Essential role of CED-4 oligomerization in CED-3 activation and apoptosis

Science

Volumn 281, Issue 5381, 1998, Pages 1355-1357

  Yang, Xiaolu ^a,c   Chang, Howard Y ^a   Baltimore, David ^a,b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CED 4 PROTEIN; CED 9 PROTEIN; CYSTEINE PROTEINASE; PROTEIN BCL 2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CAENORHABDITIS ELEGANS; ENZYME ACTIVATION; GENE MUTATION; HUMAN; HUMAN CELL; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN FAMILY;

CAENORHABDITIS ELEGANS;

EID: 0032575723     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.281.5381.1355     Document Type: Article

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27. We thank F. Chen and H. R. Horvitz for reagents and discussions, P. Svec and A. Darbinian for technical support, and V. M. Dixit, M. Gilman, S. L. Schreiber, and X. Wang for reagents. Supported by the Leukemia Society of America (to X.Y.), the Medical Scientist Training Program (to H.Y.C.), and NIH grant CA51462.