bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 6, 1997, Pages 2345-2349

  Mccurrach, Mila E ^a   Connor, Thomas M F ^a   Knudson, C Michael ^b   Korsmeyer, Stanley J ^b   Lowe, Scott W ^a  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ANIMAL CELL; APOPTOSIS; ARTICLE; CHEMOSENSITIVITY; DRUG RESISTANCE; EMBRYO; EMBRYO CELL; FIBROBLAST; GENE EXPRESSION REGULATION; GROWTH STIMULATION; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CISPLATIN; CROSSES, GENETIC; DOXORUBICIN; DRUG RESISTANCE; EMBRYO; ETOPOSIDE; FIBROBLASTS; GENES, P53; MICE; MICE, KNOCKOUT; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINATION, GENETIC; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0030938089     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.6.2345     Document Type: Article

References (27)

1. Elrouby, S., Thomas, A., Costin, D., Rosenberg, C. R., Potmesil, M., Silber, R. & Newcomb, E. W. (1993) Blood 82, 3452-3459.
2. Wattel, E., Preudhomme, C., Hecquet, B., Vanrumbeke, M., Quesnel, B., Dervite, I., Morel, P. & Fenaux, P. (1994) Blood 84, 3148-3157.
3. Bergh, J., Norberg, T., Sjogren, S., Lindgren, A. & Holmberg, L. (1995) Nat. Med. 1, 1029-1034.
4. Aas, T., Borresen, A., Geisler, S., Smith-Sorrensen, B., Johnsen, H., Varhaug, J. E., Akslen, L. A. & Lonning, P. E. (1996) Nat. Med. 2, 811-814.
5. Righetti, S. C., Della Torre, G., Pilotti, S., Menard, S., Ottone, F., Colnaghi, M. I., Pierotti, M. A., Lavarino, C., Cornarotti, M., Oriana, S., Bohm, S., Bresciani, G. L., Spatti, G. & Zunino, F. (1996) Cancer Res. 56, 689-693.
6. Lowe, S. W. (1995) Curr. Opin. Oncol. 7, 547-553.
7. Lowe, S. W., Ruley, H. E., Jacks, T. & Housman, D. E. (1993) Cell 74, 954-967.
8. Lowe, S. W., Bodis, S., McClatchey, A., Remington, L., Ruley, H. E., Fisher, D., Housman, D. E. & Jacks, T. (1994) Science 266, 807-810.
9. Fan, S. J., Eldeiry, W. S., Bae, I., Freeman, J., Jondle, D., Bhatia, K., Fornace, A. J., Magrath, I., Kohn, K. W. & O'Connor, P. M. (1994) Cancer Res. 54, 5824-5830.
10. Fujiwara, T., Grimm, E. A., Mukhopadhyay, T., Zhang, W. W., Owenschaub, L. B. & Roth, J. A. (1994) Cancer Res. 54, 2287-2291.
11. Ko, L. J. & Prives, C. (1996) Genes Dev. 10, 1054-1072.
12. Oltvai, Z. N., Milliman, C. L. & Korsmeyer, S. J. (1993) Cell 74, 609-619.
13. Selvakumaran, M., Lin, H. K., Miyashita, T., Wang, H. G., Krajewski, S., Reed, J. C., Hoffman, B. & Liebermann, D. (1994) Oncogene 9, 1791-1798.
14. Miyashita, T., Krajewski, S., Krajewska, M., Wang, H. G., Lin, H. K., Liebermann, D. A., Hoffman, B. & Reed, J. C. (1994) Oncogene 9, 1799-1805.
15. Han, J., Sabbatini, P., Perez, D., Rao, L., Modha, D. & White, E. (1996) Genes Dev. 10, 461-477.
16. Miyashita, T. & Reed, J. C. (1995) Cell 80, 293-299.
17. Knudson, C. M., Tung, K. S., Tourtellotte, W. G., Brown, G. A. & Korsmeyer, S. J. (1995) Science 270, 96-99.
18. Jacks, T., Remington, L., Williams, B. O., Schmitt, E. M., Halachmi, S., Bronson, R. T. & Weinberg, R. A. (1994) Curr. Biol. 4, 1-7.
19. Pear, W. S., Nolan, G. P., Scott, M. L. & Baltimore, D. (1993) Proc. Natl. Acad. Sci. USA 90, 8392-8396.
20. Andree, H. A., Reutelingsperger, C. P., Hauptmann, R., Hemker, H. C., Hermens, W. T. & Willems, G. M. (1990) J. Biol. Chem. 265, 4923-4928.
21. Lowe, S. W. & Ruley, H. E. (1993) Genes Dev. 7, 535-545.
22. Lowe, S. W., Jacks, T., Housman, D. E. & Ruley, H. E. (1994) Proc. Natl. Acad. Sci. USA 91, 2026-2030.
23. Chiou, S. K., Rao, L. & White, E. (1994) Mol. Cell. Biol. 14, 2556-2563.
24. Debbas, M. & White, E. (1993) Genes Dev. 7, 546-554.
25. Krajewski, S., Blomqvist, C., Franssila, K., Krajewska, M., Wasenius, V. M., Niskanen, E., Nordling, S. & Reed, J. C. (1995) Cancer Res. 55, 4471-4478.
26. Deng, C., Zhang, P., Harper, J. W., Elledge, S. J. & Leder, P. (1995) Cell 82, 675-684.
27. Brugarolas, J., Chandrasekaran, C., Gordon, J. I., Beach, D., Jacks, T. & Hannen, G. J. (1995) Nature (London) 377, 552-557.